Elevated interleukin-10, -22, -24, and -26 in serum samples of children with infectious mononucleosis.

Background: Infectious mononucleosis (IM) is an infectious disease with different stages of onset, and the pathogenesis of IM remains unclear. This study aimed to investigate the levels of interleukin (IL)-10 family cytokines IL-10, -22, -24, and -26 in serum samples of patients with infectious mononucleosis (IM) and the potential diagnostic values.

Methods: Thirty children with IM were enrolled in the study, and serum samples were collected; 30 healthy children served as the controls.

The predictive value of NLR, SII, and complement 3 in treatment response for systemic lupus erythematosus with immune thrombocytopenia.

Objective: To evaluate the predictive value of systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and complement 3 in the therapeutic outcomes of systemic lupus erythematosus-associated immune thrombocytopenia (SLE-ITP).

Methods: Clinical data from 72 patients diagnosed with SLE-ITP and admitted to the Affiliated Central Hospital of Dalian University of Technology between January 2013 and September 2024 were collected and analyzed. Associations between therapeutic outcomes and clinical characteristics, as well as laboratory findings including SII and NLR, were evaluated systematically.

Retraction notice to "Current knowledge of antisense long non-coding RNA in the occurrence and prognosis of skull base tumors" [Heliyon 10 (2024) e35960].

[This retracts the article DOI: 10.1016/j.heliyon.

Model-informed precision dosing of quetiapine in bipolar affective disorder patients: initial dose recommendation.

Objective: Bipolar affective disorder (BAD) is a mood disorder with high morbidity and mortality. Quetiapine can be used in the treatment of patients with BAD; however, the precise administration regimen of quetiapine in these patients is still unknown. In this study, a population pharmacokinetic (PPK) model of quetiapine in patients with BAD was constructed based on model-informed precision dosing (MIPD) and real-world clinical data and an optimal initial dose of quetiapine in these patients was recommended.

Immune thrombocytopenia in patients with systemic lupus erythematosus.

Immune thrombocytopenia (ITP) is a common hematological manifestation of systemic lupus erythematosus (SLE). The diversity of its clinical features and treatment responses may reveal the complex pathophysiological mechanisms of the disease. To enhance the therapeutic response rate and improve the prognosis for SLE patients with concurrent ITP, while reducing adverse events during the treatment process, it is crucial to accurately identify and apply clinical parameters to predict patients' responses to treatment.

ImageGP 2 for enhanced data visualization and reproducible analysis in biomedical research.

ImageGP is an extensively utilized, open-access platform for online data visualization and analysis. Over the past 7 years, it has catered to more than 700,000 usages globally, garnering substantial user feedback. The updated version, ImageGP 2 (available at https://www.

Novel genomic and phenotypic traits of polyhydroxyalkanoate-producing bacterium ZZQ-149, the type strain of Halomonas qinghailakensis.

Background: Polyhydroxyalkanoates (PHAs) are optimal potential materials for industrial and medical uses, characterized by exceptional sustainability, biodegradability, and biocompatibility. These are primarily from various bacteria and archaea. Bacterial strains with effective PHA formation capabilities and minimal production cost form the foundation for PHA production.

Current knowledge of antisense long non-coding RNA in the occurrence and prognosis of skull base tumors.

Antisense long non-coding RNA (AS-lncRNA) represents a novel class of RNA molecules. In recent years, it has been discovered that AS-lncRNAs play crucial roles in various biological processes, particularly in the onset and progression of tumors. Skull base tumors, originating from the base of the brain, exhibit specific expression patterns of AS-lncRNA which correlate significantly with clinical characteristics.

Aminopeptidase MNP-1 triggers intestine protease production by activating daf-16 nuclear location to degrade pore-forming toxins in Caenorhabditis elegans.

Pore-forming toxins (PFTs) are effective tools for pathogens infection. By disrupting epithelial barriers and killing immune cells, PFTs promotes the colonization and reproduction of pathogenic microorganisms in their host. In turn, the host triggers defense responses, such as endocytosis, exocytosis, or autophagy.

