Omics insights into LMY3-5 defense against in kiwifruit.

is the main cause of soft rot in kiwifruit, significantly reducing both yield and quality. While chemical treatments are commonly used, their effectiveness is limited and they may pose environmental risks. As a result, biological control using Bacillus species has emerged as a promising alternative.

Dialdehyde carboxymethyl cellulose and polyvinyl alcohol based hydrogel dressing via dual dynamic bonds with self-adaptive, hemostatic, and antibacterial activity for wound healing.

The poor mechanical properties and rigid structures of conventional hydrogel wound dressings often hinder their complete adherence to the wound surface, particularly in areas with frequent joint movement and stretching. Moreover, wounds exposed to ambient environments are susceptible to bacterial infections. To develop hydrogel wound dressing that possessed adaptive and antibacterial properties for promoting wound healing, we construct a series of double-network hydrogels (PDSR hydrogel) with polyvinyl alcohol (PVA), dialdehyde sodium carboxymethyl cellulose (DCMC), and silk fibroin (SF) as the matrix, which introduced Rhein as antibacterial agent and incorporation of borate ester bonds and dynamic Schiff base bonds to endow the hydrogel with excellent antibacterial property and adaptability.

Cmpk2 Protects Against Acute Lung Injury in Mice.

Purpose: Acute respiratory distress syndrome (ARDS)/Acute lung injury (ALI), characterized by severe hypoxemia and pulmonary edema, involves mitochondrial dysfunction. Cytidine/uridine monophosphate kinase 2 (Cmpk2), a mitochondrial metabolic enzyme, modulates inflammation and senescence, yet its role in ARDS remains unclear. We investigated Cmpk2's function in Pseudomonas aeruginosa (P.

LMY3-5 for the biocontrol of soft rot in kiwifruit: antifungal action and underlying mechanisms.

Soft rot caused by is a serious fungal disease in kiwifruit observed during the storage period, and it seriously restricts the healthy and stable development of the kiwifruit industry. In the present study, the bacterial strain LMY3-5 with high antifungal activity was isolated from healthy kiwifruit tissues. Based on gyrA and 16S rRNA sequences, a phylogenetic tree was constructed, and LMY3-5 was identified as .

A review of polysaccharide-based hydrogels: From structural modification to biomedical applications.

Hydrogels prepared from natural polysaccharide possess excellent biocompatibility and adjustable physical properties similar to those of natural extracellular matrices, and have thus been extensively utilized in the biomedical field. However, natural polysaccharide hydrogels have limited applications owing to their performance deficiencies. For instance, poor mechanical properties restrict their application in tissue engineering, while instability hinders their adaptation to complex and dynamic physiological environments.

Phycocyanin-based multifunctional hydrogel with self-healing, hemostatic, antioxidative, and antibacterial activity for wound healing.

Hydrogels have gained significant attentions in the field of wound dressing since their resemblance to the extracellular matrix and excellent biocompatibility. Oxidative damage and bacterial infections resulting from an accumulation of reactive oxygen species (ROS) present significant challenges for chronic non-healing wounds. To address the issues of excessive ROS and bacterial infections during the wound healing process, we utilized C-phycocyanin, gelatin and silk fibroin as matrices to fabricate multifunctional hydrogels (PRG hydrogel), with rhein introduced as an antibacterial agent and tetracaine for pain relief.

Chlorella-encapsulated living hydrogel based on gelatin and carrageenan with oxygen production, hemostatic and antibacterial capacity for promoting wound healing.

Hypoxia can prolong the healing time of wounds and oxygen delivery to the hypoxic tissue has been reported an effective strategy for promoting wound regeneration. Bacterial infections can interfere with the wound healing process, leading to poor skin regeneration and even more serious complications, which is also an urgent issue to be solved during the process of wound healing. To address the problem of delayed wound healing caused by hypoxia and bacterial infections, we fabricated a series of Chlorella-loaded hydrogels (CK) using gelatin, κ-carrageenan and I-carrageenan as matrixes, which introduced Chlorella and ampicillin conferred oxygen-producing and antimicrobial capacity to the hydrogel.

Hydroxypropyl methylcellulose reinforced collagen/PVA composite hydrogel wound dressing with self-adaptive, hemostasis and antibacterial ability for wound healing.

