Radiographic Healing After Intramedullary Nailing with or Without Lateral Plate Augmentation in Atypical Subtrochanteric Femoral Fractures: A Retrospective Study.

: Atypical subtrochanteric femoral fractures (ASFs), frequently linked to long-term bisphosphonate use, present significant fixation challenges due to impaired bone healing. While intramedullary (IM) nailing is the standard treatment, delayed union or nonunion remains common. This study aimed to evaluate whether supplementing IM nailing with lateral plate augmentation improves radiographic healing in patients with ASFs.

Comparison of the Therapeutic Effects of Rebamipide and Diquafosol on Apoptotic Damage of the Ocular Surface in Dry Eyes.

Dry eye disease (DED) is characterized by tear film instability and oxidative stress-induced epithelial damage. This study was conducted to compare the therapeutic effects of 2% rebamipide (REB) and 3% diquafosol (DQS) on oxidative stress-related apoptotic damage of the ocular surface in DED. Human corneal epithelial cells (HCECs) were exposed to hyperosmotic stress in vitro and treated with REB or DQS.

Association of accelerometer-measured physical activity with adverse cardiovascular outcomes in individuals with or without chronic kidney diseases: the UK biobank study.

Background: Physical activity is important for health and longevity, but little is known on patients living with chronic kidney disease (CKD). In fact, most studies in patients with CKD have relied on self-reported data, highlighting an unmet need for studies using objective measurements. We investigated the association between device-measured physical activity and adverse outcomes by CKD status.

Resistant Hypertension Treated With Extravascular Renal Denervation.

Resistant hypertension is defined as uncontrolled blood pressure (BP) even with 3 or more antihypertensive drugs. Catheter-based intravascular renal denervation has shown only modest benefits, prompting the development of extravascular renal denervation (eRDN), the HyperQure RDN System. To the best of our knowledge, this is the first reported experience of eRDN performed in 2 patients with severe resistant hypertension.

Evaluating the impact of the ASAS early axial spondyloarthritis definition on radiographic progression over 12years.

Objective: This study aims to assess the impact of the ASAS early axial spondyloarthritis (axSpA) definition on radiographic progression, one important indicator of long-term disease burden, using the Modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) across a 12-year period, comparing early and established groups.

Methods: Using data from the Korean spondyloarthropathy registry, this observational study retrospectively categorized patients into early or established axSpA groups based on the ASAS definition. Radiographic progression was assessed by analyzing annual changes in mSASSS.

Intestinal therapeutic agent delivery microrobot with magnetic targeting and pH-triggered degradation abilities.

Oral drug delivery remains a clinically preferred route for colorectal cancer therapy due to its noninvasive nature and patient compliance. However, conventional formulations suffer from premature degradation in the gastric environment and poor site-specific targeting in the intestine, significantly reducing therapeutic efficacy. Here, we introduce an intestinal therapeutic agent delivery microrobot (ITAM) composed of a therapeutic agent (TA) encapsulated core, a magnetic nanoparticle (MNP) layer for precise magnetic guidance, and a protective layer to minimize the loss of functional materials.

Expanded and activated marrow-infiltrating lymphocytes exhibit potent antimyeloma activity against autologous multiple myeloma cells.

Adoptive immunotherapy represents a promising treatment for multiple myeloma (MM), relying on the availability of sustainable tumor-specific cytotoxic T cells. This study generated potent ex vivo expanded and activated marrow-infiltrating lymphocytes (eMILs) from MM patients and evaluated their immunologic characteristics and cytotoxic potential. MILs were expanded using anti-CD3/CD28 beads in the presence of IL-2, IL-7, and IL-15.

Horizontal gaze-evoked nystagmus in pontine gaze palsy: patterns and anatomical correlates.

Background: To delineate the patterns and anatomical correlates of gaze-evoked nystagmus (GEN) in horizontal gaze palsy due to dorsal pontine lesions.

Methods: A total of 17 patients with horizontal gaze palsy and unilateral dorsal pontine lesions were retrospectively recruited from referral-based six university hospitals in Korea. The clinical characteristics, oculographic data, and MRI lesions of the patients were subjected to analysis.

