A rare cause of diffuse alveolar hemorrhage in a pediatric patient: thigh localization of INI1-deficient epithelioid sarcoma.

Background: Diffuse alveolar hemorrhage (DAH) is a group of rare but life-threatening conditions characterized by bleeding into the alveolar spaces, often associated with various etiologies. Epithelioid sarcoma (ES) is a rare and aggressive soft tissue sarcoma that has never been reported to be associated with DAH.

Methods: We report a rare case of ES in a pediatric patient presenting with DAH and intracranial hemorrhagic lesions.

Numerical simulation and field experiment study of the supersonic gas jet subsoiler based on DEM.

To tackle the challenges of high draft resistance, limited subsoiling range, and ineffective subsoiling results in conventional subsoiling methods, this study combines the structure of an air cannon with that of a wing-type subsoiler to design a novel pneumatic blast subsoiling device. First, soil bin experiments were conducted to verify the feasibility of using the air cannon for pneumatic soil fracturing. A soil model was created in EDEM (Engineering Discrete Element Method)based on field conditions to analyze the subsoiler's force distribution, ensuring the nozzle remains undeformed and the subsoiling process runs smoothly.

The limit of droplet rebound angle.

Regulating the motion state of droplets after impacting on solid surfaces is crucial in many fields including self-cleaning, energy harvesting, and microfluidics. The rebound angle of the droplet is a key factor in determining its motion state. However, up until now, the limit of droplet rebound angle remains unidentified.

Hydrogen gas therapy: A promising approach for sepsis management post-burn injury by modulating inflammation, oxidative stress, and wound healing.

Objective: Burns refers to a severe form of trauma that often leads to localized and systemic inflammatory responses, oxidative stress, and immune dysfunction. Patients with severe burns are highly susceptible to the development of postburn sepsis, a condition influenced by multiple factors, such as bacterial infection of the burn wound, alterations in immune status, and excessive release of inflammatory mediators. This study aimed to investigate the mechanisms by which hydrogen gas treatment exerts its effects on postburn sepsis, with a focus on its influence on inflammatory responses, oxidative stress, and wound healing.

A collagenase nanogel backpack improves CAR-T cell therapy outcomes in pancreatic cancer.

Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of haematological malignancies. Challenges in overcoming physical barriers however greatly limit CAR-T cell efficacy in solid tumours. Here we show that an approach based on collagenase nanogel generally improves the outcome of T cell-based therapies, and specifically of CAR-T cell therapy.

Linear magnet with fluid-solid-switchable cells for flexible devices.

Adjusting magnetization orienting and conformal assembling of high-coercivity micro-magnets at the microscale remains challenging, despite long-standing demand for space-resolved magnetic modulation in various applications. Local magnetic modulation, including remagnetization or reassembly, typically requires high fields and temperatures to overcome the coercivity and stringent conditions while suffering from low assembly efficiency or poor spatial resolution. Here, we report a linear magnet composed of a hydrogel (alginate) matrix and precisely discrete phase-change-material (PCM, eicosane) cells containing micro-magnetic particles (NdFeB, ~5 µm).

Poly(methyl methacrylate) Nanosphere-Based Photocrosslinked Hydrogels with Ultralong Phosphorescence Lifetimes for High-Precision 3D Printing.

Hydrogel-based afterglow materials offer significant potential for broadening the application field of organic room-temperature phosphorescence (RTP) materials owing to their tissue-mimetic flexibility and superior biocompatibility. However, achieving a colorful and efficient RTP in a water-rich hydrogel environment remains challenging. Here, we present a general strategy to fabricate colorful and efficient RTP hydrogels by incorporating compact and hydrophobic nanospheres loaded with chromophores, synthesized via emulsion polymerization, into photocrosslinked hydrogels with oxygen barrier properties.

Sound-controlled fluidic processor.

Precision processing of various liquids while maintaining their purity holds immense potential for many applications. However, liquids tend to leave residues that contaminate handling tools and compromise volumetric precision, necessitating contactless strategies to prevent liquid loss. Biological and chemical samples carried by fluids can be sensitive to physical stimuli, demanding mild but effective means to preserve integrity.

