De-Saturation of Single-Atom Copper Catalysts for Accelerating Propargylic Substitution Reactions.

Rational design of proximal coordination microenvironments surrounding catalytic sites to achieve optimal reaction kinetics represents a paramount pursuit in single-atom catalysts (SACs), yet continues to pose substantial synthetic challenges. Developing innovative strategies that simultaneously stabilize low-coordinated single-metal species on solid supports, while ensuring atomic precision and high activity, remains imperative. Herein, a de-saturation strategy for SACs is demonstrated (denoted as De-sat SACs) using a top-down approach based on a KOH-mediated Joule thermal shock to obtain under-coordinated and asymmetric SACs for efficient organic synthesis.

Ultraclean monolayer amorphous carbon yields a high-precision proton beam.

Ångström-scale polygonal rings in monolayer amorphous carbon (MAC) enhance its electronic and mechanical properties while providing unique ångström pores for precise subatomic species separation, essential for advancements in catalysis, energy and medicine. However, the absence of an industrial-scale synthesis method for intrinsic MAC has limited its technological applications compared with graphene and bulk amorphous materials. Herein, we report an industry-compatible disorder-to-disorder synthesis approach to achieve wafer-scale ultraclean MAC (UC-MAC) within a timescale of seconds, featuring optimized ångström polygons without detectable metal contamination, and nanosized pores.

MYCBP2 Expression Correlates With Poor Prognosis in Upper Tract Urothelial Carcinoma Patients.

The incidence of upper tract urothelial carcinoma (UTUC) in Taiwan is high, characterized by aggressive clinical behavior and a tendency to be more invasive at diagnosis. Identifying tumorigenic genes remains an important challenge. Myc binding protein 2 (MYCBP2) regulates the cAMP, p38MAPK, TSC/mTOR, and autophagy signaling pathways in mammalian cells.

Insights into infraspecific differentiation of the medicinally important species Bupleurum Chinense revealed by morphological and molecular evidence.

Background: Radix Bupleuri, derived from the dried roots of Bupleurum chinense DC., is a well-documented phytomedicine in global pharmacopoeias and a common constituent in herbal formulations. While previous studies have hinted at regional variations in the chemical composition of B.

Risk factors for pneumonia after radical gastrectomy for gastric cancer: a systematic review and meta-analysis.

Objective: The objective is to systematically gather relevant research to determine and quantify the risk factors and pooled prevalence for pneumonia after a radical gastrectomy for gastric cancer.

Methods: The reporting procedures of this meta-analysis conformed to the PRISMA 2020. Chinese Wan Fang data, Chinese National Knowledge Infrastructure (CNKI), Chinese Periodical Full-text Database (VIP), Embase, Scopus, CINAHL, Ovid MEDLINE, PubMed, Web of Science, and Cochrane Library from inception to January 20, 2024, were systematically searched for cohort or case-control studies that reported particular risk factors for pneumonia after radical gastrectomy for gastric cancer.

Effect of clinical learning environment on professional identity in intern nursing students: A parallel multivariable mediation model.

Background: The significance of the clinical learning environment for professional identity is increasingly acknowledged. However, few studies have explored the bidirectional effects of the clinical learning environment on professional identity.

Objective: This study aimed to examine the relationship between the clinical learning environment and the professional identity of nursing interns, particularly the parallel mediating roles of perceived professional benefit and role stress.

Biopsy and interventional therapy of subglottic lesions with flexible bronchoscope under protection of endotracheal intubation.

Subglottic lesions represent a complex and challenging clinical entity, often associated with high procedural risks due to their anatomical location and vascularity. While a laryngeal mask airway (LMA) is commonly employed for airway management in such cases, it has notable limitations, particularly in scenarios involving significant bleeding or the need for extended intervention. This article presents an alternative and effective approach for the biopsy and interventional treatment of subglottic lesions using a flexible bronchoscope under the protection of an endotracheal tube (ETT).

Defying the oxidative-addition prerequisite in cross-coupling through artful single-atom catalysts.

Heterogeneous single-atom catalysts (SACs) have gained significant attention for their maximized atom utilization and well-defined active sites, but they often struggle with multi-stage organic cross-coupling reactions due to limited coordination space and reactivity. Here, we report an "anchoring-borrowing" strategy combined facet engineering to develop artful single-atom catalysts (ASACs) through anchoring foreign single atoms onto specific facets of the non-innocent reducible carriers. ASACs exhibit adaptive coordination, effectively bypassing the oxidative-addition prerequisite for bivalent elevation at a single metal site in both homogenous and heterogeneous cross-couplings.

