Maternal-Fetal Interface Cell Dysfunction in Patients With Preeclampsia Revealed via Single-Cell RNA Sequencing.

Problem: Preeclampsia (PE) is a leading cause of perinatal maternal and fetal mortality. Clinical and pathological studies suggest that placental and decidual cell dysfunction may contribute to this condition. However, the pathogenesis of PE remains poorly understood.

Advancements and Innovations in Low-Temperature Hydrogen Electrochemical Conversion Devices Driven by 3D Printing Technology.

3D printing, as a versatile additive manufacturing technique, offers high design flexibility, rapid prototyping, minimal material waste, and the capability to fabricate complex, customized geometries. These attributes make it particularly well-suited for low-temperature hydrogen electrochemical conversion devices-specifically, proton exchange membrane fuel cells, proton exchange membrane electrolyzer cells, anion exchange membrane electrolyzer cells, and alkaline electrolyzers-which demand finely structured components such as catalyst layers, gas diffusion layers, electrodes, porous transport layers, and bipolar plates. This review provides a focused and critical summary of the current progress in applying 3D printing technologies to these key components.

Cadmium Availability in a Soil-Rice System Receiving Four Consecutive Seasons of Straw Removal.

Cadmium (Cd) pollution in rice agroecosystems has become a pressing worldwide environmental challenge. Straw return leads to Cd re-entering the soil, yet the impact of straw removal (SR) on Cd mobility and bioavailability within this system remains unclear. We implemented a four-season field study to evaluate how different SR intensities (NSR: no rice straw was removed; HSR: half of the rice straw was removed; TSR: all the rice straw was removed) influence Cd availability in this system.

Structure-Function Associations of Choroidal Thickness With Retinal Sensitivity in Myopia.

Purpose: The purpose of this study was to investigate the focal relationship between choroidal thickness and retinal sensitivity in myopic eyes.

Methods: Participants underwent swept-source optical coherence tomography (SS-OCT) imaging and microperimetry testing. Choroidal thicknesses were obtained by segmenting the SS-OCT scans using a deep-learning approach.

DNA Nanocage-Based Artificial Receptor Generator for Hydrophobic Interaction-Based Specific Membrane Anchoring.

Membrane receptor recognition is a specific biotargeting strategy for disease diagnosis and treatment, but it suffers from insufficient receptor expression levels. Hydrophobic interaction-based membrane anchoring strategy allows high anchoring density, but it lacks specificity. In this study, we present a DNA nanocage-based artificial receptor generator (DNARG) that combines the advantages of high specificity of receptor recognition and high density of hydrophobic membrane anchoring.

Localized Gradient Conductivity Enabled Ultrasensitive Flexible Tactile Sensors with Ultrawide Linearity Range.

The high sensitivity and wide linearity are crucial for flexible tactile sensors in adapting to diverse application scenarios with high accuracy and reliability. However, conventional optimization strategies of constructing microstructures suffer from the mutual restriction between the high sensitivity and wide linearity. Herein, a novel design of localized gradient conductivity (LGC) with partly covered low-conductivity (low-σ) carbon/Polydimethylsiloxane layer on high-conductivity (high-σ) silver nanowires film upon the micro-dome structure is proposed.

Studying the relationship between allergo-inflammation and left atrium and pulmonary vein pathological changes in allergic asthma.

Allergic asthma is an inflammatory airway disease influenced by genetic and environmental factors and orchestrated by imbalance between T helper 1 cell (Th1) and two immune responses. Inflammation contributes to pathological changes and remodeling in tissues such as the vascular, lung, heart, and beds. The purpose for this study was to evaluate the effects of allergic asthma on heart pathology and remodeling.

Boosted photocatalytic water splitting over a direct Z-scheme CdTe/CN van der Waals heterojunction: a first-principles insight into photocatalytic activity.

The quest for sustainable and clean energy sources has led to significant research into photocatalytic water splitting, a process that converts solar energy into hydrogen fuel. This study demonstrates constructing a high-performance CdTe/CN van der Waals heterojunction for solar-driven water splitting hydrogen evolution. The proposed CdTe/CN heterojunction, investigated using first-principles calculations, integrates favorable structural stability and features a direct bandgap of 1.

