ILA mitigates HFD-induced metabolic dysfunction via lipid-immune crosstalk and gut microbiota modulation in zebrafish.

High-fat-induced metabolic syndrome poses many challenges to fish farming. In our previous study, we found that probiotic Akkermansia muciniphila can increase the tryptophan microbiota metabolite indole-3-lactic acid (ILA). Therefore, this study further investigates the effect of ILA on resisting HFD-induced metabolic disorders and preliminarily explores its mechanism in zebrafish.

Surface display of Nocardia seriolae HRP1 on Bacillus subtilis and its application as live vaccine for largemouth bass.

Micropterus salmoides, adaptable and fast-growing, is a major farmed fish in China. Intensive farming causes multiple diseases, especially hard-to-treat nocardiosis. Vaccines are an effective and safe prevention and control strategy against fish diseases.

Whole-genome sequencing of coexisting bla, bla, and mcr-9.1 in a clinical carbapenem-resistant Citrobacter braakii isolate.

Objective: We aimed to characterize the molecular characteristics and clinical features of carbapenem-resistant Citrobacter braakii carrying bla, bla, and mcr-9.1 using whole-genome sequencing.

Methods: The susceptibility of C.

Whole Genome Sequencing of SSK and Its Characterization for Degradation of Inhibitors from Lignocellulosic Biomass.

Lignocellulosic biomass is widely recognized as a renewable resource for bioconversion. However, the presence of inhibitors such as furfural, 5-HMF, and acetic acid can inhibit cell growth, thereby affecting the overall efficiency of the bioconversion process. The studies on the degradation of lignocellulosic hydrolysate inhibitors by have been limited.

Single cell protein production of co-culture Kodamaea ohmeri and Lactococcus lactis in corn straw hydrolysate.

With the world population continuously increasing, the protein demand will double by 2050. Single cell protein (SCP) derived from lignocellulosic biomass offers a sustainable solution. Many inhibitors are produced during the pretreatment process of lignocellulosic biomass.

Development of 3D Cell-Based Fluorescent Reporter Assay for Screening of Drugs Downregulating Telomerase Reverse Transcriptase.

A fluorescent cell-based assay was developed for the screening of chemicals repressing the expression of human telomerase reverse transcriptase (hTERT). hTERT is reactivated during carcinogenesis and is overexpressed in more than 90% of cancers but is almost silent in normal tissue cells. Because of its critical role in cancer, hTERT is a target in various therapeutic strategies for cancer treatment.

Genome mining of an endophytic natural yeast isolate Rhodotorula sp. Y090 and production of the potent antioxidant ergothioneine.

Endophytic yeast strains are promising sources of various valuable bioactive compounds. However, studies on endophytic strains derived from lichen samples remain limited. In this study, we isolated and characterized Rhodotorula sp.

Membrane transport engineering for efficient yeast biomanufacturing.

Yeast strains have been widely recognized as useful cell factories for biomanufacturing. To improve production efficiency, their biosynthetic pathways and regulatory strategies have been continuously optimized. However, commercial production using yeasts is still limited by low product yield and high production cost.

The role of magnesium in cardiac arrest.

Cardiac arrest is a leading cause of death globally. Only 25.8% of in-hospital and 33.

Scalable deep learning framework for sentiment analysis prediction for online movie reviews.

Sentiment analysis has broad use in diverse real-world contexts, particularly in the online movie industry and other e-commerce platforms. The main objective of our work is to examine the word information order and analyze the content of texts by exploring the hidden meanings of words in online movie text reviews. This study presents an enhanced method of representing text and computationally feasible deep learning models, namely the PEW-MCAB model.

Camelus knoblochi genome reveals the complex evolutionary history of Old World camels.

Extant Old World camels (genus Camelus) contributed to the economic and cultural exchanges between the East and West for thousands of years. Although many remains have been unearthed, we know neither whether the prevalent hybridization observed between extant Camelus species also occurred between extinct lineages and the ancestors of extant Camelus species nor why some populations became extinct while others survived. To investigate these questions, we generated paleogenomic and stable isotope data from an extinct two-humped camel species, Camelus knoblochi.

Transcriptome analysis of Kluyveromyces marxianus under succinic acid stress and development of robust strains.

Kluyveromyces marxianus has become an attractive non-conventional yeast cell factory due to its advantageous properties such as high thermal tolerance and rapid growth. Succinic acid (SA) is an important platform molecule that has been applied in various industries such as food, material, cosmetics, and pharmaceuticals. SA bioproduction may be compromised by its toxicity.

