Impact of remote follow-up under an intelligent medical collaboration model on health promotion and clinical outcomes in patients with urinary calculi.

Objectives: Urinary calculi are characterized by a high recurrence rate, and patients' adherence to self-management after discharge directly affects health outcomes. Traditional offline follow-up models often face problems such as poor compliance and uneven allocation of medical resources, making it difficult to meet individualized health management needs. Remote follow-up provides a novel solution to optimize long-term management, improve health literacy, and enhance clinical outcomes.

Sunflower Enhances Photosynthesis, Grain Yields, and Stress Tolerance of Rice.

GOLDEN2-LIKEs (GLKs) are important transcription factors for the chloroplast development influencing photosynthesis, nutrition, senescence, and stress response in plants. Sunflower () is a highly photosynthetic plant; here, a -homologues gene was identified from the sunflower genome by bioinformatics. To analyze the bio-function of , transgenic rice plants overexpressing () were constructed and characterized via phenotype.

Dissected MACl Involved Reaction Pathway for Low Temperature Fabrication of High-Efficiency Flexible Perovskite Solar Cells.

FAPbI-based perovskite solar cells (PVSCs) are highly promising due to their excellent power conversion efficiency (PCE). However, the formation of stable α-FAPbI requires annealing at a temperature of at least 150 °C, which can induce significant residual stress and make the process incompatible with plastic substrates, resulting in poor crystal quality and compromised mechanical properties. To address these issues, we present a novel approach using methylammonium chloride (MACl) vapor-assisted lead iodide (PbI) to form homogeneous intermediate phases (MAPbCl and PbI).

Exacerbations, mortality risk, and pharmacotherapy in COPD: Effect of 17 different drug combinations in a cohort of 495 patients.

Objective: To assess the association between the severity of recent exacerbations and 90-day mortality risk in chronic obstructive pulmonary disease patients (COPD) with acute symptoms, focusing on the impact of the treatment regimen and involving 17 different drug combinations.

Materials And Methods: A longitudinal, retrospective analysis was carried out in 495 hospitalized COPD patients aged 40 - 75 years. Patients' clinical characteristics were recorded and the effects of drug regimens, administered pre and post hospitalization, comprising various combinations of long-acting muscarinic antagonists (LAMA), long-acting beta agonists (LABA), inhaled corticosteroids (ICS), and antibiotics, were compared.

Deciphering Immunosenescence From Child to Frailty: Transcriptional Changes, Inflammation Dynamics, and Adaptive Immune Alterations.

Aging induces significant alterations in the immune system, with immunosenescence contributing to age-related diseases. Peripheral blood mononuclear cells (PBMCs) offer a convenient and comprehensive snapshot of the body's immune status. In this study, we performed an integrated analysis of PBMCs using both bulk-cell and single-cell RNA-seq data, spanning from children to frail elderlies, to investigate age-related changes.

Online Graph Models: Tackling the Challenges of Non-Gaussian Noise in Adaptive Filtering.

Adaptive filtering faces significant challenges in handling complex non-Gaussian noise, while graph signal processing (GSP) excels at processing data with intricate structures. This brief introduces a novel method for solving non-Gaussian noise from the perspective of the graph domain for the first time. Specifically, we develop an online time-varying graph model based on the filter error signal and propose a corresponding graph topology transformation strategy.

Risk Analysis of Atrial Fibrillation Based on ECG Phenotypes: The RAF-ECP Study Protocol.

Atrial fibrillation (AF) is the most common supraventricular arrhythmia in clinical practice, and many patients exhibit silent AF. Variables based on Electrocardiogram (ECG) have shown promise in assessing AF risk in the previous study. This study protocol proposes a systematic approach, named RAF-ECP, to evaluate the role of ECG phenotypes in assessing the risk of AF.

Enteric GABAergic neuron-derived γ-aminobutyric acid initiates expression of Igfbp7 to sustain ILC3 homeostasis.