Nowadays, hydrogels have been extensively and increasingly applied in the field of wound dressings in terms of their high biocompatibility and adjustable functionality. Bacterial infection can serious hinder wound healing the incomplete contact between hydrogel and wound increased the risk of infection. Thus, hydrogel wound dressings with antibacterial and can self-adapt to wound are urgently desired and still a challenge.

Characteristic of volatile flavor compounds in 'Fengtangli' plum ( Lindl.) were explored based on GC×GC-TOF MS.

Introduction: The 'Fengtangli' plum ( Lindl.) is favoured by consumers for its characteristic flavor. The purpose of this study was to explore the characteristics of volatile flavor compounds in 'Fengtangli' plum.

C-phycocyanin and quaternized chitosan based antibiotic-free hydrogels with antioxidant and antibacterial activity for wound healing.

Hydrogels with antioxidant and antibacterial activities have received increasing attention in wound healing due to excessive reactive oxygen species (ROS) and bacterial infection are common issues associated with wounds. Herein, we constructed a series of hydrogels with C-phycocyanin (C-PC), quaternized chitosan (QCS) and silk fibroin protein (SF) as matrixes, which with tetrakis hydroxymethyl phosphonium sulfate (THPS) as crosslinking agent to form dynamic covalent bonds with C-PC and SF. The hydrogel exhibited excellent stretchability and compressibility, which with adhesion strength reached 15 ± 3 kPa and rapid self-healing properties.

A slime-inspired phycocyanin/κ-carrageenan-based hydrogel bandage with ultra-stretchability, self-healing, antioxidative, and antibacterial activity for wound healing.

Hydrogels have attracted extensive attention as wound dressing owing to their excellent multifunctionality, flexibility, and biocompatibility. Due to the frequent movement and stretching of skin as well as complex surface of wound, traditional wound dressings have difficulty to adapt to motion and irregular wounds. Furthermore, excessive reactive oxygen species (ROS) and bacterial infection can induce delayed wound healing.

Meningeal neutrophil immune signaling influences behavioral adaptation following threat.

Social creatures must attend to threat signals from conspecifics and respond appropriately, both behaviorally and physiologically. In this work, we show in mice a threat-sensitive immune mechanism that orchestrates psychological processes and is amenable to social modulation. Repeated encounters with socially cued threats triggered meningeal neutrophil (MN) priming preferentially in males.

Ball-milling preparation of ZnFeO/AgI nanocomposite with enhanced photocatalytic activity.

Semiconductor photocatalytic technology is increasingly being utilized in wastewater treatment due to its high efficiency, low energy consumption and environmental friendliness. However, single photocatalysts often exhibit low catalytic performance. In this study, a ZnFeO/AgI composite photocatalyst was initially prepared using a high-energy ball-milling method.

Construction and characterization of sodium alginate/polyvinyl alcohol double-network hydrogel beads with surfactant-tailored adsorption capabilities for efficient tetracycline hydrochloride removal.

The extensive use of tetracycline (TC) for disease control and the residuals in wastewater has resulted in the spread and accumulation of antibiotic resistance genes, posing a severe threat to the human health and environmental safety. To solve this problem, a series of double-network hydrogel beads based on sodium alginate and polyvinyl alcohol were constructed with the introduction of various surfactants to modulate the morphology. The results showed that the introduction of surfactants can modulate the surface morphology and internal structure, which can also regulate the adsorption ability of the hydrogel beads.

Comparison of the Safety and Efficacy of Remimazolam Besylate versus Dexmedetomidine for Patients Undergoing Fiberoptic Bronchoscopy: A Prospective, Randomized Controlled Trial.

Objective: Remimazolam besylate is a novel ultra-short-acting benzodiazepine that is rapidly hydrolyzed to zolpidem propionic acid by tissue lipases. We designed this study to compare the safety and efficacy of remimazolam besylate alfentanil versus dexmedetomidine-alfentanil for fiberoptic bronchoscopy (FB).

Methods: One hundred and twenty patients undergoing FB into this prospective randomized controlled trial were divided into two groups.

Corrigendum: Tpr deficiency disrupts erythroid maturation with impaired chromatin condensation in zebrafish embryogenesis.

[This corrects the article DOI: 10.3389/fcell.2021.

Corrigendum: Mutation of Gemin5 causes defective hematopoietic stem/progenitor cells proliferation in zebrafish embryonic hematopoiesis.

[This corrects the article DOI: 10.3389/fcell.2021.

TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry.

