They are more beautiful than me! How social media use increases women's body-related envy and cosmetic surgery consideration.

Background: Past research has indicated the close connection between social media use and women's envy, but so far, no research has been conducted to exclusively examine the effect and mechanism of social media use on women's body-related envy.

Objective: To fill this gap, with TikTok as a representative example of video-based social media, four studies ( = 767) were conducted to explore whether and how social media use increases women's body-related envy, and the subsequent downstream consequences.

Method And Results: In Study 1a, we employed an online questionnaire survey and found that TikTok use had a significantly positive prediction on women's body-related envy.

Can the elderly benefit from unitization? - Effects of different unitization manipulations on age-related associative memory deficit.

With the aging process, older adults performed significantly poorer than young adults at remembering the relationships between pieces of information. This phenomenon is known as age-related associative memory deficit. Associative Deficit Hypothesis posits that this deficit stems from hippocampal atrophy in older adults, leading to a decline in their ability to bind information and an impairment in hippocampus-dependent recollection.

Computational insights and activity evaluation of novel SHP-2 inhibitors for targeting type 2 diabetes mellitus.

Protein-tyrosine phosphatase-2 (SHP-2) has become a new target in the study of type 2 diabetes mellitus (T2DM). Currently, there are no marketed drugs targeting SHP-2 to study T2DM caused by insulin resistance. Therefore, this study screened out SHP-2 inhibitors with potential inhibitory activity from 2 million compounds, combined with ADME/T, Lipinski &Veber rules, molecular docking and molecular dynamics simulation.

Linear correlation between white blood cell counts and the progression and prognosis of acute kidney injury.

IntroductionWhite blood cell count, a cost-effective blood test marker, is used extensively for the diagnosis and prognosis of diseases. Nevertheless, its association with the progression and prognosis of acute kidney injury remains unclear.MethodsA retrospective analysis was conducted using data from a multicenter randomized trial on an acute kidney injury early warning system.

Recent progress in anti-atherosclerosis strategies and prospective therapeutic targets.

Atherosclerosis, a prevalent cardiovascular condition, results from the accumulation of lipids and other substances within the artery wall following intimal damage. This process leads to the development of atherosclerotic plaques, causing arterial stenosis or complete occlusion. Although current treatment strategies of atherosclerosis have obvious advantages, they are accompanied by side effects.

Latent Class Analysis with Arbitrary-Distribution Responses.

The latent class model has been proposed as a powerful tool in understanding human behavior for various fields such as social, psychological, behavioral, and biological sciences. However, one important limitation of the latent class model is that it is primarily applied to data with binary responses or categorical responses, making it fail to model real-world data with continuous or negative responses. In many applications, ignoring the weights throws out a lot of potentially valuable information contained in the weights.

Ocular Safety Evaluation of Toplic and Systemic Antifungal Medications: A Multi-Source Pharmacovigilance and Genomic Study.

Background: Antifungal agents, used topically and systemically to treat fungal infections, have been associated with ocular adverse events (AEs), yet their ocular safety profiles remain under-characterized.

Methods: This study utilized data from the FDA Adverse Event Reporting System (FAERS, 2004-2024), a single-center retrospective study validation, and systems pharmacology analyses to investigate ocular AEs linked to antifungal drugs. Disproportionality analysis identified AE signals, while retrospective clinical data validated key findings.

Yin Yang 1 (YY1) as a Central Node in Drug Resistance Pathways: Potential for Combination Strategies in Cancer Therapy.

Tumor drug resistance, a major cause of treatment failure, involves complex multi-gene networks, remodeling of signaling pathways, and interactions with the tumor microenvironment. Yin Yang 1 (YY1) is a critical oncogene overexpressed in many tumors and mediates multiple tumor-related processes, such as cell proliferation, metabolic reprogramming, immune evasion, and drug resistance. Notably, YY1 drives resistance through multiple mechanisms, such as upregulation of drug efflux, maintenance of cancer stemness, enhancement of DNA repair capacity, modulation of the tumor microenvironment, and epithelial-mesenchymal transition, thereby positioning it as a pivotal regulator of drug resistance.

Exploring the relationship between metabolic syndrome and vestibular dysfunction: NHANES data and Mendelian randomization analysis.

Metabolic syndrome (MetS) is associated with an increased risk of various health issues, with emerging evidence suggesting a potential connection to vestibular dysfunction. However, the nature of this relationship remains unclear. This study aims to evaluate the association between MetS and vestibular dysfunction using data from the National Health and Nutrition Examination Survey (NHANES) and Mendelian Randomization (MR) analysis.

