CD8 T Cell-Associated Gene Signature Correlates With Prognosis Risk and Immunotherapy Response in Patients With Lung Adenocarcinoma.

The presence of infiltrating CD8 T lymphocytes in the tumor microenvironment of lung adenocarcinoma (LUAD) is correlated with improved patient prognosis, but underlying regulatory mechanisms remain unknown. To identify biomarkers to improve early diagnosis and treatment of LUAD, we downloaded 13 immune cell line-associated datasets from the GEO database. We identified CD8 T cell-associated genes weighted correlation network analysis.

Optimal Value for Serum Anti-PLA2R Antibody in Primary Membranous Nephropathy: A Multicenter Observational Study.

Introduction: Anti-phospholipase A2 receptor antibody (PLA2R-Ab) is highly specific for primary membranous nephropathy (PMN). Here, we compare the diagnostic value of different circulating PLA2R-Ab cutoff titers in multicenter cohorts, with particular focus on determining the optimal cutoff value for Chinese patients.

Methods: In total, 288 patients with PMN and 301 with other nephropathies were recruited retrospectively from five hospitals in China between September 2011 and October 2018.

Prognostic Value of Global Longitudinal Strain in Asymptomatic Aortic Stenosis: A Systematic Review and Meta-Analysis.

Backgrounds: The presence of impaired global longitudinal strain (GLS) may be a valuable bio-marker in the early diagnosis for left ventricle (LV) impairment, which would help scrutinize asymptomatic aortic stenosis (AS) patients with high risk of adverse outcomes, such as major adverse cardiovascular events (MACE).

Methods: The study was prospectively registered in PROPSERO (CRD 42021223472). Databases, such as Pubmed, Embase, Cochrane Library, Web of science, and Scopus were searched for studies evaluating the impact of impaired GLS on MACE, all-cause mortality, and aortic valve replacement (AVR) in asymptomatic AS.

Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB.

Serine beta-lactamase-like protein (LACTB) is a mammalian mitochondrial serine protease that can specifically hydrolyze peptide bonds adjacent to aspartic acid residues and is structurally related to prokaryotic penicillin-binding proteins. Here, we determined the cryoelectron microscopy structures of human LACTB (hLACTB) filaments from wild-type protein, a middle region deletion mutant, and in complex with the inhibitor Z-AAD-CMK at 3.0-, 3.

Elevated expression of the rhythm gene NFIL3 promotes the progression of TNBC by activating NF-κB signaling through suppression of NFKBIA transcription.

Background: Epidemiological studies have confirmed that abnormal circadian rhythms are associated with tumorigenesis in breast cancer. However, few studies have investigated the pathological roles of rhythm genes in breast cancer progression. In this study, we aimed to evaluate the aberrant expression of 32 rhythm genes in breast cancer and detect the pathological roles and molecular mechanisms of the altered rhythm gene in regulating the progression of triple negative breast cancer (TNBC).

Water quality change and pollution source accounting of Licun River under long-term governance.

Urbanization and human activities have exerted a tremendous adverse influence on the water quality of the Licun River, Qingdao, China. In order to restore the water quality, a succession of measures have been carried out since 1996, mainly encompassing flood controlling, sewage intercepting and watercourse greening (before 2007), watercourse and point source control based on administrative region (2008-2017), as well as the comprehensive governance based on river basin (after 2018). In 2019, the amount of discharged industrial wastewater, chemical oxygen demand, and ammonia nitrogen decreased by 53.

Treated activated carbon as a metal-free catalyst for effectively catalytic reduction of toxic hexavalent chromium.

In this work, activated carbon treated in N atmosphere, as a non-metallic catalyst, exhibits excellent catalytic performance in reduction of Cr (VI) to Cr (III) using HCOOH as the reducing agent at room temperature. A series of characterizations and control experiments were carried out to deduce the possible reaction mechanism. The results showed that the improved catalytic performance can be attributed to the enhanced graphitization degree and basic sites such as pyrone-like, which favor electron transferring and activation of reactant.

The global landscape of neoadjuvant and adjuvant anti-PD-1/PD-L1 clinical trials.

