Can the elderly benefit from unitization? - Effects of different unitization manipulations on age-related associative memory deficit.

With the aging process, older adults performed significantly poorer than young adults at remembering the relationships between pieces of information. This phenomenon is known as age-related associative memory deficit. Associative Deficit Hypothesis posits that this deficit stems from hippocampal atrophy in older adults, leading to a decline in their ability to bind information and an impairment in hippocampus-dependent recollection.

Combined effects of nanoplastics and 3-BHA at environmentally relevant concentrations significantly aggravated kidney injury via TGF-β/SMAD signaling pathway in mice.

The increasing presence of nanoplastics (NPs) and synthetic antioxidants like 3-tert -Butyl-4-hydroxyanisole (3-BHA) in the environment has attracted widespread attention about their combined toxicological effects on human health, particularly on renal function. This study explored to the combined impacts of NPs and 3-BHA at environmentally relevant concentrations on sub-chronic kidney injury in mice. Firstly, our results confirmed that the accumulation of 80 nm NPs in renal tissues, leading to structural abnormalities such as reduced mitochondrial cristae and increased empty bubbles in mice by transmission electron microscope (TEM) analysis.

-OH/NH-promoted reductive deoxygenation of α,β-unsaturated ketones with HBpin.

A solvent- and catalyst-free protocol for the selective reductive deoxygenation of α,β-unsaturated ketones with pinacolborane (HBpin) has been developed. -OH/NH groups efficiently direct the transformation, affording 2-allylphenols and 2-allylanilines under mild conditions with excellent chemo- and regioselectivity. Mechanistic studies indicate a boron-assisted hydride transfer and carbocation pathway.

Integrating single-cell RNA sequencing and artificial intelligence for multitargeted drug design for combating resistance in liver cancer.

Hepatocellular carcinoma (HCC) is an aggressive and heterogeneous liver cancer with restricted therapy selections and poor diagnosis. Although there have been great advances in genomics, the molecular mechanisms essential to HCC progression are not yet fully implicit, particularly at the single-cell stage. This research utilized single-cell RNA sequencing technology to evaluate transcriptional heterogeneity, immune cell infiltration, and potential therapeutic targets in HCC.

Effects of bisphenol A on root traits and rhizosphere bacteria: exploring the link between rhizosphere bacterial and root growth.

Background: Bisphenol A (BPA), a widespread environmental pollutant, has been extensively studied for its effects on bacteria and plant, but its impact on rhizosphere bacterial communities and plant root traits is less understood. At the same time, the role of bacteria in helping plants resist adversity is widely recognized, but the relationship between BPA-induced with rhizosphere bacterial changes and root development is still unclear. Therefore, this study investigated the effects of varying BPA concentrations (1.

Novel Blueberry Leaf Polysaccharide-Xanthan Gum Composite Gels for Curcumin Encapsulation: Enhanced Stability and Controlled Release.

Curcumin is a natural active ingredient with various health benefits but suffers from poor water solubility, chemical instability, and rapid metabolism. This study developed a novel composite gel, blueberry leaf polysaccharide-xanthan gum (BLP-XG), for the protection and delivery of curcumin. The experimental results demonstrate that the formation of stable composite gel networks is predominantly facilitated by hydrogen bonding and electrostatic interactions between BLP and XG components.

Effects of Diethylstilbestrol on Uterus Structure and Immunological Function in Mice During Early Pregnancy.

Due to the growing environmental burden of endocrine-disrupting chemicals (EDCs), there is an increasing concern regarding the reproductive hazards posed by synthetic estrogens, particularly diethylstilbestrol (DES). However, the precise mechanisms by which DES disrupts uterine endocrine function and immune homeostasis leading to pregnancy failure remain unclear. Given that wild rodents serve as key reservoirs for zoonotic diseases such as plague, reproductive interventions targeting their pregnancy processes hold significant ecological implications for disease control.

Innovative nanocarriers: Synthetic and biomimetic strategies for enhanced drug delivery.

Effective drug delivery plays a vital role in the treatment of various biomedical conditions. Application of innovative nanocarriers could address issues faced in drug delivery such as poor drug distribution, inefficient penetration across biological barriers, targeting and security. With the development of nanotechnology, the preparation approaches, structures and properties of nanocarriers are continuously improving, while the comparison of detailed construction strategies and corresponding innovative application of different nanocarriers for enhanced drug delivery are few.

