Headache in Patients With Non-Thrombotic Internal Jugular Vein Stenosis: Clinical Characteristics and Associated Risk Factors in a Retrospective Study of 283 Cases.

Aims: This study aimed to characterize the clinical features of headache in patients with non-thrombotic internal jugular vein stenosis (IJVS) and to identify associated risk factors.

Methods: This retrospective study consecutively enrolled patients with imaging-confirmed non-thrombotic IJVS from January 2021 through July 2024. Participants were divided into IJVS-headache and IJVS-without-headache groups based on clinical symptoms.

PU.1 Facilitates Endothelial-to-Mesenchymal Transition in Cardiac Endothelial Cells.

Background: The endothelial-to-mesenchymal transition (EndMT) plays a critical role in cardiac fibrosis pathogenesis. However, the molecular mechanisms driving EndMT remain poorly understood. This study investigates the regulatory function of the transcription factor PU.

Preliminary Analysis of the Salt-Tolerance Mechanisms of Different Varieties of Dandelion ( Hand.-Mazz.) Under Salt Stress.

Soil salinization hinders plant growth and agricultural production, so breeding salt-tolerant crops is an economical way to exploit saline-alkali soils. However, the specific metabolites and associated pathways involved in salt tolerance of the dandelion have not been clearly elucidated so far. Here, we compared the transcriptome and metabolome responses of 0.

Interplay between attention-deficit/hyperactivity disorder, educational attainment, and vascular risk factors: Insights from Mendelian randomization analyses.

The causal relationships between attention-deficit/hyperactive disorder (ADHD) and vascular risk factors remain insufficiently understood. This study aimed to comprehensively investigate the causal effects of ADHD on vascular risk factors and identify crucial mediators in these relationships. Utilizing instrumental variables from genome-wide association study (GWAS) datasets, we applied two-sample Mendelian randomization (MR) to explore the causal influences of ADHD on adiposity-related traits, blood pressure regulation, glucose metabolism, lipid profiles, lifestyle habits, chronic kidney disease, and systemic inflammation.

Flavor profiling and optimization of large yellow croaker () in recirculating aquaculture systems: Effects of exercise intensity assessed by advanced analytical techniques.

Exercise training is important for improving muscle flavor in RAS-farmed fish, but its effects on the muscle flavor of remain unclear. This study investigated how different swimming intensities (0.4, 0.

Construction of OSA-starch and caffeic acid composite system driven by high pressure homogenization: Multiscale structural evolution and digestibility regulation mechanism.

The effect of modification treatments on the structure and function of starch-polyphenol complexes has become a hot research topic. Therefore, this study aims to systematically investigate the structural reorganization and digestibility modulation of octenyl succinic anhydride modified rice starch (OR)-caffeic acid complexes (ORCA) under gradient high pressure homogenization (HPH) pressures (50, 80, and 110 MPa). HPH promoted the interaction between starch and CA compared to the non-HPH-treated samples.

Identification of potential biomarkers and therapeutic targets for cerebral venous thrombosis.

Background And Aims: Cerebral venous thrombosis (CVT) is an uncommon yet potentially life-threatening subtype of stroke that predominantly affects younger individuals. This study aimed to systematically identify and validate druggable genes associated with CVT susceptibility using Mendelian randomization (MR) approaches.

Methods: We integrated two large-scale expression quantitative trait loci (eQTLs) datasets - eQTLGen (peripheral blood) and PsychENCODE (brain tissue) - as exposures, with CVT genome-wide association study (GWAS) summary statistics from FinnGen serving as the outcome.

New insights into the regulation mechanism of starch digestibility by polyphenol structures in starch-polyphenol-protein ternary system.

The study aimed to investigate the effect mechanism of polyphenol structures on starch digestibility in the starch-polyphenol-protein ternary system. Polyphenol structures affected the affinity between polyphenols and whey protein isolate (WPI), with flavonoid-based polyphenols possessing a higher affinity to WPI. The law of polyphenol structures impacting the starch multiscale structure was altered in starch-polyphenol-protein ternary system compared to starch-polyphenol binary system.

Keratin 6A Overexpression in the Lymphovascular Invasion-Associated Tumor Subgroup Promotes Progression of Triple-Negative Breast Cancer.

