An introduction to the Item Response Warehouse (IRW): A resource for enhancing data usage in psychometrics.

The Item Response Warehouse (IRW) is a collection and standardization of a large volume of item response datasets in a free and open-source platform for researchers. We describe key elements of the data standardization process and provide a brief description of the over 900 datasets in the current iteration of the IRW (version 28.2).

Triboelectric separation technology for recycling end-of-life wind turbine blades.

This study investigates the application of triboelectric separation technology for the efficient recovery of glass fibre-reinforced polymers (GFRPs) from wind turbine blade. Through systematic experiments, the effects of friction materials, electrode voltage and feed rate on separation efficiency were evaluated. The results demonstrate that using polymethyl methacrylate as the friction material, with an electrode voltage of 12.

CDK8 Inhibition Releases the Muscle Differentiation Block in Fusion-driven Alveolar Rhabdomyosarcoma.

Alveolar rhabdomyosarcoma (aRMS) is a fusion-driven pediatric cancer with poor survival and limited therapeutic options. To uncover novel vulnerabilities, we employed complex-based analysis of the DepMap functional genomic data, identifying CDK8 as a dependency in aRMS. Both knockout and pharmacologic inhibition impaired tumor cell growth and induced myogenic differentiation and .

Association between high-sensitivity C-reactive protein, cystatin C and all-cause mortality in middle-aged and elderly participants with sarcopenia.

Background: High-sensitivity C-reactive protein (hs-CRP) and cystatin C (CysC), which associate with prognosis, are widely used indicators for inflammation and kidney function respectively in clinical practice.

Aims: This study aims to determine whether elevated hs-CRP and CysC concentrations are associated with all-cause mortality in middle-aged and elderly participants with sarcopenia.

Methods: This was a retrospective study which included 612 individuals with sarcopenia from a Chinese cohort.

Dialdehyde carboxymethyl cellulose and polyvinyl alcohol based hydrogel dressing via dual dynamic bonds with self-adaptive, hemostatic, and antibacterial activity for wound healing.

The poor mechanical properties and rigid structures of conventional hydrogel wound dressings often hinder their complete adherence to the wound surface, particularly in areas with frequent joint movement and stretching. Moreover, wounds exposed to ambient environments are susceptible to bacterial infections. To develop hydrogel wound dressing that possessed adaptive and antibacterial properties for promoting wound healing, we construct a series of double-network hydrogels (PDSR hydrogel) with polyvinyl alcohol (PVA), dialdehyde sodium carboxymethyl cellulose (DCMC), and silk fibroin (SF) as the matrix, which introduced Rhein as antibacterial agent and incorporation of borate ester bonds and dynamic Schiff base bonds to endow the hydrogel with excellent antibacterial property and adaptability.

Analysis and comparison of the trends in burden of atrial fibrillation/atrial flutter in China and worldwide from 1990 to 2021 and predictions to 2036 of China.

Background: It is essential to analyze the burden, trends, and inequalities of atrial fibrillation/flutter (AF/AFL) in China and to predict future trends, with the aim of raising awareness about risk factors and exploring strategies to control the significant disease burden.

Methods: Data pertaining to AF/AFL were extracted from the comprehensive dataset of the Global Burden of Disease, Injuries, and Risk Factors Study 2021 (GBD 2021). Furthermore, we analyzed the epidemiological characteristics of AF/AFL and compared them to global prevalence trends, employing joinpoint regression, decomposition, age-period-cohort (apc), and cross-country inequality analysis methods.

Discovery of non-covalent rhinovirus 3Cpro inhibitors by molecular docking, assays, molecular dynamics simulations and DFT analyses.

Human rhinovirus 14 (HRV-14) is a leading cause of the common cold, with its 3C protease (3Cpro) playing a crucial role in viral replication by cleaving polyproteins into functional proteins and enzymes. This makes 3Cpro a promising target for therapeutic intervention. In this study, to identify novel HRV-14 3Cpro non-covalent inhibitors, we performed a virtual screening of the TopScience and TargetMol (United States) database and selected 44 potential compounds for HRV-14 3Cpro inhibitory activity evaluation.

