ILA mitigates HFD-induced metabolic dysfunction via lipid-immune crosstalk and gut microbiota modulation in zebrafish.

High-fat-induced metabolic syndrome poses many challenges to fish farming. In our previous study, we found that probiotic Akkermansia muciniphila can increase the tryptophan microbiota metabolite indole-3-lactic acid (ILA). Therefore, this study further investigates the effect of ILA on resisting HFD-induced metabolic disorders and preliminarily explores its mechanism in zebrafish.

Surface display of Nocardia seriolae HRP1 on Bacillus subtilis and its application as live vaccine for largemouth bass.

Micropterus salmoides, adaptable and fast-growing, is a major farmed fish in China. Intensive farming causes multiple diseases, especially hard-to-treat nocardiosis. Vaccines are an effective and safe prevention and control strategy against fish diseases.

Two brothers presented with rare clinical characteristics with a novel LAGE3 variant: a case report and literature review.

Background: Variants in the LAGE3 gene can lead to Galloway-Mowat syndrome (GAMOS), a rare genetic disease. Currently, there have been a total of 6 reported cases worldwide, all occurring in children under the age of 3 years old. The main features of LAGE3 variants include early-onset nephrotic syndrome, microcephaly, developmental delay, and neurological abnormalities, with a poor prognosis.

Type 2 Diabetes Mellitus: A Metabolic Model of Accelerated Aging - Multi-Organ Mechanisms and Intervention Approaches.

Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by chronic high blood sugar levels and insulin resistance (IR). Modern medicine has shown that diabetes plays a role in speeding up the aging process of the body independently of age, making it an age-related aging disease. The oxidative stress caused by chronic high blood sugar and IR can lead to dysfunctional mitochondria, which in turn promotes changes in epigenetic regulation, shortening of telomeres, and cellular senescence.

Triflumezopyrim-induced changes in the flight ability and energy metabolism of the brown planthopper, Nilaparvata lugens.

The brown planthopper (BPH), Nilaparvata lugens Stål, is a migratory pest of rice that exhibits short- and long-winged polymorphisms. The increased prevalence of long-winged individuals signals either immigration from external sources or imminent emigration from local populations. The migratory behavior of BPH is contingent upon its intrinsic flight capabilities, which have historically been managed through chemical pesticides.

Pediatric Immunodeficiency Caused by Complement Classical and Alternative Pathway Defects Due to a Homozygous CFI Variant: A Case Report.

Complement factor I (CFI) deficiency is a rare primary immunodeficiency that disrupts the classical and alternative complement pathways, potentially causing severe recurrent infections and autoimmune manifestations in pediatric patients. However, the coexistence of both pathways in a pediatric patient is extremely uncommon. We report a seven-year-old patient with a rare primary immunodeficiency disorder who presented with recurrent middle ear infections, paronychia, gastrointestinal infections, and respiratory infections.

Marek's disease virus-1 unique gene LORF1 is involved in viral replication and MDV-1/Md5-induced atrophy of the bursa of Fabricius.

Marek's disease virus (MDV), an alphaherpesvirus, causes severe immunosuppression and T cell lymphomas in chickens, known as Marek's disease (MD), an economically important poultry disease primarily controlled by vaccination. Importantly, it also serves as a comparative model for studying herpesvirus-induced tumor formation in humans. MDV encodes more than 100 genes, most of which have unknown functions.

Developmental and neurotoxic effects of dimethyl phthalate on zebrafish embryos and larvae.

Dimethyl phthalate (DMP) has been extensively utilized as a plasticizer on a global scale for many years. Its presence in the environment and its harmful effects on living organisms have raised concerns. This study aimed to examine its potential developmental neurotoxicity by utilizing zebrafish as a model.

Liverwort diversity in China: spatial and taxonomic patterns on species richness.

The diversity of liverworts in China is rich. It is of great significance to study the species distribution pattern of liverworts in China for the protection of liverworts diversity, flora research and biodiversity monitoring. On the basis of records from national and provincial liverwort lists, herbaria and online databases, a dataset of liverwort distributions was created to analyze the geographical distribution patterns of liverwort species diversity in China.

Folic acid mitigates the developmental and neurotoxic effects of bisphenol A in zebrafish by inhibiting the oxidative stress/JNK signaling pathway.

Bisphenol A (BPA) is a widespread environmental endocrine disruptor (EED) that can cause various environmental and health issues by inducing oxidative stress. The c-Jun N-terminal kinase (JNK) signaling pathway plays a crucial role in oxidative stress-mediated cellular damage. Although folic acid (FA) has demonstrated antioxidant properties, its potential protective effects against BPA-induced developmental and neurotoxicity, as well as the mechanisms involved in the JNK signaling pathway, are still not completely understood.

Current Status of Liverwort Herbaria Specimens and Geographical Distribution in China.

Specimen data play a crucial role in geographical distribution research. In this study, the collection information of liverwort specimens in China was compiled and analyzed to investigate the history, current status, and limitations of liverwort research in China. By utilizing the latest systematic research findings and corresponding environmental data, a niche model was developed to offer theoretical support for exploring the potential geographical distribution and diversity of liverwort resources.

Physiological effects of field concentrations and sublethal concentrations of sulfoxaflor on Apis mellifera.

Background: Bees (Apis mellifera), as important pollinators of agricultural crops, are at risk when pesticides are used. Sulfoxaflor is a new insecticide which acts on the nicotinic acetylcholine receptor (nAChR) in a similar way to neonicotinoids. The goal of this study is to evaluate the toxicity of sulfoxaflor and its effect on the A.

