Nutritional Immunity in Wound Infection: Unveiling the Role of Dietary Elements in Host-Pathogen Interaction.

Nutritional immunity is an essential defense process by which the host restricts the supply of critical micronutrients to invading pathogens, thus hindering their survival and growth. During wound infections, this mechanism is instrumental in determining the course of host-pathogen interactions. This article discusses the pathophysiology of wound infection, beginning with the classification of wounds as acute and chronic wounds, and emphasizes how compromised epithelial barriers and chronic inflammation provide a niche for microbial colonization.

Stabilization of OLFML1 via mA Reader IGF2BP3 Drives CSC Characteristics Through Hedgehog Pathway Activation in CRC.

Colorectal cancer (CRC) progression is closely associated with cancer stemness, which contributes to poor prognosis and therapeutic resistance. This study identifies OLFML1 as a key target accounting for CRC progression. High expression of OLFML1 promotes CRC cell proliferation and cancer stemness.

Amivantamab versus standard therapies among patients with advanced non-small cell lung cancer and epidermal growth factor receptor exon 20 insertion mutations after platinum-based therapy in China.

Objectives: There is limited data on the unmet needs of advanced non-small cell lung cancer (aNSCLC) patients with epidermal growth factor receptor exon 20 insertion mutations (EGFR exon20ins) in China. The single-arm CHRYSALIS study (NCT02609776) demonstrated durable responses of amivantamab monotherapy among aNSCLC patients with EGFR exon20ins after platinum-based chemotherapy. We aimed to leverage real-world data to describe the unmet needs of these patients and explore the clinical benefits of amivantamab monotherapy through indirect comparison to an external control (EC) from China.

Initial Low-Density Lipoprotein Cholesterol and Inflammation Status Predicts Long-Term Mortality in Patients with Acute Coronary Syndrome in the Chinese Population.

: Low-density lipoprotein cholesterol (LDL-C) is considered an important risk factor for acute coronary syndrome (ACS). Recent studies have revealed high mortality in ACS patients with low LDL-C levels. However, the association between spontaneously very low LDL-C levels and the prognosis in ACS remains unknown.

Advantages, progress, and future trends in oral medicated jellies/gels: Focus on adherence aspects.

Poor medication adherence is a pervasive issue in oral administration. Oral medicated jellies/gels are semisolid formulations that leverage the advantages of both solid and liquid formulations and have a promising potential. They help to increase patient comfort, simplify the medication process, and improve the medication experience, thereby improving medication adherence and alleviating many common barriers to adherence.

Characteristics, preparation and applicability in oral delivery systems of cellulose ether-based buccal films.

With the rapid development of buccal films (BFs), the demand for film-forming materials and preparation techniques has increased. Cellulose ethers (CEs) exhibit favorable properties, such as effective film formation, mucosal adhesion, and biocompatibility; as such, they are most commonly employed as film-forming materials, essential for BF fabrication. CE-based BFs, classified as orodispersible and buccal mucoadhesive films, can be prepared through solvent casting, inkjet printing, three-dimensional printing, electrospinning, and hot melt extrusion.

The intervention of music education on adolescents' subjective well-being from the perspective of sustainable development: a bibliometric review based on literature from 2000 to 2024.

With the United Nations' 2030 Agenda elevating Good Health and Well-Being (SDG 3) and Quality Education (SDG 4) to global priorities, music education, by virtue of its cross-cultural character and emotional resonance, is increasingly recognized as a potential pathway for fostering adolescents' sustainable development competencies. Seventy-six core publications were retrieved from the Web of Science, MEDLINE, and ProQuest databases, and bibliometric and knowledge-mapping analyses were conducted using CiteSpace and VOSviewer. The field's trajectory was deconstructed along three dimensions: temporal (annual publication output and author contribution levels), spatial (national participation and institutional collaboration density), and content (high-frequency keyword clustering and evolution of emerging themes).

OsFT coordinates photosynthetic stability and carotenoid metabolism to regulate tillering in rice.

Introduction: Photosynthesis and tillering number have been essential components determining grain yield in rice. However, the genetic mechanism of carotenoid biosynthesis pathway, which is one of the photosynthetic pigments of rice, affecting tillering of rice is rarely studied.

Objective: This study elucidates the roles of OsFT in photosynthesis and carotenoid biosynthesis, and the synergistic regulation of rice tillering by SL and ABA, providing a theoretical basis for breeding high-yielding, drought-resistant rice varieties.

Genome-wide association study uncovers a novel gene responsible for rice seedling submergence tolerance.

Submergence tolerance is crucial for the direct seeding of rice, yet long-term domestication and breeding have inadvertently reduced the adaptability of cultivated rice to submergence stress. Here, we identify a nucleic acid excision repair protein-encoding gene qSHS5 as an essential regulator of seedling height under submergence through a genome-wide association study in 322 rice accessions. Disruption of qSHS5 in mutants resulted in seedling growth inhibition under submergence, while growth remains comparable to wild-type under normal conditions.

Multidisciplinary treatment strategies for the assessment of immune, coagulation, and biomarker responses after transarterial chemoembolization for hepatocellular carcinoma.

Background: Currently, there is a notable lack of reliable studies evaluating the impact of multidisciplinary treatment strategies following transarterial chemoembolization (TACE) on patients with hepatocellular carcinoma (HCC), underscoring the urgent need for higher-level research in this area.

Aim: To investigate the association of multidisciplinary treatment strategies with the immunological, coagulation, and tumor biomarker responses after post-TACE in HCC.

