Novel Thioredoxin reductase 1 inhibitor BS1801 relieves treatment resistance and triggers endoplasmic reticulum stress by elevating reactive oxygen species in glioma.

Glioma patients will inevitably develop resistance to temozolomide (TMZ) leading to tumor recurrence. By comparing genomic differences between primary and recurrent glioma patients, Thioredoxin reductase 1 (TrxR1) was identified as a crucial role in TMZ resistance. Glioma cells elevate the expression level of TXNRD1 to against TMZ-induced reactive oxygen species (ROS), thereby conferring TMZ resistance.

An Engineered Supramolecular Fluorescent Chemosensor for Multiscale Visualization of Glutamate Dynamics in Living Systems.

Glutamate (Glu) plays a critical role in the brain, and the ability to directly measure glutamate activity is essential for understanding its physiological functions and pathological processes. Herein, we engineered a family of Glu sensors () based on host-guest interactions through the indicator displacement method (IDA) strategy. The optimized supramolecular chemosensor exhibited specificity, sensitivity, signal-to-noise ratio, rapid kinetics (∼145 ms), and photostability, enabling it to be suitable for monitoring Glu dynamics in neuronal organelles, brain tissues, and zebrafish.

Traditional Chinese Medicinal Herbs for Treating Post-Ischemic Stroke Cognitive Impairment Insights From Frequency and Association Analysis.

Background: This study analyzes medicinal herbs in Traditional Chinese Medicine (TCM) formulations for post-ischemic stroke cognitive impairment, identifying key herbs, their interactions, and potential therapeutic mechanisms through systematic review, frequency analysis, and association rule mining.

Methods: Systematic searches were performed across major databases (CBM, CNKI, VIP, Wanfang Data) to find studies on TCM for post-ischemic stroke cognitive impairment. Inclusion criteria focused on studies reporting TCM formulas and their cognitive effects.

Efficacy and safety of cold snare polypectomy for outpatient treatment of sessile polyps smaller than 10mm.

Background: Screening colonoscopy plays a critical role in reducing colorectal cancer incidence by identifying and removing polyps. Simple and safe treatment is the most common request of both doctors and patients. Cold snare polypectomy (CSP) is increasingly favored for polyps < 10 mm, yet concerns remain regarding residual tissue.

Impaired glymphatic function in relation to cumulative blood glucose exposure: A population-based cohort study.

Objective: The relationship between prolonged blood glucose exposure and glymphatic system function of the brain remains unknown. This study aimed to investigate the association between cumulative blood glucose levels and neuroimaging metrics associated with glymphatic function.

Methods: This study was conducted in a multicenter, community-based cohort study.

Combined lifestyle habits, subjective well-being, and all-cause mortality among older adults in China.

Background: Although studies have demonstrated that both lifestyles and subjective well-being (SWB) are associated with mortality risk, the joint effects of a healthy lifestyle and SWB on the risk of mortality are unclear. This study aimed to explore the combined impact of lifestyles and SWB on total mortality among the older Chinese population.

Methods: Data were obtained from the Chinese Longitudinal Healthy Longevity Survey conducted from 2002 to 2018.

Structural characteristics of Brassica rapa L. Polysaccharide and its bioactivity on alcoholic liver injury.

The global prevalence of alcoholic liver disease (ALD) has shown a concerning upward trend, with an increasing incidence among younger demographics. In this study, ultrasound-assisted extraction was employed to isolate polysaccharides from Brassica rapa L (BRL). The purified polysaccharide (BRLPP) was structurally characterized, and its protective effects against alcoholic liver disease (ALD) were investigated.

Deciphering Cd stabilization pathways by organosilicon in soil-pakchoi systems through isotope-tracing.

Cadmium (Cd) pollution in farmland soils threatens food safety, making it essential to study soil-crop Cd transport mechanisms and develop remediation strategies. While organosilicon-modified materials demonstrate potential in blocking metal uptake by crops, their underlying mechanisms remain underexplored. This study employed stable isotope Cd tracing to investigate Cd absorption, translocation, allocation in soil-pakchoi system mediated by organosilicon (DMDCS and D6).

Jasminum sambac: Progress in research on ethnopharmacology, phytochemistry, pharmacological actions and other applications.