Chlorogenic acid attenuates cardiac hypertrophy and fibrosis by downregulating galectin 3.

Chlorogenic acid, an ester of caffeic acid and quinic acid, is found in foods such as eggplant and peaches. Its role in heart disease remains poorly understood. This study investigated whether chlorogenic acid affects cardiac hypertrophy and fibrosis in animal and cellular models of isoproterenol-induced cardiac hypertrophy.

Environmental disease monitoring by regional Environmental Health Centers in Korea: a narrative review.

This study explores the development, roles, and key initiatives of the Regional Environmental Health Centers in Korea, detailing their evolution through four distinct phases and their impact on environmental health policy and local governance. It chronicles the establishment and transformation of these centers from their inception in May 2007, through four developmental stages. Originally named Environmental Disease Research Centers, they were subsequently renamed Environmental Health Centers following legislative changes.

Epidemiology and management of infectious spondylitis in Korea: a narrative review.

Infectious spondylitis, an infection of the vertebral body, intervertebral disc, or paraspinal tissues, poses diagnostic and therapeutic challenges. This review examines the clinical approach and management of infectious spondylitis in Korea. The incidence of pyogenic spondylitis has increased, primarily due to the aging population, more frequent use of invasive procedures, and higher prevalence of immunocompromising conditions.

Novel artificial intelligence model using electrocardiogram for detecting acute myocardial infarction needing revascularization.

Aims: Rapid myocardial revascularization in patients with acute myocardial infarction (AMI) is essential to improve clinical outcomes. There is still room for improvement in the timely diagnosis of AMI. This study aimed to develop an artificial intelligence (AI) model using electrocardiograms (ECGs) for detecting AMI needing revascularization.

Circular RNA circAtxn10 regulates skeletal muscle cell differentiation by targeting miR-143-3p and Chrna1.

Skeletal muscle differentiation is a complex process regulated by a network of genes and transcription factors. Recent studies have revealed the roles of circular RNAs (circRNAs) and microRNAs (miRNAs) in modulating gene expression during myogenesis. In this study, we focused on the functional interplay between circAtxn10, miR-143-3p, and the nicotinic acetylcholine receptor subunit alpha 1 (Chrna1) in skeletal muscle differentiation.

Impact of T1 Slope as a Predictor of Loss of Cervical Lordosis and Health-Related Quality of Life After Laminoplasty in Patients with Ossification of the Posterior Longitudinal Ligament : A Retrospective Cohort Study.

Objective: This study aimed to identify risk factors predicting the loss of cervical lordosis (LCL) in patients with multilevel ossification of the posterior longitudinal ligament (OPLL) after laminoplasty. Additionally, we evaluated the impact of these factors on health-related quality of life (HRQOL).

Methods: We retrospectively analyzed data from patients who underwent laminoplasty at XX University Hospital between January 2013 and December 2022.

Clinical Practice Guidelines for the Pre-hospital Stage of Acute Stroke in Korea II : Transport Decisions for Patients with Acute Ischemic Stroke.

The mothership (MS) model, where patients are directly transferred to a thrombectomy-capable center, and the drip-and-ship (DS) model, where thrombolysis is initiated at the nearest primary stroke center before transfer for thrombectomy, are the primary transport modes for patients with stroke. We aimed to establish guidelines for selecting the appropriate transfer strategy based on emergent large vessel occlusion (LVO). We developed this guideline based on evidence from systematic reviews and meta-analyses via a de novo process.

Artificial intelligence-assisted longitudinal assessment of coronary artery calcification in the Korean lung cancer screening CT program.

Purpose: The clinical implications of coronary artery calcification (CAC) growth remain underexplored. This study aims to assess CAC growth and its association with adverse cardiovascular events (ACEs) in individuals undergoing lung cancer screening (LCS) using artificial intelligence (AI)-assisted evaluation.

Methods: We included patients who underwent LCS low-dose chest CT (LDCT) between April 2017 and December 2023 with available follow-up LDCT scans.

