Conceptual Framework of Health-Literate Nursing System: A Proceduralized Grounded Theory Approach.

To develop and define a conceptual framework for a system-level nursing approach that addresses patients' health literacy needs. Health literacy has evolved beyond individual-level concerns to system-level responsibilities. While several frameworks, such as the Health Literate Healthcare Organization and Organizational Health Literacy, have guided institutional reforms, they often neglect the unique functions and contributions of the nursing system.

Branched-chain amino acids and risk of major depressive disorder: a Mendelian randomization and colocalization study.

Aims: Depression is associated with numerous metabolic pathway abnormalities, and several studies have suggested a link between depression and branched chain amino acids (BCAAs) metabolic disorders. However, the precise causality and direction remain inconclusive. Consequently, this study aims to ascertain the relationship between the risk of depression and BCAAs levels using two-sample Mendelian randomization (MR) analysis.

Wenshen Zhuanggu formula inhibits tumor-exosomes induced bone pre-metastasis niche formation in primary breast cancer mice.

Background: The therapy for breast cancer bone metastasis (BCBM) still needs profound investigation. Focusing on the formation of bone pre-metastasis niche (BPMN) is a crucial tache for BCBM treatment. Wenshen Zhuanggu Formula (WSZG) is a typical traditional Chinese medicine (TCM) prescription with ability of clinically palliating bone pain and ameliorating the quality of life of BCBM patients.

To reveal the key mechanism of Citri Reticulatae Pericarpium-Reynoutria japonica Houtt in the treatment of liver cancer and its correlation with lipid metabolism: synergetic effect with network pharmacology, molecular docking and bioinformatics.

Background: Liver cancer (LC) is a prevalent malignancy characterized by insidious onset, high recurrence rates, and significant mortality. The herbal combination "Citri Reticulatae Pericarpium-Reynoutria japonica" (CR) has traditionally been used for managing LC and related disorders, demonstrating notable therapeutic efficacy. This study aims to identify the molecular targets of CR in LC and assess its pharmacological properties and potential toxicity.

Laparoscopic Anatomical Liver Segment VII Resection with Liver Parenchymal Transection Following a Priority Approach.

Laparoscopic liver resection procedures have rapidly developed, including surgical techniques ranging from early local resection of the liver margin and superficial lesions to semi-hepatectomy and even complex liver segment resection. Segment VII of the liver is located at the base of the subphrenic space, making it difficult to access and resulting in a lengthy and challenging resection procedure. This liver segment resection involves high volumes of blood loss throughout the procedure.

A pharmacokinetic study of four bone-protective compounds after oral administration of WSZG extract in primary breast cancer mice.

Wenshen Zhuanggu Formula (WSZG) is an effective traditional Chinese medicine prescription for adjuvantly treating breast cancer (BC) bone metastasis. Four flavonoids (diosmetin, bavachin, corylifolinin and corylin) in WSZG are considered as the main bioactive compounds of preventing bone loss and protecting bone structure. This study aims to develop a sensitive LC-MS/MS method for simultaneous determination of four flavonoids from WSZG in mouse blood and further compare the pharmacokinetic differences between normal and BC mice.

Diagnosis of ulcerative colitis of colon-targeting NIR probe via monitoring peroxynitrite.

In this work, a colon-targeting near-infrared (NIR) probe (DGO) was developed to monitor peroxynitrite (ONOO) in ulcerative colitis (UC) with fast (60 s) and low detection limits (0.04 μM). DGO could effectively distinguish human colon cancer cells (HCT116) from hepatocellular cells (HepG2) and aggregate in HCT116 cells under the mediation of glucose groups, demonstrating significant colon-targeting potential.

Carboxylesterase-activated hepatocyte-targeting fluorescent probe for drug-induced liver injury diagnosis.

In this study, a novel fluorescent probe DCI-Gal-Bz toward CEs was developed. DCI-Gal-Bz exhibits excellent sensitivity and selectivity toward CEs, which is not disturbed by physiologically relevant interferences. DCI-Gal-Bz could specifically distinguish hepatocytes from A549, HeLa, and SGC-7901 cells, showing good hepatocyte-targeting potential, which is because the terminal galactose of DCI-Gal-Bz can be selectively recognized by HepG2 cells overexpressing ASGPR.

Regulating triazine number in covalent organic frameworks modified separator to achieve high-energy-density performance in aqueous zinc-iodine batteries.

