regulates heat-resistance and growth in lettuce ( L.).

Lettuce prefers a cold and cool climate, and high temperatures can lead to many problems such as tip burn that decrease yield and quality. NAC (NAM, ATAF1/2, and CUC2) proteins are important regulatory factors in abiotic stress responses. In our previous transcriptomic analysis, we identified that is involved in the response to heat stress in lettuce.

Suppression of Paclitaxel-Induced Neuropathy and Ovarian Tumor Growth by Mn Porphyrin, MnTnBuOE-2-PyP (BMX-001).

Numerous cellular and animal studies demonstrated the ability of redox-active Mn(III) -alkyl- and -alkoxyalkylpyridyporphyrins (MnPs) to protect normal tissue while suppressing tumor growth. The mechanism primarily involves the modulation of NF-кB and Nrf2 signaling pathways via catalysis of MnP/HO-driven protein thiol oxidation. Such differential protection/suppression effects have paved the way of Mn porphyrins (commonly known as mimics of superoxide dismutase) into clinical trials, therefore introducing new line of therapeutics that are affecting cellular redox status/oxidative stress, rather than specific proteins.

Prevention and control of thalassemia in Guangdong Province, Southern China: insights from an 11-year retrospective study.

Background: Thalassemia, a prevalent monogenic inherited disorder, represents a significant public health concern in southern China. This comprehensive study retrospectively analysed prenatal diagnostic data for thalassemia over an 11-year period in Guangdong Province, a high-prevalence region in southern China.

Methods: Prenatal diagnosis (PND) of thalassemia was performed on 22,127 foetuses from at-risk pregnancies, following standardized protocols for invasive sampling, foetal sample collection and laboratory processing.

Formononetin Mediates α7nAChR to Inhibit Macrophage Polarization and Ameliorate Atherosclerotic Plaque.

Objective: To explore the molecular mechanism of α7 nicotinic acetylcholine receptor (α7nAChR) mediated by Formononetin (FMN) in inhibiting macrophage inflammatory polarization and stabilizing atherosclerotic plaque.

Methods: SiRNA α7nAChR was transfected into THP-1-induced M0 cells and treated with FMN. Oil Red O staining was used to evaluate macrophage lipid deposition.

Fluorinated Pseudo-Halide Anion Enables >19% Efficiency and Durable Perovskite Quantum Dot Solar Cells.

Metal halide perovskite quantum dots (PQDs), like formamidinium lead triiodide (FAPbI), hold significant promise for next-generation photovoltaics. Surface manipulation of PQDs has been extensively reported to be crucial to their photovoltaic performance due to the dynamic binding of capping long-chain ligands. In this work, an efficient surface engineering strategy employing a multifunctional fluorinated pseudo-halide anion ligand, hexafluorophosphate (PF ) is reported for achieving efficient FAPbI PQD solar cells.

Hydrogel-Based Therapeutics for Diabetic Oral Wounds: From Mechanisms to Applications.

Diabetic oral wound healing is significantly impaired due to chronic inflammation, oxidative stress, and immune dysfunction, often resulting in delayed recovery or severe infections. Hydrogels have emerged as promising biomaterials for treating diabetic oral wounds due to their excellent biocompatibility, high drug-loading capacity, strong adhesion, and tunable degradation properties. This review examines recent advancements in hydrogel-based therapies for diabetic oral wound healing, with a particular focus on their applications in mucosal repair, periodontal tissue regeneration, and bone defect restoration.

Health Insurance and Basic Public Health Service Coverage Among the Floating Population in Hubei Province, 2014-2017.

Rationale: China's floating population has grown significantly due to rapid economic development and urbanisation. However, this population faces substantial barriers to accessing and utilising health services. Identifying factors affecting health service coverage and access among the floating population is essential for guiding targeted interventions to improve overall population health.

Correction: Epigenetic modifications in breast cancer: from immune escape mechanisms to therapeutic target discovery.

[This corrects the article DOI: 10.3389/fimmu.2025.

FMCW radar based high-precision gridless non-contact vital signs monitoring for Internet of Medical Things.

Background: Vital signs monitoring is of paramount importance in healthcare, serving as a crucial component in disease prevention, diagnosis, and management. Traditional contact-based devices, including electrocardiographs and pulse oximeters, while providing vital data, face limitations in long-term use owing to patient discomfort.

Objective: This study aims to propose a non-contact monitoring system utilizing Frequency Modulated Continuous Wave (FMCW) radar for continuous, non-invasive health monitoring.

