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In this paper, we propose a novel translation model, UniTranslator, for transforming representations between visually distinct domains under conditions of limited training data and significant visual differences. The main idea behind our approach is leveraging the domain-neutral capabilities of CLIP as a bridging mechanism, while utilizing a separate module to extract abstract, domain-agnostic semantics from the embeddings of both the source and target realms. Fusing these abstract semantics with target-specific semantics results in a transformed embedding within the CLIP space. To bridge the gap between the disparate worlds of CLIP and StyleGAN, we introduce a new non-linear mapper, the CLIP2P mapper. Utilizing CLIP embeddings, this module is tailored to approximate the latent distribution in the StyleGAN's latent space, effectively acting as a connector between these two spaces. The proposed UniTranslator is versatile and capable of performing various tasks, including style mixing, stylization, and translations, even in visually challenging scenarios across different visual domains. Notably, UniTranslator generates high-quality translations that showcase domain relevance, diversity, and improved image quality. UniTranslator surpasses the performance of existing general-purpose models and performs well against specialized models in representative tasks.
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http://dx.doi.org/10.1109/TPAMI.2025.3530099 | DOI Listing |
The purpose of the Client Oriented Scale of Improvement in Tinnitus (COSIT) is to set treatment goals and assess individual outcomes. The Tinnitus Functional Index (TFI) was developed as a comprehensive questionnaire to measure individual and population responses to tinnitus therapies. To investigate the convergent validity and responsiveness of the COSIT and TFI.
View Article and Find Full Text PDFSci China Life Sci
September 2025
Laboratory of Gene Therapy, Department of Biochemistry, College of Life Sciences, Shaanxi Normal University, Xi'an, 710062, China.
Targeted gene integration mediated by CRISPR/Cas9 is a promising therapeutic strategy for monogenic autosomal recessive diseases. In this study, we established a novel all-in-one high-capacity adenovirus (HCAd) that can pack both CRISPR/Cas9 and donor DNA into the same vector and tested it on a mouse model of mucopolysaccharidosis type VII (MPS VII) caused by mutations in the β-glucuronidase (GUSB) gene. This system allowed targeted integration of promoterless GUSB in the mouse beta-actin gene (mActb) locus and the co-expression of GUSB with the self-cleaving peptide T2A (T2A) controlled by a strong endogenous mActb promoter.
View Article and Find Full Text PDFIEEE Trans Pattern Anal Mach Intell
April 2025
In this paper, we propose a novel translation model, UniTranslator, for transforming representations between visually distinct domains under conditions of limited training data and significant visual differences. The main idea behind our approach is leveraging the domain-neutral capabilities of CLIP as a bridging mechanism, while utilizing a separate module to extract abstract, domain-agnostic semantics from the embeddings of both the source and target realms. Fusing these abstract semantics with target-specific semantics results in a transformed embedding within the CLIP space.
View Article and Find Full Text PDFJ Biol Chem
January 2025
School of Environmental Science and Engineering, Shandong University, Qingdao, China. Electronic address:
Base editing is preferable for bacterial gene inactivation without generating double-strand breaks, requiring homology recombination, or highly efficient DNA delivery capability. However, the potential of base editing is limited by the adjoined dependence on the editing window and protospacer adjacent motif. Herein, we report an unconstrained base-editing system to enable the inactivation of any genes of interest in bacteria.
View Article and Find Full Text PDFAnal Chem
November 2023
State Key Laboratory of Analytical for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Xianlin Ave 163, Nanjing, Jiangsu 210023, China.
Combining targeting ability, imaging function, and photothermal/photodynamic therapy into a single agent is highly desired for cancer theranostics. Herein, we developed a one-for-all nanoplatform with N/P/S-codoped fluorescent carbon nanodots (CNDs) for tumor-specific phototheranostics. The CNDs were prepared via a one-pot hydrothermal process using cancer cells as sources of carbon, nitrogen, phosphorus, and sulfur.
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