Purpose: Lymphovascular invasion (LVI) is a strong predictor of poor prognosis in triple-negative breast cancer (TNBC), yet its molecular basis remains unclear. This study investigates epithelial regulators associated with LVI and their functional roles in TNBC progression.

Materials And Methods: We utilized single-cell sequencing data to further characterize epithelial cell populations in TNBC, identifying dominant epithelial clusters in LVI-positive TNBC tissues.

Study on Cerebral Venous Thrombosis From 2014 to 2023: A Bibliometric Analysis via CiteSpace.

ObjectiveWe aimed to explore the development status, turning and key points, and emerging trends of the cerebral venous thrombosis (CVT).MethodsLiterature pertaining to CVT published from 2014 to 2023 in the Web of Science Core Collection database was searched. The 6.

Exploring the association between circadian rhythms and osteoporosis: new diagnostic and therapeutic targets identified via machine learning.

Background: Osteoporosis (OP) is a systemic metabolic bone disease that may increase the risk of disability or death. Increasing evidence suggests that circadian rhythms play an important role in OP, yet the specific mechanisms remain unclear. Therefore, this study aims to utilize bioinformatics and machine learning algorithms to identify novel diagnostic biomarkers related to the circadian rhythm in OP, providing new targets for early diagnosis and treatment of OP.

Normobaric Hyperoxia Therapy in Treating Stroke.

Normobaric hyperoxia (NBO) is a standard oxygenation intervention for various conditions/diseases including stroke. The present review summarizes the current literature addressing the neuroprotective mechanisms of NBO in acute ischemic stroke (AIS), intracranial hemorrhage, and chronic cerebral ischemia, as well as its combination with other therapies to identify a more appropriate and effective NBO treatment method and to benefit more patients in clinical settings. The primary mechanism of action of NBO is the elevation of the interstitial partial pressure of oxygen in arterial blood (O) in brain tissue.

Uncovering dominant drivers of Erigeron annuus distribution in Dajiuhu-Shennongjia wetland using multiscale remote sensing data.

Background: As a pernicious invasive species, Erigeron annuus (L.) pers. (EAP) poses a significant threat to the biodiversity and ecosystem in Dajiuhu-Shennongjia, China.

Mechanism of reducing rice starch digestibility by quinoa protein amyloid-like fibrils pretreated with magnetic field.

The study aimed to investigate the mechanism by which magnetic field-pretreated quinoa protein amyloid-like fibrils affected the digestive properties of rice starch. Magnetic field pretreatment induced conformational changes in quinoa protein, promoting fibrillation, and quinoa protein formed the most amyloid-like fibrils under a 3 mT magnetic field treatment. The higher amyloid-like fibrils content enhanced both the short-range and long-range ordered structures of rice starch, as evidenced by the increased R value (from 0.

Cerebral venous thrombosis during pregnancy and postpartum: A systematic review and meta-analysis.

Background: Cerebral venous thrombosis (CVT) is a rare but life-threatening condition, particularly among pregnant and postpartum women. However, estimates of its incidence, recurrence, and associated adverse outcomes remain inconsistent. Moreover, the role of antithrombotic prophylaxis in mitigating these risks has not been fully established.

A fasciclin-like arabinogalactan protein OsFLA8 is involved in Casparian strip formation and salt tolerance in rice.

FASCICLIN-LIKE ARABINOGALACTAN PROTEINs (FLAs), a subclass of plant arabinogalactan proteins (AGPs), play diverse roles in plant development, including pollen development, secondary cell wall regulation, and root and stem growth. However, the biological functions of the majority of FLA-encoded proteins in rice remain largely unexplored, particularly their roles in root development and cell wall formation. In this study, we identified OsFLA8, a member of the FLA family, as a critical component of Casparian strip (CS) formation and salt stress tolerance in rice.

Conserved genome structure and phylogenetic insights for the heterogeneous subfamily of Convallarioideae (Asparagaceae) revealed from plastome data.

Background: Convallarioideae, a subfamily of Asparagaceae, encompasses a wide range of morphologically diverse lineages previously classified under different traditional families and holds significant economic value. Despite its importance, chloroplast genome data for Convallarioideae remain limited, hindering a comprehensive understanding of their genome structural evolution and phylogenetic relationships. This study aims to provide a detailed characterization of chloroplast genome features and to conduct robust phylogenetic analyses of this subfamily using an expanded dataset of chloroplast genomes.

