Green Synthesis of Dual-Emission Tin-Doped Cesium Manganese Halide Nanocrystals with High Performance.

Manganese-based halide perovskites have gradually become a focus point for exploring photoluminescent materials due to their attractive electronic and photophysical properties. However, little attention has been paid to the dual-emission and thermochromic phenomena in all-inorganic Mn-based materials. In this study, Sn-doped CsMnBrCl is synthesized at room temperature, which exhibits bright yellow emission, with two broad emission peaks at 525 and 605 nm, corresponding to full width at half-maximum (fwhm) of 92 and 91 nm, respectively.

Flavor profiling and optimization of large yellow croaker () in recirculating aquaculture systems: Effects of exercise intensity assessed by advanced analytical techniques.

Exercise training is important for improving muscle flavor in RAS-farmed fish, but its effects on the muscle flavor of remain unclear. This study investigated how different swimming intensities (0.4, 0.

Prediction of water quality parameters and pollution exceedance analysis in typical rivers of semi-arid regions based on interpretable deep learning models.

Deep learning models that integrate environmental characteristics provide a powerful means for high-precision water quality prediction; however, their black-box nature can limit interpretability and reliability. We proposed an interpretable Attention-Gated Recurrent Unit (AT-GRU) model that integrates water quality, meteorological, and hydrological data from the semi-arid Dahei River Basin, to improve prediction accuracy and transparency of results. The model achieved superior daily-scale prediction accuracy (average R = 0.

Near-infrared fatty acid molecular probe for image-guided surgery of glioblastoma.

Metabolic reprogramming is considered a major driving factor in cancer growth and yet it remains challenging to monitor in vivo uptake of fatty acids, which are essential energy sources for many tumor types. Here, we report the development of a novel, long-chain fatty acid (FA), near-infrared (NIR) imaging reagent (FA-ICG) for real-time, non-invasive imaging of FA absorption in vitro and in vivo. Moreover, we demonstrate the application of the probe in image-guided cancer surgery, where precise assessment of tumor margins is paramount for removal.

OsFT coordinates photosynthetic stability and carotenoid metabolism to regulate tillering in rice.

Introduction: Photosynthesis and tillering number have been essential components determining grain yield in rice. However, the genetic mechanism of carotenoid biosynthesis pathway, which is one of the photosynthetic pigments of rice, affecting tillering of rice is rarely studied.

Objective: This study elucidates the roles of OsFT in photosynthesis and carotenoid biosynthesis, and the synergistic regulation of rice tillering by SL and ABA, providing a theoretical basis for breeding high-yielding, drought-resistant rice varieties.

Genome-wide association study uncovers a novel gene responsible for rice seedling submergence tolerance.

Submergence tolerance is crucial for the direct seeding of rice, yet long-term domestication and breeding have inadvertently reduced the adaptability of cultivated rice to submergence stress. Here, we identify a nucleic acid excision repair protein-encoding gene qSHS5 as an essential regulator of seedling height under submergence through a genome-wide association study in 322 rice accessions. Disruption of qSHS5 in mutants resulted in seedling growth inhibition under submergence, while growth remains comparable to wild-type under normal conditions.

A clinically applicable machine learning model for personalized survival prediction in metastatic pancreatic neuroendocrine tumors.

Introduction: Metastatic pancreatic neuroendocrine tumors (pNETs) carry a poor prognosis. Currently, no validated model exists to accurately predict survival in this population, highlighting the need for effective prognostic tools.

Materials And Methods: In this study, we developed and validated a machine learning-based survival prediction model using data from the Surveillance, Epidemiology, and End Results (SEER) database.

The OsbHLH166-OsABCB4 module regulates grain length and weight via altering auxin efflux.

Grain size is one of the key factors determining grain weight and yield. However, it remains largely unknown how the auxin signal regulates grain size in rice. Here, a quantitative trait locus qGL1 for grain length was identified with recombinant inbred lines 9311 and Nipponbare (NIP), and fine-mapped to the OsABCB4 gene, which encodes a member of the ATP Binding Cassette B (ABCB) subfamily.

Strategies to Improve γ-Aminobutyric Acid Biosynthesis in Rice via Optimal Conditions.

The γ-aminobutyric acid (GABA), a ubiquitous non-protein amino acid in plants and animals, exhibits diverse biological activities and holds promise in human disease prevention and treatment. Prior studies have shown that germination could substantially elevate GABA levels in rice, but these investigations typically focused on limited germplasms, hindering the generalization of their findings. This study aims to identify optimal conditions for enriching GABA in a diverse set of 225 rice germplasms by examining the effects of various germination times, temperatures, and soaking solution pH levels, while elucidating the key factors influencing GABA enrichment in germinated brown rice.

9311 allele of OsNAR2.2 enhances nitrate transport to improve rice yield and nitrogen use efficiency.

Improving nitrogen use efficiency (NUE) in rice is a requirement for future sustainable agricultural production. However, key factors and regulatory networks involved in NUE remain unclear. Here, QTL analysis, fine-mapping and functional validation demonstrated that qCR4 encodes a putative high-affinity nitrate transporter-activating protein 2.

A zinc metalloproteinase controls rice grain zinc content and weight.

This study identifies of a zinc metalloproteinase, ZG, that positively regulates both zinc content and grain size in rice. ZG's proteolytic activity increases with higher zinc ion concentrations. These findings, along with haplotype analysis in global rice cultivars, highlight its strong potential for enhancing both yield and nutritional value in rice breeding.

