Effects of imperatorin on chronic periodontitis associated with type 2 diabetes mellitus.

Aim: Periodontitis is a common complication of type 2 diabetes. Imperatorin is a traditional Chinese medicinal compound recognized for its anti-inflammatory, analgesic and anti-tumor properties. Nevertheless, the impact of imperatorin on chronic periodontitis and chronic periodontitis associated with type 2 diabetes mellitus remains unexplored.

Electrochemical Alkyne Semi-Hydrogenation via Proton-Coupled Electron Transfer on Cu(111) Surface.

Electrocatalytic alkyne semi-hydrogenation (EASH) powered by renewable electricity using water as a hydrogen donor provides a sustainable alternative to conventional thermocatalysis. However, the current EASH systems predominantly follow hydrogen atom transfer (HAT) pathways, which are prone to over-hydrogenation and at the same time compete with the hydrogen evolution reaction. In this work, we report a proton-coupled electron transfer (PCET) mechanism enabled on Cu(111) surface for highly efficient and selective EASH.

Research Progress on the Functional Regulation Mechanisms of ZKSCAN3.

The zinc finger protein with KRAB and SCAN domains 3 (ZKSCAN3) has emerged as a critical regulator of diverse cellular processes, including autophagy, cell cycle progression, and tumorigenesis. Structurally, ZKSCAN3 is characterized by its conserved DNA-binding zinc finger motifs, a SCAN domain mediating protein-protein interaction, and a KRAB repression domain implicated in transcriptional regulation. Post-translational modifications, such as phosphorylation and ubiquitination, dynamically modulate its subcellular localization and activity, enabling context-dependent functional plasticity.

Comparative Analysis of Directional Snare vs Cutting Seton for High Anal Fistula Treatment.

BACKGROUND The cutting seton (CS) method uses a suture knot placed in the track of an anal fistula around the anal sphincter, which is tied using tension. This study aimed to compare outcomes in 60 patients with high anal fistula treated with a disposable directional snare or CS method. MATERIAL AND METHODS Sixty patients with high anal fistula were selected and randomly divided into 2 groups, with 30 patients in each group.

Engineering Local Coordination and Electronic Structures of Dual-Atom Catalysts.

Heterogeneous dual-atom catalysts (DACs), defined by atomically precise and isolated metal pairs on solid supports, have garnered significant interest in advancing catalytic processes and technologies aimed at achieving sustainable energy and chemical production. DACs present board opportunities for atomic-level structural and property engineering to enhance catalytic performance, which can effectively address the limitations of single-atom catalysts, including restricted active sites, spatial constraints, and the typically positive charge nature of supported single metal species. Despite the rapid progress in this field, the intricate relationship between local atomic environments and the catalytic behavior of dual-metal active sites remains insufficiently understood.

Accelerated Oxide-Zeolite Catalyst Design for Syngas Conversion by Reaction Phase Diagram Analysis and Machine Learning.

Oxide-zeolite (OXZEO) catalyst design concept provides an alternative approach for the direct syngas-to-olefins (STO) with superior selectivity. Enhancing the activity of oxide components remains a critical and long-pursued target in this field. However, rational design strategies for optimizing oxides and improving the catalyst performance in such complex reaction networks are still lacking.

Experimental and Model Calculation Research on Shrinkage of Hybrid Fiber-Reinforced Recycled Aggregate Concrete.

Recycled aggregate concrete (RAC), which is made by replacing all natural coarse and fine aggregates with recycled aggregate, plays a significant role in improving the recycling rate of construction materials, reducing carbon emissions from construction, and alleviating ecological degradation issues. However, due to its low strength and significant shrinkage and deformation problems, RAC has limited application. The effort of fiber type, fiber admixture, and fiber hybridization on autogenous shrinkage were studied to improve the structural safety of building materials and broaden the application of RAC.

One-for-All: Towards Universal Domain Translation With a Single StyleGAN.