Fully Amorphous Cerium/Carbon-Doped Manganese Oxides with Tailor-Made Pore and Electronic Properties for Superior Catalytic Ozone Decomposition.

Metal oxides are promising for catalytic ozone (O) decomposition to tackle the O pollution problem. However, reported metal oxides for O decomposition are predominantly crystalline and often suffer from low active site exposure and easy deactivation. Here, fully amorphous Ce/C-doped MnO materials with tailor-made macro-mesopores and electronic properties are developed.

Optimizing precision in ICU arterial access: the impact of ultrasound-guided dynamic needle tip positioning.

Objective: This study aims to evaluate the efficacy of ultrasound-guided dynamic needle tip positioning (DNTP) in arterial puncture and catheterization among ICU patients.

Methods: A cohort of 55 patients in shock, requiring arterial catheterization in the ICU from April 2020 to July 2024, was enrolled and randomly stratified into groups based on distinct ultrasound-guided puncture techniques. Of these, 27 patients who underwent the ultrasound-guided direct entry (UGDE) method were designated as the control group, while 28 patients who received arterial catheterization via the ultrasound-guided DNTP technique were assigned to the observation group.

Preparation and Functional Characterization of Konjac Glucomannan Oligosaccharide as an Immunomodulator Against DC3000 in .

Plant-derived oligosaccharides are promising ecofriendly elicitors of plant immunity. In this study, a β-1,4-mannanase (ManA) from was characterized with broad pH stability, relatively low-temperature activity, and high specificity for konjac glucomannan (KGM), efficiently producing KGM oligosaccharides (KGMOS, DP 2-13). Treatment with KGMOS (10-50 mg/L) enhanced resistance against pv DC3000 ( DC3000), reducing bacterial colonization and disease symptoms while suppressing pathogen-responsive genes.

Comparative Effects of Maturity and Processing on Chemical Composition and Bioactivities in Leaves.

("Heiyouchun") is a traditional Chinese woody vegetable, the leaves of which can also be processed into tea, known for its distinctive flavor and diverse bioactivities. However, the effects of leaf maturity and processing methods on its phytochemical composition and functional properties remain unclear. In this study, metabolomic analysis revealed 35 significantly different metabolites between tender and mature leaves, with higher concentrations of flavonoids, flavonoid glycosides, limonoids, and amino acids in tender leaves.

Evaluation of Immunoprotective Activities of White Button Mushroom () Water Extract Against Major Pathogenic Bacteria ( or ) in Goldfish ().

The white button mushroom () is a widely cultivated edible and medicinal mushroom, which contains various active substances, and has application value against pathogenic bacteria in aquaculture. Firstly, water extract (AB-WE) was prepared. Through the detection kits, it was found that the polysaccharide, protein, and polyphenol components of AB-WE were 9.

Cross-Modal Complementarity Learning for Fish Feeding Intensity Recognition via Audio-Visual Fusion.

Accurate evaluation of fish feeding intensity is crucial for optimizing aquaculture efficiency and the healthy growth of fish. Previous methods mainly rely on single-modal approaches (e.g.

Catalyst-Free Regioselective 1,6-Aza-Michael Addition of -Quinone Methides with Tetrazoles in Water.

A facile catalyst-free regioselective 1,6-aza-Michael addition of -quinone methides with tetrazoles was efficiently developed using water as a green solvent. This process exhibited broad substrate compatibility, including benzotriazole, pyrazole, and indazole, yielding the corresponding -substituted azoles with excellent efficiency and regioselectivity. To demonstrate the practicality of this methodology, gram-scale reactions were successfully conducted.

Spatio-temporal distribution characteristics and driving factors of urban resilience in the Yangtze River Delta.

Against the backdrop of the widespread acceptance of high-quality development and sustainable development concepts, scientifically exploring the intrinsic connection between urban resilience and sustainable development is of vital importance for enhancing regional risk-resistance capabilities and achieving long-term prosperity. This study constructs a comprehensive evaluation system encompassing four dimensions: economy, society, ecology and infrastructure development, using the entropy method. Additionally, it employs two emerging methods, Necessary Condition Analysis (NCA) and Qualitative Comparative Analysis (QCA), to examine the spatio-temporal evolution characteristics and driving factors of urban resilience in the Yangtze River Delta from 2008 to 2021.