Neuronal signals have emerged as critical factors that regulate group 3 innate lymphoid cell (ILC3) response and tissue homeostasis, but the molecular mechanisms underlying this regulation remain largely elusive. Here, we identified that the enteric GABAergic neuron-derived neurotransmitter γ-aminobutyric acid (GABA) inhibited proliferation and IL-17A production in ILC3s in a manner dependent on the GABA receptors Gabbr1 and Gabbr2. Conditional deletion of Gabbr1 or ablation of GABAergic neurons caused increased IL-17A production and aggravated colitis.

The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer.

Most patients with colorectal cancer do not achieve durable clinical benefits from immunotherapy, underscoring the existence of alternative immunosuppressive mechanisms. Here we found that activation of the lactate receptor HCAR1 signaling pathway induced the expression of chemokines CCL2 and CCL7 in colorectal tumor cells, leading to the recruitment of immunosuppressive CCR2 polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) to the tumor microenvironment. Ablation of Hcar1 in mice with colorectal tumors significantly decreased the abundance of tumor-infiltrating CCR2 PMN-MDSCs, enhanced the activation of CD8 T cells and, consequently, reduced tumor burden.

Reaction-Diffusion and Crystallization Kinetics Modulation of Two-Step Deposited Tin-Based Perovskite Film via Reducing Atmosphere.

The two-step deposition method effectively mitigates the efficiency decline observed in tin-based perovskite solar cells (TPVSCs) with increasing cell area, stemming from film in-homogeneity. However, the high solubility of SnI in the conventionally used solvent isopropyl alcohol, coupled with the absence of effective modulation of reaction-diffusion process, results in inadequate film coverage and conversion. In this study, we introduce formic acid as the second-step solvent and introduce dithiothreitol (DTT) to regulate reaction-diffusion/crystallization kinetics meticulously.

A Novel Aerial-Aquatic Unmanned Vehicle Using Flapping Wings for Underwater Propulsion.

Aerial-aquatic unmanned vehicles are a combination of unmanned aerial vehicles and unmanned submersibles, capable of conducting patrols in both the air and underwater domains. This article introduces a novel aerial-aquatic unmanned vehicle that integrates fixed-wing configuration and flapping-wing configuration. In order to improve the low efficiency of the classic diagonal motion trajectory, this paper proposed an improved diagonal motion trajectory based on joint optimization of the stroke angle and angle of attack curve.

Knowledge mapping of trained immunity/innate immune memory: Insights from two decades of studies.

This study employs knowledge mapping and bibliometric techniques to analyze the research landscape of trained immunity over the past 20 years and to identify current research hotspots and future development directions. The literature related to trained immunity was searched from the Web of Science Core Collection database, spanning 2004 to 2023. VOSViewer, CiteSpace and Bibliometrix were used for the knowledge mapping analysis.

An enhanced snow ablation optimizer for UAV swarm path planning and engineering design problems.

The Snow Ablation Optimizer (SAO) is an advanced optimization algorithm. However, it suffers from slow convergence and a tendency to become trapped in local optima. To address these limitations, we propose an Enhanced Snow Ablation Optimization algorithm (ESAO).

Generalized interacting multiple model Kalman filtering algorithm for maneuvering target tracking under non-Gaussian noises.

The traditional interacting multiple model Kalman filtering algorithm (IMM-KF) can deal with the maneuvering target problem under Gaussian noise by soft switching among possible motion models. In practice, its performance is likely to degrade when handling non-Gaussian noise. We introduce the Gaussian mixture model (GMM) into the IMM-KF, and the GMM is utilized to model the non-Gaussian measurement noise as a mixture of multiple Gaussian probability densities with a certain probability.

Extending Shelf-Life of Two-Step Method Precursor Solutions through Targeted Regulation for Highly Efficient and Reproducible Perovskite Solar Cells.