Impact of longer diabetes duration and lower estimated glomerular filtration rate on cardiovascular complications and mortality: A nationwide population-based study.

Background: Decreased renal function is a well-known risk factor for cardiovascular diseases (CVD) and death. However, the impact of diabetes duration and the glomerular filtration rate (GFR) on cardiovascular complications in patients with type 2 diabetes has not been well studied.

Aim: To investigate the complex impact of longer diabetes duration and GFR on CVD and mortality.

Exercise intensity and the risk of end-stage renal disease in diabetes: A nationwide population-based study.

Background: Exercise plays a key role in managing chronic conditions such as diabetes mellitus (DM), a major contributor to end-stage renal disease (ESRD), a serious public health issue.

Aim: To investigate the relationship between exercise intensity, DM duration, and ESRD incidence.

Methods: This retrospective cohort study analyzed data from 2495031 individuals with DM who underwent the Korean National Health Screening between 2015 and 2016, with follow-up through 2022.

Regulating astrocytic activity in the dorsal striatum mitigates L-dopa-induced dyskinesia in Parkinson's disease.

In Parkinson's disease (PD), long-term 3,4-dihydroxy-L-phenylalanine (L-dopa) therapy leads to the development of motor complications, including L-dopa-induced dyskinesia (LID). Increased numbers of reactive astrocytes in the brains of patients with PD are a key feature of this disease. Astrocytes are involved in the development of LID; however, whether the regulation of astrocytic activity influences LID development remains unclear.

Analysis of Helicobacter pylori Infection Status and Clarithromycin-resistant Strains in Patients With Gastric Mucosa-associated Lymphoid Tissue Lymphoma Using Real-time Polymerase Chain Reaction: A Single-center Korean Study.

Background: Helicobacter pylori (HP) is a well-known risk factor for gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, the prevalence of clarithromycin-resistant (CLR) HP strains in patients with gastric MALT lymphoma compared with the general population is largely unknown.

Materials And Methods: HP test was performed on samples from 4686 patients who underwent gastric biopsy, including 89 patients who were diagnosed with gastric MALT lymphoma.

BACES score: a predictor of health-related quality of life and associated factors in patients with nontuberculous mycobacterial pulmonary disease.

The evaluation of health-related quality of life (HRQOL) is gaining importance among patients with nontuberculous mycobacterial pulmonary disease (NTM-PD). We assessed whether the BACES score reflects HRQOL and associated factors in these patients. Data were collected from the nationwide NTM-KOREA prospective cohort of patients with NTM-PD who started antibiotic treatment and included symptoms, Quality of Life-Bronchiectasis (QOL-B) questionnaire, nutritional status using the Mini Nutritional Assessment-Short Form (MNA-SF) and Prognostic Nutritional Index (PNI), physical activity, body composition, spirometry, handgrip strength, and 6-min walking distance.

Reevaluating the timing of specific immunoglobulin E measurement after anaphylaxis.

The anergic period is defined as a period of around 3-6 weeks following a systemic allergic reaction when skin test results are negative. Therefore, most guidelines recommend that physicians should conduct skin test 6 weeks after an immediate hypersensitivity reaction. However, in vitro tests, including serum-specific immunoglobulin E (IgE) measurement, are generally deemed unaffected by the anergic period.

Postoperative conventional versus hypofractionated intensity-modulated radiation therapy with concurrent chemotherapy in cervical cancer: a prospective multicenter randomized phase III trial (POHIM_P3 trial).

Background: For patients with high-risk factors such as pelvic lymph node metastasis, positive surgical margins, or parametrial involvement, concurrent chemoradiotherapy (CCRT) with whole-pelvic radiotherapy significantly improves survival outcomes. Hypofractionated radiation therapy, which delivers higher radiation doses over fewer sessions, enhances tumor control but raises concerns about increased normal tissue toxicity. A recent Korean phase II study (POHIM-CCRT) evaluated the safety of hypofractionated intensity-modulated radiation therapy (IMRT), delivering 40 Gy in 16 fractions with weekly cisplatin following radical surgery.