Hidden threat: The high-efficacy herbicidal R-NAP isomer drives heavy metal accumulation in plants via growth stimulation and coordination of metal transporters.

The widespread coexistence of chiral herbicides and heavy metals (HMs) in agricultural soils poses significant ecological risks to crop safety, yet their combined ecotoxicological effects are not well understood. This study systematically investigated the enantiomer-specific effects of napropamide (R/S-NAP) on plant HMs accumulation. Results showed that S-NAP application reduced plant biomass and HMs accumulation, while R-NAP exhibited distinct effects, increasing root biomass and HMs accumulation in roots.

Removal of antibiotics from anaerobically digested biosolids via synergistic release using ethylenediaminetetraacetic acid disodium salt dihydrate and sodium persulfate oxidation.

Large-scale anaerobic treatment involves a high risk of antibiotic pollution in anaerobically digested (AD) biosolids, which hinders the efficient utilization of farmland AD biosolids. Herein, a process for the in situ removal of antibiotics from AD biosolids using ethylenediaminetetraacetic acid disodium salt dihydrate as the release agent synergized with sodium persulfate oxidation is reported. The developed process was used to remove antibiotics from actual AD biosolids.

Comparative analysis of machine learning based dissolved oxygen predictions in the Yellow River Basin: The role of diverse environmental predictors.

Dissolved oxygen (DO) is a key water quality indicator reflecting river health. Modeling and understanding the spatiotemporal dynamics of DO and its influencing factors are crucial for effective river management. Machine learning (ML) models have gained popularity in water quality prediction; however, their accuracy strongly depends on the predictor variables.

Problematic mobile phone use and Shyness: A network perspective on User differences.

Problematic mobile phone use (PMPU) has become increasingly prevalent among young adults, raising concerns about its psychological underpinnings. While shyness has been linked to PMPU, few studies have explored the symptom-level mechanisms that differentiate problematic from non-problematic users. This study employed psychological network analysis to examine the structure and central symptoms of PMPU in two groups: problematic and non-problematic mobile phone users.

Multi-component collaborative design yields robust hydrogel sensors with superior environmental adaptability for machine learning-assisted gesture recognition.

Developing high-performance wearable flexible sensors that can adapt well to complex environments has become a hotspot. Herein, a polyvinyl alcohol based composite hydrogel sensor with high mechanical strength, desirable frost/swelling resistance, and highly sensitive sensing performance was proposed by a multi-component collaborative design strategy. Meanwhile, an intelligent gesture recognition system was established by combining machine learning algorithm.

Repurposing zafirlukast confers renal protection in ischemia-reperfusion injury via suppressing macrophage METosis.

Tacrolimus is widely used to prevent post-transplant acute kidney injury (AKI) but causes severe toxicities (e.g., nephrotoxicity, hyperglycemia).

Therapeutic potentials of mesenchymal stem cells and their extracellular vesicles on liver diseases by modulating mitochondrial function of macrophages.

Macrophages play crucial roles in the progression of liver diseases. Increasing studies have shown that mesenchymal stem cells (MSCs) and their extracellular vesicles (MSC-EVs) could reshape the liver immune microenvironment by regulating the function and phenotype of macrophages, thereby exerting a therapeutic effect on liver diseases. Mitochondria, apart from being the central hub of energy metabolism, also finely regulate macrophage-mediated innate immune responses by modulating reactive oxygen species levels, cell polarization, and cell death.

Reproduction, metabolic enzyme activity, and metabolomics in earthworms Eisenia fetida exposed to different polymer microplastics.

Plastics degradation generates microplastics (MPs), posing a risk to soil function and organisms. Currently, the impact of MPs derived from different polymers remains poorly understood. In this study, the effects of three polymers (polypropylene (PP), polylactic acid (PLA), and polybutylene adipate terephthalate (PBAT)) were investigated at environmentally relevant levels (0, 0.

