Molecular Layer Atrophy Mediates the Association of Cumulative Blood Pressure Exposure With Cognitive Decline.

Background: High blood pressure (BP) is a known risk factor for cognitive decline and dementia, but the underlying mechanisms are largely unknown. We investigated the associations of cumulative BP exposure with hippocampal subfield volume and cognitive function and determined whether hippocampal subfield atrophy mediates the association between cumulative BP exposure and cognitive decline.

Methods: Between December 2020 and March 2023, participants were prospectively included from the Kailuan study.

Impaired glymphatic function in relation to cumulative blood glucose exposure: A population-based cohort study.

Objective: The relationship between prolonged blood glucose exposure and glymphatic system function of the brain remains unknown. This study aimed to investigate the association between cumulative blood glucose levels and neuroimaging metrics associated with glymphatic function.

Methods: This study was conducted in a multicenter, community-based cohort study.

Correlation between carotid artery ultrasound parameters and lacunar infarction.

Objective: This study aims to investigate the correlation between the imaging characteristics of lacunar infarction (LI) and carotid artery ultrasound parameters within a community-based population.

Methods: A total of 630 participants were included to undergo brain MRI and carotid ultrasound examinations, with their demographic and clinical characteristics systematically documented. Ultrasound imaging was used to quantify the structural, hemodynamic, and stiffness parameters of the common carotid artery (CCA) and internal carotid artery (ICA).

Clinical information prompt-driven retinal fundus image for brain health evaluation.

Background: Brain volume measurement serves as a critical approach for assessing brain health status. Considering the close biological connection between the eyes and brain, this study aims to investigate the feasibility of estimating brain volume through retinal fundus imaging integrated with clinical metadata, and to offer a cost-effective approach for assessing brain health.

Methods: Based on clinical information, retinal fundus images, and neuroimaging data derived from a multicenter, population-based cohort study, the KaiLuan Study, we proposed a cross-modal correlation representation (CMCR) network to elucidate the intricate co-degenerative relationships between the eyes and brain for 755 subjects.

Long-term Blood Pressure Exposure and Cerebral Microbleeds: a Retrospective Study from the META-KLS Cohort.

Introduction: The relationship between long-term blood pressure factors and cerebral microbleeds (CMBs) in community populations remains unclear. This study aimed to elucidate the associations between various long-term blood pressure factors and the occurrence of CMBs within the Kailuan cohort.

Methods: Data were obtained from adults participating in the Multi-Modality Medical Imaging Study Based on the Kailuan Study (META-KLS), a prospective longitudinal community study initiated in 2006, involving participants aged 18-98 years.

Sustained high Life's Essential 8 is associated with lower risk of cerebral small vessel disease: a community-based study.

Objective: We aimed to investigate the influence of Life's Essential 8 (LE8) score trajectories on cerebral small vessel disease (CSVD).

Methods: A total of 1,162 subjects from the Kailuan prospective cohort study were enrolled. The LE8 score trajectories were developed from 2006 to 2021 using trajectory modeling of the SAS procedure Proc Traj.

Exposure to Multiple Metals and Cerebral White Matter Hyperintensity in Chinese Population: A Cross-Sectional Study.

Background: Evidence about the impact of multiple metal exposure on brain neuroimaging metrics remains limited. We aim to investigate the effects of single and mixed metal exposure on white matter hyperintensities (WMHs).

Methods: This cross-sectional study included 1183 subjects without stroke history from the META-KLS (Multi-modality Medical Imaging Study Based on Kailuan Study), which is an existing prospective cohort in Tangshan, China.

Vaginal Microbiome and Metabolome Profiles Among HPV Positive and HPV Negative Women Based on Stratification of Vaginitis.

This study investigated the differences in vaginal microbiota and metabolism between HPV positive and HPV negative women based on the stratification of vaginitis. This was a case-control study. A total of 164 women were included in this study analysis with a ratio of 1:3 for HPV positive and HPV negative women.

Nonpharmacological mental health interventions for adolescent patients with polycystic ovary syndrome: a scoping review.

Objectives: This study aimed to summarize nonpharmacological mental health interventions that are beneficial for adolescent patients with polycystic ovary syndrome (PCOS) and to identify the limitations of existing studies.

Material And Methods: Following the recommendations of the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-SCR), we conducted a scoping review of nonpharmacological interventions aimed at improving mental health in adolescents with PCOS.

Results: Six randomized controlled trials (RCTs), two quasiexperimental studies, two case reports, one prospective study, one predictive correlation study, and one field trial study were included, resulting in 13 articles.

Retinal Vascular Morphology Reflects and Predicts Cerebral Small Vessel Disease: Evidences from Eye-Brain Imaging Analysis.

Cerebral small vessel disease (SVD) involves ischemic white matter damage and choroid plexus (CP) dysfunction for cerebrospinal fluid (CSF) production. Given the vascular and CSF links between the eye and brain, this study explored whether retinal vascular morphology can indicate cerebrovascular injury and CP dysfunction in SVD. We assessed SVD burden using imaging phenotypes like white matter hyperintensities (WMH), perivascular spaces, lacunes, and microbleeds.

Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19.

Background: COVID-19 continues to show long-term impacts on our health. Limited effective immune-mediated antiviral drugs have been launched.

Methods: We conducted a Mendelian randomization (MR) and colocalization analysis using 26,597 single-cell expression quantitative trait loci (sc-eQTL) to proxy effects of expressions of 16,597 genes in 14 peripheral blood immune cells and tested them against four COVID-19 outcomes from COVID-19 Genetic Housing Initiative GWAS meta-analysis Round 7.

Ambient air pollution exposure in relation to cerebral small vessel disease in Chinese population: A cranial magnetic resonance imaging-based study.

Cerebral small vessel disease (CSVD), a chronic and progressive vascular disorder closely associated with stroke and dementia, is primarily identified and diagnosed in cranial magnetic resonance imaging (MRI). Given the limited evidence on the relationship between air pollution and CSVD, this study aimed to investigate the links between multiple air pollutants exposure and CSVD risk. Eligible subjects and their cranial MRI data were obtained from the Multi-modality Medical Imaging Study Based on Kailuan Study, totaling 1216 participants.

Effect of cetuximab plus FOLFOX4 regimen on clinical outcomes in advanced gastric carcinoma patients receiving evidence-based care.

Background: Although chemotherapy is effective for treating advanced gastric carcinoma (aGC), it may lead to an adverse prognosis. Establishing a highly effective and low-toxicity chemotherapy regimen is necessary for improving efficacy and outcomes in aGC patients.

Aim: To determine the efficacy and safety of cetuximab (CET) combined with the FOLFOX4 regimen (infusional fluorouracil, folinic acid, and oxaliplatin) as first-line therapy for patients with aGC, who received evidence-based care (EBC).

Associations of serum uric acid variability with neuroimaging metrics and cognitive decline: a population-based cohort study.

Background: The relationship between variation in serum uric acid (SUA) levels and brain health is largely unknown. This study aimed to examine the associations of long-term variability in SUA levels with neuroimaging metrics and cognitive function.

Methods: This study recruited 1111 participants aged 25-83 years from a multicenter, community-based cohort study.

Gray matter volume mediates the association of long-term blood pressure variability with cognitive function in an adult population.

Introduction: We delineated the associations among long-term blood pressure variability (BPV), brain structure, and cognitive function.

Methods: We included 1254 adult participants from the Kailuan study. BPV was calculated from 2006 to 2020.

Hippocampal volume mediates the association of arterial stiffness with cognitive impairment in adult population.

Objectives: To investigate the association of arterial stiffness with brain perfusion, brain tissue volume and cognitive impairment in the general adult population.

Materials And Methods: This prospective study included 1488 adult participants (age range: 22.8-83.

Silencing DDX3 Attenuates Interleukin-1β-Induced Intervertebral Disc Degeneration Through Inhibiting Pyroptosis.

Intervertebral disc degeneration (IVDD) is a common disorder associated with chronic inflammation and cell death. In this study, an IVDD rat model was created through Interleukin-1β (IL-1β) injection. The degeneration of intervertebral disc tissues was assessed using magnetic resonance imaging (MRI), followed by hematoxylin and eosin (H&E) and terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) staining.

Serum uric acid is associated with midbrain enlarged perivascular spaces: Results from Multi-modality Medical imaging sTudy bAsed on KaiLuan Study (META-KLS).

Background: Serum uric acid (SUA) is a major cause of cardiovascular and cerebrovascular diseases. Whether and to what extent the excess risk of enlarged perivascular spaces (EPVS) conferred by SUA is unknown. The study was conducted to investigate the association between SUA and EPVS in different brain regions.

Association between Body Mass Index and Brain Health in Adults: A 16-Year Population-Based Cohort and Mendelian Randomization Study.

The cumulative effect of body mass index (BMI) on brain health remains ill-defined. The effects of overweight on brain health across different age groups need clarification. We analyzed the effect of cumulative BMI on neuroimaging features of brain health in adults of different ages.

Characterization of Novel PHEX Variants in X-linked Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation.

Background: X-linked hypophosphatemia (XLHR) is the most common genetic form of hypophosphatemic rickets (HR), which is caused by phosphate regulating endopeptidase homolog X-linked (PHEX) gene mutation. At present, the genotype-phenotype relationship of XLHR and the pathogenic role of PHEX are not fully understood.

Methods: In this study, we summarized clinical features in a new cohort of 49 HR patients and detected 16 novel PHEX and 5 novel non-PHEX variants.

Association of variability in body size with neuroimaging metrics of brain health: a population-based cohort study.

Background: The relationship between the fluctuation in body size and brain health is poorly understood. This study aimed to examine the associations of long-term variability in body mass index (BMI) and waist-to-hip ratio (WHR) with neuroimaging metrics that approximate brain health.

Methods: This cohort study recruited 1114 participants aged 25-83 years from a multicenter, community-based cohort study in China.