A Novel Therapeutic Strategy for Bone Marrow Failure: Niche Rejuvenation Using Costal Cartilage-Derived Stem Cells.

The bone marrow (BM) niche plays a critical role in maintaining hematopoietic stem cell function but is highly vulnerable to damage from chemotherapy and radiation. However, current therapeutic strategies for BM niche failure remain significantly limited. The previous study demonstrate that costal cartilage-derived stem cells (CDSCs) exhibit substantial self-renewal and bone-forming capacity; however, whether and how CDSCs contribute to BM microenvironment maintenance remains unknown.

The underexplored effects of economic transition on intellectual property rights protection: An economic geography perspective.

As an institutional guarantee of technology and innovation, intellectual property rights (IPRs) protection at the national and supranational level has long been an important focus of economics and politics. However, very few studies have examined IPRs protection in the fields of geography and urban studies. Thus, this study aims to investigate IPRs protection within evolutionary economic geography (EEG) by highlighting the effect of economic transition.

Synergistic antibacterial, anti-adhesion, and lubricating hydrogel coating with carbon quantum dots for urinary catheters: A multifaceted strategy against catheter-associated infections.

Urinary catheters (UCs) encounter persistent challenges, including catheter-associated urinary tract infections (CAUTIs) and friction-induced tissue damage. Here, we developed multifunctional carbon quantum dots (CQDs) - polyacrylic acid (PAA) - polyethylene glycol (PEG) - poly-N-isopropyl acrylamide (PNIPAM) (CAPPN) hydrogel coatings for polyvinyl chloride (PVC) UCs, which integrated CQDs with interfacial engineering to achieve synergistic antibacterial, anti-adhesion, and lubrication properties. The hydrothermally synthesized CQDs (3.

Rosmarinic acid improves intestinal barrier integrity through PI3K/AKT/Nrf2-mediated regulation of tight junction protein expression.

Rosmarinic acid (RA), a polyphenolic compound, exhibits diverse pharmacological activities, including anti-inflammatory, antioxidant, and antitumor effects. Despite its therapeutic potentials, the mechanisms underlying its efficacy in ulcerative colitis (UC), a chronic inflammatory bowel disease characterized by intestinal epithelial barrier dysfunction, remain incompletely elucidated. This study investigates RA's protective effects in UC using complementary in vivo and in vitro models.

Enhancing Tight Oil Recovery in Aqueous-Affected Reservoirs: Experimental Investigation of Triphilic Surfactant Synergy with CO Huff-and-Puff Stimulation.

CO huff-and-puff demonstrates excellent injectivity and gas channeling resistance in tight reservoirs, yet aqueous phase invasion significantly diminishes its oil recovery efficiency. To investigate the mechanisms of aqueous phase impacts, CO huff-and-puff experiments were conducted under varying water saturation levels, complemented by extended core displacement tests with different injection patterns. A triphilic surfactant, CEOPOCOOCH (CEPC), was introduced to mitigate aqueous phase interference.

RCLM-net: A rich-club properties based lightweight deep neural network for multimodal sequence spine MR images segmentation.

The diagnosis of spinal diseases relies on the comprehensive assessment of multimodal sequence MR images. As a prior foundation for intelligent aid diagnosis, it is important to design an efficient MR image segmentation model. However, previous models for multimodal images tend to have a large number of parameters, which is not suitable for low-computing-power application scenarios, especially for primary medical sites.

Ligand-Mediated Tailoring of Self-Supported MnO@Ni(OH) Nanoheterostructures with Enhanced OER Performance.

We report a colloidal synthesis strategy for producing MnO@Ni(OH) nanoheterostructures under mild conditions, i.e., low temperature and ambient pressure.

Antifouling Cyclic Peptide Nanotubes Combined with Rh-TiCT Multifunctional Nanozyme for the Sensitive Detection of CA125 in Complex Biological Samples.

Although linear peptides exhibit advantageous physicochemical properties and biocompatibility for antifouling biosensing applications, the intrinsic structural flexibility of natural linear peptides makes them susceptible to enzymatic degradation, compromising their long-term practical applications. To address these limitations, cyclic peptide nanotubes (CPNTs) were prepared via a self-assembly strategy of cyclic peptides, which imparted exceptional enzymatic stability due to their intramolecular hydrogen bonds and rigid tubular structure. Moreover, the densely arranged hydrophilic residues on the surface of the nanotubes (such as serine, histidine, and glutamic acid) formed a dynamic hydration layer through hydrogen bonding with free water molecules, thereby achieving a 2.