A Light-Driven Electrochromic Materials-Based Nanomotor for HS-Controlled Drug Release in Synergistic Cancer Chemotherapy Immunotherapy.

Nanomotors hold tremendous potential for drug delivery. However, current nanomotors face limitations that compromise efficiency of drug utilization, including the use of inorganic materials with suboptimal soft interface and biocompatibility, uncontrollable drug release, insufficient directional control, and slow movement speeds. Herein, we present a novel near-infrared (NIR) light-driven porous unsymmetric nanomotor with ultrafast motion, which utilizes hydrogen sulfide (HS)-responsive cationic organic π-electron structure-based electrochromic material (F1) for the payload and controlled release of anionic anticancer drugs, enabling synergistic cancer chemotherapy and immunotherapy.

Ratiometric Photoacoustic Imaging Probe for Self-Predicting Nanozyme Therapeutic Effects.

Nanozymes with intrinsic enzyme-like properties have garnered significant attention in cancer treatment. However, effective methods to evaluate in situ the catalytic activity of nanozymes in living systems remain lacking. Herein, we pioneeringly present a novel probe (-FCuSA) for self-reporting nanozyme catalytic activity, which integrates a diene electrochromic material (EM ) and a copper single-atom nanozyme (FCuSA) with peroxidase (POD)-like activity.

Dual-Locked Near-Infrared Fluorescent Probe for Real-Time Imaging of Hydrogen Sulfide/Matrix Metallopeptidase-2 In Vivo.

Hydrogen sulfide (HS) and matrix metallopeptidase 2 (MMP-2) are inextricably linked in the occurrence and development of diseases and the treatment of diseases. However, most of the activatable imaging probes currently developed are single-locked probes that do not simultaneously detect HS and MMP-2 levels at disease sites and severely hinder the real-time and accurate analysis of the dynamic relationship between the two interrelated biomarkers. Herein, we report a dual-locked HS/MMP-2-activatable near-infrared (NIR) fluorescent imaging probe through a dual-Förster resonance energy transfer (FRET) mechanism that specifically detects tumors or acute lung injury (ALI) and establishes the dynamic relationship between the HS level and MMP-2 expression.

MoC/CoP Janus Structure Embedded Carbon Frame for Boosting Hydrazine Oxidation and Hydrogen Evolution Reactions.

The integration of hydrazine electrooxidation (HzOR) and hydrogen evolution reaction (HER) presents an efficient pathway for high-purity hydrogen production. However, developing bifunctional catalysts remains challenging for the demands of multiple active-centers and tailored electronic properties. Here, a unique Janus nano-catalysts of MoC/CoP embedded on carbon frameworks (MoC/CoP@C) is introduced, featuring dual electronic states (depletion and accumulation)driven by charge redistribution within MoC/CoP, acting as dual active-sites (DAS) for both HER and HzOR.

Atomic Gap-State Engineering of MoS for Alkaline Water and Seawater Splitting.

Transition-metal dichalcogenides (TMDs), such as molybdenum disulfide (MoS), have emerged as a generation of nonprecious catalysts for the hydrogen evolution reaction (HER), largely due to their theoretical hydrogen adsorption energy close to that of platinum. However, efforts to activate the basal planes of TMDs have primarily centered around strategies such as introducing numerous atomic vacancies, creating vacancy-heteroatom complexes, or applying significant strain, especially for acidic media. These approaches, while potentially effective, present substantial challenges in practical large-scale deployment.

Risk factors of skin tear in older persons: a protocol for systematic review and meta-analysis.

Introduction: Skin tear (ST) will prolong the hospitalisation time of an older person, increase the cost of medical expenses and the difficulty in care for nursing staff, and seriously affect the quality of life of the older person. Early identification and intervention of the elderly at risk of ST are key factors in preventing the occurrence of ST in older persons. At present, risk factors for ST in older persons have not been systematically evaluated, let alone summarised to analyse risk factors for ST in older persons.

Light Switchable Bioorthogonal Reaction Manifold for Modulation of Hydrogel Properties.

