Formyl Phloroglucinol Meroterpenoids From the Fruits of Eucalyptus globulus.

Two formyl phloroglucinol meroterpenoids, namely eurobusone E-F (1 and 2), along with one simple phloroglucinol derivative, 1-(2,4-dihydroxy-6-methoxyphenyl)-2-methyl-1-butanone (3), were isolated from the fruits of Eucalyptus globulus. Their chemical structures were elucidated by comprehensive spectral analysis, and the absolute configurations were established by electronic circular dichroism calculations. Compound 1 features an unusual carbon skeleton, in which a humulane-type sesquiterpene is linked to a phloroglucinol core via a dihydropyran ring.

Conserved genome structure and phylogenetic insights for the heterogeneous subfamily of Convallarioideae (Asparagaceae) revealed from plastome data.

Background: Convallarioideae, a subfamily of Asparagaceae, encompasses a wide range of morphologically diverse lineages previously classified under different traditional families and holds significant economic value. Despite its importance, chloroplast genome data for Convallarioideae remain limited, hindering a comprehensive understanding of their genome structural evolution and phylogenetic relationships. This study aims to provide a detailed characterization of chloroplast genome features and to conduct robust phylogenetic analyses of this subfamily using an expanded dataset of chloroplast genomes.

The discovery of an anti-Candida xanthone with selective inhibition of Candida albicans GAPDH.

Objectives: This study aimed to discover novel antifungals targeting Candida albicans glyceraldehyde-3-phosphate dehydrogenase (CaGAPDH), have an insight into inhibitory mode, and provide evidence supporting CaGAPDH as a target for new antifungals.

Methods: Virtual screening was utilized to discover inhibitors of CaGAPDH. The inhibitory effect on cellular GAPDH was evaluated by determining the levels of ATP, NAD, NADH, etc.

Retinoid X receptor 1 is a specific lethal RNAi target disturbing chitin metabolism during hatching of Tetranychus cinnabarinus.

RNA interference (RNAi) can be developed as an alternative method of chemical pesticides for pest control. In this study, we noticed a specifically expressed gene (retinoid X receptor 1, TcRXR1) in the egg stage of T. cinnabarinus.

Serum MCP-1 and NGAL Play an Important Role in the Acute Inflammatory Event of Chronic Obstructive Pulmonary Disease.

NGAL is mainly secreted by neutrophils which play the core role in AECOPD. MCP-1 is secreted specifically by monocytes and macrophages. Both biomarkers are involved in the core process of acute inflammatory reaction in COPD.

The Active Ingredients Identification and Antidiarrheal Mechanism Analysis of L. Superfine Powder.

L. is a natural medicinal plant that has been widely used for its various pharmacological effects such as antidiarrheal, anti-inflammatory, and wound healing. This study aims to explore the antidiarrheal active ingredients of L.

Analysis of multidrug resistance in ATCC 700794 under tylosin stress.

is an important zoonotic pathogen. The massive use of tylosin and other antibiotics in swine production has led to the emergence of resistant phenotypes of . However, there are no adequate measures available to address the problem of bacterial resistance.

Study on microwave assisted extraction of chrysophanol and its intervention in biofilm formation of .

A microwave assisted extraction technology was used to extract chrysophanol from rhubarb. The present study will focus on the optimum extraction conditions of chrysophanol and discuss the inhibitory effect of chrysophanol on the biofilm formation of (). A Box-Behnken design based on single-factor experiments was applied to optimize the microwave assisted extraction process and to study the factors' relationships with each other.

Discovery of Potential Anti-infective Therapy Targeting Glutamine Synthetase in .

Glutamine synthetase (GS), which catalyzes the production of glutamine, plays essential roles in most biological growth and biofilm formation, suggesting that GS may be used as a promising target for antibacterial therapy. We asked whether a GS inhibitor could be found as an anti-infective agent of (). Here, computational prediction followed by experimental testing was used to characterize GS.

Chitosan Grafted With β-Cyclodextrin: Synthesis, Characterization, Antimicrobial Activity, and Role as Absorbefacient and Solubilizer.

We synthesized chitosan grafted with β-cyclodextrin (CD-g-CS) from mono-6-deoxy-6-(p-toluenesulfonyl)-β-cyclodextrin and chitosan. Two different amounts of immobilized β-cyclodextrin (β-CD) on CD-g-CS (Q: 0.643 × 10 and 0.

Spectrum-Effect Relationships Between the Bioactive Ingredient of Lindl. Leaves and Its Role in Inhibiting the Biofilm Formation of .

Lindl. () has been used in herbal medicines for treating bacterial diseases. It is also thought to inhibit () biofilm formation.

Homology Modeling and Virtual Screening to Discover Potent Inhibitors Targeting the Imidazole Glycerophosphate Dehydratase Protein in .

The imidazole glycerophosphate dehydratase (IGPD) protein is a therapeutic target for herbicide discovery. It is also regarded as a possible target in () for solving mastitis in the dairy cow. The 3D structure of IGPD protein is essential for discovering novel inhibitors during high-throughput virtual screening.