Association between three-timepoint maternal blood pressure trajectories during pregnancy and low birth weight: a longitudinal study based on NHANES 2005-2006.

Background: Dynamic changes in maternal blood pressure influence neonatal birth weight however, studies investigating the association between blood pressure trajectories during pregnancy and low birth weight (LBW) remain limited. This study aims to identify maternal blood pressure trajectories based on three time points using group-based trajectory modeling (GBTM) and explore their association with LBW.

Methods: This study was based on the NHANES 2005-2006 database and included 330 pregnant women meeting the eligibility criteria (41 cases in the LBW group and 289 in the control group).

Prognostic analysis of lymph node resection and liver resection for T1b and T2 gallbladder cancer: a multi-center retrospective study.

Background: Survival benefit of extended cholecystectomy including lymph node resection (LNR) and liver resection (LR) is still debating.

Methods: Patients pathologically diagnosed with T1b and T2 stage GBC in 6 medical centers from 2012 to 2022 were included and retrospectively analyzed. Clinical variables, including patient characteristics, overall survival (OS), disease-free survival (DFS), surgical approaches, and adjuvant treatments were collected.

Urine Metabolomics Reveals the Intervention Effects and Mechanism of Shenhua Tablets in IgA Nephropathy.

Shenhua tablets (SHT), a traditional Chinese medicine (TCM), have shown significant clinical efficacy in treating IgA nephropathy (IgAN), but the underlying mechanisms are not fully understood. This study aims to elucidate the renoprotective effects of SHT on IgAN and explore the potential mechanisms of its action using metabolomics approaches. The renoprotective effects of SHT on IgAN were evaluated in a Thy-1 antibody-induced IgAN rat model.

Efficient generation of multi-order Raman radiation in aqueous solutions derived from -CH and -NH vibrations via cascaded four-wave mixing and Stokes processes.

Multiple coherent radiations are achieved in a water-3-aminopropanol (3AP) mixed solution through cascaded four-wave mixing (C-FWM) and cascaded Stokes (C-Stokes) processes, both driven by stimulated Raman scattering (SRS) in this work. The O-H vibration peak from water is replaced by the emergence of the -NH symmetric stretching Raman peaks from 3AP, with intensity approaching that of the -CH symmetric stretching peak. The dual-wavelength SRS signals for the -NH and -CH stretching vibrations have a relatively small frequency interval of about 400 cm (16 nm).

Rapid Characterization of the Constituents in Shenhua Tablets by UHPLC-Q-Orbitrap-LTQ-MS.

Shenhua Tablet (SHT), a Chinese herbal medicine comprising seven crude drugs, is utilized in the treatment of immunoglobulin A nephropathy (IgAN). However, due to its complex composition, the chemical constituents of SHT in vitro are still incompletely known, which has restricted the comprehensive development and utilization of SHT in clinical practice. In the present study based on ultra-high performance liquid chromatography-quadrupole-orbitrap-linear ion trap mass spectrometry (UHPLC-Q-Orbitrap-LTQ-MS) in data dependent acquisition mode, combining the accurate mass and structural information, the profiling and characterization of chemical constituents in SHT were carried out.

Multifunctional GAN-based optimization for X-ray tomography under different conditions.

Based on the generative adversarial network (GAN), we present a multifunctional X-ray tomographic protocol for artifact correction, noise suppression, and super-resolution of reconstruction. The protocol mainly consists of a data preprocessing module and multifunctional GAN-based loss function simultaneously dealing with ring artifacts and super-resolution. The experimental protocol removes ring artifacts and improves the contrast-to-noise ratio (CNR) and spatial resolution (SR) of reconstructed images successfully, which shows the capability to adaptively rectify ring artifacts with varying intensities and types while achieving super-resolution.

Antagonistic Effect of Nitrate Conversion on Photocatalytic Reduction of Aqueous Pertechnetate and Perrhenate.

Sustainable photocatalysis can effectively reduce the radioactive TcO to less soluble TcO·HO(s), but the reduction efficiency is highly susceptible to coexisting nitrate (NO). Here, we quantitatively investigate photocatalytic remediation conditions for Tc-contaminated water stimulated by the analogue perrhenate (ReO) in the presence of NO, and we elucidate the influence mechanism of NO by in situ characterizations. The interfering NO can compete with Re(VII) for the carbonyl radical (·CO) produced by formic acid (HCOOH) oxidation to generate nitrogen-containing products such as NH, NO, and NO, resulting in the decrease in the Re(VII) reduction ratio.

