Molecular Layer Atrophy Mediates the Association of Cumulative Blood Pressure Exposure With Cognitive Decline.

Background: High blood pressure (BP) is a known risk factor for cognitive decline and dementia, but the underlying mechanisms are largely unknown. We investigated the associations of cumulative BP exposure with hippocampal subfield volume and cognitive function and determined whether hippocampal subfield atrophy mediates the association between cumulative BP exposure and cognitive decline.

Methods: Between December 2020 and March 2023, participants were prospectively included from the Kailuan study.

The effectiveness of escape rooms for nursing students' knowledge, clinical skills and critical thinking: A systematic review and meta-analysis.

Aim: To evaluate the effectiveness of escape room-based learning on nursing students' knowledge, clinical skills and critical thinking through a systematic review and meta-analysis.

Background: Traditional nursing education faces limitations in promoting active learning and higher-order cognitive skills. Escape rooms, as gamified interventions, offer immersive scenarios to enhance engagement and competency development.

Sustained high Life's Essential 8 is associated with lower risk of cerebral small vessel disease: a community-based study.

Objective: We aimed to investigate the influence of Life's Essential 8 (LE8) score trajectories on cerebral small vessel disease (CSVD).

Methods: A total of 1,162 subjects from the Kailuan prospective cohort study were enrolled. The LE8 score trajectories were developed from 2006 to 2021 using trajectory modeling of the SAS procedure Proc Traj.

Prediction Models for Health Care Workers' Exposure to Type II Workplace Violence: A Systematic Review and Meta-Analysis.

Background: Workplace violence poses a serious threat to safety and well-being of health care workers.

Purpose: The purpose of this systematic review was to assess the accuracy and applicability of predictive models for workplace violence risk among health care workers.

Methods: Ten databases were searched through May 2025.

Nurses' moral distress and ethical climate: A systematic review and meta-analysis.

BackgroundMoral distress is a pervasive challenge in nursing practice, adversely impacting nurses' well-being, career development, patient safety, and organizational performance. Ethical climate, as a modifiable organizational factor, plays a pivotal role in mitigating moral distress. Understanding the association between nurses' moral distress and ethical climate is critical for clinical practice, management, and policymaking.

Placental epigenetic age: Associations with prenatal maternal psychosocial adversities and preschool emotional and behavioral problems.

Background: The link between prenatal psychosocial adversity and offspring behavioral problems is well-established; however, the underlying pathways are still being explored.

Methods: Data was a random sample from the Shanghai Maternal-Child Pairs Cohort including women enrolled at early pregnancy and followed children 3-6 years old. The current study comprised 82 mother-offspring dyads based on the availability of placental DNA methylation.

Outdoor Time Could Regulate the Effects of Green Environment on Myopia in Chinese Children and Adolescents.

Purpose: To explore the relationship between myopia and green space, and the mediation effects of outdoor time.

Methods: We used large-scale, cross-sectional observational data from Shanghai, China. Participants were aged 3~20 years and underwent visual acuity and non-cycloplegic refraction in 2021.

The effect of PM exposure on placenta and its associated metabolites: A birth cohort study.

The placenta is an important organ for fetal growth. Air pollution during pregnancy may cause adverse effects on offsprings via placental dysfunction. However, the metabolites underlie the effects of PM on placenta have not been well studied.

Efficacy of wearable transcutaneous electrical acupoint stimulation bracelet on moderate-to-severe postoperative nausea and vomiting in patients after general anesthesia: a study protocol for a multicenter randomized controlled trial.

Background: Postoperative nausea and vomiting (PONV) is the most common complication following general anesthesia. Currently, pharmaceutical therapy is the primary method of treatment, but it has reached a plateau, and it is accompanied by inherent adverse reactions and high costs. Stimulation of the wrist acupuncture point PC6 is recommended as an effective means of preventing PONV.

Human milk microbiota and oligosaccharides in colostrum and mature milk: comparison and correlation.

Background: The interaction between the human breast milk microbiota and human milk oligosaccharides (HMOs) plays a crucial role in the healthy growth and development of infants. We aimed to clarify the link between the breast milk microbiota and HMOs at two stages of lactation.

Methods: The microbiota and HMOs of 20 colostrum samples (C group, 1-5 days postpartum) and 20 mature milk samples (S group, 42 days postpartum) collected from postpartum mothers were analyzed using 16S rRNA gene high-throughput sequencing and high-performance liquid chromatography-tandem mass spectrometry.

Prenatal ozone exposure is associated with children overweight and obesity: Evidence from the Shanghai Maternal-Child Pairs Cohort.

Prenatal ozone (O) exposure may disrupt normal offspring growth. However, epidemiological evidence that prenatal O exposure affects the physical development of offspring early in life is far from adequate. A total of 4909 maternal-child pairs from the Shanghai Maternal-Child Pairs Cohort were included.

Early-life exposure to per- and polyfluoroalkyl substances: Analysis of levels, health risk and binding abilities to transport proteins.

Per- and polyfluoroalkyl substances (PFAS) can pass through the placenta and adversely affect fetal development. However, there is a lack of comparison of legacy and emerging PFAS levels among different biosamples in pregnant women and their offspring. This study, based on the Shanghai Maternal-Child Pairs Cohort, analyzed the concentrations of 16 PFAS in the maternal serum, cord serum, and breast milk samples from 1,076 mother-child pairs.

