Rigid cationic ligands enable high-efficiency NIR-II photoluminescence in copper(i) iodide hybrid semiconductors.

Near-infrared (NIR) luminescent materials are pivotal for advanced optoelectronic and biomedical applications, yet attaining efficient emission in the NIR-II region (950-1400 nm) remains challenging. Here, we introduce a ligand cationization strategy for designing copper(i) iodide-organic hybrid materials that emit in the NIR-II region (920-1120 nm) with PLQYs up to 8.58%.

Optical rotation and cell control based on the LP21 mode and a tapered microcavity optical waveguide.

This paper innovatively proposes a single-fiber optical tweezers probe based on a tapered microcavity optical waveguide. This design leverages the dual characteristics of the fiber LP21 mode to achieve dual-mode, high-precision rotational manipulation of cells: on one hand, by precisely controlling the fiber twist angle, the LP21 mode spot can be rotated regularly, driving cells trapped by the optical tweezers on the outer wall of the tapered microtube to undergo controlled "orbital rotation" along the tube wall in the y-z plane; on the other hand, by adjusting the fiber stretching degree to modulate the LP21 mode spot energy distribution, the multi-physical fields (including optical, flow fields, etc.) at the microtube port are altered, inducing an optically induced vortex to drive cells at the port to perform controlled "spin rotation" in the x-y plane.

The relationship between disease activity and quality of life in rheumatoid arthritis patients: a network analysis.

Background: The relationship between disease activity and quality of life (QoL) in rheumatoid arthritis (RA) patients was explored using network analysis. The focus of network analysis has recently shifted from studying individual groups to comparing the network structures of different subgroups. RA patients with depressive symptoms generally have lower QoL scores, so we compared the QoL networks of RA patients with and without depressive symptoms to test for differences.

A Comprehensive Analysis and Forecast of Rabies Epidemic and Elimination Challenges - China, 2005-2023.

Introduction: The 2030 global target for eliminating dog-mediated human rabies, jointly proposed by the World Health Organization (WHO) and other international organizations, presents significant challenges for China. This study analyzes epidemiological trends (2005-2023), forecasts future case numbers, and compares China's progress with elimination strategies from the United States, Japan, and Brazil to optimize national rabies prevention and control approaches.

Methods: Descriptive statistics were used to analyze the spatiotemporal distribution of human rabies cases across China.

High-entropy Prussian blue analogues-mediated flexible field-effect transistor for wearable sweat dopamine monitoring.

Wearable sensor offers a non-invasive platform for continuous monitoring of biomarkers, but their application remains challenging due to low target level and stability issue in sweat. Here, we proposed a wearable sensing system comprising a flexible field-effect transistor (FET) integrated with a microfluidic sweat collection channel for real-time monitoring of dopamine in sweat. By functionalizing the recognition layer of FET using high-entropy Prussian blue analogues (HEPBAs), the sensor not only enables direct and selective catalysis of dopamine but also amplifies the response signal for trace dopamine determination.

Association of microtubule-based processes gene expression with immune microenvironment and its predictive value for drug response in oestrogen receptor-positive breast cancer.

Objective: The development of acquired endocrine resistance and reduced chemosensitivity in oestrogen receptor-positive (ER+) breast cancer presents significant challenges. Microtubule-based process-related genes (MBPRGs) play essential biological roles in the cell cycle and the development of migration. This study aimed to establish a novel prognostic signature based on MBPRGs to improve patient outcomes and offer additional treatment options for those with ER+ breast cancer.

Non-axial optical design of a multi-pass spectral absorption cell: algorithms.

A 3×3 matrix-based algorithm is, to our knowledge, first proposed for designing a multi-pass optical absorption cell with higher precision. Compared to previous publications based on the traditional 2×2 matrix, the proposed algorithm can effectively avoid paraxial approximation and directional astigmatism simultaneously by defining matrix elements with five key parameters. To demonstrate its applicability, various numerical simulations were investigated theoretically and verified with experimental results; a good agreement was also obtained by comparing with commercial TracePro software.

Model for Predicting Central Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Study Based on Ultrasound Viscosity Imaging.

Objective: To investigate the association between ultrasound (US) viscosity imaging and central lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC) and to develop a new model for predicting CLNM based on patient clinical data, grey-scale US characteristics and US viscosity imaging parameters.

Materials And Methods: This prospective study enrolled patients with PTC who underwent preoperative US viscosity from June 2024 to September 2024. Using histological results as the reference standard, optimal cutoff values for the viscosity parameter were established to predict central lymph node metastasis (CLNM).