Morin combined with meropenem is a potent inhibitor of NDM-1 against NDM-1-producing E. coli.

Some β-lactam antibiotics are hydrolyzed by the enzyme New Delhi metallo-β-lactamase 1 (NDM-1), increasing antibiotic resistance and posing a significant threat to public health. Thus, there is an urgent need to develop and use potent inhibitors of NDM-1 and other β-lactamases. This study evaluated the effects of the flavonoid morin (3,5,7,2',4'-pentahydroxyflavone) on the antimicrobial activity of β-lactams and the interaction between morin and NDM-1.

Association Between Dietary Patterns and All-Cause Mortality in Individuals with Hypertension and Osteoporosis: A Retrospective Cohort Study.

Objective: To explore the association of dietary patterns with all-cause mortality in individuals with hypertension and osteoporosis.

Methods: Data on individuals aged ≥20 years who completed bone mineral density tests were retrieved from the National Health and Nutrition Examination Survey database. Three dietary patterns were Mediterranean Diet Score (MeDS), Alternative Health Eating Index (AHEI) and Dietary Approaches to Stop Hypertension (DASH).

Ordering the Coordination Environment of Solvated Ionic Liquid Gel Electrolytes: Pathway to High-Efficiency 4.5 V Lithium Metal Batteries.

Solvated ionic liquids (SILs) are promising candidates for lithium metal battery (LMB) electrolytes owing to their facile synthesis and high safety. However, the high-voltage stability and ionic conductivity of ether-based SILs are compromised by their chaotic coordination structure, characterized by bulky solvation shells and poor oxidation stability. Here, optimizing electrolyte performance is proposed by incorporating weakly coordinating fluoroethylene carbonate (FEC) and a hydrogen-bond (H-bond)-rich polymer into SILs.

Hyperangulated videolaryngoscope for difficult airway management: a protocol for a systematic review with meta-analysis and trial sequential analysis.

Introduction: Videolaryngoscopes are recommended as the top preference for tracheal intubation in adults, children, infants and neonates, and even in patients with anticipated difficult airways, since they are generally easier to use and quicker to master than fibreoptic bronchoscopes. Compared with standard videolaryngoscopes, hyperangulated videolaryngoscopes possess a more sharply curved blade or blade tip, resulting in a higher first-attempt success rate among patients with anticipated difficult airways. However, hyperangulated videolaryngoscopes also pose challenges in advancing the tracheal tube, which decreases the first-attempt success rate while increasing the tracheal intubation time when the tracheal tube introducer is unsuitable.

Penehyclidine combined with antiemetics for preventing postoperative nausea and vomiting: A meta-analysis of randomized control trials and trial sequential analysis.

Background: Postoperative nausea and vomiting (PONV) is one of the most common adverse complications associated with anesthesia and after surgical procedures. PONV is related to patient dissatisfaction and can lead to several postoperative complications. This study aimed to examine the efficacy and safety of penehyclidine combined with antiemetics in preventing PONV.

A High-entropy Antiperovskite Nitride Enables Efficient Anion Exchange Membrane Water Electrolysis.

Despite the availability of many (oxy)hydroxide-based oxygen evolution reaction (OER) electrocatalysts with favorable intrinsic activity, few perform well in anion exchange membrane water electrolyzers (AEMWEs). Their poor electrical conductivity confines the OER to the boundary between the current collector and electrocatalyst, resulting in poor catalyst utilization. Herein, the use of highly conductive antiperovskite nitride is proposed as a platform to develop robust OER electrodes for AEMWEs with outstanding performance.

Enhancing Ion Transport in Polymer Electrolytes by Regulating Solvation Structure via Hydrogen Bond Networks.

Polymer electrolytes (PEs) provide enhanced safety for high-energy-density lithium metal batteries (LMBs), yet their practical application is hampered by intrinsically low ionic conductivity and insufficient electrochemical stability, primarily stemming from suboptimal Li solvation environments and transport pathways coupled with slow polymer dynamics. Herein, we demonstrate a molecular design strategy to overcome these limitations by regulating the Li solvation structure through the synergistic interplay of conventional Lewis acid-base coordination and engineered hydrogen bond (H-bond) networks, achieved by incorporating specific H-bond donor functionalities (N,N'-methylenebis(acrylamide), MBA) into the polymer architecture. Computational modeling confirms that the introduced H-bonds effectively modulate the Li coordination environment, promote salt dissociation, and create favorable pathways for faster ion transport decoupled from polymer chain motion.