Development of palmatine chloride-loaded chitosan nanoparticles for enhanced and safe cervical cancer therapy.

Cervical cancer remains a significant global health issue, highlighting the need for novel drug delivery strategies to improve the efficacy of anticancer agents against it. In this study, palmatine chloride-loaded chitosan nanoparticles (PC-CSNPs) were developed via ionic gelation as biocompatible nanocarriers for cervical cancer therapy. The physical properties of PCNPs were characterized using SEM, FTIR, XRD, and DLS, revealing a spherical morphology and average particle sizes of 55 nm (chitosan) and 58 nm (PCNPs).

Distribution of human-pathogenic spp., , and in crab-eating macaques in China.

Introduction: The positive rates and genetic identity of spp., (), and () were unclear in crab-eating macaques in Suzhou and Beijing, China.

Methods: A total of 504 fecal samples were collected from crab-eating macaques on commercial farms in Beijing and Suzhou, China.

Preoperative albumin-bilirubin grade combined with sarcopenia predicts long-term outcomes after laparoscopic gastrectomy for advanced gastric cancer.

Background: This retrospective study evaluated the predictive value of preoperative albumin–bilirubin (ALBI) grade combined with sarcopenia for the long-term prognosis of patients with advanced gastric cancer (AGC) undergoing laparoscopic radical surgery.

Methods: This study analyzed clinical and pathological data from 731 patients who underwent laparoscopic gastrectomy for AGC in 2011–2019. The training and validation datasets comprised 538 and 193 cases, respectively.

Comprehensive Insights into Ethyl Carbamate in Baijiu: Occurrence, Metabolic Pathways, Advanced Detection Techniques, and Innovative Mitigation Strategies.

Ethyl carbamate (EC) is a hazardous substance commonly found in fermented foods, such as Baijiu, and its toxicity has raised widespread concerns. As a potential food safety risk, the presence of EC not only affects the quality and safety of Baijiu but also poses a threat to consumer health. Therefore, this systematic review discusses the forms, analytical methods, formation mechanisms, and control strategies of EC in Baijiu.

Comparative analysis of metabolite signatures and hypoglycemic effects in Toona sinensis leaves processed by two distinct methods.

The tender buds of "Heiyouchun" (), a traditional Chinese specialty variety, are highly favored as a unique woody vegetable. However, the mature leaves exhibit distinct bitterness and lack aromatic compounds, resulting in low resource utilization. This study innovatively developed toon leaf tea (TLT) using black tea processing techniques.

Electrochemically Oxidative C-H/N-H Cross-Coupling Reactions of Sulfoximines with Imidazopyridines.

An electrochemically induced C-H/N-H cross-coupling of sulfoximines with imidazopyridines was achieved. This protocol provides a sustainable approach for the synthesis of C-3 sulfoximidoyl-functionalized imidazo[1,2-]pyridines in the absence of exogenous oxidants and metal catalysts.

The association between remnant cholesterol and the risk of osteoporotic vertebral fracture in older adults.

Background: Serum lipid levels have been shown to influence bone mineral density. Additionally, a limited number of studies have suggested that remnant cholesterol (RC) may be linked to the risk of osteoporosis. However, the relationship between RC and fracture risk remains unclear.

Tea Polyphenol Self-Assembly Nanocomposite Coating for Fruit Preservation.

Fruit spoilage has led to significant food waste and economic losses and poses risks to human health. Currently, widely used plastic bag preservation techniques exhibit limited effectiveness, often leading to environmental pollution and potential health hazards. Moreover, many emerging nanopreservation materials lack comprehensive safety evaluations, raising concerns regarding their biological safety and stability.

Genome-Wide Analysis of Gene Family in Maize Reveals Its Role in the Cadmium Stress Response.

Background: Phytoremediation is an efficient approach for remediating heavy metal-contaminated soils. Heavy metal-associated isoprenylated plant proteins (HIPPs)-crucial for metal ion homeostasis-are unique to vascular plants, featuring a heavy metal-associated (HMA) domain and an isoprenylated CaaX motif. However, genes have not been systematically or functionally characterized in maize.