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In the domain of Chinese clinical medical question-answering (QA), traditional Large Language Models (LLMs) encounter challenges such as hallucinations and difficulties in updating knowledge for knowledge-intensive tasks. To address these issues, this research presents a Chinese clinical medical QA model that integrates Retrieval-Augmented Generation (RAG) and a medical knowledge graph, named CMedRAGBot. First, a Chinese medical knowledge graph encompassing multiple entity types-including diseases, medications, and symptoms-is constructed. Based on this knowledge graph, a Named Entity Recognition (NER) model built on a Chinese-RoBERTa and BiGRU architecture is designed, with data augmentation strategies employed to enhance its generalization capability. In addition, prompt engineering techniques are used to implement intent recognition for user queries, mapping them to predefined intent categories. Finally, the aforementioned modules are integrated to form a complete Chinese clinical medical QA system. In the experimental evaluation, CMedRAGBot is deployed on five state-of-the-art LLMs (including ChatGPT-4o, ChatGPT-o1, DeepSeek-R1, Llama-3.3-70B-Instruct, and Gemini 2.0 Flash) and tested using specialized question banks derived from the Chinese Clinical Medical Qualification Examinations and Residency Standardization Training Examinations from 2000 to 2023. The results indicate that the integration of CMedRAGBot significantly improves the test accuracy of all models, with increases of up to approximately 10%. Furthermore, ablation experiments reveal that data augmentation enhances NER model's F1 score from 95.27% to 97.55%, while the inclusion of an intent recognition module markedly improves the model's ability to understand complex queries, thereby further boosting answer accuracy. Source code of the research is available at https://github.com/zhdongfang/CMedRAGBot .
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http://dx.doi.org/10.1007/s12539-025-00715-5 | DOI Listing |
Adv Sci (Weinh)
September 2025
Department of Orthodontics, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key
Clear aligners offer aesthetic and comfort advantages in orthodontics, yet their ability to deliver effective forces relies heavily on empirical judgment or large-scale optical scanning, lacking real-time quantitative evaluation. Integrating pressure sensors into aligners is a promising solution, but challenges in miniaturization, multi-dimensional sensing, measurement accuracy, and biocompatibility hinder clinical application. Here, an all-in-one Orthodontic Force Acquisition System (OFAS) is presented that enables real-time, 3D force monitoring using a cross-shaped iontronic sensing array and an origami-inspired, wireless battery-free readout circuit miniaturized for single-tooth placement.
View Article and Find Full Text PDFFood Funct
September 2025
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
: The therapeutic potential of vegetarian diets in metabolic dysfunction-associated steatotic liver disease (MASLD) remains understudied in Asian populations. This randomized controlled trial aimed to evaluate the effects of a culturally adapted 6-month lacto-ovo-vegetarian diet (LOV-D) on hepatic steatosis and cardiometabolic risk factors through weight loss. : In this randomized trial, 220 Chinese adults with MASLD were assigned to LOV-D ( = 110) or an omnivore diet ( = 110) for 6 months.
View Article and Find Full Text PDFZhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Nephropathy and Rheumatology, Third Xiangya Hospital, Central South University, Changsha 410013.
Dent disease is a rare X-linked recessive inherited renal tubular disorder characterized by low molecular weight proteinuria (LMWP), hypercalciuria, nephrocalcinosis, and other clinical features, and can lead to progressive renal failure. It is primarily caused by mutations in the gene. This article reports the case of a 10-year-old male patient of Chinese descent who was incidentally found to have asymptomatic proteinuria during a routine health examination.
View Article and Find Full Text PDFZhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Maxillofacial Surgery, Xiangya Hospital of Stomatology, Central South University, Changsha 410013, China.
Peptide-based drugs possess several advantages, including high specificity, low immunogenicity, minimal accumulation, and fewer drug-drug interactions, making them a novel and efficient therapeutic class for various diseases. In recent years, peptide-based drugs have shown great potential and broad application prospects in the treatment of oral infectious diseases, tissue injury and repair, tumors, and complex oral mucosal disorders, acting either through direct mechanisms or indirect modulation. Oral administration remains the preferred route due to its non-invasive, painless nature and ease of management; however, gastrointestinal pH can inactivate or even degrade peptide drugs.
View Article and Find Full Text PDFZhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Outpatient, Third Xiangya Hospital, Central South University, Changsha 410013.
Objectives: Urinary calculi are characterized by a high recurrence rate, and patients' adherence to self-management after discharge directly affects health outcomes. Traditional offline follow-up models often face problems such as poor compliance and uneven allocation of medical resources, making it difficult to meet individualized health management needs. Remote follow-up provides a novel solution to optimize long-term management, improve health literacy, and enhance clinical outcomes.
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