Effect of Constant Cyclic Stress Coupling on the Fatigue Behavior of 304LN Stainless Steel.

The stress state of the primary circuit main pipeline is very complex mixed constant stress and periodic cyclic stress during the operation of nuclear power plants, which often affects the failure behavior of the stainless steel (SS) pipe. The fatigue behavior of 304LN SS under mixed constant stress and cyclic stress was investigated, and it was found that the coupling effect of constant stress and cyclic stress has a significant collaborative acceleration on the fatigue behavior. The research results showed that the cracks in the 304LN SS did not propagate even after 78 days under both constant load conditions of 5 KN and 7.

Prospective, non-blinded, randomized controlled trial on early administration of pulmonary surfactant guided by lung ultrasound scores in very preterm infants: study protocol.

Background: Bedside lung ultrasonography has been widely used in neonatal intensive care units (NICUs). Lung ultrasound scores (LUS) may predict the need for pulmonary surfactant (PS) application. PS replacement therapy is the key intervention for managing moderate to severe neonatal respiratory distress syndrome (NRDS), with early PS administration playing a positive role in improving patient outcomes.

Photocatalytic Reduction of Perrhenate and Pertechnetate in a Strongly Acidic Aqueous Solution.

Pertechnetate (TcO), a physiologically toxic radioactive anion, is of great concern due to its high mobility in environmental contamination remediation. Although the soluble oxyanion can be photoreduced to sparingly soluble TcO·HO, its effective removal from a strongly acidic aqueous solution remains a challenge. Here, we found that low-crystalline nitrogen-doped titanium oxide (N-TiO, 0.

Selective SERS Detection of TATB Explosives Based on Hydroxy-Terminal Nanodiamond-Multilayer Graphene Substrate.

Selective surface-enhanced Raman scattering (SERS) detection of target explosives with good reproducibility is very important for monitoring soldiers' health and ecological environment. Here, the specific charge transfer pathway was constructed between a stable nanodiamond-multilayer graphene (MGD) film substrate and the target explosives. Two-step wet chemical oxidation methods of HO (30%) and HNO (65%) solutions were used to regulate the terminal structure of MGD films.

Targeting PNPO to suppress tumor growth via inhibiting autophagic flux and to reverse paclitaxel resistance in ovarian cancer.

Our previous study showed that pyridoxine 5'-phosphate oxidase (PNPO) is a tissue biomarker of ovarian cancer (OC) and has a prognostic implication but detailed mechanisms remain unclear. The current study focused on PNPO-regulated lysosome/autophagy-mediated cellular processes and the potential role of PNPO in chemoresistance. We found that PNPO was overexpressed in OC cells and was a prognostic factor in OC patients.

Celastrol ameliorates lupus by promoting apoptosis of autoimmune T cells and preventing autoimmune response in MRL/lpr mice.

Objective: Celastrol is a bioactive constituent extracted from (thunder god vine). It has been demonstrated to have a therapeutic effect on experimental disease models for chronic inflammatory and immune disorders. In the present study, we investigated whether and how celastrol exerts a regulatory effect on the autoimmune response in MRL/lpr mice.

Prediction Model for Therapeutic Responses in Ovarian Cancer Patients using Paclitaxel-resistant Immune-related lncRNAs.

Background: Ovarian cancer (OC) is the deadliest malignant tumor in women with a poor prognosis due to drug resistance and lack of prediction tools for therapeutic responses to anti- cancer drugs.

Objective: The objective of this study was to launch a prediction model for therapeutic responses in OC patients.

Methods: The RNA-seq technique was used to identify differentially expressed paclitaxel (PTX)- resistant lncRNAs (DE-lncRNAs).

Insulin-like growth factor 2 mRNA-binding protein 2 is a therapeutic target in ovarian cancer.

Ovarian cancer (OC) is a fatal gynecologic disease. The most common treatment for OC patients is surgery combined with chemotherapy but most patients at advanced stages eventually develop relapse due to chemoresistance. This study examined the role and function of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) in OC.

Electrochemical oxidation of tetrahydrofurfuryl acohol on boron-doped diamond anode: Influence of current density and electrolyte solution.