Coat protein complex I (COPI) vesicles mediate the retrograde transfer of cargo between Golgi cisternae and from the Golgi to the endoplasmic reticulum (ER). However, their roles in the cell cycle and proliferation are unclear. This study shows that TANGO6 associates with COPI vesicles via two transmembrane domains.

Valsartan attenuates LPS-induced ALI by modulating NF-κB and MAPK pathways.

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common respiratory disease characterized by persistent hypoxemia and an uncontrolled inflammatory response. Valsartan, an angiotensin II type 1 receptor antagonist, is clinically used to treat hypertension and has anti-inflammatory and antioxidant effects on gefitinib-induced pneumonia in rats. However, the potential therapeutic effects of valsartan on lipopolysaccharide (LPS)-induced ALI remain unclear.

TRAIL and Celastrol Combinational Treatment Suppresses Proliferation, Migration, and Invasion of Human Glioblastoma Cells via Targeting Wnt/β-catenin Signaling Pathway.

Objective: To investigate the mechanistic basis for the anti-proliferation and anti-invasion effect of tumor necrosis factor-related apoptosis-induced ligand (TRAIL) and celastrol combination treatment (TCCT) in glioblastoma cells.

Methods: Cell counting kit-8 was used to detect the effects of different concentrations of celastrol (0-16 µmol/L) and TRAIL (0-500 ng/mL) on the cell viability of glioblastoma cells. U87 cells were randomly divided into 4 groups, namely control, TRAIL (TRAIL 100 ng/mL), Cel (celastrol 0.

An overview on recent advances of reversible fluorescent probes and their biological applications.

Due to the simplicity and low detection limit, fluorescent probes are widely used in both analytical sensing and optical imaging. Compared to conventional fluorescent probes, reversibility endows the reversible fluorescent probe outstanding advantages and special properties, making reversible fluorescent probes with capable of quantitative, repetitive or circulatory. Reversible fluorescent probes can also monitor the concentration dynamics of target analytes in real time, such as metal ions, proteins and enzymes, as well as intracellular redox processes, which have been widely applied in various fields.

Identification of histone deacetylase inhibitors as neutrophil recruitment modulators in zebrafish using a chemical library screen.

Tissue injury-induced neutrophil recruitment is a prerequisite for the initiation and amplification of inflammatory responses. Although multiple proteases and enzymes involved in post-translational modification (PTM) of proteins regulate leukocyte recruitment, an unbiased functional screen of enzymes regulating inflammatory leukocyte recruitment has yet to be undertaken. Here, using a zebrafish tail fin amputation (TFA) model to screen a chemical library consisting of 295 compounds that target proteases and PTM enzymes, we identified multiple histone deacetylase (HDAC) inhibitors that modulate inflammatory neutrophil recruitment.

Multi-Responsive Afterglows from Aqueous Processable Amorphous Polysaccharide Films.

Polymer-based room-temperature phosphorescence (RTP) materials, especially polysaccharide-based RTP materials, earn sustained attention in the fields of anti-counterfeiting, data encryption, and optoelectronics owing to their green regeneration, flexibility, and transparency. However, those with both ultralong phosphorescence lifetime and excitation wavelength-dependent afterglow are rarely reported. Herein, a kind of amorphous RTP material with ultralong lifetime of up to 2.

Synthesis of AgBr/TiC@TiO ternary composite for photocatalytic dehydrogenation of 1,4-dihydropyridine and photocatalytic degradation of tetracycline hydrochloride.

In this work, AgBr/TiC@TiO ternary composite photocatalyst was prepared by a solvothermal and precipitation method with the aims of introducing TiC as a cocatalyst and TiO as a compositing semiconductor. The crystal structure, morphology, elemental state, functional groups and photoelectrochemical properties were studied by XRD, SEM, TEM, XPS, FI-IR and EIS. The photocatalytic performances of the composites were investigated by the photodehydrogenation of diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate (1,4-DHP) and the photodegradation of tetracycline hydrochloride (TCH) under visible light irradiation ( > 400 nm).

Sfxn5 Regulation of Actin Polymerization for Neutrophil Spreading Depends on a Citrate-Cholesterol-PI(4,5)P2 Pathway.

Cell spreading is an initial and critical step in neutrophil adhesion and migration, leading to neutrophil recruitment to inflammatory tissues. Sideroflexin (Sfxn) family proteins are metabolite transporters located in the mitochondrial membrane. Recombinant SFXN5 protein is a citrate transporter in vitro; however, whether Sfxn5 regulates any cellular behavior or function remains unknown.