Selective inhibition of ERO1α with M6766, a novel small-molecule inhibitor, prevents arterial thrombosis and ischemic stroke in mice.

Using endoplasmic reticulum oxidoreductase 1α (ERO1α) conditional knockout (CKO) mice, a recent study underscores the crucial role of ERO1α in platelet activation under thrombotic conditions. Through a high-throughput screen of 39,901 compounds, we identify M6766 as a selective inhibitor of ERO1α with an IC of 1.4 μM and a K of 1.

Failure analysis of 3Cr oil pipe body fracture.

With the green and low-carbon development of oilfield, more and more repaired oil tube is used as oil and gas transportation pipeline, but there is a difference between the manufacturing and repairing standard of oil tube, and some problems inevitably occur in the use process. In this paper, we studied a 3Cr repaired oil tube body fracture accident that occurred in an oilfield oil and gas well. In order to determine the reason for the repaired oil tube fracture, macro-morphological analysis, magnetic particle detection, chemical composition analysis, mechanical properties analysis, metallographic analysis, scanning electron microscopy (SEM), energy spectrum analysis and corrosion product XRD analysis were used to analyze the repaired oil tube body.

Gut microbiota links to histological damage in chronic HBV infection patients and aggravates fibrosis via fecal microbiota transplantation in mice.

Gut microbiota dysbiosis has been observed in HBV-related cirrhosis, but its role in early-stage disease and its correlation with liver pathology remain unclear. Moreover, whether dysbiosis is a cause or consequence of liver cirrhosis is still debated. We recruited 20 treatment-naïve patients with chronic HBV infection, assessing liver injury via biopsy.

Synthesis and biological evaluation of Sulforaphane derivatives with dual functions: Ischemia-reperfusion injury protection and antitumor effects.

Reperfusion therapy for the treatment of acute myocardial infarction (AMI) often leads to ischemia-reperfusion (I/R) injuries, characterized by excessive ROS. Sulforaphane (SFN) homologous, known for their anti-inflammatory and antioxidant properties, activate the nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway and reduce mitochondrial ROS but are limited by poor stability and short half-life. SFN derivatives were synthesized through structural modifications of the dithiocarbamate and thiourea moieties at the isothiocyanate group, aiming to enhance stability and maintain therapeutic efficacy.

SLAMF7-mediated macrophage polarization dysregulation: A novel mechanism in pneumonia.

Background: Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Despite advances in antibiotic therapy, treatment outcomes remain suboptimal due to increased pathogen resistance and dysregulated host immune responses. Macrophage polarization plays a crucial role in pulmonary inflammation, and its dysregulation can lead to uncontrolled inflammatory responses.

Long-term dynamics and driving mechanisms of plant communities in a temperate estuary in eastern China based on pollen analysis: a case study of the Liaohe Estuary.

Introduction: The Liaohe Estuary, a representative estuarine ecosystem in eastern China, has experienced significant shifts in plant community characteristics due to climate change and anthropogenic influences in recent decades.

Methods: This study employed sediment 210Pb dating, pollen analysis, and environmental factor indicators to comprehensively assess the composition, trends, and drivers of plant communities in the Liaohe Estuary from 1944 to 2022.

Results: The findings revealed that herbaceous plants dominated the estuary's vegetation under a cool and humid climate, though humidity exhibited a declining trend over time.

Genome-wide characterization of AhBAG genes in peanut reveals their role in bacterial wilt resistance and hormone response.

Background: The BAG gene family, encoding Bcl-2-associated anti-apoptotic proteins, plays pivotal roles in regulating plant growth, development, and stress responses. Peanut (Arachis hypogaea L.), a globally significant oilseed and cash crop, is highly valued for its economic importance.

Smart gel polymer electrolytes enlightening high safety and long life sodium ion batteries.

