Potential regulatory mechanism of overexpression of phosphatidylinositol glycan anchor biosynthesis class U on the glycolytic pathway in hepatocellular carcinoma.

Objective: To explore the potential molecular regulatory mechanisms of phosphatidylinositol glycan anchor biosynthesis class U (PIGU) in glycolysis in hepatocellular carcinoma (HCC).

Methods: This study initially employed public databases of global bulk RNA (including multi-center microarray and bulk RNA sequencing), in-house immunohistochemistry (IHC), proteomics, and single-cell RNA sequencing (scRNA-seq) to detect the comprehensive overexpression of PIGU in HCC. Combined with CRISPR knockout screen analysis, the impact of knocking out PIGU on HCC cell lines was assessed.

Whole Genome Sequencing of SSK and Its Characterization for Degradation of Inhibitors from Lignocellulosic Biomass.

Lignocellulosic biomass is widely recognized as a renewable resource for bioconversion. However, the presence of inhibitors such as furfural, 5-HMF, and acetic acid can inhibit cell growth, thereby affecting the overall efficiency of the bioconversion process. The studies on the degradation of lignocellulosic hydrolysate inhibitors by have been limited.

How has the field of immunogenic cell death in breast cancer evolved and impacted clinical practice over the past eleven years?

This study elucidates the research landscape of immunogenic cell death (ICD) in breast cancer through a bibliometric analysis of 457 Web of Science articles. Contributions from China and the USA are particularly prominent, with notable international collaborations. Core journals such as published influential studies, while researchers like Huang Y made impactful contributions.

Current Status and Future Directions of Ferroptosis Research in Breast Cancer: Bibliometric Analysis.

Background: Ferroptosis, as a novel modality of cell death, holds significant potential in elucidating the pathogenesis and advancing therapeutic strategies for breast cancer.

Objective: This study aims to comprehensively analyze current ferroptosis research and future trends, guiding breast cancer research advancements and innovative treatment strategies.

Methods: This research used the R package Bibliometrix (Department of Economic and Statistical Sciences at the University of Naples Federico II), VOSviewer (Centre for Science and Technology Studies at Leiden University), and CiteSpace (Drexel University's College of Information Science and Technology), to conduct a bibliometric analysis of 387 papers on breast cancer and ferroptosis from the Web of Science Core Collection.

Nitidine chloride inhibits the progression of hepatocellular carcinoma by suppressing IGF2BP3 and modulates metabolic pathways in an mA-dependent manner.

Background: Hepatocellular carcinoma (HCC) stands as a major health concern due to its significant morbidity and mortality. Among potential botanical therapeutics, nitidine chloride (NC) has garnered attention for its potential anti-HCC properties. However, the underlying mechanisms, especially the possible involvement of the mA pathway, remain to be elucidated.