Aim Of The Study: This paper reviews the progress of research on the botany, traditional uses, phytochemistry, pharmacology, modern uses and toxicity of Jasminum sambac (L.) Aiton (JS).

Materials And Methods: Literature for this paper on JS was obtained from databases such as Web of Science, PubMed, ACS Publications, Google Scholar, Baidu Scholar, and CNKI.

Interactions between astrocytes and cerebral endothelial cells in central nervous system diseases.

Endothelial cells and astrocytes are the two main types of cells in the blood-brain barrier, and each plays a pivotal role in the central nervous system. Although they have different functional characteristics, they can mutually communicate and cooperate with each other to maintain the normal function of the neurovascular unit and are substantially altered during pathology. Understanding the relationship between astrocytes and endothelial cells can lay the foundation for advancing protective therapies against central nervous system diseases.

DJ-1 counteracts Caveolin-1-mediated necroptosis to inhibit epithelial barrier dysfunction in colitis.

Caveolin-1 (CAV1), a pivotal protein implicated in endothelial cell-mediated angiogenesis, assumes an ambiguous role with elusive underlying mechanisms in the pathogenesis of inflammatory bowel disease (IBD). In this investigation, we delineated the involvement of CAV1 in murine models of dextran sulfate sodium (DSS)-induced colitis. CAV1 knockout mice manifested attenuated pathological and inflammatory damage to the epithelium, whereas mice overexpressing CAV1 exhibited contrasting outcomes.

Characterization of the Mitochondrial Genome of subsp. Rousi Based on High-Throughput Sequencing and Elucidation of Its Evolutionary Mechanisms.

ssp. Rousi a species of significant ecological and economic value that is native to the Qinghai-Tibet Plateau and arid/semi-arid regions. Investigating the mitochondrial genome can elucidate stress adaptation mechanisms, population genetic structure, and hybrid evolutionary history, offering molecular insights for ecological restoration and species conservation.

Correction: Palladium-catalysed alleneamination of γ,δ-unsaturated hydrazones with propargylic acetates: access to tetrahydropyridazines bearing allenes.

Correction for 'Palladium-catalysed alleneamination of γ,δ-unsaturated hydrazones with propargylic acetates: access to tetrahydropyridazines bearing allenes' by Shuaijie Wu , , 2025, , 6647-6650, https://doi.org/10.1039/D4CC06716A.

Ozone-coupled photocatalytic HO synthesis via Mn/Ce bimetallic metal organic framework: synergistic catalysis and sacrificial agent-free efficiency.

Typically, photocatalytic HO synthesis faces efficiency limitations due to sacrificial agent dependence and sluggish oxygen activation. Herein, we present, for the first time, an ozone-coupled bimetallic MIL-100(MnCe) photocatalytic approach to HO synthesis. This novel strategy yields an impressive 1602 μmol·g·h HO in pure water without sacrificial agents.

The lncRNA Jpx participates in testosterone-induced H9c2 cell hypertrophy by targeting the miR-145-5p/Nfatc3 axis.

Cardiac hypertrophy is an adaptive cardiac response to overload. The ensuing decompensation eventually leads to heart failure or sudden death. Testosterone can induce cardiomyocyte hypertrophy, although the underlying mechanism has not been completely elucidated.

[ biofilm formation regulated by acyl-homoserine lactones and its application in UO electrosorption].

MR-1, a Gram-negative bacterium with a significant role in the adsorption and reduction of uranium in wastewater and a quorum-sensing effect, can be used to remove uranium from wastewater. Exogenous signaling molecules (acyl-homoserine lactones, AHLs) can be added to induce the quorum sensing behavior for rapid biofilm formation, thereby improving the removal efficiency of this bacterium for uranium. Extracellular polymeric substances (EPS), as the significant components of biofilm, play a key role in biofilm formation.

Joint Extraction of Cyber Threat Intelligence Entity Relationships Based on a Parallel Ensemble Prediction Model.

The construction of knowledge graphs in cyber threat intelligence (CTI) critically relies on automated entity-relation extraction. However, sequence tagging-based methods for joint entity-relation extraction are affected by the order-dependency problem. As a result, overlapping relations are handled ineffectively.

The secondary effects of Vibrio parahaemolyticus on noble scallop Chlamys nobilis with black shell disease.