The development of separator by tunning the zincophilic and iodide ion-repulsive properties of covalent organic frameworks (COFs) that regulate cycle lifespan and capacity of aqueous zinc-iodine (Zn-I) batteries is one of challenges. In this work, we have shown a systematic strategic-driven investigation to elucidate the role of functional triazine properties in COF modified separator towards overall performance of aqueous Zn-I batteries. As such, three COFs with the same topology but different triazine number in their structures, have been synthesized, among which the triazine-richest framework, TAPA-TTB-COF-based separator demonstrated to be most effective to guide uniform Zn flux and simultaneously inhibit polyiodide shuttling due to the zincophilic nature and good iodide ion-repulsive capability of triazine.

SNORA74A Drives Self-Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis Through Activation of Notch3 Signaling.

Liver cancer stem cells (CSCs) account for tumor initiation, heterogeneity and therapy resistance. However, the role of small nucleolar RNAs (snoRNAs) in the regulation of liver CSCs remains largely unclear. Here, this work identifies a conserved H/ACA box snoRNA SNORA74A which is highly expressed in liver CSCs.

Endovascular treatment for cerebral venous thrombosis: a multicenter study in China.

Background: Endovascular treatment (EVT) is gaining popularity for the management of severe forms of cerebral venous thrombosis (CVT), but the evidence supporting its efficacy and safety is limited.

Methods: This multicenter study included patients with CVT admitted to 104 hospitals in 31 provinces/cities in China between January 2018 and June 2022. Propensity score weighting models were used to adjust baseline confounding variables to determine the association of EVT on the primary outcome of good functional status, defined as score 0 - 1 on the modified Rankin Scale after hospital discharge.

Sand frying-induced assembly of coix seeds starch with oils into stable structures: A comprehensive investigation based on starch-lipid interaction.

Processing (Paozhi) is a pre-treatment step before the application of crude herbs in traditional Chinese medicine (TCM), which has been employed for centuries to regulating the functional properties of raw material. Current work aims at exploring how paozhi treatment tailors the composite behavior and physicochemical properties of coix seed starch-oils mixtures system, through inspecting the interactions between starch and oils under simulated sand frying conditions. The results indicate that processing induces significant morphological changes, leading to the formation of a porous starch-like structure.

Exploring the association between urticaria subtypes, anxiety, and depression and potential role of gut microbiota.

Aims: In observational studies, the causal relationship between urticaria and the risk of psychiatric disorders (anxiety and depression) remains inconclusive. Furthermore, there is growing evidence that gut microbiota (GM) contributes to the pathogenesis of urticaria. This study aimed to assess the causal relationships between the genetically predicted urticaria subtypes and psychiatric disorders and further examined the role of GM in influencing the risk of these urticaria subtypes.

Enteric GABAergic neuron-derived γ-aminobutyric acid initiates expression of Igfbp7 to sustain ILC3 homeostasis.

Neuronal signals have emerged as critical factors that regulate group 3 innate lymphoid cell (ILC3) response and tissue homeostasis, but the molecular mechanisms underlying this regulation remain largely elusive. Here, we identified that the enteric GABAergic neuron-derived neurotransmitter γ-aminobutyric acid (GABA) inhibited proliferation and IL-17A production in ILC3s in a manner dependent on the GABA receptors Gabbr1 and Gabbr2. Conditional deletion of Gabbr1 or ablation of GABAergic neurons caused increased IL-17A production and aggravated colitis.

Efficient Diffusion Model for Image Restoration by Residual Shifting.

While diffusion-based image restoration (IR) methods have achieved remarkable success, they are still limited by the low inference speed attributed to the necessity of executing hundreds or even thousands of sampling steps. Existing acceleration sampling techniques, though seeking to expedite the process, inevitably sacrifice performance to some extent, resulting in over-blurry restored outcomes. To address this issue, this study proposes a novel and efficient diffusion model for IR that significantly reduces the required number of diffusion steps.

A near-infrared fluorescent probe toward β-Gal with dual-targeting potential of hepatocytes and lysosomes: Design, synthesis, and evaluation.

