-OH/NH-promoted reductive deoxygenation of α,β-unsaturated ketones with HBpin.

A solvent- and catalyst-free protocol for the selective reductive deoxygenation of α,β-unsaturated ketones with pinacolborane (HBpin) has been developed. -OH/NH groups efficiently direct the transformation, affording 2-allylphenols and 2-allylanilines under mild conditions with excellent chemo- and regioselectivity. Mechanistic studies indicate a boron-assisted hydride transfer and carbocation pathway.

Catalyst-Free Regioselective 1,6-Aza-Michael Addition of -Quinone Methides with Tetrazoles in Water.

A facile catalyst-free regioselective 1,6-aza-Michael addition of -quinone methides with tetrazoles was efficiently developed using water as a green solvent. This process exhibited broad substrate compatibility, including benzotriazole, pyrazole, and indazole, yielding the corresponding -substituted azoles with excellent efficiency and regioselectivity. To demonstrate the practicality of this methodology, gram-scale reactions were successfully conducted.

Electrochemically Oxidative C-H/N-H Cross-Coupling Reactions of Sulfoximines with Imidazopyridines.

An electrochemically induced C-H/N-H cross-coupling of sulfoximines with imidazopyridines was achieved. This protocol provides a sustainable approach for the synthesis of C-3 sulfoximidoyl-functionalized imidazo[1,2-]pyridines in the absence of exogenous oxidants and metal catalysts.

One-pot electrochemical synthesis of -trifluoromethylthio sulfoximines from sulfoximines N-SCN intermediates.

We reported an electrochemical method for the generation of -thiocyanato sulfoximines from sulfoximines and ammonium thiocyanate. With NHI as the mediator and electrolyte, the presynthesis of N-Br sulfoximines was avoided. Moreover, this sustainable approach can be applied in the synthesis of -trifluoromethylthio sulfoximines in one pot by varying the sulfoximines.

Synthesis of disulfides and 3-sulfenylchromones from sodium sulfinates catalyzed by TBAI.

A new synthetic method for disulfides and 3-sulfenylchromones is reported. This innovative approach is based on the tetrabutylammonium iodide (TBAI)/HSO reduction system using sodium sulfinate as key component, thus eliminating the need for thiols and redox reagents commonly used in traditional methods. Various disulfides and 3-sulfenylchromones were obtained in moderate to excellent yields through this methodology.

Electrochemically Enable -Sulfenylation/Phosphinylation of Sulfoximines via Oxidative Dehydrocoupling Reaction.

An electrochemical oxidative cross-coupling strategy for the synthesis of -sulfenylsulfoximines from sulfoximines and thiols was accomplished, giving diverse -sulfenylsulfoximines in moderate to good yields. Moreover, this strategy can be extended to construct the N-P bond of -phosphinylated sulfoximines. With electrons as reagents, the oxidative dehydrogenation cross-coupling reaction proceeds smoothly in the absence of traditional redox reagents.

Electrocatalytic C-H/S-H Coupling of Amino Pyrazoles and Thiophenols: Synthesis of Amino Pyrazole Thioether Derivatives.

A mild method for the C-H/S-H coupling of pyrazol-5-amines and thiophenols was developed via electrochemistry, giving diverse amino pyrazole thioether derivatives in 37-98% yields. This electrochemical reaction is sustainable and an atom-efficient approach with good functional group tolerance and scalability by avoiding metal and external chemical oxidants.

Catalyst-Free Synthesis of Thiosulfonates and 3-Sulfenylindoles from Sodium Sulfinates in Water.

This paper presents a green and efficient aqueous-phase method for the synthesis of thiosulfonates, which has the benefits of no need for catalysts or redox reagents and a short reaction time, providing a method with great economic value for synthesizing thiosulfonates. Furthermore, 3-Sulfenylindoles can be easily synthesized using this method, which expands the potential applications of this reaction.