Risk of depression in chronic immune-mediated neuropathies: A nationwide cohort study in South Korea.

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) are among the most common immune-mediated neuropathies, characterized by a chronic, disabling disease course. While depression significantly impacts outcomes in various neurological disorders, its risk remains underexplored in patients with CIDP or MMN. This study aimed to investigate the association between CIDP or MMN and new-onset depression using a nationwide cohort in South Korea.

Cardiovascular Risk Across Blood Pressure Categories Defined by the 2024 ESC and 2023 ESH Hypertension Guidelines: Insights from a Korean Nationwide Cohort Study.

Background And Aims: The most recent guidelines from the European Society of Cardiology (ESC) categorize blood pressure (BP) into three groups: (1) non-elevated BP, (2) elevated BP and (3) hypertension. This study aimed to determine whether the 2024 guidelines from the ESC for elevated BP and hypertension accurately identify populations at increased risk of future cardiovascular diseases.

Methods: In a population-based cohort derived from the Korean National Health Insurance Service database, we included individuals aged ≥40 years who underwent national health examinations in 2009.

The Association betweend Rheumatoid Arthritis and Stroke Risk by Serologic Status and Stroke Subtypes.

Background: Rheumatoid arthritis (RA) has been associated with an increased stroke risk, but associations by serostatus (seropositive RA (SPRA) vs. seronegative RA (SNRA)) and with subtypes of stroke (ischemic stroke (IS) or hemorrhagic stroke (HS)) are not well established. In addition, it is not well-known whether the use of biologic and targeted synthetic disease modifying anti-rheumatic drugs (b/tsDMARDs) are associated with altered stroke risk.

Smoking and the risk of sudden cardiac arrest in young-aged adults: a Korean nationwide population-based study.

Aims: Smoking is a risk factor for cardiovascular events. Regarding the different aetiology of sudden cardiac arrest (SCA) in younger individuals compared with the elderly, we investigated the linkage between smoking and the risk of SCA in young-aged adults.

Methods And Results: In this retrospective analysis, an observational longitudinal cohort was obtained from the national health screening database in South Korea.

Associations of Cardiocerebrovascular Risks and Exercise According to Menopausal Status in Women with Type 2 Diabetes Mellitus: A Nationwide Cohort Study.

Background: Menopausal status can increase the risk of cardiocerebrovascular diseases (CCVDs) in women with type 2 diabetes mellitus (T2DM). Regular exercise is well-known to reduce this risk. This study explored the impact of exercise on CCVD and mortality in women with T2DM according to their menopausal status.

Increased risk of atrial fibrillation in uterine fibroid patients: a nationwide population-based study.

The association between atrial fibrillation (AF) and uterine fibroids (UF) is unclear, though UF are linked to an elevated risk of cardiovascular disease. This study aimed to investigate the AF risk in UF patients. Females aged 20-39 who received health examinations from 2009 to 2012 were included.

Impact of longer diabetes duration and lower estimated glomerular filtration rate on cardiovascular complications and mortality: A nationwide population-based study.

Background: Decreased renal function is a well-known risk factor for cardiovascular diseases (CVD) and death. However, the impact of diabetes duration and the glomerular filtration rate (GFR) on cardiovascular complications in patients with type 2 diabetes has not been well studied.

Aim: To investigate the complex impact of longer diabetes duration and GFR on CVD and mortality.

Exercise intensity and the risk of end-stage renal disease in diabetes: A nationwide population-based study.

Background: Exercise plays a key role in managing chronic conditions such as diabetes mellitus (DM), a major contributor to end-stage renal disease (ESRD), a serious public health issue.

Aim: To investigate the relationship between exercise intensity, DM duration, and ESRD incidence.

Methods: This retrospective cohort study analyzed data from 2495031 individuals with DM who underwent the Korean National Health Screening between 2015 and 2016, with follow-up through 2022.

Development and validation of a risk prediction model for abdominal aortic aneurysm: a nationwide population-based cohort study.

Abdominal aortic aneurysm (AAA) is characterized by irreversible localized dilatation of the abdominal aorta. It poses a significant health risk. As AAA size tends to increase over time, there is a heightened risk of rupture, resulting in a substantially high mortality rate.