Study on the Quality Change and Regulation Mechanism of 'Shannongsu' Pear Under Low-Temperature Storage.

'Shannongsu' pear is a new high-quality cultivar. To ascertain the storage characteristics of 'Shannongsu' pears at low temperatures (0 ± 0.5 °C), the following parameters were determined: fruit firmness, ethylene, aromatic compounds, sugar content, acidity, ascorbic acid, and the expression levels of ethylene-related genes and texture-softening genes.

Analysis of the Abnormal Characteristics of Alveolar Sounds in Postoperative Palatoplasty Patients and Rehabilitation Methods.

The aim of this study was to analyze and compare the error types of alveolar sounds /s/, /ts'/, and /ts/ (ie, fricative and affricate sounds) in different ethnic groups (Han, Uyghur, Kazakh) after palatoplasty. The goal was to provide a basis for clinical assessment and effective intervention. A total of 68 patients who had undergone palatoplasty in our hospital's maxillofacial surgery department were retrospectively selected; all presented with alveolar sound abnormalities.

Pyridoxine dehydrogenase SePdx regulates photosynthesis via an association with the phycobilisome in a cyanobacterium.

Vitamin B6 (VitB6) deficiency is known to have a deleterious effect on photosynthesis, although the precise mechanism remains unclear. Pyridoxine dehydrogenase is a key protein involved in VitB6 biosynthesis, which facilitates the reversible reduction of pyridoxal (PL) and the oxidation of pyridoxine (PN), thereby contributing to VitB6 production. This study demonstrated the enzymatic activity of a pyridoxine dehydrogenase, SePdx, from the cyanobacterium Synechococcus elongatus PCC 7942 in the oxidation of PN.

Influence maximization in multilayer networks based on adaptive coupling degree.

Influence maximization (IM) aims to identify highly influential nodes to maximize influence spread in a network. Previous research on the IM problem has mainly concentrated on single-layer networks, disregarding the comprehension of the coupling structure that is inherent in multilayer networks. To solve the IM problem in multilayer networks, we first propose an independent cascade model (MIC) in a multilayer network where propagation occurs simultaneously across different layers.

Discovery of novel inhibitors of dengue viral RNA-dependent RNA polymerase by molecular docking, in vitro assay, DFT, and MD simulations.

Dengue virus (DENV) is a significant significant mosquito-borne pathogen. Its RNA-dependent RNA polymerase (RdRp) plays a crucial role in viral replication, making it a critical target for antiviral drug development. The goal of this study was to identify potential inhibitors of the DENV RdRp through virtual screening and experimental assays.

Hydroxypropyl methylcellulose reinforced collagen/PVA composite hydrogel wound dressing with self-adaptive, hemostasis and antibacterial ability for wound healing.

Nowadays, hydrogels have been extensively and increasingly applied in the field of wound dressings in terms of their high biocompatibility and adjustable functionality. Bacterial infection can serious hinder wound healing the incomplete contact between hydrogel and wound increased the risk of infection. Thus, hydrogel wound dressings with antibacterial and can self-adapt to wound are urgently desired and still a challenge.

Identification of novel inhibitors of dengue viral NS5 RNA-dependent RNA polymerase through molecular docking, biological activity evaluation and molecular dynamics simulations.

The DENV-NS5 RNA-dependent RNA polymerase (RdRp) is essential for viral replication, and one of the targets of anti-virus. In this study, the Uni-VSW module was used to virtual screen 1.6 million compounds in the ChemDiv and TargetMol (USA) database, 27 candidates were obtained.

C-phycocyanin and quaternized chitosan based antibiotic-free hydrogels with antioxidant and antibacterial activity for wound healing.