The neoadjuvant and adjuvant anti-PD-1/PD-L1 treatment has been increasingly noticed. To summarize the global landscape of these clinical trials will provide essential data for all the stakeholders of drug development. Based on the Trialtrove database, a total of 668 clinical trials initiated by the end of 2020 were retrospectively analyzed.

Highly undersampling dynamic cardiac MRI based on low-rank tensor coding.

Dynamic cardiac magnetic resonance imaging (CMRI) is an important tool for the non-invasive assessment of cardiovascular disease. However, dynamic CMRI suffers from long acquisition times due to the need of obtaining images with high temporal and spatial resolution, whole-heart coverage. Conventionally, a multidimensional dataset in dynamic CMRI is treated as a series of two-dimensional matrices, and then various matrix/vector transforms are used to explore the sparsity of MR images.

Dendrobium nobile Lindl. Alkaloids Ameliorate Aβ25-35-Induced Synaptic Deficits by Targeting Wnt/β-Catenin Pathway in Alzheimer's Disease Models.

Background: Dendrobium nobile Lindl. alkaloids (DNLA) are effective in ameliorating cognitive deficit in SAMP8, AβPP/PS1, and LPS-induced AD animal models, and prevented Aβ-induced synaptic degeneration in cultured hippocampal neurons. However, the underlying mechanisms remain unexplored.

HfAlO/AlO Bilayer Dielectrics for a Field Effect Transistor on a Hydrogen-Terminated Diamond.

In this work, a hydrogen-terminated (H-terminated) diamond field effect transistor (FET) with HfAlO/AlO bilayer dielectrics is fabricated and characterized. The HfAlO/AlO bilayer dielectrics are deposited by the atomic layer deposition (ALD) technique, which can protect the H-terminated diamond two-dimensional hole gas (2DHG) channel. The device demonstrates normally-on characteristics, whose threshold voltage (V) is 8.

Integrated Metabolomic and Transcriptomic Analysis Reveals Differential Mechanism of Flavonoid Biosynthesis in Two Cultivars of .

is a traditional Chinese medicinal plant that has been primarily used as a blood tonic. It largely relies on its bioactive metabolites, which include ferulic acid, volatile oils, polysaccharides and flavonoids. In order to improve the yield and quality of , the two cultivars Mingui 1 (M1), with a purple stem, and Mingui 2 (M2), with a green stem, have been selected in the field.

Detecting pore size distribution of activated carbon by low-field nuclear magnetic resonance.

In this study, the transverse relaxation time (T ) of activated carbon (AC) in different relative environment humidity was detected firstly by low-field nuclear magnetic resonance (LFNMR). The pore size (diameter) of AC distributions was calculated by the relationship between T and surface relaxation rate (ρ), where ρ was obtained by the detection of nine porous materials with known pore size. The results showed that the pore size distributions of AC calculated by ρ < 0.

Effect of Process Parameters on the Microstructure and Performance of TiO-Loaded Activated Carbon.

In this study, the visible-light-driven photocatalytic regeneration performance of TiO-loaded activated carbon (TiO/AC) was effectively improved. By carefully controlling the activation condition at 700 °C for 2 h with a 60% HPO concentration and 3:1 TBT (tetrabutyl titanate) impregnation ratio, 90.5% of methylene blue (50 mg/L) was removed within 2 h by a low-dose TiO/AC (0.

Current Progress and Future Perspectives of Immune Checkpoint in Cancer and Infectious Diseases.

The inhibitory regulators, known as immune checkpoints, prevent overreaction of the immune system, avoid normal tissue damage, and maintain immune homeostasis during the antimicrobial or antiviral immune response. Unfortunately, cancer cells can mimic the ligands of immune checkpoints to evade immune surveillance. Application of immune checkpoint blockade can help dampen the ligands expressed on cancer cells, reverse the exhaustion status of effector T cells, and reinvigorate the antitumor function.

Comprehensive Analysis of Subtype-Specific Molecular Characteristics of Colon Cancer: Specific Genes, Driver Genes, Signaling Pathways, and Immunotherapy Responses.

Colon cancer is a complex, heterogeneous disease. The Colorectal Cancer Subtyping Consortium reported a novel classification system for colon cancer in 2015 to better understand its heterogeneity. This molecular classification system divided colon cancer into four distinct consensus molecular subtypes (CMS 1, 2, 3, and 4).

