Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
In recent years, mannitol has been widely used in the pharmaceutical industry as a substitute for lactose. Mannitol is widely available and can be produced by a variety of methods. Due to its water solubility, low hygroscopicity and chemical inertness, it is commonly added to various formulations, especially tablet formulations. A better understanding of the Critical Material Attributes (CMAs) of raw materials can help guide tablet quality improvement and mannitol development based on quality by design. In addition, co-processing of mannitol can introduce more desirable properties to the resulting particles. In this review, we focused specifically on the recent advances and development of mannitol on direct compression (DC) tableting, including the functions in tablet formulations, potential CMAs, and mannitol-based co-processed excipients, therefore providing a reference for further studies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijpharm.2025.125595 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Isolation of Mutants Overproducing Mannitol Directly from CO via Laboratory Evolution under Increasing Salt Concentration.
ACS Synth Biol
September 2025
Molecular Microbial Physiology Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Science Park 904, Amsterdam 1098 XH, The Netherlands.
Mannitol is a naturally occurring C(6) polyol with a wide range of applications in the food and pharmaceutical industry. In a previous study, mannitol production was achieved via the direct conversion of CO in sp. PCC6803.
View Article and Find Full Text PDFComparison of utilizing a hypertonic saline solution and mannitol to improve brain relaxation during craniotomy in patients with brain tumours: a prospective randomized controlled trial.
Sci Rep
August 2025
Department of Anesthesiolology, Faculty of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand.
Hyperosmolar therapy, specifically the use of mannitol, has been employed to improve brain relaxation, but mannitol use may cause hypovolemia and electrolyte imbalance. Given these risks, hypertonic saline was introduced as an alternative; however, data on its efficacy and safety are limited. Researchers conducted a prospective, double-blind, randomized controlled trial.
View Article and Find Full Text PDFPalatable Orally Disintegrating Tablets of Losartan Potassium Developed by Spray-drying Technique and Direct Compression Intended for Pediatric Use.
AAPS PharmSciTech
August 2025
Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS), San Juan 670, 8000, Bahía Blanca, Buenos Aires, Argentina.
Several diseases that affect the pediatric population, e.g., heart diseases, cannot be efficiently treated because of the absence of a suitable dosage form.
View Article and Find Full Text PDFA dual-strategy approach to improve GS-441524 therapy in feline infectious peritonitis: salt engineering and orally disintegrating tablet development.
Int J Pharm
October 2025
College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea. Electronic address:
Feline infectious peritonitis (FIP) is a fatal disease caused by mutations in feline enteric coronavirus, posing significant challenges in feline medicine. GS-441524 (GS), the active metabolite of remdesivir, has demonstrated efficacy in FIP treatment. However, its poor solubility and low oral bioavailability require high doses for therapeutic effect, limiting its practicality.
View Article and Find Full Text PDFThe dysregulation of high glucose-induced iPSC-neural stem cells differentiation by caspase-1.
Neurosci Lett
August 2025
Department of Pharmacy & Clinical Trial Pharmacy, Kaohsiung Veterans General Hospital, Kaohsiung City 813414, Taiwan; Preventive Medicine Program, Center for General Education, Chung Yuan Christian University, Taoyuan City 320314, Taiwan; Department of Pharmacy and Master Program, College of Pharmac
Maternal diabetes (MD) increases the risk for neurodevelopmental disorders and leads to neural tube defects (NTDs) which are severe anomalies of the nervous system. In order to elucidate the etiology and pathological mechanisms causing NTDs in MD and try to search for new therapeutic strategies as well, the exposure of induced pluripotency stem cell (iPSC)-neural stem cells (NSCs) to high glucose (HG) may be associated with fetal progressive deterioration of neuronal functions in utero ultimately leading to MD-related NTDs. In the present study, although HG (25 mM) had no effect on the viability of undifferentiated iPSC-NSCs compared with the positive control mannitol (25 mM), HG attenuated iPSC-NSCs cell proliferation and induced the presence of decreased βIII-tubulin and neurite network length during 7-day neuronal differentiation, resulting in the inability of nerve-to-nerve connections to communicate effectively.
View Article and Find Full Text PDF