Changes in citizens' anxiety, depression, and PTSD after the Seoul Halloween crowd crush in 2022.

This study aims to understand the mental health of South Koreans one year after the Seoul Halloween crowd disaster(hereafter referred to as the Seoul Halloween disaster), an anthropogenic disaster that occurred in 2022. In total, 651 participants completed three online surveys to measure anxiety, depression, and post-traumatic stress disorder (PTSD) over a year after the disaster. The collected data were then analyzed with descriptive statistics, repeated-measures analysis of variance (ANOVA), and independent samples t-tests using the SPSS 28 program.

Intestinal therapeutic agent delivery microrobot with magnetic targeting and pH-triggered degradation abilities.

Oral drug delivery remains a clinically preferred route for colorectal cancer therapy due to its noninvasive nature and patient compliance. However, conventional formulations suffer from premature degradation in the gastric environment and poor site-specific targeting in the intestine, significantly reducing therapeutic efficacy. Here, we introduce an intestinal therapeutic agent delivery microrobot (ITAM) composed of a therapeutic agent (TA) encapsulated core, a magnetic nanoparticle (MNP) layer for precise magnetic guidance, and a protective layer to minimize the loss of functional materials.

Comprehensive Osteosarcoma Treatment with Multifunctional Composite Hydrogels Enabling Combined Photothermal Cancer Ablation and Osteoinductive Tissue Regeneration.

Osteosarcoma treatment can lead to considerable loss of bone tissue, creating a challenging microenvironment for recovery. Here, a novel biomaterial is described for tumor treatment via photothermal therapy and bone-tissue regeneration. Multifunctional composite hydrogels can be fabricated by incorporating mineralized magnetic fibers (G-mMFs) into a gelatin-genipin hydrogel.

Single and Multiple Doses of Seladelpar Decrease Diurnal Markers of Bile Acid Synthesis in Mice.

Peroxisome proliferator-activated receptors (PPARs) modulate bile metabolism and are important therapeutic options in cholestatic diseases. This study was aimed at understanding the effects of single and multiple doses of seladelpar, a PPAR (peroxisome proliferator-activated receptor delta) agonist, on plasma C4 (a freely diffusible metabolite accepted as a proxy for de novo bile acid biosynthesis), Fibroblast Growth Factor 21 (Fgf21), and gene expression changes in the liver of male and female mice. C57BL/6 mice were treated with seladelpar 10 mg/kg/day or vehicle through oral gavage before lights out on Day 1 (single dose) or from Day 1 to Day 7 (multiple doses).

Development and Effect of an Interactive Simulated Education Program for Psychological First Aid: A Randomized Controlled Trial.

Background: Considering the importance of psychological first aid, which is the first priority when a disaster occurs, developing a web-based simulation training program for nurses and confirming its effectiveness is necessary.

Aim: This study aimed to develop an interactive simulated education program as a psychological first aid program for nurses and verify its effectiveness. .

The Profile of Gut Microbiota in Carcinogenesis Driven by Mutant EGFR in Non-Small Cell Lung Cancer.

Purpose: Accumulating evidence has clarified that gut dysbiosis is involved in lung cancer development and progression. Although the relationship between tumors and gut microbiota has been extensively studied using clinical samples, no studies have examined the association between mutant EGFR-induced lung carcinogenesis and dysbiosis in gut microbiota. Therefore, we investigated the gut microbiota profiles in stool samples from human lung-specific conditional EGFR-mutant transgenic mice during lung tumor carcinogenesis.

Using a mobile app comprising neurofeedback-based meditation and binaural beat music to treat PTSD symptoms: A qualitative analysis.

Background: There is a significant need for an effective and convenient symptom management and healing program for people experiencing post-traumatic stress disorder (PTSD) symptoms; however, research on this topic is lacking.

Objective: This study explored the experiences of individuals with PTSD who used a mobile traumatic stress management app with neurofeedback-based meditation and binaural beat music to promote their psychological recovery.

Methods: This study used a qualitative research method to explore the experiences of neurofeedback-based meditation and binaural beat music using a mobile traumatic stress management app to promote the psychological recovery of people experiencing chronic traumatic stress.

Mental Health Status and Related Factors of Citizens 6 Months after Mass Death and Injury Due to Crowd Crush Incident: Focused on the Itaewon Disaster in 2022.

Objective: Crowd crush disasters result in psychological risks such as anxiety, depression, and post-traumatic stress disorder (PTSD). This descriptive research study identified the mental health status of Koreans after the Itaewon crowd crush disaster and explored related factors.

Methods: Data were collected May 2-9, 2023 using an online survey.

Inhibition of AXL ameliorates pulmonary fibrosis attenuation of M2 macrophage polarisation.

Rationale: Although a relationship between the growth arrest-specific 6 (GAS6)/anexelekto (AXL) pathway and pulmonary fibrosis has been suggested, the precise mechanisms and clinical implications of the AXL pathway in idiopathic pulmonary fibrosis are still unclear.