Artificial intelligence for difficult airway assessment: a protocol for a systematic review with meta-analysis.

Introduction: Identifying difficult airways and avoiding unanticipated difficult airways through difficult airway assessment are crucial for patient safety prior to airway management. Therefore, accurately predicting difficult airways through airway assessment is a fundamental and significant technique in airway management by clinicians. Artificial intelligence (AI) is a rapidly evolving science with greater data processing ability than humans.

Comprehensive analysis of the prognosis and tumor immune microenvironment of ubiquitin-conjugating enzyme transport-related gene UBE2C in hepatocellular carcinoma.

Ubiquitin-conjugating enzyme E2 C (UBE2C) is involved in tumor progression and cellular processes in many cancers and is implicated in cell cycle regulation. However, its prognostic significance in Hepatocellular carcinoma (HCC) and the mechanism of tumor immune response are unknown. The expression of UBE2C genes in HCC and normal tissue samples was investigated based on The Cancer Genome Atlas (TCGA) LIHC dataset and validated by Gene Expression Omnibus and Human Protein Atlas.

mTOR blockade mitigates chemotherapy drug-induced intestinal toxicity via inhibition of pyroptosis.

Mammalian target of rapamycin (mTOR) signaling constitutes a crucial intracellular signaling pathway indispensable for regulating a variety of pathophysiological processes, including cancers. Intriguingly, the inhibition of mTOR can reverse the adverse effects induced by chemotherapy drugs; however, the fundamental mechanism underlying this phenomenon remains unclear. In this study, we demonstrate that mTOR signaling blockade can mitigate etoposide- or cisplatin-induced intestinal injury in mice.

Constructing Dissolution-Resistant Interphases for Long-Life Sodium-Ion Batteries at Elevated Temperatures.

Rechargeable sodium-ion batteries (SIBs) utilizing NaPF-carbonate electrolytes consistently exhibit unsatisfactory cycle life at elevated temperatures, posing a significant challenge for their large-scale commercialization. This is mainly caused by the instability of interphase layers at elevated temperatures, especially the high solubility of interphase components (especially NaF) in carbonate solvents. In this study, a novel additive of sodium difluorobis(oxalato) phosphate (NaDFBOP) is synthesized and introduced into NaPF-carbonate electrolytes to enhance the cycle life of commercial SIBs composed of NaNiFeMnO (NFM) cathode and hard carbon (HC) anode, particularly at 50 °C.

Epigenetic modifications in breast cancer: from immune escape mechanisms to therapeutic target discovery.

Breast cancer (BC) is one of the most prevalent malignant tumors among women globally, with the number of cases accounting for even more than 1/3 of all tumor patients in women. Recent studies have found that the incidence of BC is increasing every year. Despite the great progress made in BC treatment, the characteristics of BC cells, such as strong immune evasion, easy recurrence and drug resistance, are still the main reasons limiting the survival of BC patients.

Endoscopic variceal ligation combined with carvedilol versus endoscopic variceal ligation combined with propranolol for the treatment of oesophageal variceal bleeding in cirrhosis: study protocol for a multicentre, randomised controlled trial.

Introduction: Liver cirrhosis and its severe complication, oesophageal variceal bleeding (EVB), pose significant health risks. Standard treatment for EVB combines non-selective beta-blockers (NSBB) with endoscopic variceal ligation (EVL). Carvedilol, an NSBB with additional benefits, is preferred for compensated cirrhosis.

Biomarker of pressure injuries in critically ill adults based on large-scale medical Datasets:A multi-center prospective study.

Objectives: Pressure injuries (PIs) are a global health concern, particularly in the context of an ageing population. They impose significant economic and social burdens, serve as key indicators of nursing quality, and are associated with increased mortality and morbidity.

Methods: We conducted a multi-center prospective descriptive study involving 3867 critically ill adults admitted to ICUs across 28 hospitals in Gansu Province, China, from April 1, 2021, to July 31, 2023.

MK5 Regulates Microglial Activation and Neuroinflammation in Experimental Stroke Models.

Objective: Microglial activation plays a crucial role in neuroinflammation following ischemic stroke. This study was conducted to investigate the role and potential mechanisms of MK5 within microglial cells in the inflammatory response following ischemic stroke in mice in vivo and in vitro.

Methods: Microglia-specific conditional MK5 knockout (MK5 cKO) mice and their control mice (MK5) were subjected to middle cerebral artery occlusion (MCAO).