Novel Roles of the Greatwall Kinase Rim15 in Yeast Oxidative Stress Tolerance through Mediating Antioxidant Systems and Transcriptional Regulation.

The Greatwall-family protein kinase Rim15 is associated with the nutrient starvation response, whereas its role in oxidative stress responses remains unclear. Here, acetic acid and peroxide were used as two oxidative stress elicitors. The antioxidant indicator assay under acetic acid stress revealed the impaired growth in Δ related to the regulation of antioxidant systems.

Editorial for the Special Issue, 'Secondary Metabolites from Microorganisms or Microorganism-Host Interaction?'.

In this Special Issue, there are 13 published papers from over 10 countries [...

Regulatory Effects of , , and Extract Formulation on Gut Microbiota and Fecal Metabolomics in Mice.

The bioactivities of , , and have been extensively studied and documented. However, the effects of their complexes on the structural properties of intestinal microbiota and fecal metabolism remain unclear. Therefore, this paper aims to present a preliminary study to shed light on this aspect.

Engineering yeast cell factories to produce biodegradable plastics and their monomers: Current status and prospects.

Traditional plastic products have caused serious environmental pollution due to difficulty to be degraded in the natural environment. In the recent years, biodegradable plastics are receiving increasing attention due to advantages in natural degradability and environmental friendliness. Biodegradable plastics have potential to be used in food, agriculture, industry, medicine and other fields.

Amentoflavone attenuates cell proliferation and induces ferroptosis in human gastric cancer by miR-496/ATF2 axis.

Amentoflavone (AF) is a natural multifunctional biflavonoid that has been revealed to possess multiple biological activities, including anticancer activity. Here, this work focused on exploring the functions and mechanism of AF in gastric cancer (GC). Levels of genes and proteins were examined by quantitative real-time PCR and western blotting.

[Advances on the production of organic acids by yeast].

Organic acids are organic compounds that can be synthesized using biological systems. They often contain one or more low molecular weight acidic groups, such as carboxyl group and sulphonic group. Organic acids are widely used in food, agriculture, medicine, bio-based materials industry and other fields.

Effectiveness and safety of mono-anlotinib mono therapy or in combination with chemotherapy in platinum-resistant recurrent ovarian cancer: a single-center retrospective study.

Objective: To evaluate the clinical efficacy of mono-anlotinib therapy by itself or in combination with chemotherapy in platinum-resistant recurrent ovarian cancer (PROC).

Methods: The clinical data of 35 patients with platinum-resistant recurrent ovarian cancer admitted to the First Affiliated Hospital of Anhui Medical University from March 2019 to July 2020 were retrospectively analyzed. All the patients received anlotinib mono- or combined chemotherapy.

Effects of fermented feed of on growth performance, oxidative stress, immunity and gastrointestinal microflora of Boer goats under thermal stress.

Introduction: This study was conducted to evaluate the effects of fermented feed of () on growth performance, oxidative stress, immunity and gastrointestinal microflora of Boer goats under thermal stress.

Methods: The study was conducted during 45 days using twenty 2 months Boer goats. The goats were randomly allocated into two groups: NPG ( = 10; normal ) and FPG ( = 10; fermented feed of ), and the ratio of concentrates to roughage was 3:2.

Automatic Registration of Homogeneous and Cross-Source TomoSAR Point Clouds in Urban Areas.

Building reconstruction using high-resolution satellite-based synthetic SAR tomography (TomoSAR) is of great importance in urban planning and city modeling applications. However, since the imaging mode of SAR is side-by-side, the TomoSAR point cloud of a single orbit cannot achieve a complete observation of buildings. It is difficult for existing methods to extract the same features, as well as to use the overlap rate to achieve the alignment of the homologous TomoSAR point cloud and the cross-source TomoSAR point cloud.

Analysis of Interpolation Methods in the Validation of Backscattering Coefficient Products.

Validation is the basis of synthetic aperture radar (SAR) image quantification applications. Based on the point target of the field site, the radiation characteristics of the backscattering coefficient image can be used to optimize the SAR imaging, and the product production system can be more closely targeted, to ensure the image product accuracy in the actual quantification application. In this study, the validation of the backscattering coefficient image was examined using calibrators, and the radiometric properties of the image were evaluated by extracting the radar cross-section of each point target.