Tetrahydrofurfuryl alcohol (THFA), a widely applied raw materials, intermediate and solvent in the fields of agricultural, industry (especially in nuclear industry), is a potentially hazardous and non-biodegradable pollutant in wastewater. In this study, the electrochemical degradation pathways of THFA by a boron-doped diamond (BDD) anode with different current density (j = 20, 40 and 60 mA cm) and electrolyte solution (KNO, KCl and KSO) was carefully investigated. The results exhibit that high chemical oxygen demand (COD) removal and mineralization rates were achieved by rapid non-selective oxidation in electrolyte solutions mediated by hydroxyl radicals (∙OH) and active chlorine (sulfate) under constant current electrolysis.

Cyclin dependent kinase 14 as a paclitaxel-resistant marker regulated by the TGF-β signaling pathway in human ovarian cancer.

Cyclin dependent kinase 14 (CDK14) plays a central role in the control of cell proliferation and cell cycle progression. However, the specific function and regulatory mechanism of CDK14 on paclitaxel (PTX) resistance in ovarian cancer (OC) remain unclear. The present study demonstrated that CDK14 was overexpressed in OC tissues and cells at mRNA and protein levels detected by qRT-PCR, Western blot, and immunohistochemistry.

RBM15‑mediating MDR1 mRNA mA methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer.

Ovarian cancer (OC) lacks effective biomarkers for diagnosis at an early stage and often develops chemoresistance after the initial treatment at an advanced stage. RNA‑binding motif protein 15 (RBM15) is an RNA m6A methylation mediator that serves an oncogenic role in some cancers. However, the function and molecular mechanisms of RBM15 in ovarian tumorigenesis and chemoresistance remain to be elucidated.

Second-trimester miscarriage caused by recurrent Klebsiella pneumoniae infection: a case report.

Background: Klebsiella pneumoniae (K. pneumoniae) can cause hospital- and community-acquired pneumonia, and urinary tract, wound, and blood infections. As there are few reports on K.

Fast and Deep Diagnosis Using Blood-Based ATR-FTIR Spectroscopy for Digestive Tract Cancers.

Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) of liquid biofluids enables the probing of biomolecular markers for disease diagnosis, characterized as a time and cost-effective approach. It remains poorly understood for fast and deep diagnosis of digestive tract cancers (DTC) to detect abundant changes and select specific markers in a broad spectrum of molecular species. Here, we present a diagnostic protocol of DTC in which the in-situ blood-based ATR-FTIR spectroscopic data mining pathway was designed for the identification of DTC triages in 252 blood serum samples, divided into the following groups: liver cancer (LC), gastric cancer (GC), colorectal cancer (CC), and their different three stages respectively.

miRNA-141-5p Affects the Levels of Neutrophil Elastase in Preeclampsia by Regulating MAPK1.

Objective: The objective of this study was to investigate the expression levels of microRNA-141-5p(miRNA-141-5p), MAPK1 and neutrophil elastase in patients with and without preeclampsia (PE), and the relationship between miRNA-141-5p and MAPK1 with respect to the secretion of elastase by neutrophils in patients with PE.

Methods: Thirty patients with PE and 30 healthy pregnant (HP) women were recruited from The Second Hospital of Shanxi Medical University, Taiyuan, China, between February 2017 and July 2018. Neutrophils were isolated from 8 mL peripheral blood samples and cultured.

The miR-33a-5p/CROT axis mediates ovarian cancer cell behaviors and chemoresistance the regulation of the TGF-β signal pathway.

Due to the lack of symptoms and detection biomarkers at the early stage, most patients with ovarian cancer (OC) are diagnosed at an advanced stage and often face chemoresistance and relapse. Hence, defining detection biomarkers and mechanisms of chemoresistance is imperative. A previous report of a cDNA microarray analysis shows a potential association of carnitine O-octanoyltransferase (CROT) with taxane resistance but the biological function of CROT in OC remains unknown.

Micrometer-Resolution X-ray Imaging Enabled by a Flexible Perovskite Screen.

Spatial resolution improvement has been keenly sought recently in the perovskite-based scintillation community. Here, micrometer resolution (∼2.0 μm) was achieved by using an X-ray imaging screen of self-assembled perovskite nanosheets.