Gallic Acid Inhibits the Proliferation and Migration of Ovarian Cancer Cells via Inhibition of the PI3K-AKT Pathway and Promoting M1-Like Macrophage Polarization.

Ovarian cancer is one of the leading malignant women tumors that causes higher mortality, and immunotherapy has shown high potential in the treatment of advanced ovarian cancer patients by activating and mobilizing the human immune system, which can improve patient prognosis and survival. Natural compounds are a big resource for screening and finding effective lead compounds to treat diseases. Gallic acid (GA) is a natural organic acid with broad-spectrum antibacterial, antiviral, and antitumor effects.

Investigating the protective effect of hydroxylated fullerenes on cognitive function in rats with temporal lobe epilepsy.

The objective of this study was to explore the protective effects of hydroxy fullerenes (HFs) on cognitive function in rats with temporal lobe epilepsy (TLE) and to elucidate the underlying mechanisms. Eighteen Sprague-Dawley (SD) rats were randomly selected and administered pilocarpine (50 mg/kg) intraperitoneally to establish a TLE model, and were then randomly assigned to the TLE group and the TLE + HFs group. An additional nine SD rats were served as a normal control group (CON group).

Endovascular treatment for cerebral venous thrombosis: a multicenter study in China.

Background: Endovascular treatment (EVT) is gaining popularity for the management of severe forms of cerebral venous thrombosis (CVT), but the evidence supporting its efficacy and safety is limited.

Methods: This multicenter study included patients with CVT admitted to 104 hospitals in 31 provinces/cities in China between January 2018 and June 2022. Propensity score weighting models were used to adjust baseline confounding variables to determine the association of EVT on the primary outcome of good functional status, defined as score 0 - 1 on the modified Rankin Scale after hospital discharge.

Exploring glucagon-like peptide-1 receptor agonists as potential disease-modifying agents in autoimmune diseases.

Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists are emerging with therapeutic agents for the treatment of two of the most prevalent metabolic disorders: diabetes and obesity. However, the causal relationship between GLP-1R agonists and autoimmune diseases is still unclear.

Methods: The available cis-eQTLs for drug target genes (GLP-1Rs) were used as proxies for exposure to GLP-1R agonists.

Kitag. (Binpu-3) root extract inhibits tumor invasion via Notch signaling in and human breast cancer MDA-MB-231 cells.

Metastasis is the primary cause of death in patients with malignant tumors. Therefore, effectively controlling or reversing tumor cell growth and metastasis is crucial for treating malignant tumors. In this study, we investigated the effects and underlying mechanisms of Binpu-3 (a strain of Kitag.

A Study of Variation in the Major Phenolic Acid Components of Dandelions Across Different Regions, and the Potential Molecular Mechanisms of Their Anti-Inflammatory Activity.

This study explores the variation in the content of major phenolic acid components in dandelions from different regions, and the potential molecular mechanisms underlying their anti-inflammatory activity. High-performance liquid chromatography (HPLC) was employed to analyze dandelion leaves collected from four different regions in Hebei Province across eight harvest periods. The results indicated that chlorogenic acid had the highest content (0.

Lipoprotein(a), remote ischemic conditioning, and stroke recurrence in patients with symptomatic intracranial atherosclerotic stenosis.

This study is to determine symptomatic intracranial atherosclerotic stenosis (ICAS), a significant stroke cause with high recurrence risks, by examining the relationship between lipoprotein(a) and ischemic stroke recurrence. Analyzing data from the RICA trial (chronic remote ischemic conditioning in patients with symptomatic ICAS) involving 1286 patients aged 40-80 years across 84 Chinese stroke centers, we found that participants with lipoprotein(a) levels above 17.4 ​mg/dL experienced markedly higher stroke recurrence rates (adjusted hazard ratio [HR], 1.

Escin Rescues Blood-brain Barrier and Inhibits NLRP3 Inflammasome-mediated Pyroptosis in Rats with Superior Sagital Sinus Thrombosis.

The purpose of this study is to investigate the therapeutic value of escin and its potential mechanisms in rats with superior sagittal sinus thrombosis (SSST). The motor function of rats was assessed using the open field, balance beam, and rotarod tests following one week of escin treatment. Laser Speckle Contrast Imaging (LSCI) was used to evaluate the blood flow in the superior sagittal sinus.