Early-Onset Dementia Risk Escalates with Diabetes Duration: Insights from a Nationwide Cohort Study.

Background: The prevalence of diabetes mellitus and early-onset dementia (EOD), defined as dementia diagnosed at an age <65 years, is increasing worldwide, with significant socioeconomic implications. We investigated the association between diabetes, prediabetes, and EOD, focusing on the influence of diabetes duration on EOD risk.

Methods: Using the Korean National Health Insurance Service database, we analyzed data from 1,979,509 patients aged 40-60 years who underwent health checkups in 2009.

Association of temporal MASLD with type 2 diabetes, cardiovascular disease and mortality.

Background: We investigated the risk of type 2 diabetes (T2DM) and related comorbidities including cardiovascular disease (CVD), and mortality, based on changes in metabolic dysfunction associated steatotic liver disease (MASLD).

Methods: We analyzed data from the Korean National Health Insurance Service for individuals aged ≥ 20 years. MASLD was defined as a fatty liver index (FLI), a prediction formula based on metabolic parameters, with a cutoff of ≥ 60.

Associations of Alcohol Consumption with All-Cause and Cancer Mortalities in Patients with Type 2 Diabetes Mellitus: A Nationwide Population Cohort Study.

Background: To investigate the impact of alcohol consumption on all-cause and cancer mortalities in patients with type 2 diabetes (T2D).

Methods: This nationwide cohort study included Korean patients with T2D aged >20 years from a national health exams cohort (2009 to 2012). Participants were categorized based on alcohol consumption: non, mild (<30 g/day), and heavy drinkers (≥30 g/day).

Diabetic retinopathy and chronic kidney disease synergistically increase the risk of incident cardiovascular disease in type 2 diabetes: Insights from two cohort studies.

Aims: Chronic kidney disease (CKD) is a well-established cardiovascular risk factor for type 2 diabetes (T2D); however, the role of diabetic retinopathy (DR) remains unclear. This study evaluated the individual and combined effects of DR and CKD on cardiovascular disease (CVD) in T2D.

Methods: We analyzed individuals with T2D and no prior CVD from the Korean NHIS cohort (n = 2,064,406) and the UK Biobank (n = 21,350).

Risk of pancreatic cancer according to glycemic status in nonalcoholic fatty liver disease: a nationwide cohort study.

We investigated the association between glycemic status and pancreatic cancer risk in individuals with nonalcoholic fatty liver disease (NAFLD). This study included 1,093,832 individuals with NAFLD who underwent the Korean national health screening in 2009. NAFLD was defined as fatty liver index ≥ 30 after excluding heavy alcohol use and viral hepatitis.

Early Rhythm Control of Atrial Fibrillation in Cancer Survivors: A Nationwide Population-Based Study.

Background: Although early rhythm control (ERC) is effective in reducing stroke in patients with atrial fibrillation (AF), its benefits have not been well elucidated in cancer survivors. This study aimed to compare the risk of ischemic stroke between ERC and usual care in cancer survivors with AF.

Methods: This nationwide observational study was conducted using the Korean National Health Insurance Service database.

Risk of hepatocellular carcinoma according to body mass index and waist circumference in nonalcoholic fatty liver disease.

Background: The association between adiposity parameters and incident hepatocellular carcinoma (HCC) in individuals with nonalcoholic fatty liver disease (NAFLD) is yet to be evaluated.

Aim: To investigate the risk of HCC according to body mass index (BMI) and waist circumference (WC) in people with NAFLD.

Methods: This population-based cohort study included Korean National Health Insurance Service examination participants with NAFLD ( = 1110773).

Korean Cardiovascular Health Status Assessed by Life's Essential 8 in Korean Adult Population: Based on Data From the Korean National Health and Nutrition Examination Survey 2014-2021.

Background And Objectives: Cardiovascular disease is a leading cause of mortality globally and in South Korea. The American Heart Association (AHA) developed Life's Essential 8 (LE8) to evaluate cardiovascular health (CVH) through 8 metrics. However, LE8 has not been studied in the Korean population.