Fluorination of Fe, Sn, N atoms doped carbon enables the balance of activity and stability for oxygen reduction.

The development of highly active and durable carbon-based electrocatalysts for the oxygen reduction reaction (ORR) is of critical importance. In this study, a heteroatom-doped carbon catalyst (FeSn-NFC) was synthesized through the chelation of Fe and dopamine hydrochloride, followed by Sn/F co-doping and carbonization. The resulting FeSn-NFC catalyst exhibits an ultrahigh specific surface area of 2387.

Does green credit promote real economic development? Dual empirical evidence of scale and efficiency.

Green credit has emerged as a new engine for economic transformation and a core driving force behind high-quality development. By using panel data from 30 provinces in China, this paper comprehensively examines the influence of green credit on the real economy. The research findings suggest that green credit has a significantly positive effect on the scale of the real economy but a significantly negative effect on the efficiency of the real economy.

X-Aggregation Enhanced Room Temperature Phosphorescence from Terphenylamine.

Organic room temperature phosphorescence (RTP) materials have drawn wide attention because of their unique photoluminescence performances. As is known, their molecular aggregation shows determined influences on their RTP performances. However, the regulation mechanism of the molecular aggregation is still unclear.

Research progress on stiffness controllable scaffolds based on gelatin methacryloyl hydrogels for tissue repair and reconstruction.

The extracellular matrix (ECM) maintains tissue morphology and regulates cellular behavior through its network of biochemical components and biophysical signals. Matrix stiffness, as a key physical parameter in cell-matrix interactions, has attracted widespread attention and has been recognized as a crucial regulator of cellular behavior. Tissue engineering mimics the biomechanical environment of the ECM to promote the repair of damaged tissues.

Rooted in and beyond interaction: A systematic review of interactive affordances of chatbots for language learning amidst the rise of large language models.

As chatbots evolve from scripted responders to reasoning companions, their role in language education is rapidly shifting. Yet, while their presence is expanding, a deeper understanding of how they interact-not just respond-with learners remains elusive. This systematic review repositions interaction as the core of chatbot-assisted language learning, drawing on 100 peer-reviewed studies published between 2009 and 2024.

Mechanistic insights into the impact of multi-dimensional microplastic stress on nitrogen removal by heterotrophic nitrifying-aerobic denitrifying bacteria: A meta-transcriptomic analysis.

Heterotrophic nitrification-aerobic denitrification (HN-AD) bacteria possess considerable potential for treating high-ammonia wastewater; however, their denitrification characteristics and response mechanisms under microplastics (MPs) stress remain inadequately understood. This study systematically investigated the effects of typical MPs on the denitrification performance of HN-AD bacteria strain TAC-1 through batch experiments, metatranscriptomic and ultrastructural analysis. The findings demonstrated that hydrophobic nature of polyvinyl chloride (PVC) disrupted the intermolecular interactions among lipid molecules, reducing cell membrane density and forming permeable channels.

Quorum sensing signaling molecules enhance the treatment performance of the HN-AD bacteria-Chlorella symbiotic system in MABR.

To enhance the stability of membrane aerated biofilm reactor (MABR) and accelerate the formation of biofilm, this study introduced a symbiotic system composed of heterotrophic nitrification-aerobic denitrification (HN-AD) bacteria and Chlorella into the MABR, and compared it with a control system inoculated with HN-AD bacteria and activated sludge. The effects of adding 0.8 μM exogenous C8-HSL on biofilm formation and the efficiency of nitrogen and phosphorus removal were investigated by comparing systems with and without the signaling molecule.

Performance and mechanism of Cr(VI) removal from aqueous solution by polydopamine/Ce-UIO-66 co-modified glutaraldehyde crosslinked chitosan matrix composite.

In this study, polydopamine/Ce-UIO-66 co-modified glutaraldehyde crosslinked chitosan (CGCP) composite was prepared by chemical cross-linking and oxidative polymerization methods and used to remove Cr(VI) from aqueous solution. The removal efficiency of Cr(VI) by CGCP gradually decreased with increasing pH, and the highest removal efficiency of 94.18 % was achieved at pH = 2.