Response to Climate Change and GAP Analysis of Nakai.

Due to global warming and increased human activity, the wild population of Nakai () has dropped, placing it in danger. An understanding of the response of to climate change and the determination of priority conservation areas are tremendously critical for proper conservation. Using sixty-nine distribution points and seven environmental factors, the Maxent model was used to predict potentially suitable areas and spatial variation patterns of and the Marxan conservation planning model was used to evaluate conservation gap areas.

A key ABA biosynthetic gene is a positive regulator in resistance to in .

The gene encoding 9-cis-epoxycarotenoid dioxygenase 3 () functions in abscisic acid (ABA) biosynthesis, plant growth and development, and tolerance to adverse temperatures, drought and saline conditions. In this study, three rice lines were used to explore the function of , these included an OsNCED3-overexpressing line (), a knockdown line () and wild-type rice (WT). These rice lines were infested with the brown plant hopper (BPH; ) and examined for physiological and biochemical changes, hormone content, and defense gene expression.

Efficacy and Safety of DPP-4 Inhibitors and Metformin Combinations in Type 2 Diabetes: A Systematic Literature Review and Network Meta-Analysis.

Objective: Several oral antidiabetic regimens are available for treating type 2 diabetes mellitus (T2DM), dipeptidyl peptidase-4 inhibitors (DPP4i) being one of them. We conducted a network meta-analysis (NMA) comparing DPP4i plus metformin (Met) combination with other Met-based oral antidiabetic drug (OAD) combinations used in treating patients with T2DM.

Methods: We searched PubMed and Embase from inception until 19th April, 2022 for phase II and phase III trials in patients with T2DM on Met-based traditional OADs.

CNOT7 regulates lipid deposition in nonalcoholic fatty liver disease.

Background: In recent years, the incidence rate of nonalcoholic fatty liver disease (NAFLD) has ascended with the increasing number of metabolic diseases such as obesity and diabetes, which will bring great medical burden to society. At present, multiple scientific experiments have found that the CCR4-NOT complex can participate in regulating obesity and energy metabolism. This study is designed to explore the role and mechanism of CCR4-NOT transcription complex subunit 7 (CNOT7), a subunit of the CCR4-NOT complex in liver lipid deposition.

[Expansion of the genotypic and phenotypic spectrum and treatment of four children with Steroid-resistant nephrotic syndrome due to variants of TRPC6 gene].

Objective: To summarize the clinical and genetic characteristics, treatment and prognosis of four children with Steroid-resistant nephrotic syndrome (SRNS) due to variants of TRPC6 gene.

Methods: Clinical data of four children with SRNS admitted to Children's Hospital Affiliated to Zhengzhou University between May 2020 and August 2022 were collected. Peripheral blood samples were collected from the children and their parents, and whole exome sequencing was carried out.

Exogenous ABA promotes resistance to Sitobion avenae (Fabricius) in rice seedlings.

Background: Over the course of evolution, plants have developed various sophisticated defense mechanisms to resist pests and diseases. The phytohormone abscisic acid (ABA) has an important role in the growth and development of plants and confers tolerance to selected abiotic stressors, such as drought. Previous studies have shown that ABA promotes the deposit of callose in response to piercing/sucking insect pests.

[ genotypes and clinical characteristics of children with Alport syndrome].

Objectives: To investigate the genotypes of the pathogenic gene and the characteristics of clinical phenotypes in children with Alport syndrome (AS).

Methods: A retrospective analysis was performed for the genetic testing results and clinical data of 19 AS children with gene mutations.

Results: Among the 19 children with AS caused by gene mutations, 1 (5%) carried a new mutation of the gene, i.

Diagnosis, treatment and genetic analysis of 11β -hydroxylase deficiency caused by gene mutation.

Congenital adrenal hyperplasia (CAH) is an autosomal recessive hereditary disease, and the 11β- hydroxylase deficiency is the second most common syndrome in different types of CAH. The occurrence of 11β- hydroxylase deficiency is related to the mutation of gene on human autosome 8. In this report, we detected the gene mutation sites of a 14-year-old patient with 11β-hydroxylase deficiency by whole exon sequencing (WES), verified the suspected mutation by Sanger sequencing, and analyzed its characteristics.

Transcriptome profiling in rice reveals a positive role for OsNCED3 in defense against the brown planthopper, Nilaparvata lugens.

9-cis-epoxycarotenoid dioxygenase (NCED) is the rate-limiting enzyme for abscisic acid (ABA) biosynthesis in higher plants. In rice, OsNCED3 was shown to promote ABA synthesis, and improve abiotic stress tolerance, but the function of OsNCED3 in regulating rice defense against the brown planthopper (Nilaparvata lugens; BPH) has been unclear. In this study, several parameters were used to assess rice resistance to BPH, including the average injury level, the functional plant loss index, and electrical penetration graph analysis.

Transcriptome Analysis Reveals Crosstalk between the Abscisic Acid and Jasmonic Acid Signaling Pathways in Rice-Mediated Defense against .

The brown planthopper (BPH) impacts both rice yield and quality. The exogenous application of abscisic acid (ABA) and jasmonic acid (JA) has been previously shown to induce rice resistance to BPH; however, the regulation of rice-mediated defense by these plant growth regulators is unclear. We applied exogenous JA and ABA to rice and analyzed molecular responses to BPH infestation.