Prognostic Role of Serum Soluble Tim-3 in Severe Traumatic Brain Injury: A Prospective Observational Study.

Objective: T cell immunoglobulin and mucin domain-3 (Tim-3) may be implicated in neuroinflammation. Herein, we attempted to discern the role of serum soluble (s) Tim-3 as an inflammatory prognostic biomarker of severe traumatic brain injury (sTBI).

Methods: In this prospective observational study of 112 sTBI patients and 112 controls, serum sTim-3 levels were determined, Rotterdam computed tomography (CT) classification and Glasgow coma scale (GCS) were selected as the two severity indicators, serum C-reactive protein (CRP) was regarded as an inflammatory biomarker, and poor prognosis was referred to as extended Glasgow outcome scale (GOSE) scores 1-4 at 180 days after trauma.

Composition-Aware Image Steganography Through Adversarial Self-Generated Supervision.

Steganography is an important and prevailing information hiding tool to perform secret message transmission in an open environment. Existing steganography methods can mainly fall into two categories: predefined rule-based and data-driven methods. The former is susceptible to the statistical attack, while the latter adopts the deep convolution neural networks to promote security.

Synthesis of FeO@CdS@CQDs ternary core-shell heterostructures as a magnetically recoverable photocatalyst for selective alcohol oxidation coupled with HO production.

Photocatalytic aerobic oxidation of aromatic alcohols to corresponding aldehydes coupled with producing hydrogen peroxide (HO) represents one of the most efficient strategies for converting solar energy into chemical energy. In this work, a magnetically recoverable photocatalyst of FeO@CdS@CQDs ternary core-shell heterostructures is elaborately fabricated through the hydrothermal growth of CdS on FeO nanospheres with in-situ incorporation of carbon quantum dots (CQDs) and used for selective alcohol oxidation coupled with HO production. The FeO@CdS@CQDs photocatalyst possess distinct advantages of full solar spectral absorption, efficient charge separation, and high stability.

Effects of cimetidine on ciclosporin population pharmacokinetics and initial dose optimization in aplastic anemia patients.

The present study aimed to explore the effects of cimetidine on ciclosporin population pharmacokinetics and initial dose optimization in aplastic anemia patients. Aplastic anemia patients were used to establish a population pharmacokinetic model by the nonlinear mixed effect (NONMEM), and concentrations of ciclosporin were simulated by Monte Carlo method. With the same weight, the ciclosporin clearance rates were 0.

Not every sample is efficient: Analogical generative adversarial network for unpaired image-to-image translation.

Image translation is to learn an effective mapping function that aims to convert an image from a source domain to another target domain. With the proposal and further developments of generative adversarial networks (GANs), the generative models have achieved great breakthroughs. The image-to-image (I2I) translation methods can mainly fall into two categories: Paired and Unpaired.

Draft Genome Sequence of Bacillus thuringiensis ZZQ-130 with Multiple Pesticidal Genes, Isolated from Caka Salt Lake, China.

Bacillus thuringiensis is a typical pesticide, with global application for over 40 years. Here, we report the draft genome sequence of B. thuringiensis ZZQ-130 from a salt lake; this strain has 31 pesticidal genes, including five genes, one gene, two genes, and two genes.

Draft Genome Sequence of Bacillus wiedmannii Biovar ZZQ-138, Isolated from a Saline Lake.

Ecologically sound approaches to control mosquitoes like Anopheles stephensi, which are obligatory vectors for malaria transmission, are urgently needed because of increasing insecticide resistance. Bacteria from are important resources. Here, we report the whole-genome sequence of Bacillus wiedmannii biovar ZZQ-138, which was isolated from sediment from a saline lake.

Serum hypoxia-inducible factor 1alpha emerges as a prognostic factor for severe traumatic brain injury.