Transcriptomic Analysis and Experimental Verification of Ferroptosis Signature Genes in Osteoarthritis.

Osteoarthritis is a systemic disease that primarily damages articular cartilage and also affects the synovium, ligaments, and bone tissues. The key mechanisms involved are chondrocyte death and degradation of the extracellular matrix. This study aims to identify differentially expressed genes (DEGs) associated with ferroptosis and investigate their roles in the development of osteoarthritis.

Neuronal dynamics of cerebellum and medial prefrontal cortex in adaptive motor timing.

Precise temporal control of sensorimotor coordination and adaptation is a fundamental basis of animal behavior. How different brain regions are involved in regulating the flexible temporal adaptation remains elusive. Here, we investigated the neuronal dynamics of the cerebellar interposed nucleus (IpN) and the medial prefrontal cortex (mPFC) neurons during temporal adaptation between delay eyeblink conditioning (DEC) and trace eyeblink conditioning (TEC).

A Repurposed Drug Selection Pipeline to Identify CNS-Penetrant Drug Candidates for Glioblastoma.

Background: Glioblastoma is an aggressive and incurable type of brain cancer. Little progress has been made in the development of effective new therapies in the past decades. The blood-brain barrier (BBB) and drug efflux pumps, which together hamper drug delivery to these tumors, play a pivotal role in the gap between promising preclinical findings and failure in clinical trials.

NRAV promoted the malignant progression of gastric cancer.

Gastric cancer (GC) has been ranked as the third incidence tumors globally. Long non-coding RNA (lncRNA) NRAV has been reported as a tumor-enhancer in the development of human cancers, whereas the function of NRAV in GC remains to be elucidated. The aim of this research was to explore the underlying function of NRAV in GC.

Survival benefit of adjuvant TACE for patients with hepatocellular carcinoma and child-pugh B7 or B8 after hepatectomy.

Background & Aims: The benefit of postoperative adjuvant transcatheter arterial chemoembolization (pTACE) for patients with hepatocellular carcinoma (HCC), especially those with Child-Pugh (CP) B, remains controversial. This study aimed to assess the survival benefit of pTACE for HCC patients with CP B.

Methods: Data from 297 HCC patients with CP B7 or B8 were analyzed, dividing them into groups with and without pTACE (70, 23.

Smartphone-assisted colorimetric biosensor for the rapid visual detection of natural antioxidants in food samples.

Quantitative monitoring of the concentrations of epigallocatechin gallate (EGCG) and cysteine (Cys) is of great significance for promoting human health. In this study, iron/aluminum bimetallic MOF material MIL-53 (Fe, Al) was rapidly prepared under room temperature using a co-precipitation method, followed by investigating the peroxidase-like (POD-like) activity of MIL-53(Fe, Al) using 3,3',5,5'-tetramethylbenzidine (TMB) as a chromogenic substrate. The results showed that the Michaelis -Menten constants of TMB and HO as substrates were 0.

Hypoxia-inducible factor-1α promotes macrophage functional activities in protecting hypoxia-tolerant large yellow croaker () against infection.

The immune system requires a high energy expenditure to resist pathogen invasion. Macrophages undergo metabolic reprogramming to meet these energy requirements and immunologic activity and polarize to M1-type macrophages. Understanding the metabolic pathway switching in large yellow croaker () macrophages in response to lipopolysaccharide (LPS) stimulation and whether this switching affects immunity is helpful in explaining the stronger immunity of hypoxia-tolerant .

Contrasting Impacts of Ubiquitin Overexpression on Arabidopsis Growth and Development.

In plants, the ubiquitin (Ub)-26S proteasome system (UPS) regulates numerous biological functions by selectively targeting proteins for ubiquitylation and degradation. However, the regulation of Ub itself on plant growth and development remains unclear. To demonstrate a possible impact of Ub supply, as seen in animals and flies, we carefully analyzed the growth and developmental phenotypes of two different () gene overexpression plants of .

Prognostic value of the Naples prognostic score in patients with intrahepatic cholangiocarcinoma after hepatectomy.

Background: The Naples Prognostic Score (NPS), integrating inflammatory and nutritional biomarkers, has been reported to be associated with the prognosis of various malignancies, but there is no report on intrahepatic cholangiocarcinoma (ICC). This study aimed to explore the prognostic value of NPS in patients with ICC.

Methods: Patients with ICC after hepatectomy were collected, and divided into three groups.

Multicenter propensity score-matched analysis to compare perioperative morbidity after laparoscopic or robotic complex hepatectomy for solitary hepatocellular carcinoma.

Background: Postoperative complications are vital factors affecting the prognosis of patients with hepatocellular carcinoma (HCC), especially for complex hepatectomy. The present study aimed to compare perioperative complications between laparoscopic and robotic complex hepatectomy (LCH vs. RCH).

Survival benefit from adjuvant TACE combined with lenvatinib for patients with hepatocellular carcinoma and microvascular invasion after curative hepatectomy.

Background And Aims: The prognosis of patients with hepatocellular carcinoma (HCC) undergoing hepatectomy is unsatisfactory, especially for those with microvascular invasion (MVI). This study aimed to determine the impact of adjuvant transcatheter arterial chemoembolization (TACE) and Lenvatinib on the prognosis of patients with HCC and MVI after hepatectomy.

Methods: Patients diagnosed with HCC and MVI were reviewed, and stratified into four groups according to adjuvant TACE and/or Lenvatinib.