In this work, a novel near-infrared fluorescent probe of benzopyranonitrile toward β-Gal was developed with high selectivity and low detection limits. DCM-Mor-Gal could effectively distinguish hepatocellular cells (HepG2) from SGC7901, HeLa, A549, and human normal liver cells (HL-7702) under the mediation of the galactose group, and effectively aggregate in the lysosomes under the acidity-alkalinity attraction, showing a notable dual-targeting potential of hepatocytes and lysosomes. The zebrafish experiments confirmed the utility of DCM-Mor-Gal in detecting β-Gal in vivo, which is expected to be an effective tool for the clinical detection of related diseases.

Development and validation of the pain management competency scale for nurses and a nationwide survey of Chinese nurses.

Background: Nurses' competency in pain management is essential for effectively alleviating patients' acute pain, controlling chronic pain, and promoting patient recovery. However, reliable tools for evaluating these competencies across different clinical specialties and healthcare settings are lacking. This study aimed to develop and validate a Pain Management Competency Scale for Nurses (PMCSN) and to assess the pain management competencies of nurses in China through a nationwide survey.

MA -mediated lncRNA SCIRT stability promotes NSCLC progression through binding to SFPQ and activating the PI3K/Akt pathway.

Non-small cell lung cancer (NSCLC) has emerged as one of the most prevalent malignancies worldwide. N6-methyladenosine (mA) methylation, a pervasive epigenetic modification in long noncoding RNAs (lncRNAs), plays a crucial role in NSCLC progression. Here, we report that mA modification and the expression of the lncRNA stem cell inhibitory RNA transcript (SCIRT) was significantly upregulated in NSCLC tissues and cells.

Adiponectin facilitates the cell cycle, inhibits cell apoptosis and induces temozolomide resistance in glioblastoma via the Akt/mTOR pathway.

Adiponectin (ADN) regulates DNA synthesis, cell apoptosis and cell cycle to participate in the pathology and progression of glioblastoma. The present study aimed to further explore the effect of ADN on temozolomide (TMZ) resistance in glioblastoma and the underlying mechanism of action. Glioblastoma cell lines (U251 and U87-MG cells) were treated with ADN and TMZ at different concentrations; subsequently, 3.

Laparoscopic anatomical SVIII resection middle hepatic fissure approach: Caudal or cranio side.

Background: Laparoscopic hepatectomy is a proven safe and technically feasible approach for liver tumor resection, but laparoscopic anatomical SVIII resection (LASVIIIR) remains rarely reported due to poor accessibility, difficult exposure, and the deep-lying Glissonean pedicle. This study examined the safety, feasibility, and perioperative outcomes of LASVIIIR a middle hepatic fissure approach at our institution.

Aim: To investigate the safety, feasibility, and perioperative outcomes of LASVIIIR a middle hepatic fissure approach at our institution.

A read-through circular RNA RCRIN inhibits metabolic dysfunction-associated steatotic liver disease.

Background & Aims: The molecular mechanisms underlying metabolic dysfunction-associated steatotic liver disease (MASLD) remain elusive and whether non-coding RNAs can serve as biomarkers and therapeutic targets in MASLD has not been determined.

Methods: Exon capture RNA-sequencing analysis was used to identify read-through circular RNAs (rt-circRNAs) in livers from three patients with MASLD and three controls without MASLD. Hepatocyte-specific deletion or overexpression of rt-circRNA RCRIN were utilized to study MASLD pathogenesis.

Dynamic/static pressure-induced copolymerization and property changes of lotus seed starch with chlorogenic acid.

Pressure promotes the formation of starch-polyphenol complexes, but their classification and properties are still unclear. This study aimed to elucidate the effects of dynamic high-pressure homogenization (10-50 MPa) and static hydrostatic pressure (100-500 MPa) on the copolymerization behavior and properties of lotus seed starch (LS)-endogenous polyphenol chlorogenic acid (CA) complexes. The results showed that both pressures induced LS-CA to form stable inclusion-type complexes and easily destructible noninclusion-type complexes.

Exploration of iodine adsorption performance of pyrene-based two-dimensional covalent organic frameworks.

Radioiodine (mainly I and I) is known to be dangerous nuclear waste due to its high toxicity, fast mobility and long radioactive half-life. As an emerging class of novel porous organic polymers, covalent organic frameworks (COFs) have demonstrated tremendous application potential in the field of radioactive iodine capture because of their high specific surface area and tunable pore structure. Herein, three π-conjugated pyrene-based COFs, namely PyTTA-BPDA-COF, PyTTA-BPY-COF, and PyTTA-BT-COF, have been successfully prepared and used as highly efficient adsorbents for iodine capture.