Theoretical stress mechanism and structural integrity of viscoelastic propellant grains with variable Poisson's ratio.

For the propellant grain of solid rocket motors (SRMs) with circular inner surfaces, the generalized Maxwell model (GMM) and the generalized Kelvin-Voigt model (GKV) are used to characterize the relaxation properties of the grain's elastic modulus and the creep properties of Poisson's ratio, respectively. Based on the elastic-viscoelastic correspondence principle, an analytical expression for viscoelastic stress that simultaneously considers the time-dependent nature of elastic modulus and Poisson's ratio is derived. Based on this, a parametric analysis of the stress distribution in the grain under internal pressure is conducted.

A Comparative Analysis of the Clinical Application of a Novel Serum Antibody Typing Test and the C-Urea Breath Test.

: To compare and analyze the application of a (, Hp) serum antibody typing test (Hp-sATT) and the C-urea breath test (C-UBT) in the diagnosis of Hp infection against an empirical therapy background. : The detection of Hp-sATT using a combination of the quantum dot immunofluorescence method and the C-UBT was carried out in 237 patients who visited the Department of Gastroenterology at Beijing Tsinghua Changgung Hospital. The diagnostic consistency and correlation with gastric lesions of the two detection methods were analyzed by integrating the detection results, clinical information, and special staining of Hp in histopathological tissues (SS-Hp).

Metabolomic profiling of rectal microorganisms in Tibetan sheep across cold and warm seasons.

The intestinal metabolites of Tibetan sheep play a vital role in the integrated regulation of the host and the microbe-gut-brain axis. The current study sought to investigate the characteristics of alterations in rectal metabolites and their functional implications during the cold and warm seasons in Tibetan sheep. A cohort of 12 ewes, approximately 1 week ± 1 month in age, exhibiting good body condition and a similar genetic background, was selected for metabolomic analysis of rectal contents collected during the warm season (August) and the cold season (December).

Mechanism and design strategy of ice-phobic surface: A comprehensive review.

Ice accumulation on the surface can significantly impact the normal operation of industrial facilities and even lead to damage, resulting in economic losses. Modifying the physical structure and chemical state of the surface can effectively mitigate ice nucleation, growth, and adhesion processes. Building upon previous definitions of ice-phobic surfaces, this review provides a refined definition of ice-phobicity and reviews recent advancements in ice-phobic surfaces research.

Palladium-Catalyzed Dearomative Fluoroallylation of Pyrroles with -Difluorinated Cyclopropanes.

We herein report the development of a novel Pd-catalyzed dearomative functionalization of pyrroles with -difluorinated cyclopropanes (-FCPs). This dearomative/ring-opening strategy streamlines the diversity-oriented synthesis (DOS) of α-quaternary 2-fluoroallylic 2-pyrroles with a broad scope and excellent functional group tolerance, which enables the efficient late-stage transformation of complex bioactive molecule-derived -FCPs. Derivation of the resulting fluoroallylic 2-pyrroles to different synthetically useful fluoroallylic 2-pyrrole motifs demonstrated the synthetic value of this methodology.

The Diagnostic Value of Interleukin-2 and Interferon-γ Induced by Fusion Protein (ESAT-6/CFP-10/Rv1985c) for Active Mycobacterium tuberculosis Infection.

Objective: This study aimed to evaluate the diagnostic ability of interleukin 2 (IL-2) and interferon gamma (IFN-γ) release assay induced by the fusion protein (ESAT-6/CFP-10/Rv1985c) for detecting active tuberculosis (ATB) in clinically visiting patients.

Methods: A total of 970 subjects (215 in ATB group and 755 in non-ATB group) underwent both an interferon-γ release assay (IGRA) and a TB-DNA PCR assay. Using clinical diagnosis as the gold standard, both qualitative and quantitative test results for IL-2 and IFN-γ were analyzed.

Improving panicle blast resistance and fragrance in a high-quality rice variety through breeding.

Introduction: Huruan1212 (HR1212) is well-regarded for its superior eating and cooking quality in the lower reaches of the Yangtze River in China. Still, its high susceptibility to rice panicle blast and lack of fragrance have limited its further spread and utilization. and are two dominant genes known for their stable broad-spectrum resistance against rice blast fungus , while is the crucial gene that regulates rice aroma.