Precursor solution aging process can cause significant influence on the photovoltaic performance of perovskite solar cells (PVSCs). Notably, we first observe that the aging phenomenon is more severe in the precursor of two-step sequential method compared to that in one-step method due to that the protic solvent isopropanol facilitates amine-cation side reaction and iodide ions oxidation. Herein, we report a novel approach for selectively stabilizing both organic amine salt and lead iodide (PbI) precursor solutions in two-step method.

The role of circHmbox1(3,4) in ferroptosis-mediated cognitive impairments induced by manganese.

Excessive environmental exposure to manganese (Mn) has been linked to cognitive impairments, circular RNAs (circRNAs) have been recognized for their roles in epigenetic regulation in various biological processes, including neurological pathogenesis. Previous studies found that ferroptosis, an iron ion-dependent programmed cell death, may be involved in cognitive impairments. However, specific mechanisms underlying the relationship among circRNA, ferroptosis, and neurotoxicity of Mn are not well-understood.

Gossypetin targets the liver-brain axis to alleviate pre-existing liver fibrosis and hippocampal neuroinflammation in mice.

Liver fibrosis occurs in response to chronic damage and inflammation to the liver. Leaving untreated, it can lead to decreased liver function and can eventually progress to cirrhosis, a more advanced and irreversible state of liver damage. Clinical investigations showed that chronic liver disease associated with neurological symptoms including anxiety, depression, and cognitive decline.

Specific BCG-related gene expression levels correlate with immune cell infiltration and prognosis in melanoma.

Melanoma, caused by malignant melanocytes, is known for its invasiveness and poor prognosis. Therapies are often ineffective due to their heterogeneity and resistance. Bacillus Calmette-Guérin (BCG), primarily a tuberculosis vaccine, shows potential in treating melanoma by activating immune responses.

Bioinspired Solar-Driven Osmosis for Stable High Flux Desalination.

The growing global water crisis necessitates sustainable desalination solutions. Conventional desalination technologies predominantly confront environmental issues such as high emissions from fossil-fuel-driven processes and challenges in managing brine disposal during the operational stages, emphasizing the need for renewable and environmentally friendly alternatives. This study introduces and assesses a bioinspired, solar-driven osmosis desalination device emulating the natural processes of mangroves with effective contaminant rejection and notable productivity.

Amine-releasable Mediator In situ Repair Perovskites for Efficient and Stable Perovskite Solar Cells.

Residual lead iodide (PbI) is deemed to a double-edged sword in perovskite film as small amounts of PbI are beneficial to the photovoltaic performance, but excessive will cause degradation of photovoltaic performance and stability. Herein, an in situ repair strategy has been developed by introducing amine-releasable mediator (methylammonium pyridine-2-carboxylic, MAPyA) to eliminate over-residual PbI and regulate the crystal quality of perovskite film. Notably, MAPyA can be partially decomposed into methylamine (MA) gas and pyridine-2-carboxylic (PyA) during high temperature annealing.

Circular RNA circRest regulates manganese induced cell apoptosis by targeting the mmu-miR-6914-5p/Ephb3 axis.

Overexposure to manganese (Mn) can lead to neurotoxicity, the underlying mechanisms remain incompletely understood. Circular RNAs (circRNAs) have emerged as important regulators in various biological processes. It is plausible that circRNAs may be involved in the biological mechanisms underlying Mn caused neurotoxicity.

Manganese-induced neurological pyroptosis: Unveiling the mechanism through the ROS activaed Caspase-3/GSDME signaling pathway.

Manganese (Mn) is an essential micronutrient in maintaining homeostasis in the human body, while excessive Mn exposure can lead to neurological disorders. To investigate whether there is an association between elevated ROS and pyroptosis caused by Mn exposure using both in vitro and in vivo models. We exposed BV2 and N2a, which represent microglial cells and Neuroblastoma cells in the brain, respectively, to different concentrations of Mn for 24 h.