Impact of diabetes duration and hyperglycemia on the progression of diabetic kidney disease: Insights from the KNHANES 2019-2021.

Background: Diabetes is a significant risk factor for chronic kidney disease, and diabetic kidney disease (DKD) is prevalent among patients with diabetes. Previous studies have indicated that the duration of diabetes and poor glycemic control are associated with an increased risk of DKD, but data on how the duration and severity of hyperglycemia specifically relate to DKD progression are limited.

Aim: To investigate the relationship between diabetes duration and glycemic control, and DKD progression in South Korea.

Impact of steatotic liver diseases on diabetes mellitus risk in patients with atrial fibrillation: a nationwide population study.

Background: Atrial fibrillation (AF) frequently coexists with diabetes mellitus (DM), leading to a worse prognosis if both are present. Steatotic liver disease (SLD) may also predispose to DM, but its impact among AF patients is unclear. We aimed to determine whether metabolic dysfunction-associated SLD (MASLD), MASLD with increased alcohol intake (MetALD), or alcohol-related liver disease (ALD) elevates DM risk in AF.

Associations of body mass index and waist circumference with incidence of overall and of 27 site-specific cancers: a population-based retrospective cohort study.

Background: Overweight and obesity are known risk factors for cancer. The aim of this study was to investigate associations of body mass index (BMI) and waist circumference (WC) with incidence of 27 site-specific cancers stratified by sex and menopausal status accounting for non-linearity.

Methods: We performed a population-based retrospective cohort study using the Korean National Health Insurance Service (KNHIS 2009-2020) database.

Nationwide Epidemiology and Management Time Trends for Atrial Fibrillation: Insights From the Korean AF Factsheet.

Atrial fibrillation (AF) represents the most prevalent cardiac arrhythmia in clinical practice, with its incidence rising globally. Korea's comprehensive national health insurance system facilitates the meticulous collection and management of health care utilization data for its entire population. This robust data infrastructure has enabled numerous recent studies on AF in Korea, encompassing its prevalence, incidence, anticoagulation treatment rates, health care burden, and associated complications.

Decrease in low-density lipoprotein cholesterol is associated with an increased risk of mortality in patients with diabetes mellitus.

Introduction: Research on the effect of low-density lipoprotein (LDL)-cholesterol levels and its serial change on all-cause mortality is limited. This study investigated serial change in LDL-cholesterol and its association with all-cause mortality or sudden cardiac arrest (SCA) in patients with diabetes mellitus.

Methods: Data was obtained from the nationwide health insurance database of South Korea.

Proteinuria is risk factor for abdominal aortic aneurysm: a nationwide population-based study.

Background: Proteinuria is a well-known risk factor for cardiovascular disease. However, the impact of proteinuria on abdominal aortic aneurysm (AAA) remains unclear. In this study, we aimed to investigate the association between proteinuria and AAA.

Association between proteinuria changes and colorectal cancer incidence: evidence from a nationwide cohort study.

Background: The presence of excess proteins in the urine, known as proteinuria, has been linked to various health conditions, including chronic kidney disease and cancer. Emerging evidence suggests an association between proteinuria and colorectal cancer, a leading global cause of cancer-related morbidity and mortality. However, the impact of changes in proteinuria status on colorectal cancer risk remains unclear.

Impact of Remnant Cholesterol on the Risk for End-Stage Renal Disease in Type 2 Diabetes Mellitus: A Nationwide Population-Based Cohort Study.

Background: Remnant cholesterol (remnant-C) has been linked to the risk of various vascular diseases, but the association between remnant-C and end-stage renal disease (ESRD) in patients with type 2 diabetes mellitus (T2DM) remains unclear.

Methods: Using a nationwide cohort, a total of 2,537,149 patients with T2DM without ESRD, who had participated in the national health screening in 2009, were enrolled and followed up until 2020. Low-density lipoprotein cholesterol (LDL-C) levels were assessed by the Martin-Hopkins method, and remnant-C was calculated as total cholesterol-LDL-C-high-density lipoprotein cholesterol.