Effects of food-derived Staphylococcus equorum, Staphylococcus succinus and Staphylococcus xylosus on volatile compounds production during soybean fermentation.

To investigate differences in volatile compound production among Staphylococcus species during soybean fermentation, Staphylococcus equorum, S. succinus, and S. xylosus isolated from fermented food were inoculated as starter cultures.

Radiotherapy quality assurance program of ongoing clinical trial using stereotactic ablative radiation therapy for recurrent ovarian cancer (SABR-ROC): a dummy run study of a prospective, randomized, multicenter phase III trial (KGOG 3064/KROG 2204).

Background: Recurrent ovarian cancer is often treated with chemotherapy, but many patients experience multiple recurrences with progressively shorter intervals and poorer prognosis. Repeated chemotherapy reduces patients' quality of life. Stereotactic Ablative Radiation Therapy for Recurrent Ovarian Cancer (SABR-ROC) (KGOG3064/KROG 2204) is an ongoing trial investigating the clinical efficacy of stereotactic ablative radiation therapy (SABR) for recurrent ovarian cancer.

Identification of Ni-N Active Sites in Atomically Dispersed Ni Catalysts for Efficient Chlorine Evolution Reaction.

Chlorine (Cl) is one of the most important chemicals in the chemical industry, which is primarily produced by the electrochemical chlorine evolution reaction (CER) in the chlor-alkali process. While platinum-group metal (PGM)-based dimensionally stable anodes (DSAs) have dominated over the last half century, atomically dispersed catalysts (ADCs) have recently emerged as a promising class of CER catalysts; however, they still rely on PGMs. In this work, we prepared a series of non-PGM (Fe, Co, Ni, and Cu)-based ADCs and investigated their CER reactivity trends.

Postoperative conventional versus hypofractionated intensity-modulated radiation therapy with concurrent chemotherapy in cervical cancer: a prospective multicenter randomized phase III trial (POHIM_P3 trial).

Background: For patients with high-risk factors such as pelvic lymph node metastasis, positive surgical margins, or parametrial involvement, concurrent chemoradiotherapy (CCRT) with whole-pelvic radiotherapy significantly improves survival outcomes. Hypofractionated radiation therapy, which delivers higher radiation doses over fewer sessions, enhances tumor control but raises concerns about increased normal tissue toxicity. A recent Korean phase II study (POHIM-CCRT) evaluated the safety of hypofractionated intensity-modulated radiation therapy (IMRT), delivering 40 Gy in 16 fractions with weekly cisplatin following radical surgery.

Efficacy of Holmium Laser Enucleation of the Prostate in Patients With Detrusor Underactivity or Acontractile Bladder.

Purpose: This study evaluates the efficacy of holmium laser enucleation of the prostate (HoLEP) as a deobstructive surgical intervention for patients with detrusor underactivity (DU) or an acontractile bladder (AcB).

Methods: Between April 2021 and May 2024, patients undergoing HoLEP for benign prostatic obstruction (BPO) were selected based on urodynamic study results indicating DU or AcB. The primary outcome was the change in voiding efficiency (VE) following HoLEP.

Mobilizable multidrug resistance plasmid identified in Staphylococcus xylosus isolated from fermented soybean food.

We identified two Staphylococcus xylosus strains that were isolated from the same Korean fermented soybean food with different antibiotic resistance (AR) profiles. Strain 14BME10 showed multidrug resistance to erythromycin and tetracycline, whereas strain 14BME18 was resistant to tetracycline only. We sought to elucidate the genetic background of the AR in these strains.

Safety and amino acid profiles of Bacillus safensis in soybean fermentation.

This study evaluated the antibiotic resistance, toxigenic potential, and amino acid (AA) production profiles of four Bacillus safensis strains in soybean fermentation. Minimum inhibitory concentration tests revealed intrinsic resistance to chloramphenicol and clindamycin, supported by the chromosomal presence of the catA gene. No other acquired resistance genes were identified.

Effects of dental implant surface treated with sandblasting large grit acid-etching and femtosecond laser on implant stability, marginal bone volume, and histological results in a rabbit model.

Purpose: The purpose of this study was to compare the surface characteristics and healing patterns after implantation of implants treated with SLA and those treated with both SLA and femtosecond laser.

Materials And Methods: A total of 10 male New Zealand white rabbits were used to compare recovery levels between implants treated with SLA (SLA group) and those treated with both SLA and femtosecond laser (SF group). The implants' surface characteristics were determined through topographic evaluation, element analysis, surface roughness, and wettability evaluation.

Long-term risk of major cardiac events in breast cancer patients treated with intensity-modulated and 3-dimensional conformal radiotherapy: Secondary analysis of a randomized clinical trial.

