Intestinal therapeutic agent delivery microrobot with magnetic targeting and pH-triggered degradation abilities.

Oral drug delivery remains a clinically preferred route for colorectal cancer therapy due to its noninvasive nature and patient compliance. However, conventional formulations suffer from premature degradation in the gastric environment and poor site-specific targeting in the intestine, significantly reducing therapeutic efficacy. Here, we introduce an intestinal therapeutic agent delivery microrobot (ITAM) composed of a therapeutic agent (TA) encapsulated core, a magnetic nanoparticle (MNP) layer for precise magnetic guidance, and a protective layer to minimize the loss of functional materials.

Electroconductive Polythiophene Nanocomposite Fibrous Scaffolds for Enhanced Osteogenic Differentiation via Electrical Stimulation.

Biophysical cues are key distinguishing characteristics that influence tissue development and regeneration, and significant efforts have been made to alter the cellular behavior by means of cell-substrate interactions and external stimuli. Electrically conductive nanofibers are capable of treating bone defects since they closely mimic the fibrillar architecture of the bone matrix and deliver the endogenous and exogenous electric fields required to direct cell activities. Nevertheless, previous studies on conductive polymer-based scaffolds have been limited to polypyrrole, polyaniline, and poly(3,4-ethylenedioxythiophene) (PEDOT).

Antimicrobial Electrospun Nanofibrous Mat Based on Essential Oils for Biomedical Applications.

Polyurethane (PU) nanofibers containing three different essential oils (teatree, cinnamon bark, clove) were produced by electrospinning method. Morphology of the electrospun nanofibrous was studied using Field Emission Scanning Electron Microscope (FE-SEM). We were studying to reveal that different concentration of essential oil display different mechanical properties for the nanofibrous mat.

Development of Highly Expandable Wrinkled Nanofiber Mat Using Metal Bundle Collector.

Nanofibers are used to improve performance in various fields such as biosensors and medical scaffolds. However, when it is used closely with a biological tissue, it is difficult to properly implement the original function due to the deformation caused by the constant movement of tissue. In this study, we developed a wrinkled nanofiber mats with excellent expandability using a novel metal bundle collector.