In this paper, we propose a novel translation model, UniTranslator, for transforming representations between visually distinct domains under conditions of limited training data and significant visual differences. The main idea behind our approach is leveraging the domain-neutral capabilities of CLIP as a bridging mechanism, while utilizing a separate module to extract abstract, domain-agnostic semantics from the embeddings of both the source and target realms. Fusing these abstract semantics with target-specific semantics results in a transformed embedding within the CLIP space.

MoC/CoP Janus Structure Embedded Carbon Frame for Boosting Hydrazine Oxidation and Hydrogen Evolution Reactions.

The integration of hydrazine electrooxidation (HzOR) and hydrogen evolution reaction (HER) presents an efficient pathway for high-purity hydrogen production. However, developing bifunctional catalysts remains challenging for the demands of multiple active-centers and tailored electronic properties. Here, a unique Janus nano-catalysts of MoC/CoP embedded on carbon frameworks (MoC/CoP@C) is introduced, featuring dual electronic states (depletion and accumulation)driven by charge redistribution within MoC/CoP, acting as dual active-sites (DAS) for both HER and HzOR.

Boosted 1,2-Dichloroethane Deep Destruction over CoRu/AlO Bifunctional Catalysts Surface Oxygen and Water Molecule Synergistic Activation.

Developing efficacious catalysts with superior Cl resistance and polychlorinated byproduct inhibition capability is crucial for realizing the environmentally friendly purification of chlorinated volatile organic compounds (CVOCs). Activating CVOC molecules and desorbing Cl species by modulating the metal-oxygen property is a promising strategy to fulfill these. Herein, a bifunctional CoRu/AlO catalyst with synergistic Co and Ru interactions (Ru-O-Co species) was rationally fabricated, which possesses abundant surface Co and Ru sites and collaboratively facilitates the activation of lattice oxygen (O) and molecular oxygen (O → O → O), accelerating 1,2-dichloroethane (1,2-DCE) decomposition the reaction route of enolic species → aldehydes → carboxylate/carbonate.

Study on the fire extinguishing effect of compressed nitrogen foam on 280 Ah lithium iron phosphate battery.

This study conducted experimental analyses on a 280 Ah single lithium iron phosphate battery using an independently constructed experimental platform to assess the efficacy of compressed nitrogen foam in extinguishing lithium-ion battery fires. Based on theoretical analysis, the fire-extinguishing effects of compressed nitrogen foam at different outlet pressures from foam mixture tanks were analyzed, examining factors such as battery surface temperature, flame temperature, and thermal weight loss. The results indicate that the compressed nitrogen foam can extinguish the open flame of the battery in 14 s at 0.

Electrochemical Generation of Te Vacancy Pairs in PtTe for Efficient Hydrogen Evolution.

Two-dimensional (2D) van der Waals materials are increasingly seen as potential catalysts due to their unique structures and unmatched properties. However, achieving precise synthesis of these remarkable materials and regulating their atomic and electronic structures at the most fundamental level to enhance their catalytic performance remain a significant challenge. In this study, we synthesized single-crystal bulk PtTe crystals via chemical vapor transport and subsequently produced atomically thin, large PtTe nanosheets (NSs) through electrochemical cathode intercalation.

Plasma and urine proteomics and gut microbiota analysis reveal potential factors affecting COVID-19 vaccination response.

The efficacy of COVID-19 vaccination relies on the induction of neutralizing antibodies, which can vary among vaccine recipients. In this study, we investigated the potential factors affecting the neutralizing antibody response by combining plasma and urine proteomics and gut microbiota analysis. We found that activation of the LXR/FXR pathway in plasma was associated with the production of ACE2-RBD-inhibiting antibodies, while urine proteins related to complement system, acute phase response signaling, LXR/FXR, and STAT3 pathways were correlated with neutralizing antibody production.

Advances in heterogeneous single-cluster catalysis.

Heterogeneous single-cluster catalysts (SCCs) comprising atomically precise and isolated metal clusters stabilized on appropriately chosen supports offer exciting prospects for enabling novel chemical reactions owing to their broad structural diversity with unparalled opportunities for engineering their properties. Although the pioneering work revealed intriguing performance trends of size-selected metal clusters deposited on supports, synthetic and analytical challenges hindered a thorough understanding of surface chemistry under realistic conditions. This Review underscores the importance of considering the cluster environment in SCCs, encompassing the development of robust metal-support interactions, precise control over the ligand sphere, the influence of reaction media and dynamic behaviour, to uncover new reactivities.