Protective Effects of Hydrogen Treatment Against High Glucose-Induced Oxidative Stress and Apoptosis via Inhibition of the AGEs/RAGE/NF-κB Signaling Pathway in Skin Cells.

Background: Diabetic wounds are major clinical challenges, often complicated by oxidative stress and free radical generation. Hydrogen (H2), a selective antioxidant, offers potential as a therapeutic agent for chronic diabetic wounds. However, its precise mechanisms remain underexplored.

Freiburg flap used as vaginal applicator with/without free-hand interstitial needles in three-dimensional high-dose-rate brachytherapy for vaginal stump recurrence of cervical cancer.

Purpose: To present an innovative deformable applicator that used Freiburg flap as vaginal applicator with or without free-hand interstitial needles in three-dimensional (3D) high-dose-rate (HDR) brachytherapy for vaginal stump recurrence of cervical cancer.

Material And Methods: Between September 2017 and January 2020, all patients with vaginal stump recurrence after radical hysterectomy of cervical cancer treated with vaginal stump brachytherapy using Freiburg flap as vaginal applicator with or without free-hand interstitial needles were retrospective analyzed. Characteristics related to patients and treatment modality as well as preliminary outcomes and side effects were investigated.

Hermetic hydrovoltaic cell sustained by internal water circulation.

Numerous efforts have been devoted to harvesting sustainable energy from environment. Among the promising renewable resources, ambient heat exhibits attractive prospects due to its ubiquity and inexhaustibility, and has been converted into electricity through water evaporation-induced hydrovoltaic approaches. However, current hydrovoltaic approaches function only in low-humidity environments and continuously consume water.

Electroacupuncture alleviated post-stroke cognitive impairment via the mTOR/NLRP3-mediated autophagy-inflammatory pathway.

Background: Post-stroke cognitive impairment (PSCI) severely reduces quality of life of patients with stroke. This study aimed to assess the effects of electroacupuncture (EA) on PSCI and the role of the mTOR/NLRP3-mediated autophagy-inflammatory pathway in this process.

Methods: The rat focal cerebral ischemia model was established using middle cerebral artery occlusion (MCAO).

Improved Interfacial Interactions by Core-Shell CoFeO@SiO Composites to Enhance the Ability of Corrosion Resistance and Electromagnetic Wave Absorption.

With the rapid development of science and technology, stealth and anti-corrosion activities in oceans have attracted widespread attention. This study successfully prepares CoFeO@SiO with a core-shell structure. This core-shell structure endows the CoFeO@SiO with good impedance matching and interfacial polarization.

Electroacupuncture Suppresses Oxidative Stress and Ferroptosis by Activating the mTOR/SREBP1 Pathway in Ischemic Stroke.

Ischemic stroke (IS) is one of the leading causes of death and disability worldwide. Electroacupuncture (EA) has been shown to exert a neuroprotective effect in IS. However, its specific anti-IS mechanisms remain to be fully elucidated.

High Ion-Conducting PVA Nanocomposite Hydrogel-Based Wearable Piezoelectric and Triboelectric Sensors for Harsh Environments.

Traditional hydrogel-based wearable sensors with flexibility, biocompatibility, and mechanical compliance exhibit potential applications in flexible wearable electronics. However, the low sensitivity and poor environmental resistance of traditional hydrogels severely limit their practical application. Herein, high-ion-conducting poly(vinyl alcohol) (PVA) nanocomposite hydrogels were fabricated and applied for harsh environments.

Active Dynamic Weighting for multi-domain adaptation.

Multi-source unsupervised domain adaptation aims to transfer knowledge from multiple labeled source domains to an unlabeled target domain. Existing methods either seek a mixture of distributions across various domains or combine multiple single-source models for weighted fusion in the decision process, with little insight into the distributional discrepancy between different source domains and the target domain. Considering the discrepancies in global and local feature distributions between different domains and the complexity of obtaining category boundaries across domains, this paper proposes a novel Active Dynamic Weighting (ADW) for multi-source domain adaptation.