Can the elderly benefit from unitization? - Effects of different unitization manipulations on age-related associative memory deficit.

With the aging process, older adults performed significantly poorer than young adults at remembering the relationships between pieces of information. This phenomenon is known as age-related associative memory deficit. Associative Deficit Hypothesis posits that this deficit stems from hippocampal atrophy in older adults, leading to a decline in their ability to bind information and an impairment in hippocampus-dependent recollection.

Achieving Distributed Convex Optimization Within Prescribed Time For High-Order Nonlinear Multiagent Systems.

This article addresses the distributed prescribed-time convex optimization (DPTCO) problem for high-order nonlinear multiagent systems (MASs) under undirected connected graphs. A cascade design framework is proposed that divides the DPTCO implementation into distributed optimal trajectory generator design and local reference trajectory tracking controller design. The DPTCO problem is then transformed into the prescribed-time stabilization problem of a cascaded system.

Integrated Transcriptomic and Metabolomic Analyses Reveal Key Antioxidant Mechanisms in Under Combined Salt and Heat Stress.

Combined abiotic stresses often impose greater challenges to plant survival than individual stresses. In this study, we focused on elucidating the physiological and molecular mechanisms underlying the response of to combined salt and heat stress by integrating physiological, transcriptomic, and metabolomic analyses. Our results demonstrated that high temperature plays a dominant role in the combined stress response.

Telitacicept plus low-dose mycophenolate mofetil in the treatment of IgA nephropathy: a retrospective study.

Presently, no specific therapies have been recognized for immunoglobulin A nephropathy (IgAN). Mycophenolate mofetil (MMF) has been verified effective for Chinese patients with IgAN. Telitacicept is a full-human TACI-FC fusion preventing B cells maturation and activation, and it has been proven to be beneficial for IgAN in a phase II clinical trial.

Integrated Omics Reveal Lindl.'s Anti-Diabetic Mechanisms via Arginine/Proline and Glycerophospholipid Pathways.

: Lindl. (DNL), a traditional dietary supplement, exhibits therapeutic potential for type 2 diabetes mellitus (T2DM), yet its mechanisms remain unclear. : T2DM was induced in / mice.

Blocking IL-6 down-regulates PD-L1 expression and mitigates pulmonary fibrosis by inhibiting the STAT3 signaling pathway.

Pulmonary fibrosis is a fatal lung disease. Owing to its unknown pathogenesis, treatment options are limited. Interleukin (IL)-6, a multifunctional cytokine, is overexpressed in pulmonary fibrosis and may contribute to its development through multiple pathways, mainly the signal transduction and transcriptional activator 3 (STAT3) signaling pathway.

Abernethy malformation (Type II) presenting in a 6-day-old boy with Noonan syndrome: a case report.

Background: Abernethy malformation (AM) is a rare vascular anomaly characterized by the diversion of splanchnic venous blood directly into the systemic circulation, bypassing the liver. We present the clinical features, diagnostic workup, and follow-up of a 6-day-old Chinese male with type II AM combined with Noonan syndrome (NS).

Case Presentation: The patient was prenatally suspected of having AM based on ultrasonographic findings, which were postnatally confirmed through enhanced computed tomography (CT) and magnetic resonance (MR) imaging.

Assembly dynamics of magnetotactic bacterial actin-like protein MamK under shielded geomagnetic fields: In vitro evidence of inhibited filament formation.

The geomagnetic field (GMF) influences biological processes across diverse species, however, the molecular mechanisms underlying magnetoreception remain poorly understood. In this study, we examined the effects of hypomagnetic field (HypoMF) conditions-where the GMF is effectively shielded-on the assembly dynamics of the bacterial actin-like protein MamK in Magnetospirillum magneticum AMB-1. Through in vitro assays, we observed that HypoMF conditions disrupt MamK assembly, diminishing its ability to form elongated filaments.

Atmospheric source of mercury to the ocean constrained by isotopic model.

Mercury is a potent neurotoxin that poses significant health risks to humans, primarily through seafood consumption. Atmospheric deposition is the largest source of oceanic mercury, in either oxidized (Hg) or elemental (Hg) form. Understanding the relative contributions of atmospheric Hg and Hg to the ocean is essential for accurately assessing global mercury budgets.

Impact of fiberoptic bronchoscopy on systemic inflammatory markers and outcomes in neonatal patients with respiratory conditions.

Background: Fiberoptic bronchoscopy is an essential tool in neonatal respiratory medicine, facilitating both diagnosis and management of complex respiratory disorders. Despite its widespread use, the procedure's impact on systemic health parameters, including inflammation, remains under-evaluated. This study investigates the effects of fiberoptic bronchoscopy on respiratory function and systemic inflammatory markers, such as the systemic immune-inflammation index (SII), in neonatal patients.

Anti-herpes simplex virus type 1 activity of the Rohdea chinensis (Baker) N. Tanaka aqueous extracts.

Ethnopharmacological Relevance: Herpes simplex virus type 1 (HSV-1) is a prevalent neurotropic pathogen that establishes lifelong latency in the peripheral nervous system, posing substantial clinical challenges due to its recurrent infections and emerging drug resistance. Rohdea chinensis (Baker) N. Tanaka, a traditional Chinese herbal medicine, has been historically used for heat-clearing, detoxifying, wind-dampness dispelling, blood-stasis removing, and pain-relieving properties.

Quantitative assessment of muscle atrophy and structural changes in children with spinal muscular atrophy using ultrasound imaging.

Background: Spinal muscular atrophy (SMA) in children is a hereditary neuromuscular disorder characterized by motor neuron degeneration, which leads to progressive muscle weakness and impaired movement. Ultrasound imaging, owing to its non-invasive, radiation-free, and cost-effective nature, provides an invaluable tool for visualizing muscle morphology. This technique offers a significant advantage in the clinical evaluation of SMA.