Generic Intravenous Amisulpride (QLG2069) for the Prevention of Postoperative Nausea and Vomiting in Adults: A Phase III, Multicenter, Randomized, Placebo-Controlled Study.

Background: The dopamine D2/D3 antagonist amisulpride has demonstrated its superiority and efficacy in prophylaxis of postoperative nausea and vomiting (PONV). Given the branded intravenous amisulpride (Barhemsys) has not been approved in China, there is unmet clinical need for amisulpride. Our primary objective was to ascertain the efficacy and safety of the generic intravenous amisulpride (QLG2069) in the prophylaxis of PONV.

Calibration Transfer of Deep Learning Models among Multiple Raman Spectrometers via Low-Rank Adaptation.

While deep learning-enhanced Raman spectroscopy enables rapid sample analysis, model portability among spectrometers remains hindered by systematic interdevice variations. In this study, a Low-Rank Adaptation-based Calibration Transfer method (LoRA-CT) is proposed to perform parameter-efficient fine-tuning of deep learning models across spectrometers. By decomposing weight updates into low-rank matrices, LoRA-CT achieves superior calibration transfer with minimal samples, reducing trainable parameters by 600× compared to full parameter fine-tuning.

Genetically predicted causal relationship between aspirin and colorectal cancer in individuals of European ancestry.

Previous studies have suggested a potential preventive effect of aspirin on colorectal cancer (CRC), but the causal relationship remains unclear. Based on the summary statistics of genome-wide association studies, Mendelian randomization (MR) method was used to assess the genetically predicted effect of aspirin use on CRC risk. Inverse variance weighted (IVW) was used as the main analysis method.

Association between vitamin K intake and periodontitis in American elderly population: a cross-sectional analysis of NHANES data.

Background: An increasing amount of data has been acquired on the close relationship between Vitamin K intake and the progression of periodontitis. The purpose of this study was to estimate whether Vitamin K intake is associated with periodontitis among older adults in America using information from the National Health and Nutrition Examination Survey (NHANES) database.

Methods: A cross-sectional analysis of data on periodontal indices and vitamin K intake among American adults aged 60 years and older in the 2009-2014 NHANES database was extracted.

A New Method of Lower Eyelid Blepharoplasty with Tear Trough Deformity and Mid-face Rejuvenation: Elevating Suborbicularis Oculi Fat and Suturing the Orbital Septum and Orbital Fat as a Whole for Fixation.

Objective: Exploring the clinical effects of the method using elevating the suborbicularis oculi fat (SOOF) and suturing it with the orbital septum and orbital fat as a whole for fixation to correct lower eyelid bags and tear trough deformities.

Methods: A retrospective analysis was conducted on clinical data of patients who underwent transcutaneous lower eyelid blepharoplasty at Hunan Provincial People's Hospital from January 2019 to January 2021. The method involved elevating the suborbicularis oculi fat and suturing it with the orbital septum and orbital fat as a whole for fixation to correct lower eyelid bags and tear trough deformities, and follow-up to evaluate the correction of eyelid bags, tear troughs, and mid-face ptosis, as well as patient satisfaction.

Efficacy and safety of guselkumab in Chinese patients with moderate-to-severe plaque psoriasis: A randomized, double-blind, placebo-controlled trial.

Background: Guselkumab is effective in treating moderate-to-severe plaque psoriasis; however, data from randomized controlled trials in the Chinese population are limited. This study evaluated and verified the efficacy and safety profile of guselkumab in Chinese patients with moderate-to-severe plaque psoriasis.

Methods: This was a randomized, double-blind, placebo-controlled, phase 4 study.

[Stiffness of scleral fibroblasts and extracellular matrix remodeling in models of cellular senescence].

To explore the effects of aging on the stiffness of human scleral fibroblast (HSF) and the remodeling of the extracellular matrix. This experimental study was conducted from January 2022 to June 2024. HSFs were cultured, and after cell passage, β-galactosidase staining was conducted.

Identification of a carotenoid cleavage dioxygenase gene TeCCD4a regulating flower color and carotenoid content of marigold.

Marigold (Tagetes erecta) serves as both an ornamental and economically significant species, owing to its diverse floral coloration and exceptionally high petal carotenoid content. Carotenoid cleavage dioxygenase (CCD), as the key enzymatic component, mediates the carotenoid degradation process. In this study, we cloned and functionally characterized a CCD4 gene to elucidate its regulatory function in petal color and carotenoid biosynthesis.