Taurine stimulates protein synthesis and proliferation of C2C12 myoblast cells through the PI3K-ARID4B-mTOR pathway.

Taurine (Tau) has many profound physiological functions, but its role and molecular mechanism in muscle cells are still not fully understood. In this study, we investigated the role and underlying molecular mechanism of Tau on protein synthesis and proliferation of C2C12 myoblast cells. Cells were treated with Tau (0, 60, 120, 180 and 240 μM) for 24 h.

Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.

Amino acids can activate mTOR to promote milk synthesis in mammary epithelial cells (MECs), but the underlying molecular mechanism is still largely unknown. The objective is to investigate the regulatory mechanism of amino acids (Met and Leu) in stimulating mRNA expression of mTOR in MECs. We found that the protein abundance of AT-rich interaction domain 1A (ARID1A) was poorly expressed in mouse mammary gland tissues of lactating period.

Progressive attention module for segmentation of volumetric medical images.

Purpose: Medical image segmentation is critical for many medical image analysis applications. 3D convolutional neural networks (CNNs) have been widely adopted in the segmentation of volumetric medical images. The recent development of channelwise and spatialwise attentions achieves the state-of-the-art feature representation performance.

CLEC12B suppresses lung cancer progression by inducing SHP-1 expression and inactivating the PI3K/AKT signaling pathway.

Lung cancer is the leading cause of cancer mortality worldwide. CLEC12B, a C-type lectin-like receptor, is low-expressed in lung cancer tissues. However, the function of CLEC12B in lung cancer and its underlying mechanism remain unclear.

Tranexamic Acid versus Epsilon-Aminocaproic Acid in Total Knee Arthroplasty: A Meta-Analysis.

Objective: At present, the effect of tranexamic acid (TXA) and epsilon-aminocaproic acid (EACA) on total knee arthroplasty (TKA) remains controversial. Therefore, the aim of this meta-analysis is to compare the differences between the effects of TXA and EACA in TKA.

Methods: We used electronic databases, including PubMed, Embase, MEDLINE, Ovid, ScienceDirect, Cochran Library, Google Scholar, clinical trial, and Chinese related databases, for literature search to find any effect of TXA and EACA in TKA.

Polyphenylene Sulfide-Based Solid-State Separator for Limited Li Metal Battery.

The urgent need for high energy batteries is pushing the battery studies toward the Li metal and solid-state direction, and the most central question is finding proper solid-state electrolyte (SSE). So far, the recently studied electrolytes have obvious advantages and fatal weaknesses, resulting in indecisive plans for industrial production. In this work, a thin and dense lithiated polyphenylene sulfide-based solid state separator (PPS-SSS) prepared by a solvent-free process in pilot stage is proposed.

The construction of an artificial light-harvesting system with two-step sequential energy transfer based on supramolecular polymers.

An artificial light-harvesting system with two-step sequential energy transfer was constructed in aqueous media based on cyano-substituted -phenylenevinylene derivative (PPTA) and bis-(-sulfonatocalix[4]arenes) (BSC4) supramolecular polymers formed through host-guest interactions, in which two different fluorescent dyes, eosin Y (EY) and sulforhodamine (SR101), were employed as energy acceptors. The obtained artificial light-harvesting system can achieve an efficient two-step energy transfer process from PPTA-BSC4 to EY and then to SR101 with high energy-transfer efficiencies of up to 36.6% and 40.

High-Resolution Fluorescence Spectra of Airborne Biogenic Secondary Organic Aerosols: Comparisons to Primary Biological Aerosol Particles and Implications for Single-Particle Measurements.

Aqueous extracts of biogenic secondary organic aerosols (BSOAs) have been found to exhibit fluorescence that may interfere with the laser/light-induced fluorescence (LIF) detection of primary biological aerosol particles (PBAPs). In this study, we quantified the interference of BSOAs to PBAPs by directly measuring airborne BSOA particles, rather than aqueous extracts. BSOAs were generated by the reaction of -limonene (LIM) or α-pinene (PIN) and ozone (O) with or without ammonia in a chamber under controlled conditions.