Rapid removal of small particle-sized microplastics utilizing superhydrophobic wood membranes.

Microplastic pollution poses a significant threat to both ecosystems and human health, making the development of efficient and environmentally friendly removal methods critically important. Filtration has emerged as a primary technique for microplastic removal due to its operational convenience and high efficiency. However, most existing filter materials still do not meet industrial demands, particularly regarding their effectiveness in eliminating small particle-sized microplastics.

Redox mechanism of glycerophospholipids and relevant targeted therapy in ferroptosis.

Ferroptosis, an iron-dependent form of regulated cell death driven by redox dysregulation, is defined by iron overload, reactive oxygen species overproduction, and subsequent peroxidation of polyunsaturated fatty acid-containing phospholipids, notably glycerophospholipids. This review comprehensively delineates the enzymatic such as lipoxygenases and non-enzymatic including Fenton reaction pathways governing glycerophospholipid peroxidation. Furthermore, we systematically dissect fine regulation of iron ions, including absorption, transport, and redox state transition.

An attractive vaccine candidate based on AP205 VLPs fusing with a receptor-binding domain of a newly emerged porcine deltacoronavirus strain in China.

Emerging swine enteric coronaviruses (SeCoV) pose significant threats to global pork security, with zoonotic porcine deltacoronavirus (PDCoV) demonstrating cross-species transmission potential. Here, we identified a new PDCoV strain, CHN/GD/2023, which was isolated from porcine intestinal epithelium, showing phylogenetic clustering with China-endemic variants through viral spike (S) protein evolutionary tracing. A vaccine candidate for PDCoV was produced by genetically fusing the receptor-binding domain (RBD) of CHN/GD/2023 to the C-terminus of the AP205 gene.

Spatial transcriptomics reveals macrophage domestication by epithelial cells promotes immunotherapy resistance in small cell lung cancer.

Small cell lung cancer (SCLC) remains a lethal malignancy. Although immunochemotherapy regimens have improved patient survival rates, drug resistance still occurs in a significant subset of patients, highlighting the importance of elucidating the mechanisms within the tumor microenvironment. Here, we applied spatial single-cell transcriptomics to investigate the spatial characteristics of SCLC and their associations with immunochemotherapy resistance.

Nutritional management adherence via an ePRO platform in patients with cancer: a machine learning model study.

Background: Electronic patient-reported outcome (ePRO) systems have significant potential for providing individualized and continuous nutritional management for patients with cancer. However, adherence to ePRO-guided nutritional interventions varies significantly, and the key factors associated with adherence remain poorly understood. This study aimed to assess adherence to nutritional targets via ePRO platforms and identify predictors influencing adherence to optimize management strategies.

Stereotactic body radiation therapy plus adoptive vNKT cell therapy for pancreatic cancer: protocol of a phase II trial.

Aims: Novel and multimodal immunotherapy approaches are required for pancreatic cancer. A novel subset of NKT cells, called CD8+ NKT-like cells or variant NKT (vNKT) cells, which are CD8 CD56, CD1d-independent with variant TCR, have been reported to provide potent anti-tumor immunity. With positive immune regulations of stereotactic body radiation therapy (SBRT) reported in previous studies, we hypothesize that there might be a synergy of SBRT with immunotherapy.

Prediction of contralateral central lymph node metastasis in unilateral papillary thyroid carcinoma based on radiomics.

This study aims to examine the determinants of contralateral central lymph node metastasis in cases of unilateral papillary thyroid carcinoma, utilizing clinical pathological parameters and ultrasound radiomics. The goal is to develop an optimal predictive model that can inform clinical decisions regarding contralateral central lymph node dissection in patients with unilateral papillary thyroid cancer. A cohort of 329 patients diagnosed with unilateral papillary thyroid carcinoma, all of whom underwent bilateral thyroidectomy and bilateral central lymph node resection, were analyzed.

Intra-Arterial Thrombolysis Following Endovascular Recanalization for Large Vessel Occlusion Stroke: A Systematic Review and Meta-Analysis.

Background And Objectives: This systematic review and meta-analysis aims to evaluate the treatment effects of intra-arterial thrombolysis (IAT) after endovascular recanalization in patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO). Endovascular recanalization is the standard treatment for large vessel occlusion (LVO) stroke. Despite successful reperfusion after thrombectomy, fewer than half of the patients regain functional independence at 90 days, highlighting the potential role of impaired microcirculation in poor neurologic outcomes.