Microbial regulation of organic solid waste composting: Lignocellulose degradation (fertilization), process gas emissions, and containment of typical pollutants.

Microbial agents represent a valuable class of additives that can enhance the value and effectiveness of compost products. This paper provides a comprehensive review of the mechanisms and applications of microorganisms in regulating lignocellulose degradation, controlling gas emissions, and managing typical pollutants during the composting of organic solid wastes. Inoculation with microbial agents can significantly improve the degradation efficiency, quality, and environmental friendliness of compost.

Design, Synthesis and Biological Evaluation of 7-(1-Methyl-1-indole-3-yl)-5-pyrrolo[2,3-]pyrazine Derivatives as Novel Covalent pan-FGFR Inhibitors to Overcome Clinical Resistance.

Aberrant activation of fibroblast growth factor receptors (FGFRs) plays a critical role in tumorigenesis across multiple cancer types, driving the development of various FGFR inhibitors. Despite clinical advances, therapeutic efficacy remains limited by the emergence of drug resistance, primarily mediated by gatekeeper mutations in FGFRs. To overcome this challenge, we designed and synthesized a novel series of 7-(1-methyl-1-indole-3-yl)-5-pyrrolo[2,3-]pyrazine derivatives as covalent pan-FGFR inhibitors targeting both wild-type and gatekeeper mutants.

Flexibility-Induced Robustness in Molecular Catalysts for Electrocatalytic CO Reduction.

CO electroreduction to produce fuels and chemicals is of great significance. Molecular catalysts offer valuable advantages in light of their well-defined active sites and tunable structural and electronic properties. However, their stability is often compromised by rigid conjugated structures.

Targeting the gut-liver axis with dietary polyphenols to ameliorate metabolic dysfunction-associated steatotic liver disease: advances in molecular mechanisms.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a condition that results from metabolic disorders. In addition to genetic factors, irregular and high-energy diets may also significantly contribute to its pathogenesis. Dietary habits can profoundly alter the composition of gut microbiota and metabolites.

Downregulation of FOXC1 Modified by METTL3/YTHDF1 Axis Aggravates NLRP3-Mediated Inflammasomes Formation and Cell Pyroptosis in Epilepsy.

Epilepsy is a common chronic nervous system disease that threatens human health. However, the role of FOXC1 and its relations with pyroptosis have not been fully studied in epilepsy. Sprague-Dawley rats were obtained for constructing temporal lobe epilepsy (TLE) models.

Optical system for a strontium optical lattice clock aboard the Chinese Space Station.

We report the design and in-orbit demonstration of a compact optical system for a 87Sr optical lattice clock aboard the Chinese Space Station. This system adopts a compact and robust vertically stacked architecture with a total volume of 0.11 m3 and a mass of 53.

Clinical Characteristics, Radiological, and Outcomes of Mucormycosis: A 14-Year Retrospective Study From Southern China.

Background: Mucormycosis is a rare, rapidly progressive fungal infection with a high mortality rate. However, clinical data of mucormycosis patients, especially those related to adverse outcomes in China, remain limited.

Objective: To enhance understanding of the clinical characteristics of different infection site mucormycosis and identify the factors associated with adverse outcomes.

A Design for Achieving Robustness in Molecular Machines Based on Self-Assembled Pyrene Cavitands.

We designed a molecular switch based on a cavitand and pyrene. The controllable switching properties of the cavitand paired with flexible chains are some of the best combinations for achieving robustness in complex environments. A rigid chain cavitand was also synthesized as a control, and its single crystals with high molecular weights were obtained.

Uninfected cell-specific enzymes coordinate carbon supply and nitrogen assimilation in Medicago truncatula nodules.

In legume root nodules, rhizobia invade host cells to form symbiosomes that drive atmospheric nitrogen fixation. Although the metabolic roles of infected cells (ICs) are well established, the contributions of adjacent uninfected cells (UCs) have remained largely unexplored. Here, through forward genetics methods, we identify DEBINO4, a phosphoenolpyruvate carboxylase (PEPC) uniquely expressed in UCs, as a pivotal regulator of carbon metabolism essential for sustaining symbiosome function and nitrogen assimilation.