Hydrogels with antioxidant and antibacterial activities have received increasing attention in wound healing due to excessive reactive oxygen species (ROS) and bacterial infection are common issues associated with wounds. Herein, we constructed a series of hydrogels with C-phycocyanin (C-PC), quaternized chitosan (QCS) and silk fibroin protein (SF) as matrixes, which with tetrakis hydroxymethyl phosphonium sulfate (THPS) as crosslinking agent to form dynamic covalent bonds with C-PC and SF. The hydrogel exhibited excellent stretchability and compressibility, which with adhesion strength reached 15 ± 3 kPa and rapid self-healing properties.

Jointly modeling responses and omitted items by a competing risk model: A survival analysis approach.

Item response theory models are commonly adopted in educational assessment and psychological measurement. Such models need to be modified to accommodate practical situations when statistical sampling assumptions are violated. Omission is a common phenomenon in educational testing.

Acute hyperglycemia impedes spinal cord injury recovery via triggering excessive ferroptosis of endothelial cells.

Spinal cord injury (SCI) is a serious central nervous system injury that often causes sensory and motor dysfunction in patients. Diabetes seriously destroys the blood spinal cord barrier (BSCB) and aggravates SCI. Ferroptosis is a new type of programmed cell death.

Cold-active β-galactosidase from Weissella confusa SW1 for the preparation of low-lactose milk.

β-Galactosidases can be used to degrade lactose in milk to prepare lactose-free milk, which is sweeter than ordinary milk and suitable for people with lactose intolerance. The β-galactosidase gene (WcGal2809) was cloned from Weissella confusa SW1 and successfully expressed in Escherichia coli BL21(DE3). The active WcGal2809 was identified to be a heterodimer composed of two distinct proteins LacL (72.

Lactobacillus reuteri metabolites alleviate apple replant disease (ARD) by driving beneficial bacteria to reshape the core root microbiome.

Previous studies have shown that the bacterial fertilizer Lactobacillus reuteri (LBR) significantly alleviates apple replant disease (ARD), but the mechanism behind its effectiveness remains unclear. This study investigated the effects of key LBR metabolites on the rhizosphere microbial community. The biocontrol function of extracellular polysaccharides (EPS) was examined and shown to be further enhanced after optimizing the fermentation conditions.

Identification of novel SARS-CoV-2 3CLpro inhibitors by molecular docking, assays, molecular dynamics simulations and DFT analyses.

Introduction: SARS-CoV-2 pandemic has presented a significant threat to global health and the economy, necessitating urgent efforts to develop effective antiviral drugs. The main protease (3CLpro) of SARS-CoV-2 is a critical target for antiviral therapy due to its essential role in viral replication.

Methods: In order to find new structural types of 3CLpro inhibitors to facilitate the solution to the problem of new virus resistance.

MCMC stopping rules in latent variable modelling.

Bayesian analysis relies heavily on the Markov chain Monte Carlo (MCMC) algorithm to obtain random samples from posterior distributions. In this study, we compare the performance of MCMC stopping rules and provide a guideline for determining the termination point of the MCMC algorithm in latent variable models. In simulation studies, we examine the performance of four different MCMC stopping rules: potential scale reduction factor (PSRF), fixed-width stopping rule, Geweke's diagnostic, and effective sample size.

mediates aroma volatiles accumulation by activating MdLOX1a in apple.

Fruit aroma is an important organoleptic quality, which influences consumer preference and market competitiveness. Aroma compound synthesis pathways in plants have been widely identified, among the lipoxygenase pathway is crucial for fatty acid catabolism to form esters in apple. However, the regulatory mechanism of this pathway remains elusive.

Biofunctional attributes and storage study of milk fermented by Enterococcus italicus.

Lactic acid bacteria are probiotics in the intestines and have been widely used as natural antioxidants in the food industry. In this study, Enterococcus italicus FM5 with strong antioxidant ability was isolated from fresh milk. The safety evaluation showed that E.