We assess the relationship between radiation dose to the heart and cardiac disease within the context of modern radiotherapy techniques of 3-dimensional and intensity-modulated radiotherapy (IMRT). The KROG 15-03 study was a multicenter phase III trial involving 693 breast cancer patients who underwent breast-conserving surgery (BCS). Patients were randomly assigned to receive either IMRT or 3D-CRT following BCS.

Double difference accumulation SERS strategy for rapid separation and detection of probiotic Bacillus endospores and vegetative cells.

Although probiotic Bacillus already has a large-scale market throughout the world, there is a lack of methods for rapid separation and detection of endospores and vegetative cells of probiotic Bacillus. In this study, a "double differential accumulation" SERS strategy was constructed by combining FeO@AgNPs@Van and AuNPs-PA-COFs substrates. While realizing the rapid separation and enrichment of endospores and vegetative cells of probiotic Bacillus, the SERS signals form a "cliff-like" signal difference (10-fold), which was conducive to the rapid differentiation of endospores and vegetative cells.

The impact of pelvic radiation on artificial urinary sphincter cuff survival and optimal timing for implantation.

Purpose: To evaluate the impact of pelvic radiation therapy on artificial urinary sphincter cuff outcomes and to determine the optimal timing of artificial urinary sphincter insertion after radiation therapy in patients with post-prostatectomy stress urinary incontinence.

Methods: This retrospective study included 283 patients who underwent artificial urinary sphincter placement between 2003 and 2023. Cuff revision and removal rates were analyzed using Kaplan-Meier survival analyses and competing risk models.

Effect of Pixel Offset Adjustments for XY Plane Dimensional Compensation in Digital Light Processing 3D Printing on the Surface Trueness and Fit of Zirconia Crowns.

This study aimed to evaluate the effect of pixel offset adjustments in digital light processing (DLP) three-dimensional (3D) printing on the marginal and internal fit and surface trueness of zirconia crowns. Zirconia crowns were designed using dental computer-aided design software (Dentbird; Imagoworks) and fabricated with a vat photopolymerization DLP 3D printer (TD6+; 3D Controls) under three pixel offset conditions (-1, 0, and 1). Pixel offset refers to the controlled modification of the outermost pixels in the XY plane during printing to compensate for potential dimensional inaccuracies.

Clinical Characteristics and Long-Term Prognosis of Colorectal Mucosa-Associated Lymphoid Tissue Lymphoma According to the Endoscopic Classification and Treatment Modality: A Multicenter Study.

: The clinical characteristics of colorectal mucosa-associated lymphoid tissue (MALT) lymphoma remain poorly defined, and there is no standardized treatment for the disease. Therefore, we investigated the clinical characteristics of colorectal MALT lymphoma and its prognosis based on different treatment modalities. : A retrospective analysis was performed on patients diagnosed with colorectal MALT lymphoma from 2003 to 2021 across six hospitals in Korea's Busan-Ulsan-Gyeongnam area.

Fasting is not always good: perioperative fasting leads to pronounced ketone body production in patients treated with SGLT2 inhibitors: a case report.

Ketone bodies produced by sodium-glucose cotransporter 2 (SGLT2) inhibitors can be advantageous, providing an efficient and stable energy source for the brain and muscles. However, in patients with diabetes, ketogenesis induced by SGLT2 inhibitors may be harmful, potentially resulting in severe diabetic ketoacidosis (DKA). During fasting, ketone body production serves as an alternative and efficient energy source for the brain by utilizing stored fat, promoting mental clarity, and reducing dependence on glucose.

Risk Factors of Missed Adenoma Detected by Colonoscopic Polypectomy and Its Impact of the Endoscopic System.

Background: The adenoma detection rate is a key colonoscopy quality indicator, but the adenoma miss rate (AMR) is more strongly linked to post-colonoscopy colorectal cancer risk. While studies examined high-definition colonoscopy and AMR, no studies have assessed its impact on consecutive polypectomy.

Aim: This study aimed to identify adenomas missed in screening or surveillance colonoscopy and determine if the endoscopic system affects the miss rate.

Large modulation of the bottlebrush diblock copolymer morphology and structural color through solvent selectivity.

Bottlebrush block copolymers (BBCPs), characterized by densely grafted side chains along their backbone, have emerged as promising materials for structural color applications. Their unique architecture prevents entanglement and facilitates rapid assembly kinetics, enabling the formation of various photonic crystals with high tunability of structural color from the visible to the infrared range. However, accessing non-1D structures has been largely limited to synthetic approaches.

Mutation of the gidB gene causes intrinsic streptomycin resistance in Bacillus velezensis.

Bacillus velezensis strain DMB07, isolated from the traditional fermented Korean soybean meju, exhibits resistance to streptomycin [minimum inhibitory concentration (MIC) 128 mg/L]. To shed light on the genetic background behind this phenotype, this study determined the complete genome sequence of strain DMB07 and compared it with the genomes of two B. velezensis strains that are sensitive to streptomycin.