The noble scallop Chlamys nobilis is the main cultured economic bivalve on the south coast of China. However, parasitic and bacterial infections have caused great economic losses on the scallop in recent years. Our previous study showed that the black shell disease caused by polychaete parasites leads to increased mortality and slow growth of the scallop.

Impact of Obesity on Immunity to the Influenza Virus: Gut Microbiota, Mechanisms, and Novel Therapeutic Strategies.

Obesity affects millions of individuals globally, and a deeper understanding of its associated physiological disturbances is essential for addressing key public health concerns. It has been demonstrated that the influenza virus possesses substantial global epidemic potential, with higher incidence rates observed in obese individuals and prolonged recovery times. Obese individuals exhibit impaired immune organ function, decreased immune cell activity, disrupted metabolism characterized by mitochondrial dysfunction, and an imbalance in gut microbiota associated with intestinal mucosal barrier damage.

Fecal microbiota transplantation for refractory chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation: a pilot open-label, non-placebo-controlled study.

Background: Dysbiosis of the intestinal microbiota plays a crucial role in the initiation and development of graft-versus-host disease (GVHD). Fecal microbiota transplantation (FMT) has been reported to be effective for refractory acute GVHD; however, whether FMT is effective for refractory chronic GVHD (cGVHD) remains unknown.

Methods: To investigate the efficacy and safety of FMT for refractory cGVHD and the underlying mechanism, 12 patients with refractory cGVHD received FMT via colonoscopy, and the response was evaluated at 12 weeks after FMT.

Predictive model for coronavirus disease 2019 severity based on blood biomarkers: a retrospective study.

Objective: To develop and validate a clinical prediction model for assessing the severity of coronavirus disease 2019 (COVID-19) using blood biomarkers, aiming to support clinical decision-making and treatment guidance.

Methods: A retrospective cohort study was conducted at Beijing Shijitan Hospital on January 5, 2023, including SARS-CoV-2 positive patients with initial chest CT-detected from outpatient and emergency departments. Data on demographics, symptoms, and blood biomarkers were collected.

Case Report: A rare case of MET-amplified gastric cancer with systemic metastasis: remarkable efficacy of crizotinib and the role of precision medicine.

Gastric cancer remains one of the most prevalent gastrointestinal malignancies, with certain subtypes, such as poorly cohesive carcinoma-including signet ring cell carcinoma (SRCC)-exhibiting aggressive progression and poor prognosis. Mesenchymal epithelial transition (MET) amplification, a relatively rare oncogenic driver in gastric cancer (~2-10.2% of cases), has been associated with resistance to conventional therapies and dismal survival (median <6 months in metastatic cases).

Cyclometallated Ir(III) complexes exhibit antitumor activity through angiogenesis inhibition.

Targeting angiogenesis remains a pivotal therapeutic approach in cancer treatment, aiming to impede tumor growth and metastasis. In this study, three novel cyclometallated Ir(III) complexes (Ir1, Ir2, and Ir3) were synthesized and systematically assessed for their in vitro cytotoxic effects across a range of cancer cell lines. Mechanistic studies revealed that these complexes are internalized by MCF-7 cells via energy-dependent pathways and predominantly accumulate within lysosomes or the endoplasmic reticulum.

The Association of Mother and Infant Characteristics with the Macronutrient Content of Donor Human Milk.

In southern China, little is known about the macronutrient content of donor human milk (DHM), which varies among donor mothers. This study aimed to evaluate the association of mother and infant characteristics with the macronutrient content of DHM. A retrospective analysis was conducted on the anthropometric data, age of delivery, and mode of delivery of 365 healthy donor mothers.

Microchannel-confined droplet-based electricity generator for biomechanical energy conversion and sensing.

Triboelectric nanogenerators (TENGs) are positioned as a critical sustainable power solution for harvesting low-frequency mechanical energy or sensing. Although solid-solid contact-based TENGs can provide sustainable power to diminish external battery reliance and enhance portability and operational longevity, suboptimal energy output at low-frequency excitation, irreversible material damage under long-term operation and inadequate energy supply remain a challenge. Solid-liquid contact-based TENGs present an alternative approach, but rigid and bulky configurations hinder their integration toward wearable devices and the development of real applications.