Chemical reaction systems that can occur via multiple pathways in a controllable fashion are highly attractive for advanced materials applications and biological research. In this report, we introduce a bioorthogonal reaction manifold based on a chalcone pyrene () moiety that can undergo either red-shifted photoreversible [2 + 2] cycloaddition or thiol-Michael addition click reaction. By coupling the to a water-soluble poly(ethylene glycol) end group, we demonstrate the efficient polymer dimerization and cleavage by blue light (λ = 450 nm) and UV light (λ = 340 nm), respectively.

An alternative bronchoscopic transparenchymal nodule access by "invisible tunnel" technique under electromagnetic navigation without the transbronchial access tool.

Background: The diagnosis of peripheral pulmonary lesions (PPL) is still challenging. We describe a novel method for sampling PPL without bronchial signs by creating invisible tunnel under electromagnetic navigation without the transbronchial access tool (TABT).

Methods: During electromagnetic navigation, we adjust the angle of the edge extended working channel catheter based on the real-time position of the lesion in relation to the locating guide rather than preset route.

Air-Stable Wafer-Scale Ferromagnetic Metallo-Carbon Nitride Monolayer.

The pursuit of robust, long-range magnetic ordering in two-dimensional (2D) materials holds immense promise for driving technological advances. However, achieving this goal remains a grand challenge due to enhanced quantum and thermal fluctuations as well as chemical instability in the 2D limit. While magnetic ordering has been realized in atomically thin flakes of transition metal chalcogenides and metal halides, these materials often suffer from air instability.

Prediction models for skin tears in the elderly: A systematic review and meta-analysis.

Background: The prevalence of risk prediction models for skin tears in the elderly is growing; however, there is still debate regarding the usefulness and suitability of these models for clinical use and additional study.

Objective: The purpose of this work is to perform a systematic review and meta-analysis of published research on skin tear risk prediction models in the elderly.

Methods: We conducted a comprehensive search of various databases, including Cumulative Index to Nursing and Allied Health Literature (CINAHL), Embase, PubMed, Web of Science, MEDLINE, Scopus, The Cochrane Library, Wanfang Database, China Science and Technology Journal Database (VIP), and China National Knowledge Infrastructure (CNKI), from the beginning until November 27, 2023.

Bioorthogonal Cu Single-Atom Nanozyme for Synergistic Nanocatalytic Therapy, Photothermal Therapy, Cuproptosis and Immunotherapy.

Single-atom nanozymes (SAzymes) with atomically dispersed active sites are potential substitutes for natural enzymes. A systematic study of its multiple functions can in-depth understand SAzymes's nature, which remains elusive. Here, we develop a novel ultrafast synthesis of sputtered SAzymes by in situ bombarding-embedding technique.

Association of major depression, schizophrenia and bipolar disorder with thyroid cancer: a bidirectional two-sample mendelian randomized study.

Background: Major depressive disease (MDD), schizophrenia (SCZ), and bipolar disorder (BD) are common psychiatric disorders, and their relationship with thyroid cancer has been of great interest. This study aimed to investigate the potential causal effects of MDD, SCZ, BD, and thyroid cancer.

Methods: We used publicly available summary statistics from large-scale genome-wide association studies to select genetic variant loci associated with MDD, SCZ, BD, and thyroid cancer as instrumental variables (IVs), which were quality controlled and clustered.

NTRK3 exhibits a pro-oncogenic function in upper tract urothelial carcinomas.

Neurotrophic receptor tyrosine kinase 3 (NTRK3) has pleiotropic functions: it acts not only as an oncogene in breast and gastric cancers but also as a dependence receptor in tumor suppressor genes in colon cancer and neuroblastomas. However, the role of NTRK3 in upper tract urothelial carcinoma (UTUC) is not well documented. This study investigated the association between NTRK3 expression and outcomes in UTUC patients and validated the results in tests on UTUC cell lines.

Association between educational attainment and thyroid cancer: evidence from a univariable and multivariable Mendelian randomization study.

Background: Thyroid cancer and educational attainment have been related in observational studies. It is unclear if these correlations indicate causative relationships.

Methods: Using large-scale genome-wide association studies (GWAS) datasets, we conducted an univariable and multivariable Mendelian randomization (MR) study to assess a potential connection between educational attainment and thyroid cancer.

The effect of micronutrient on thyroid cancer risk: a Mendelian randomization study.

Background: The effect of micronutrients on thyroid cancer has been studied in observational studies, however, the cause of relationships has not yet been determined. Thyroid cancer was the subject of a Mendelian randomization (MR) analysis of micronutrients. Aimed to determine whether micronutrient intake has a causal impact on the chance of developing thyroid cancer.