Lyotropic Liquid Crystal Mediated Assembly of Donor Polymers Enhances Efficiency and Stability of Blade-Coated Organic Solar Cells.

Conjugated polymers can undergo complex, concentration-dependent self-assembly during solution processing, yet little is known about its impact on film morphology and device performance of organic solar cells. Herein, lyotropic liquid crystal (LLC) mediated assembly across multiple conjugated polymers is reported, which generally gives rise to improved device performance of blade-coated non-fullerene bulk heterojunction solar cells. Using D18 as a model system, the formation mechanism of LLC is unveiled employing solution X-ray scattering and microscopic imaging tools: D18 first aggregates into semicrystalline nanofibers, then assemble into achiral nematic LLC which goes through symmetry breaking to yield a chiral twist-bent LLC.

Bibliometric Analysis of Probiotic Bacillus in Food Science: Evolution of Research Trends and Systematic Evaluation.

With the in-depth and comprehensive research on probiotic Bacillus, it has become a hot topic in food science. However, the current status of research using bibliometric analysis to assess the application of probiotic Bacillus in food science has not been comprehensively reviewed. The Web of Science (WOS) database was used in this review's bibliometric analysis to determine the hotspots for research as well as the extent of completed experiments.

Specificity of Amino Acid Profiles Produced in Soybean Fermentations by Three spp.

We compared the salt tolerance and proteolytic activity of 120 strains of each of , , and . Most strains exhibited growth in 12% (w/v) NaCl and showed proteolytic activity in 10% or 11% NaCl. The majority of strains grew in 14% NaCl and showed proteolytic activity in 12% or 13% NaCl.

Comparison of the prognosis and lymph node metastasis between no tumor budding and low-grade tumor budding in T1 and T2 colorectal cancer.

Tumor budding is a significant prognostic factor in colorectal cancer (CRC) management and is graded as follows: 0-4 buds as low, 5-9 buds as intermediate, and > 10 buds as high. However, the specific prognostic difference between cases with 0 buds (BD0) and those with 1-4 buds (BD1) is not well established owing to a lack of comparative studies. This study aimed to examine and compare the rate of lymph node (LN) metastasis and prognosis by distinguishing between BD0 and BD1 within the low-grade category (0-4 buds) of tumor budding in submucosa (T1) and muscularis propria (T2) CRC.

Efficacy of Oral Sulfate Tablet and 2 L-Polyethylene Glycol With Ascorbic Acid for Bowel Preparation: A Prospective Randomized KASID Multicenter Trial.

Background: Oral sulfate tablets (OSTs) are bowel preparation agents that combine oral sulfate solution and simethicone. This study compared the efficacy, tolerability, and safety of OST compared to 2 L-polyethylene glycol plus ascorbic acid (2 L-PEG/ASC).

Methods: This prospective, randomized, controlled, single-blinded, multicenter, noninferiority trial enrolled 211 healthy adults who underwent colonoscopy between May 2020 and September 2022 at 13 university hospitals.

Development of a Deep Learning-Based Predictive Model for Improvement after Holmium Laser Enucleation of the Prostate According to Detrusor Contractility.

Purpose: Predicting improvements in voiding symptoms following deobstructive surgery for male lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) is challenging when detrusor contractility is impaired. This study aimed to develop an artificial intelligence model that predicts symptom improvement after holmium laser enucleation of the prostate (HoLEP), focusing on changes in maximum flow rate (MFR) and voiding efficiency (VE) 1-month postsurgery.

Methods: We reviewed 1,933 patients who underwent HoLEP at Samsung Medical Center from July 2008 to January 2024.

Rapid screening and identification strategy of lactic acid bacteria and yeasts based on Ramanomes technology and its application in fermented food.

There is an urgent need for quick, sensitive, thorough, and low-cost preliminary screening and rapid identification method for probiotic resource development. Here, we constructed a culture-free, accurate and sensitive "separation-enrichment-detection" rapid evaluation and identification method of probiotics in fermented food based on Ramanomes technology, and established a Ramanome reference of lactic acid bacteria and yeasts by AgNPs nanostructure array (AgNPs NSA) chips with uniform "hot spots" and high signal enhancement ability as SERS substrates. Systematic cluster analysis could clearly distinguish among different genera of lactic acid bacteria and yeast, and could indicate the affinity and difference between lactic acid bacteria of the same genus and yeast of the same genus.

Dynamic analysis of bovine bone high-temperature hydrolysate emulsion formation based on microstructure and physicochemical interactions.

In the food industry, the emulsifying process alters both the stability and quality of the emulsified products prepared by bovine bone high-temperature hydrolysate (BBHH). The microstructure and interactions of BBHH emulsion were characterized by cryo-scanning electron microscopy (Cryo-SEM) and Raman spectroscopy during emulsification. Notably, BBHH emulsion exhibited the best properties under emulsifying for 120 s, attributed to its interfacial adsorption characteristics.