Methods: This retrospective analysis included 100 patients with HCC who were categorized based on the treatment approach into the control (patients treated with TACE alone) and experimental groups (patients receiving multidisciplinary treatment strategies post-TACE).

Hypoxia-inducible factor-prolyl hydroxylase inhibitors in treatment of anemia with chronic disease.

Anemia of chronic disease (ACD) is the most frequent clinical issue in patients with chronic disease. ACD is usually secondary to chronic kidney disease (CKD), cancer, and chronic infection, which is associated with poor health outcomes, increased morbidity and mortality, and substantial economic costs. Current treatment options for ACD are very limited.

Strategies to Improve γ-Aminobutyric Acid Biosynthesis in Rice via Optimal Conditions.

The γ-aminobutyric acid (GABA), a ubiquitous non-protein amino acid in plants and animals, exhibits diverse biological activities and holds promise in human disease prevention and treatment. Prior studies have shown that germination could substantially elevate GABA levels in rice, but these investigations typically focused on limited germplasms, hindering the generalization of their findings. This study aims to identify optimal conditions for enriching GABA in a diverse set of 225 rice germplasms by examining the effects of various germination times, temperatures, and soaking solution pH levels, while elucidating the key factors influencing GABA enrichment in germinated brown rice.

Cardiomyocyte-specific NHE1 overexpression confers protection against myocardial infarction during hyperglycemia.

Background: Acute hyperglycemia on admission is frequently observed during the early phase after acute myocardial infarction (MI), even without the history of diabetes mellitus. We previously reported that inhibiting Na/H exchanger 1 (NHE1) activity post-MI may improve outcomes, but not in the setting of MI with acute hyperglycemia. However, the precise role of NHE1 in the pathophysiology of MI with acute hyperglycemia remains to be elucidated, and there are no effective strategies for its prevention or treatment.

Mannitol in direct compression: Production, functionality, critical material attributes and co-processed excipients.

In recent years, mannitol has been widely used in the pharmaceutical industry as a substitute for lactose. Mannitol is widely available and can be produced by a variety of methods. Due to its water solubility, low hygroscopicity and chemical inertness, it is commonly added to various formulations, especially tablet formulations.

Immune modulation for the patterns of epithelial cell death in inflammatory bowel disease.

Inflammatory bowel disease (IBD) is an inflammatory disease of the intestine whose primary pathological presentation is the destruction of the intestinal epithelium. The intestinal epithelium, located between the lumen and lamina propria, transmits luminal microbial signals to the immune cells in the lamina propria, which also modulate the intestinal epithelium. In IBD patients, intestinal epithelial cells (IECs) die dysfunction and the mucosal barrier is disrupted, leading to the recruitment of immune cells and the release of cytokines.

Microalgae-carrying nanomedicine for bioadhesive drug delivery for treating chemotherapy-induced intestinal injury.

Gastrointestinal tract toxicity represents a serious adverse effect of chemotherapy, leading to reduced quality of life and survival. For instance, irinotecan (CPT-11) usually causes severe gastrointestinal toxicity, with a lack of effective therapeutic interventions, making treatment often unsustainable. Therefore, development of an effective and safe therapy is crucial for improving chemotherapy efficacy and the patients' quality of life.

Gravity-Driven Air-Liquid Interface Flexible Sensor for Human Motion Detection.

This study introduces a novel gravity-driven air-liquid interface flexible sensor (GALIFS) for detecting human motions. GALIFS leverages gravity-induced liquid flow to generate angle-dependent electrical signals, eliminating the need for material deformation (e.g.

9311 allele of OsNAR2.2 enhances nitrate transport to improve rice yield and nitrogen use efficiency.

Improving nitrogen use efficiency (NUE) in rice is a requirement for future sustainable agricultural production. However, key factors and regulatory networks involved in NUE remain unclear. Here, QTL analysis, fine-mapping and functional validation demonstrated that qCR4 encodes a putative high-affinity nitrate transporter-activating protein 2.

Nonpharmacological mental health interventions for adolescent patients with polycystic ovary syndrome: a scoping review.

Objectives: This study aimed to summarize nonpharmacological mental health interventions that are beneficial for adolescent patients with polycystic ovary syndrome (PCOS) and to identify the limitations of existing studies.

Material And Methods: Following the recommendations of the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-SCR), we conducted a scoping review of nonpharmacological interventions aimed at improving mental health in adolescents with PCOS.

Results: Six randomized controlled trials (RCTs), two quasiexperimental studies, two case reports, one prospective study, one predictive correlation study, and one field trial study were included, resulting in 13 articles.

[Medium- and long-term efficacy of percutaneous mechanical thrombectomy with stent implantation in patients with iliac vein stenosis and thrombosis].

Objectives: To investigate the medium- and long-term efficacy of percutaneous mechanical thrombectomy (PMT) combined with stent implantation for treatment of iliac vein stenosis with lower extremity deep venous thrombosis (LEDVT).

Methods: Clinical and follow-up data of 125 patients with iliac vein stenosis and LEDVT who underwent PMT and stent implantation at five hospitals in northern Zhejiang province from January 2017 to June 2021 were collected. The thrombus clearance rate, thrombus recurrence rate, patency rate of iliac vein stents and post-thrombotic syndrome (PTS) occurrence rate were documented, and safety indicators such as bleeding, death, pulmonary embolism, stent fracture and displacement were assessed.