Methods: Constitutive and conditional AXL-knockout mice were generated and injected with bleomycin to induce pulmonary fibrosis. The expression of AXL and macrophage subtypes in bleomycin-injected mice and patients with idiopathic pulmonary fibrosis was analysed using flow cytometry.

Feasibility of a mobile app for traumatic stress management using neurofeedback-based meditation and binaural beat music: A pilot randomized controlled trial.

Objective: Individuals who have experienced traumatic events often encounter a variety of changes in their lives and and may suffer from them. To help and alleviate these traumatic stress, we developed an evidence-based mobile application (app) for easy accessibility. This study aimed to test the effects of the mobile app for traumatic stress management using neurofeedback-based meditation and binaural beat music.

Mediating effect of bicultural acceptability among multicultural adolescents in the relationship between depression and life satisfaction.

Aim: This descriptive study examines the mediating and moderating effects of an attitude of bicultural acceptance on the relationship between depression and life satisfaction among multicultural adolescents in South Korea.

Method: This study analyzes 2018 data provided by the National Youth Policy Institute using the R statistics 4.1.

Experiences of Family Caregivers of Older Adults With Dementia in Korea During the COVID-19 Pandemic: A Qualitative Analysis.

Purpose: To explore the experiences of family caregivers of older adults with dementia in Korea during the coronavirus disease 2019 pandemic.

Method: In-depth interviews were conducted with eight family caregivers of older adults with dementia from September to October 2021. Collected data were analyzed using Giorgi's phenomenological methodology.

Still in there-citizens' well-being and PTSD after Seoul Halloween crowd crush in Korea: a cross-sectional study.

The October 29, 2022, Seoul Halloween Crowd Crush (SHCC) caused the loss of 159 lives, making it the deadliest global mass-gathering disaster between 2018 and 2022. Despite the fact that years have passed since the incident, there remains a significant gap in research addressing the mental health of citizens to evaluate their recovery progress. Therefore, in this study, a survey was conducted to assess citizens' anxiety, depression, post-traumatic stress disorder (PTSD), and well-being after the SHCC.

Survey on caregiver competency and retraining needs.

Objectives: This study investigated caregivers' job image, abilities, and educational needs, which are rapidly increasing owing to an aging society.

Design: A self-administered written survey was conducted at 12 general hospitals in Korea from February 1, 2022 to March 15, 2023.

Sample: A total of 451 caregivers participated in the survey as subjects of analysis, and 560 nurses participated as external observers.

Effectiveness of a Fire Disaster PFA Simulation Game: A Single-Blinded Trial.

Objective: As societies become more complex, disasters are increasing in frequency and magnitude. To respond to the psychological problems that may arise in such situations, it is necessary to develop the psychological first aid (PFA) training program that is more engaging for disaster relief workers and less limited in time and space. This study aimed to investigate the effectiveness of a web-based PFA simulation game for disaster relief workers to provide to fire disaster victims.

Efficacy of a virtual nursing simulation-based education to provide psychological support for patients affected by infectious disease disasters: a randomized controlled trial.

Background: Virtual simulation-based education for healthcare professionals has emerged as a strategy for dealing with infectious disease disasters, particularly when training at clinical sites is restricted due to the risk of infection and a lack of personal protective equipment. This research evaluated a virtual simulation-based education program intended to increase nurses' perceived competence in providing psychological support to patients affected by infectious disease disasters.

Methods: The efficacy of the program was evaluated via a randomized controlled trial.

Effects of a web-based education for community mental health case managers on physical healthcare for clients with severe mental illness.

This study aimed to develop and verify the effects of a web-based physical healthcare education program for community mental health case managers during the time of COVID-19. Six modules of mental health case management physical health education program were developed and provided using the EdWith education platform, which enables real-time streaming, lecture participant management and whether participants have watched the video and watch time. A total of 51 community mental health case managers participated in the study.

Identification of exosomal microRNA panel as diagnostic and prognostic biomarker for small cell lung cancer.

Background: Small cell lung cancer (SCLC) has an exceptionally poor prognosis; as most of the cases are initially diagnosed as extensive disease with hematogenous metastasis. Therefore, the early diagnosis of SCLC is very important and may improve its prognosis.

Methods: To investigate the feasibility of early diagnosis of SCLC, we examined exosomal microRNAs (miRNAs) present in serum obtained from patients with SCLC.

AXL receptor tyrosine kinase inhibition improves the anti-tumor effects of CD8 T cells by inducing CD103 dendritic cell-mediated T cell priming.

AXL is a member of TAM receptor family and has been highlighted as a potential target for cancer treatment. Accumulating evidence has uncovered the critical role of the AXL signaling pathway in tumor growth, metastasis, and resistance against anti-cancer drugs, as well as its association with cancer immune escape. However, the function of AXL as a manipulator of the immune system in the tumor microenvironment (TME) remains unclear.