Smart functional binders empowering lithium-sulfur cathodes with enhanced atmospheric stability and catalytic kinetics.

Although lithium-sulfur (Li-S) batteries have attracted considerable research attention, several critical barriers must be overcome to bridge the gap between laboratory-scale achievements and practical commercial applications. For example, the notorious polysulfide shuttle effect, severe electrode volume changes, and challenging solid-liquid-solid conversion reactions. In this study, we have developed a multifunctional binder by incorporating cobalt(II) phthalocyanine (CoPc) into conventional poly(vinylidene fluoride) (PVDF) at a relatively lower processing temperature, which induces the phase transformation of α-PVDF to β-PVDF, thereby constructing an enhanced localized electric field with three advantages: (1) superior adsorption capabilities and catalytic activity, (2) robust mechanical properties that accommodate substantial volume fluctuations during cycling, and (3) excellent hydrophobic properties allowing for long-term storage in air.

Security analysis of simultaneous classical communication and CVQKD with a local local oscillator under the phase reference pulse intensity attack.

The simultaneous classical and continuous variable quantum communication can allow classical communication and continuous variable quantum key distribution with a local local oscillator (LLO CVQKD) to be implemented simultaneously using the same communication architecture. Such scheme enables LLO CVQKD to be integrated with classical communication at the minimum cost, but the existence of reference pulses will bring security loopholes to the simultaneous communication system, allowing eavesdroppers to launch attacks. In this paper, we analyze and simulate the performance of the system by introducing the trusted noise model under the phase reference pulse intensity attack, where Eve can hide her attack by manipulating the intensity of the reference pulse using a phase insensitive amplifier.

Effect of different levels of Scutellaria baicalensis straw on slaughter performance and rumen microorganisms of rams.

The shortage of forage supply has become an issue for the development of high-quality animal husbandry. Utilizing functional diets can mitigate forage shortages while enhancing animal performance and product quality. This study aimed to investigate the effects of different levels of Scutellaria baicalensis straw (SBS) on the slaughter performance, rumen fermentation, and microbial diversity of rams.

RD21 enhances resistance to the strawberry vein banding virus by promoting autophagy-mediated degradation of the viral silencing suppressor P6 protein.

Responsive to desiccation 21 (RD21) is a papain-like cysteine protease (PLCP). PLCPs are involved in plant growth and development, as well as stress and plant immune responses. Currently, few studies have reported on the involvement of PLCPs in defence against viral infections.

Huangqi fuling decoction inhibits the invasion and metastasis of gastric cancer via the TNF signaling pathway.

Gastric cancer (GC) is a prevalent digestive tract malignancy, and Huangqi Fuling decoction (HF) has shown potential in enhancing immune function and exhibiting anti-GC activity. However, its mechanisms remain unclear. This study utilized network pharmacology, molecular docking, and in vitro experiments to preliminarily explore the mechanisms by which HF inhibits gastric cancer invasion and metastasis while promoting apoptosis.

High plant diversity alleviates the negative effects of nitrogen deposition on soil nitrogen cycling multifunctionality.

Introduction: Changes in plant diversity and increased atmospheric nitrogen deposition independently influence soil nitrogen cycling in terrestrial ecosystems. However, the interactive effects of plant diversity and nitrogen deposition on soil nitrogen cycling multifunctionality (NCMF) in grassland ecosystems remain poorly understood.

Methods: We conducted a fully factorial microcosm experiment to quantify the responses and underlying mechanism of soil NCMF to nitrogen addition (0, 5, and 10 g N m yr.

Glass scintillator: A window to future high-energy radiation detection.

With the significant progress of high-energy physics, nuclear science, and technology, the demand for high-performance scintillators is growing rapidly. Among solid-state scintillators, glass scintillators would play a vital role in the field of high-energy radiation detections because of their merits including low cost, batch production, and arbitrariness in shape. In this review article, the research and development of glass scintillators is introduced with respect to the following key parameters including: density, light yield, scintillation decay time, and radiation hardness.

SLoRD: Structural Low-Rank Descriptors for Shape Consistency in Vertebrae Segmentation.

Automatic and precise multi-class vertebrae segmentation from CT images is crucial for various clinical applications. However, due to similar appearances between adjacent vertebrae and the existence of various pathologies, existing single-stage and multi-stage methods suffer from imprecise vertebrae segmentation. Essentially, these methods fail to explicitly impose both contour precision and intra-vertebrae voxel consistency constraints synchronously, resulting in the intra-vertebrae segmentation inconsistency, which refers to multiple label predictions inside a singular vertebra.