Quantitative analysis of gait parameters in Parkinson's disease and the clinical significance.

Background: Gait disorder is one of the clinical manifestations of Parkinson's disease (PD). Investigating the characteristics of gait disorder in patients with PD and the changes in gait before and after taking levodopa is crucial for the recognition, diagnosis and treatment of gait disorders in PD patients.

Methods: In this study, we measured the gait parameters of 20 patients with PD and 17 healthy controls and analyzed the changes of gait parameters of these patients before and after taking levodopa.

Modular RCA-CRISPR/Cas12a amplification on a multi-volume SlipChip for ultrafast, single-copy quantification of circRNA and miRNA in ovarian cancer.

The aberrant expression of RNAs in ovarian cancer (OC) progression highlights their potential as clinical biomarkers. However, rapid and accurate quantification of these RNAs in biosamples remains a significant challenge. In this study, we develop a modular isothermal rolling circle amplification (RCA)-activated Cas12a loop-enhanced (MIRACLE) amplification method for circRNA and miRNA quantification without the need of reverse transcription.

Perceived social support mediates the relationship between self-efficacy and depression/anxiety in patients with cardiovascular disease.

This study aimed to assess the psychological characteristics of patients with cardiovascular disease (CVD), focusing on perceived social support, self-efficacy, and emotional symptoms such as depression and anxiety. Additionally, we investigated whether perceived social support mediates the relationship between self-efficacy and these mood disorders. This cross-sectional survey involved 1,144 CVD patients drawn from the 2021 China Family Health Index Survey Report.

Breast Cancer Diagnosis Using a Dual-Modality Complementary Deep Learning Network With Integrated Attention Mechanism Fusion of B-Mode Ultrasound and Shear Wave Elastography.

Objective: To develop and evaluate a Dual-modality Complementary Feature Attention Network (DCFAN) that integrates spatial and stiffness information from B-mode ultrasound and shear wave elastography (SWE) for improved breast tumor classification and axillary lymph node (ALN) metastasis prediction.

Methods: A total of 387 paired B-mode and SWE images from 218 patients were retrospectively analyzed. The proposed DCFAN incorporates attention mechanisms to effectively fuse structural features from B-mode ultrasound with stiffness features from SWE.

FAP deficiency attenuates T2DM-associated HFpEF by suppressing the CaMKIIδ-Calcineurin A-NFATc2 signaling pathway.

Heart failure with preserved ejection fraction (HFpEF) represents the initial phase of cardiac dysfunction associated with type 2 diabetes mellitus (T2DM). To date, the pathophysiological mechanisms underlying T2DM-induced HFpEF are complex and elusive. Fibroblast activation protein (FAP) is a prolyl-specific serine protease that its inhibition or vaccination has been shown to enhance cardiac repair following myocardial infarction (MI).

Endovascular Therapy Versus Medical Management for Large Ischemic Infarct: 1-Year Outcomes of the ANGEL-ASPECT Trial.

Background: Several trials have shown the benefit and safety of endovascular therapy (EVT) compared with medical management (MM) of patients with a large ischemic core in the 90-day follow-up. However, the 1-year outcome comparison between EVT and MM in Asian patients with a large ischemic core has not been investigated. Our aim was to evaluate the 1-year outcomes of patients in the ANGEL-ASPECT trial (Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients with a Large Infarct Core).

Graph-based multi-modality network for axillary lymph node metastasis prediction in early-stage breast cancer.

Background And Objective: Accurate evaluation of the axillary lymph node (ALN) status in early-stage breast cancer is crucial for prognosis and guiding treatment decisions, while also preventing unnecessary surgeries and postoperative complications. Numerous methods have been proposed for ALN status classification using radiomic images which face the challenge of low diagnostic accuracy. This study aims to explore the potential of multi-modality that integrates clinical parameters and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to provide complementary information for image features, thereby enhancing the model's ability to predict ALN metastasis.

GGTLC1 Is a Prognostic Biomarker in Renal Clear Cell Carcinoma.

Kidney renal clear cell carcinoma (KIRC), the most common type of renal cell carcinoma, is an immunobiologically and metabolically distinct tumor. Its clinical management is closely related to the tumor microenvironment (TME). Identifying its potential markers is important for improving prognosis.

Discussion on the Application of Mindfulness Therapy in the Treatment of Diabetic Peripheral Neuropathy: A Narrative Review.

Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes. It has a slow and insidious onset, mainly manifested as sensory and motor dysfunction, and increases susceptibility to psychological problems such as anxiety and depression, seriously affecting the quality of life of patients. The current treatment strategies focus on effective metabolic management and lifestyle intervention, but the results are not satisfactory.

4-Hydroxychalcone alleviated Angiotensin II-induced atrial fibrillation via immunoproteasome-IKK-NF-κB signaling pathway modulation.

Atrial Fibrillation (AF) is the most common type of cardiac arrhythmia and a significant contributor to stroke occurrence. Although 4-Hydroxychalcone (4HCH) has notable anti-inflammatory and antioxidant properties, playing critical therapeutic roles in hypertensive nephropathy and cardiac remodeling, its effects on AF are somewhat unclear, thus forming the basis of this study. Herein, AF was induced in mice via continuous infusion of Angiotensin II (Ang II) at a dose of 2000 ng/kg/min for three weeks.

Transcatheter aortic valve implantation in pure aortic regurgitation: one-year outcomes of the AURORA trial.