Association between different stages of cardiovascular-kidney-metabolic syndrome and the risk of all-cause mortality.

Background And Aims: Poor cardiovascular-kidney-metabolic (CKM) health is a major determinant of all-cause mortality, which poses a significant burden on global public health systems and socio-economics. However, the association between different stages of CKM syndrome and the risk of all-cause mortality remains unclear. This study aimed to evaluate the association between different stages of CKM syndrome and risk of all-cause mortality.

Longitudinal association between maternal cardiovascular health in pregnancy and child birth outcomes.

The American Heart Association has updated its definition of cardiovascular health (CVH) with a new framework known as Life's Essential 8 (LE8). Although gestational CVH assessment has been recommended, its significance based on LE8 for birth outcomes is unknown. We thus evaluated the status of gestational CVH based on LE8 in 3036 pregnant women of the Shanghai Maternal-Child Pairs Cohort and the population of China Maternal Nutrition and Health Sciences Survey, and also examined the association between gestational CVH and child birth outcomes.

Gray matter volume mediates the association of long-term blood pressure variability with cognitive function in an adult population.

Introduction: We delineated the associations among long-term blood pressure variability (BPV), brain structure, and cognitive function.

Methods: We included 1254 adult participants from the Kailuan study. BPV was calculated from 2006 to 2020.

Prospective Associations of Maternal Cardiometabolic Health With Children Cardiometabolic Health at Ages 3 to 6 Years.

Objective: Maternal cardiometabolic health (MCMH) may have critical effects on offspring lifetime cardiometabolic health (CMH), whereas evidence on the relationship between MCMH during pregnancy and children CMH (CCMH) at ages 3∼6 years remains unknown.

Method: The study included 1478 mother-child dyads from the Shanghai Maternal-Child Pairs Cohort study. MCMH was examined at a mean of 27.

Impact of ophthalmic clinical service use in mitigating myopia onset and progression in preschool children: a retrospective cohort study.

Background: Although school screenings identify children with vision problems and issue referrals for medical treatment at an ophthalmic hospital, the effectiveness of this approach remains unverified.

Objective: To investigate the impact of ophthalmic clinical services on the onset and progression of myopia in preschool children identified with vision impairment.

Methods: Using data from the Shanghai Child and Adolescent Large-scale Eye Study (SCALE), this retrospective cohort study evaluated the visual development of children from three districts-Jing'an, Minhang, and Pudong-which are representative of geographic diversity and economic disparity in Shanghai's 17 districts.

Hippocampal volume mediates the association of arterial stiffness with cognitive impairment in adult population.

Objectives: To investigate the association of arterial stiffness with brain perfusion, brain tissue volume and cognitive impairment in the general adult population.

Materials And Methods: This prospective study included 1488 adult participants (age range: 22.8-83.

Prenatal maternal stress, sleep quality, and neonatal birth weight: A prospective cohort study.

To assess if the impacts of prenatal maternal stress (PNMS) on neonatal physical development including birth weight and body length vary by trimesters, and to explore the mediating effect of sleep quality in the relationships. A total of 2778 pregnant women were included from the Shanghai Maternal-Child Pairs Cohort. PNMS and sleep quality were measured in the first trimester (12-16 gestational weeks) and third trimester (32-36 gestational weeks) using the Life Event Scale for Pregnant Women (LESPW) and Pittsburgh Sleep Quality Index, respectively.

Barriers and facilitators to using ophthalmic clinical health services following school vision screening: a mixed-methods study.

Objective: To identify determinants of the utilisation of ophthalmic clinical health services among students who failed school vision screening.

Methods: This study employed a sequential explanatory mixed methods design, underpinned by Andersen's Behavioural Model of Health Service Utilisation. Data were initially gathered through interviews with 27 stakeholders-comprising 5 ophthalmologists, 7 community doctors, 7 public health professionals and 8 teachers.

Prenatal organophosphate esters exposure and neurodevelopment trajectory in infancy: Evidence from the Shanghai Maternal-Child Pairs Cohort.

Background: Concerns remain about the neurotoxic properties of the ubiquitous organophosphate esters (OPEs), the replacement of the toxicant polybrominated diphenyl ethers.

Objectives: We examined the associations of prenatal exposure to OPEs and their mixtures with early-life neurodevelopment trajectories.

Methods: Totally 1276 mother-child pairs were recruited from the Shanghai Maternal-Child Pairs Cohort.

Serum uric acid is associated with midbrain enlarged perivascular spaces: Results from Multi-modality Medical imaging sTudy bAsed on KaiLuan Study (META-KLS).

Background: Serum uric acid (SUA) is a major cause of cardiovascular and cerebrovascular diseases. Whether and to what extent the excess risk of enlarged perivascular spaces (EPVS) conferred by SUA is unknown. The study was conducted to investigate the association between SUA and EPVS in different brain regions.

Prenatal PFAS exposure, gut microbiota dysbiosis, and neurobehavioral development in childhood.

Studies on the role of the gut microbiota in the associations between per- and polyfluoroalkyl substance (PFAS) exposure and adverse neurodevelopment are limited. Umbilical cord serum and faeces samples were collected from children, and the Strengths and Difficulties Questionnaire (SDQ) was conducted. Generalized linear models, linear mixed-effects models, multivariate analysis by linear models and microbiome regression-based kernel association tests were used to evaluate the associations among PFAS exposure, the gut microbiota, and neurobehavioural development.