Effects of λ-cyhalothrin on the behavior and physiology of Leschenault's rousette bat (Rousettus leschenaultii).

In addition to exerting direct toxic effects, pesticides disrupt the complex physiology and behavioral patterns of bats. Previous studies have focused on quantifying pesticide residues in bats. However, limited studies have examined the effects of pesticides on acoustic behavior, auditory health, and gene expression in bats.

Modeling and Parameter Analysis of Basic Single Channel Neuron Mass Model for SSVEP.

While steady-state visual evoked potentials (SSVEPs) are widely used in brain-computer interfaces (BCIs) due to their robustness to rhythmic visual stimuli, their generation mechanisms remain poorly understood. Challenges such as experimental complexity, inter-subject variability, and limited physiological interpretability hinder the development of efficient BCI systems. This study employed a single-channel neural mass model (NMM) of V1 cortical dynamics to investigate the biophysical underpinnings of SSVEP generation.

Identification of m6 A-regulated ferroptosis biomarkers for prognosis in laryngeal cancer.

Laryngeal cancer (LC) is a malignant tumor that occurs in the larynx. N6-methyladenosine (m6A) RNA methylation, a pivotal and prevalent epigenetic modification in eukaryotic mRNA, intricately intertwines with ferroptosis, and together, they play a crucial role in the development of LC. Accordingly, further research on related molecular mechanisms and pathology of LC is necessary.

Multiple non-covalent bonds reinforced pH/glucose-responsive alginate-stabilized Pickering emulsion for diacylated anthocyanin intestinal delivery.

The effective management of Type 2 Diabetes Mellitus (T2DM) depends on the development of streamlined, sustainable, and intelligent delivery systems. In this context, targeted stimulus-responsive Pickering emulsions (PEs) derived from biomass have emerged as a promising candidate. However, the interfacial films of PEs exhibit insufficient strength to endure the harsh gastric environment and lack the capability for targeted and responsive delivery.

Inhibition of DJ-1 induces TFAM secretion from cancer cells to suppress tumor growth via promoting M1 macrophage polarization.

DJ-1, also known as PARK7 (Parkinson's disease protein 7), which is involved in cell viability, apoptosis, transcriptional regulation, and oxidative stress adaptation, is also involved in the pathogenesis of various human diseases including carcinogenesis. Here, we aimed to determine the novel mechanism by which DJ-1 inhibition suppresses tumor growth. Our results showed that DJ-1 knockdown in cancer cells promoted the secretion of a significantly larger amount of mitochondrial transcription factor A (TFAM) into the cell culture medium.

A Novel Multi-Dynamic Coupled Neural Mass Model of SSVEP.

Steady-state visual evoked potential (SSVEP)-based brain-computer interfaces (BCIs) leverage high-speed neural synchronization to visual flicker stimuli for efficient device control. While SSVEP-BCIs minimize user training requirements, their dependence on physical EEG recordings introduces challenges, such as inter-subject variability, signal instability, and experimental complexity. To overcome these limitations, this study proposes a novel neural mass model for SSVEP simulation by integrating frequency response characteristics with dual-region coupling mechanisms.

The landscape of N-methyladenosine in localized primary prostate cancer.

N-methyladenosine (mA), the most abundant internal RNA modification in humans, regulates most aspects of RNA processing. Prostate cancer is characterized by widespread transcriptomic dysregulation; therefore, we characterized the mA landscape of 162 localized prostate tumors with matched DNA, RNA and protein profiling. mA abundance varied dramatically across tumors, with global patterns emerging via complex germline-somatic cooperative regulation.

Host-guest interfacial recognition of alginate-based β-cyclodextrin/dendrobine supra-amphiphiles reinforced the physicochemical stability and sustained-release properties of Pickering emulsions.

Achieving high bioavailability of dendrobine (DDB) necessitates the development of simplified available and efficient delivery systems. Pickering emulsions (PEs) derived from biomass represent a promising option. However, the physicochemical properties of PEs interfacial films were insufficient to prevent DDB leakage, thereby reducing bioavailability.

Angle Rigidity-Based Communication-Free Adaptive Formation Control for Nonlinear Multiagent Systems With Prescribed Performance.

Angle-constrained formation control has garnered significant attention owing to the advantage of interedge angles invariant under translation, rotation, and scaling. However, most existing approaches addressing this problem are applicable only to single- or double-integrator dynamics, which are often impractical in real-world scenarios. In this article, an angle rigidity-based adaptive formation control framework is introduced for nonlinear multiagent systems subject to mismatched uncertainties.

Discovery of anti-inflammatory molecules from Dendrobium officinale based on activity labelled molecular networking and its alleviation effect on ulcerative colitis.

The present study aimed to discover anti-inflammatory molecules from Dendrobium officinale using mass spectrometry-based molecular networking technology and evaluate its therapeutic potential against ulcerative colitis (UC). We employed activity-labeled molecular networking (ALMN) to identify anti-inflammatory molecules from D. officinale extracts.

Alleviation of DSS-induced colitis by Meconopsis polysaccharides correlated with reduced PI3K/AKT signaling and gut microbiome diversity.

Introduction: Inflammatory bowel disease (IBD) is a recurrent gastrointestinal disorder that significantly impacts patients' quality of life globally. This study focuses on the polysaccharides (MP) extracted from , to investigate its role in alleviating DSS (dextran sulfate sodium)-induced colitis in mice.

Methods: The study commenced with a comprehensive chemical characterization of .

A global overview of transcriptome dynamics during the late stage of flower bud development in Camellia oleifera.

Camellia oleifera Abel., recognized as a significant oil plant, is of immense potential health and economic value. Due to the self-incompatibility of C.