Association of preoperative cerebrospinal fluid sTREM2 concentration with postoperative delirium and three-year mortality in patients total knee or hip arthroplasty: a prospective cohort study.

Background: As a common postoperative neurological complication, postoperative delirium (POD) can lead to poor postoperative recovery in patients, prolonged hospitalization, and even increased mortality. However, POD's mechanism remains undefined and there are no reliable molecular markers of POD to date. The present work examined the associations of cerebrospinal fluid (CSF) sTREM2 with CSF POD biomarkers, and investigated whether the effects of CSF sTREM2 on POD were modulated by the core pathological indexes of POD (Aβ42, tau, and ptau).

Non-invasive prediction of invasive lung adenocarcinoma and high-risk histopathological characteristics in resectable early-stage adenocarcinoma by [18F]FDG PET/CT radiomics-based machine learning models: a prospective cohort Study.

Background: Precise preoperative discrimination of invasive lung adenocarcinoma (IA) from preinvasive lesions (adenocarcinoma in situ [AIS]/minimally invasive adenocarcinoma [MIA]) and prediction of high-risk histopathological features are critical for optimizing resection strategies in early-stage lung adenocarcinoma (LUAD).

Methods: In this multicenter study, 813 LUAD patients (tumors ≤3 cm) formed the training cohort. A total of 1,709 radiomic features were extracted from the PET/CT images.

Accelerating Transition State Search and Ligand Screening for Organometallic Catalysis with Reactive Machine Learning Potential.

Organometallic catalysis lies at the heart of numerous industrial processes that produce bulk and fine chemicals. The search for transition states and screening for organic ligands are vital in designing highly active organometallic catalysts with efficient reaction kinetics. However, identifying accurate transition states necessitates computationally intensive quantum chemistry calculations.

Expert consensus regarding the clinical application of liver contrast-enhanced US with Sonazoid (Sonazoid CEUS).

Sonazoid, a combined blood pool and Kupffer-cell agent, can be specifically phagocytosed by Kupffer cells in the liver, allowing lesion detection and characterization of focal liver lesions (FLLs) at the post-vascular phase apart from the vascular phase which is similar to that of other second-generation US contrast agents. Sonazoid CEUS is currently approved for use in some Asian countries. With the increasing use of Sonazoid CEUS for FLLs in clinical practice, developing consensus or guidelines to help standardize its use is required.

Guideline adherence in surgical decisions for T1 colorectal cancer after endoscopic resection: large language models vs clinicians.

Background: Patients with T1 colorectal cancer (CRC) often show poor adherence to guideline-recommended treatment strategies after endoscopic resection. To address this challenge and improve clinical decision-making, this study aims to compare the accuracy of surgical management recommendations between large language models (LLMs) and clinicians.

Methods: This retrospective study enrolled 202 patients with T1 CRC who underwent endoscopic resection at three hospitals.

Comparison of short- and long-term outcomes between transcatheter and surgical aortic valve replacement for bicuspid aortic valve stenosis: a systematic review and meta-analysis.

Objective: This meta-analysis aimed to compare the perioperative safety and efficacy of transcatheter aortic valve replacement (TAVR) versus surgical aortic valve replacement (SAVR) in bicuspid aortic valve (BAV) stenosis.

Methods: We systematically analyzed studies from PubMed, Cochrane Library, Embase, and CNKI comparing TAVR and SAVR in BAV stenosis. Outcomes included postoperative mortality, complications, all-cause survival, and freedom from stroke.

Bladder cancer risk factors: a comprehensive umbrella review of meta-analyses.

Background: Bladder cancer represents a significant global health challenge, characterized by poorly understood risk factors. This study aims to synthesize meta-analytical evidence, quantify risk associations, and inform prevention strategies.

Methods: We conducted a comprehensive literature search in PubMed, Embase, Web of Science, and Cochrane Library up to October 2024.

The impact of surgeons' visual angle misperception on acetabular cup positioning accuracy: a retrospective multicentre cohort study.

Background: Precise acetabular cup placement in total hip arthroplasty (THA) heavily relies on surgeons' visual judgment of angles. However, whether inherent visual angle misperception among surgeons affects surgical outcomes remains unclear. This study is the first to reveal that surgeons universally exhibit visual angle misperception, a key factor causing the cup implant positioning deviations in THA.

Causes of Death After Surgery Among Cancer Patients: A Population-based Cohort Study.

Introduction: Recent advancements in surgical techniques and perioperative care have improved cancer survival rates, yet postoperative comorbidity and mortality remain a critical concern. Despite progress in cancer control, systematic analyses of long-term mortality trends and competing risks in surgery-intervened cancer populations are lacking. This study aimed to quantify temporal patterns of postoperative mortality causes across 21 solid cancers and identify dominant non-cancer risk factors to inform survivorship care strategies.