Background: Transcatheter aortic valve implantation (TAVI) in pure aortic regurgitation (AR) remains challenging because of inadequate anchoring forces. Traditional approaches, which rely solely on virtual annulus oversizing, have demonstrated limited success. We propose a novel anatomical classification system and dual-anchoring theory to optimise the TAVI strategy in patients with pure AR.

Molecular stratification of prostate cancer through sensory perception-related multi-omics analysis reveals chemoresistant mechanisms.

Background: Advanced prostate cancer (PCa) displays significant genetic heterogeneity and therapy resistance, yet the role of sensory perception pathways in its progression remains unclear.

Methods: We performed an integrative multi-omics analysis of sensory perception-linked mRNAs and lncRNAs from TCGA and scRNA-seq data. Unsupervised consensus clustering defined three molecular subtypes (CS1-CS3).

Targeting VCAM-1 with chimeric antigen receptor and regulatory T cell for abdominal aortic aneurysm treatment.

Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by the dilation of the abdominal aorta, leading to a high risk of rupture. Current treatment options are limited, particularly for patients ineligible for surgical interventions. This study explores a novel immunotherapeutic approach using chimeric antigen receptor Treg cells targeting vascular cell adhesion molecule-1 (VCAM-1) to mitigate AAA progression.

Transition metal-catalysed asymmetric umpolung reactions of electron-deficient π-unsaturated systems.

The umpolung reaction of electrophilic π-unsaturated compounds represents a powerful strategy to reverse inherent polarity, enabling unconventional bond formations. While organic σ-Lewis base catalysts are classically utilised, in this feature article, recent advances in the low valent transition metal-mediated asymmetric umpolung reactions of diverse electron-poor unsaturated systems, usually in a diene form, are reviewed, proceeding through either an oxidative cyclometallation or a π-Lewis base activation mechanism. The contents are organised according to transition metal categories, with emphasis on catalytic mechanisms, regio- and stereoselectivity control, and limitations.

FSS in CTE triggers neuronal apoptosis through Piezo1-induced Ca homeostasis disruption.

The altered cerebrospinal fluid dynamics induced by strenuous competitive sports result in repeated exposure of neurons to abnormal fluid shear stress (FSS). Although the stress intensity did not result in diffuse axonal injury, prolonged stimulation still induced chronic traumatic encephalopathy (CTE), characterized by neuronal dysfunction and apoptosis. However, the mechanism underlying the effects of elevated FSS in axon-intact cells remains unclear.

Naphthalimide-Based Fluorescent Probe for Portable and Rapid Response to γ-Glutamyl Transpeptidase.

γ-Glutamyl transpeptidase (GGT) is overexpressed in a variety of diseases, making it an important diagnostic criterion for diseases. Herein, a new fluorescence probe based on naphthalimide (Glu-MDA) was developed and employed for the rapid detection of GGT in tumor cells or samples. Alkynylated naphthalimide is the fluorescent core for excellent fluorescence response.

A Randomized Controlled Trial of Botulinum Toxin Combined with Non-Cross-Linked Bovine Collagen for Improving Periorbital Wrinkles.

Background: This study examined the clinical efficacy of botulinum toxin type A (BTX-A) combined with non-cross-linked bovine collagen in improving periorbital wrinkles.

Methods: Forty participants with periorbital wrinkles were recruited from the Plastic Surgery and Aesthetic Department of the Central Hospital Affiliated to Dalian University of Technology in China between November 2021 and August 2022. Participants were randomly assigned to either an observation group or a control group, with each group comprising 20 participants.

The predictive value of NLR, SII, and complement 3 in treatment response for systemic lupus erythematosus with immune thrombocytopenia.

Objective: To evaluate the predictive value of systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and complement 3 in the therapeutic outcomes of systemic lupus erythematosus-associated immune thrombocytopenia (SLE-ITP).

Methods: Clinical data from 72 patients diagnosed with SLE-ITP and admitted to the Affiliated Central Hospital of Dalian University of Technology between January 2013 and September 2024 were collected and analyzed. Associations between therapeutic outcomes and clinical characteristics, as well as laboratory findings including SII and NLR, were evaluated systematically.

Berberine-loaded mesoporous silica nanomaterials inhibit pancreatic cancer targeting cancer stem cells.

Objectives: To investigate the anti-pancreatic ductal adenocarcinoma (PDAC) effect of mesoporous silica nanoparticles loaded with berberine (MSN-BBR) both in vitro and in vivo.

Methods: Disulfide-bridged MSN loaded with berberine (BBR) was synthesized and characterized. The study assessed the anti-PDAC effect and the impact on the stemness of pancreatic cancer stem cells (PCSCs) in Panc1 cells and mice.

Endovascular Thrombectomy Efficacy in Basilar Artery Occlusion: Impact of Collateral Circulation and Etiology on Functional Outcomes.

Background And Objectives: Endovascular treatment (EVT) is widely regarded as superior to best medical treatment (BMT) for basilar artery occlusion. However, the benefit of EVT in patients with poor collateral circulation remains uncertain.

Methods: We conducted a post hoc analysis of data from the ATTENTION study.

Global, regional, and national burden of sudden infant death syndrome and the impact of COVID-19: a trend and health inequality analysis based on the global burden of disease study 2021.

Background: Current sudden infant death syndrome (SIDS) epidemiological patterns and COVID-19 impacts remain uncertain. We therefore conducted this global, regional, and national epidemiological study using data from the Global Burden of Disease Study (GBD) 2021.

Methods: This study analyzed GBD-based population data on SIDS disability-adjusted life years (DALYs).