The overall performance of sodium-ion batteries, particularly regarding safety and cycle life, remains below expectations due to severe degradation of electrode materials and the electrode/electrolyte interphase. Herein, we develop a smart gel polymer electrolyte for hard carbon||NaNiFeMnO batteries through the in situ radical polymerization of a cyanoethylurea-containing methacrylate monomer and an isocyanate-based methacrylate monomer in conventional NaPF-carbonate-based electrolytes. We demonstrate that the smart gel polymer electrolyte facilitates the formation of robust electrode/electrolyte interphase layers, thus improving the thermal and chem-electrochemical stability of the electrodes.

Effects of low temperature on rhizosphere phosphate-mineralizing microbial populations in constructed wetlands.

In constructed wetlands (CWs), the rhizosphere acts as a critical zone for phosphorus (P) mineralization and the sustenance of microbial activity. However, low temperatures can significantly inhibit microbial processes and enzyme activities, particularly phosphatase activities that are crucial for P mineralization. Despite this, the impact of low temperatures on phosphorus-related phosphatase activities and the composition and function of microbial communities during the winter is not fully comprehended.

Gut microbiota and short-chain fatty acids signatures in postmenopausal osteoporosis patients: A retrospective study.

Studies have shown that gut microbiota (GM) and its metabolites, short-chain fatty acids (SCFAs), are associated with the development of postmenopausal osteoporosis (PMO). This study explored the clinical and laboratory evidence of the relationship of GM and SCFAs to PMO and attempted to determine the potential mechanism of action. 18 patients (Collected from the First Affiliated Hospital of Guangdong Pharmaceutical University between January 2021 and August 2021) were included in this retrospective study, including 10 PMO women and 8 healthy young women as the healthy control (HC) group from Guangzhou, China.

A 34-Year-Old Man With Fragile Vessels and Recurrent Hemoptysis.

A 34-year-old man who did not use tobacco complained of hemoptysis with a small volume, severe dry cough, and low-grade fever for 5 months. He denied dyspnea, chest pain, night sweats, or weight loss. Chest CT scanning showed nodules with a cavity in the lower left lung.

Synthesis and in vitro evaluation of novel compounds and discovery of a promising iodine-125 radioligand for purinergic P2X7 receptor (P2X7R).

The purinergic P2X ligand-gated ion channel 7 receptor (P2X7R) plays a critical role in various inflammatory processes and other diseases. Fast determination of compounds P2X7R binding potency and discovery of a promise PET radiotracer for imaging P2X7R require a P2X7R suitable radioligand for radioactive competitive binding assay. Herein, we designed and synthesized thirteen new P2X7R ligands and determined the in vitro binding potency.

SHIP-1 regulates the differentiation and function of Tregs via inhibiting mTORC1 activity.

Cell metabolism is crucial for orchestrating the differentiation and function of regulatory T cells (Tregs). However, the underlying mechanism that coordinates cell metabolism to regulate Treg activity is not completely understood. As a pivotal molecule in lipid metabolism, the role of SHIP-1 in Tregs remains unknown.

Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Disease: Success Rate and Complications among Different Patient Populations.

Introduction: Balloon pulmonary angioplasty (BPA) is an effective intervention for patients with chronic thromboembolic pulmonary disease (CTEPD). We aimed to identify the patient group with a low success rate or high complication rate of BPA, which is still unclear.

Methods: Both CTEPD patients with or without pulmonary hypertension (CTEPH and NoPH-CTEPD) were included.

The output of cataract surgery performed by trained non-ophthalmologist physicians in rural areas: study of cataract outcomes and up-take of services report 7.

Background: Cataract is the leading cause of blindness worldwide and surgery can restore vision in most patients. Some patients have little access to surgical services due to lack of cataract surgeons and the unaffordable costs. In 2005 we built a service model that trained rural non-ophthalmologist physicians to perform cataract surgeries in rural China.

Bead-based spontaneous Raman codes for multiplex immunoassay.

In the immunoassay process, for fulfilling the need to identify multiple analytes in a small amount of complex sample matrix, it is desirable to develop highly efficient and specific multiplex suspension array technology. Raman coding strategy offers an attractive solution to code the suspension arrays by simply combing narrow spectral bands with stable signal intensities through solid-phase synthesis on the resin beads. Based on this strategy, we report the bead-based spontaneous Raman codes for multiplex immunoassay.