Atomically precise vacancy-assembled quantum antidots.

Patterning antidots, which are regions of potential hills that repel electrons, into well-defined antidot lattices creates fascinating artificial periodic structures, leading to anomalous transport properties and exotic quantum phenomena in two-dimensional systems. Although nanolithography has brought conventional antidots from the semiclassical regime to the quantum regime, achieving precise control over the size of each antidot and its spatial period at the atomic scale has remained challenging. However, attaining such control opens the door to a new paradigm, enabling the creation of quantum antidots with discrete quantum hole states, which, in turn, offer a fertile platform to explore novel quantum phenomena and hot electron dynamics in previously inaccessible regimes.

RNF112-mediated FOXM1 ubiquitination suppresses the proliferation and invasion of gastric cancer.

Forkhead box M1 (FOXM1) plays a critical role in development physiologically and tumorigenesis pathologically. However, insufficient efforts have been dedicated to exploring the regulation, in particular the degradation of FOXM1. Here, the ON-TARGETplus siRNA library targeting E3 ligases was used to screen potential candidates to repress FOXM1.

Triggering Pt Active Sites in Basal Plane of Van der Waals PtTe Materials by Amorphization Engineering for Hydrogen Evolution.

Exposing active sites and optimizing their binding strength to reaction intermediates are two essential strategies to significantly improve the catalytic performance of 2D materials. However, pursuing an efficient way to achieve these goals simultaneously remains a considerable challenge. Here, using 2D PtTe van der Waals material with a well-defined crystal structure and atomically thin thickness as a model catalyst, it is observed that a moderate calcination strategy can promote the structural transformation of 2D crystal PtTe nanosheets (c-PtTe NSs) into oxygen-doped 2D amorphous PtTe NSs (a-PtTe NSs).

Electrocatalytically Activating and Reducing N Molecule by Tuning Activity of Local Hydrogen Radical.

Decarbonizing N conversion is particularly challenging, but essential for sustainable development of industry and agriculture. Herein, we achieve electrocatalytic activation/reduction of N on X/Fe-N-C (X=Pd, Ir and Pt) dual-atom catalysts under ambient condition. We provide solid experimental evidence that local hydrogen radical (H*) generated on the X site of the X/Fe-N-C catalysts can participate in the activation/reduction of N adsorbed on the Fe site.

Catalytically active atomically thin cuprate with periodic Cu single sites.

Rational design and synthesis of catalytically active two-dimensional (2D) materials with an abundance of atomically precise active sites in their basal planes remains a great challenge. Here, we report a ligand exchange strategy to exfoliate bulk [Cu(OH)][OS(CH)SO] cuprate crystals into atomically thin 2D cuprate layers ([Cu(OH)]). The basal plane of 2D cuprate layers contains periodic arrays of accessible unsaturated Cu(II) single sites (2D-CuSSs), which are found to promote efficient oxidative Chan-Lam coupling.

FOXM1 increases hTERT protein stability and indicates poor prognosis in gastric cancer.

Gastric cancer is one of most lethal diseases across the world. However, the underlying mechanism of gastric cancer carcinogenesis and development is still not fully known. Forkhead box M1 (FOXM1) belongs to the FOX family and has crucial roles in transactivation of multiple oncogenes in several cancer types, including gastric cancer.

Realization of Oriented and Nanoporous Bismuth Chalcogenide Layers via Topochemical Heteroepitaxy for Flexible Gas Sensors.

Most van der Waals two-dimensional (2D) materials without surface dangling bonds show limited surface activities except for their edge sites. Ultrathin BiSe, a topological insulator that behaves metal-like under ambient conditions, has been overlooked on its surface activities. Herein, through a topochemical conversion process, ultrathin nanoporous BiSe layers were epitaxially deposited on BiOCl nanosheets with strong electronic coupling, leading to hybrid electronic states with further bandgap narrowing.