Telerobotic surgery: a comprehensive two-decade evolution and the integration of emerging technologies.

Telerobotic surgery has undergone remarkable advances over the past two decades, driven by the integration of sophisticated robotic platforms and modern communication technologies, thereby alleviating many constraints of conventional surgical procedures. Building upon previous studies that focused on individual specialties or specific innovations, this review provides a comprehensive and integrated perspective by tracing the evolution of the field and highlighting applications in gastroenterology, urology, neurology, and cardiology. Landmark achievements include the 2001 transatlantic remote cholecystectomy and the introduction of next-generation platforms such as the Hinotori surgical robot, enabling low-latency remote interventions.

Correction: Distinct autophagy-inducing abilities of similar-sized nanoparticles in cell culture and live .

Correction for 'Distinct autophagy-inducing abilities of similar-sized nanoparticles in cell culture and live ' by Qin Wang , , 2018, , 23059-23069, https://doi.org/10.1039/C8NR05851B.

Blackcurrant polyphenol extract improves alcoholic liver disease through the FGF21-NET/c-FOS pathway.

Blackcurrant is rich in polyphenolic substances with corresponding antioxidant and anti-inflammatory properties. Therefore, based on the identification of typical functional components of blackcurrant polyphenols (BCP), the present study investigated the therapeutic effects of BCP on alcoholic liver disease (ALD) by modulating fibroblast growth factor 21 (FGF21) in both an HepG2 cell model and an C57BL/6J mouse model of acute alcoholism. In total, 892 polyphenols and 45 anthocyanins were identified in blackcurrant.

Tumor-phrenic nerve spatial relationship and intraoperative traction-induced injury during mediastinal tumor resection: implications for real-time protective strategies.

Background: Phrenic nerve injury during mediastinal tumor resection can lead to significant postoperative diaphragmatic dysfunction. Current intraoperative protection techniques are imprecise and lack real-time feedback. We aimed to develop and validate a quantifiable, multimodal neuroprotective strategy.

Three-dimensionally printed navigational template technology for lung biopsy: a non-inferiority, randomised trial.

Background: Percutaneous transthoracic lung biopsy (PTNB) guided by Computed Tomography (CT) greatly depends on the operators' skill for accuracy. This study aimed to evaluate whether three-dimensionally(3D) printed navigational templates for percutaneous transthoracic lung biopsy achieve diagnostic yield comparable to conventional computed tomography guidance.

Materials And Methods: Conducted from 1 November 2020, to 27 July 2023, this noninferiority randomized clinical trial included 159 patients with peripheral lung masses (≥30 mm).

Water hardness and digestive diseases: a large-scale population-based prospective cohort study.

Background: Water hardness, which refers to the level of dissolved calcium and magnesium salts, is of significant public health concern due to its potential impact on health. The association between water hardness and digestive diseases remains underexplored, with limited evidence from small-scale clinical studies. Given the rising prevalence of digestive disorders worldwide, large-scale cohort studies are needed to address this gap in the literature.

Development and validation of a novel nomogram model for predicting postoperative survival of T4N0M0 NSCLC: a population-based survival analysis.

Objective: The risk factors of postoperative survival in T4N0M0 NSCLC patients are not fully understood. This study aimed to develop and validate a nomogram model for predicting postoperative survival in patients with T4N0M0 non-small cell lung cancer (NSCLC).

Methods: Clinicopathological data of patients were collected from Surveillance, Epidemiology, and End Results (SEER) database.

subsp. B-53 Alleviated Abnormalities of Glycolipid Metabolism and Oxidative Stress in T2DM Mice Through Regulating Gut Microbiota and GLP-1 Secretion.

Creating effective treatments for type 2 diabetes mellitus (T2DM) remains a critical global health challenge. This study investigates the antidiabetic mechanisms of subsp. B-53 ( B-53) in T2DM mice.

Efficient Fully-Solution-Processed Inverted Red Quantum Dot Light-Emitting Diodes Enabled by Charge-Exciton Regulation.

Inverted quantum dot light-emitting diodes (QLEDs) show great promise for next-generation displays due to their compatibility with integrated circuit architectures. However, their development has been hindered by inefficient exciton utilization and charge transport imbalance. Here, we present a strategy for regulating charge-exciton dynamics through the rational design of a multifunctional hole transport layer (HTL), incorporating polyethylenimine ethoxylated (PEIE) as a protective interlayer in fully-solution-processed inverted red QLEDs.