The effect of mindfulness-based cognitive therapy on the Clinical efficacy and psychological state in patients with functional dyspepsia.

Background And Aim: To observe the clinical therapeutic effect and mental state of mindfulness-based cognitive therapy (MBCT) in patients with functional dyspepsia (FD).

Methods: In this study, 80 patients suffering from FD in an outpatient clinic were enrolled from January to December 2020. Patients were randomly allocated into the control group (conventional treatment) and observation group (MBCT treatment).

Design, synthesis, and biological evaluation of multiple F-18 S1PR1 radiotracers in rodent and nonhuman primate.

Here we report our design and synthesis of 28 new fluorine-containing compounds as potential F-18 radiotracers for CNS imaging of sphingosine-1-phosphate receptor 1 (S1PR1), and determination of their binding potency and selectivity toward S1PR1 over other S1PR subtypes. Nine potent and selective compounds, 7c&d, 9a&c, 12b, 15b, and 18a-c with IC values ranging from 0.6-12.

An Electrode-Crosstalk-Suppressing Smart Polymer Electrolyte for High Safety Lithium-Ion Batteries.

Electrode crosstalk between anode and cathode at elevated temperatures is identified as a real culprit triggering the thermal runaway of lithium-ion batteries. Herein, to address this challenge, a novel smart polymer electrolyte is prepared through in situ polymerization of methyl methacrylate and acrylic anhydride monomers within a succinonitrile-based dual-anion deep eutectic solvent. Owing to the abundant active unsaturated double bonds on the as-obtained polymer matrix end, this smart polymer electrolyte can spontaneously form a dense crosslinked polymer network under elevated temperatures, effectively slowing down the crosstalk diffusion kinetics of lithium ions and active gases.

Evaluating the efficacy of balloon pulmonary angioplasty using quantitative analysis of SPECT pulmonary ventilation/perfusion scintigraphy in patients with chronic thromboembolic pulmonary hypertension.

Background: Single-photon emission computed tomography (SPECT) ventilation perfusion imaging is the main imaging method for the diagnosis of pulmonary embolism, and its application in the diagnosis and efficacy evaluation of chronic thromboembolic pulmonary hypertension (CTEPH) has been paid more and more attention. In recent years, with the development of computer software technology, ventilation/perfusion (V/Q) imaging quantitative analysis technology has become more and more mature. The objective of this study was to investigate the utility of quantitative analysis of pulmonary V/Q scintigraphy in evaluating the efficacy of balloon pulmonary angioplasty (BPA) in patients with CTEPH.

Development of highly sensitive dual-enhanced fluorescence quenching immunochromatographic test strips based on Pt nanoprobes.

The fluorescence-quenching method is crucial in vitro analysis, particularly for immunochromatographic test strips (ICTs) using noble metal nanoparticles as probes. However, ICTs still fall short in meeting the requirements for the detection of traces biomarkers due to the noble metal nanoparticles can only quench fluorescence of the dyes within a confined distance. Interestingly, noble metal nanoparticles, such as Pt NPs cannot only perform fluorescence-quenching ability based on the Förster resonance energy transfer (FRET), but also show perfect oxidase-like catalytic performance on many kinds of substrates, such as 3,3',5,5' -tetramethylbenzidine (TMB).

A Molecular-Sieving Interphase Towards Low-Concentrated Aqueous Sodium-Ion Batteries.

Aqueous sodium-ion batteries are known for poor rechargeability because of the competitive water decomposition reactions and the high electrode solubility. Improvements have been reported by salt-concentrated and organic-hybridized electrolyte designs, however, at the expense of cost and safety. Here, we report the prolonged cycling of ASIBs in routine dilute electrolytes by employing artificial electrode coatings consisting of NaX zeolite and NaOH-neutralized perfluorinated sulfonic polymer.