Background: Hypoxia-inducible factor 1alpha (HIF-1α) is implicated in the cell's response to hypoxia. We investigated whether serum HIF-1α concentrations are correlated with the severity and clinical outcome of severe traumatic brain injury (sTBI).

Methods: Serum HIF-1α concentrations were quantified in 104 sTBI patients and 80 healthy controls.

Synthesis of Ni modified Au@CdS core-shell nanostructures for enhancing photocatalytic coproduction of hydrogen and benzaldehyde under visible light.

The development of visible light responsive photocatalysts for simultaneous production of hydrogen (H) fuel and value-added chemicals is greatly promising to solve the energy and environmental issues by improving the utilization efficiency of solar energy. Herein, the three-component Ni/(Au@CdS) core-shell nanostructures were constructed by the hydrothermal synthesis followed with photodeposition. The intimate integration of plasmonic Au nanospheres and visible-light responsive CdS shells modified with Ni cocatalyst facilitated the generation and separation of electron-hole pairs as well as reduced the overpotential of hydrogen evolution.

Generative Adversarial Network with Multi-branch Discriminator for imbalanced cross-species image-to-image translation.

There has been an increased interest in high-level image-to-image translation to achieve semantic matching. Through a powerful translation model, we can efficiently synthesize high-quality images with diverse appearances while retaining semantic matching. In this paper, we address an imbalanced learning problem using a cross-species image-to-image translation.

Modulating oxygen vacancies on bismuth-molybdate hierarchical hollow microspheres for photocatalytic selective alcohol oxidation with hydrogen peroxide production.

Photocatalytic selective oxidation of alcohols into high value-added carbonyl compounds accompanied by producing hydrogen peroxide (HO) is undoubtedly a more efficient solar energy conversion strategy with high atom economy. Herein, we have developed an efficient photocatalyst of bismuth-molybdate (BiMoO) hierarchical hollow microspheres with tunable surface oxygen vacancies (OVs) for promoting the photocatalytic selective alcohol oxidation with HO production. The effect of surface OVs on the photocatalytic efficiency is studied systematically by comparing the performance of different photocatalysts.

Imine bond transformation of a dynamic Sm(III) macrocycle-based chemosensor: The indirect approach for detecting cyanuric chloride.

Herein, we report our strategy to develop the efficient chemosensor and real-time monitoring technique for cyanuric chloride (TCT) detection. A luminescent macrocyclic mononuclear Sm(III) complex Sm-2 bearing with two dynamic imine bonds has been constructed via the template synthesis between dialdehyde HQ and matched diamine 1,2-bis(2-aminoethoxy)ethane. Sensing experiments reveal that complex Sm-2 exhibits the turn-off fluorescent and colorimetric response for TCT in CHOH.

The CRISPR-Cas systems were selectively inactivated during evolution of Bacillus cereus group for adaptation to diverse environments.

CRISPR-Cas systems are considered as barriers to horizontal gene transfer (HGT). However, the influence of such systems on HGT within species is unclear. Also, little is known about the impact of CRISPR-Cas systems on bacterial evolution at the population level.

Complete genome sequence of Y-1-1 reveals the genetic basis for its hemicellulosic/cellulosic substrate-inducible xylanase and cellulase activities.

ZY-1-1 was isolated from the larval gut of the lignocellulose-rich diet-fed scarab beetle, , and confirmed to possess extremely high xylanase (48153.8 ± 412.1 U/L) and relatively moderate cellulase activity (610.

Disturbance of Mammary UDP-Glucuronosyltransferase Represses Estrogen Metabolism and Exacerbates Experimental Breast Cancer.

The progression of breast cancer is closely related to the levels of estrogens within the body. UDP-glucuronosyltransferase (UGT) is an important class of phase II metabolizing enzymes, playing a pivotal role in detoxifying steroid hormone. In the present study, we aim at uncovering the potential dysregulation pattern of UGT and its role in estrogen metabolism and in the pathogenesis of breast cancer.