Novel plant growth-promoting endophytic bacteria, Stenotrophomonas maltophilia SaRB5, facilitate phytoremediation by plant growth and cadmium absorption in Salix suchowensis.

Seven plant growth-promoting bacteria (PGPB) were isolated from extracts of surface-sterilized Sedum alfredii Hance. Among the seven isolates, the strain SaRB5 identified as Stenotrophomonas maltophilia through 16S rDNA sequence analysis, exhibited highest levels of heavy metal resistance and plant growth-promoting traits. SaRB5 tolerated high concentrations of cadmium (Cd) (1.

Relationships among humanistic literacy competencies in Chinese clinical nurses: A network analysis.

Aim: This study examined the network structure of the competency cluster of humanistic literacy among clinical nurses in China, identifying key and bridging competencies within the network cluster.

Background: With the increasing demand for high-quality healthcare services and the growing complexity of nurse-patient relationships, the humanistic competence of clinical nurses has received increasing attention. However, compared with the international level and professionalism, the humanistic literacy and education of nursing staff in Chinese medical institutions still has significant room for improvement.

Research on the detecting method for cracks on perforated embryo eggs based on acoustic responses.

During the vaccine production through the chick embryo cultivation method, harmful cracks may occur from the perforation of a trocar on the eggshell, around the impact hole, leading to the failure of cultivation. To detect the perforative cracks, this study proposes a method based on acoustic responses. By stimulating the embryo eggs and collecting the acoustic signals, 7 characteristic values were extracted from the time and the frequency domains: The maximum value in the time domain; The difference in the time domain; The frequency-domain peaks, 870 Hz, 1250 Hz, 1470 Hz and 1770 Hz; The mean value of the waveform.

Prognostic value of Nanopore sequencing-based metagenomics next-generation sequencing in clinical infectious cases: A retrospective observational study.

Objectives: This study aimed to evaluate the prognostic value of metagenomic next-generation sequencing(mNGS) using Nanopore sequencing technology (NST) versus traditional culture methods in infectious disease cases.

Methods: We conducted a retrospective, single-center observational study comparing clinical outcomes between patients and specimen types in NST group and those in culture-based control group. Cox Proportional Hazards regression and Kaplan-Meier survival analysis were conducted to evaluate the association between diagnostic strategy and 28-day mortality.

Asymmetric Fe-O-Ni Pair Sites in Two-Step Dealloyed Prussian Blue Analogue Nanocubes Enrich Linear-Adsorbed Intermediates for Efficient Oxygen Evolution.

Ni-Fe (oxy)hydroxides are among the most active oxygen evolution reaction (OER) catalysts in alkaline media. However, achieving precise control over local asymmetric Fe-O-Ni active sites in Ni-Fe oxyhydroxides for key oxygenated intermediates' adsorption steric configuration regulation of the OER is still challenging. Herein, we report a two-step dealloying strategy to fabricate asymmetric Fe-O-Ni pair sites in the shell of NiOOH@FeOOH/NiOOH heterostructures from NiFe Prussian blue analogue (PBA) nanocubes, involving anion exchange and structure reconstruction.

Molecular Mechanisms Underlying Parasitoid-Derived Host Manipulation Strategies.

Parasitoid wasps are a diverse group of insects with a unique parasitic lifestyle that allows them to spend their lives closely interacting with their insect hosts, facilitated by parasitic effectors, including venom, polydnaviruses, and teratocytes. These effectors manipulate various aspects of insect host biology to increase the survival of the parasitoids' offspring. During the last two decades, omics and functional studies have significantly advanced our understanding of how parasitoids manipulate their hosts at the molecular level.

Programmable Dual-Phase Electrochemical Biosensor Combines Homogeneous CRISPR/Cas12a Activation with Interfacial Poly-G Signaling for miRNA-21 Detection.

Despite the promise of electrochemical biosensors in amplified nucleic acid diagnostics, existing high-sensitivity platforms often rely on a multilayer surface assembly and cascade amplification confined to the electrode interface. These stepwise strategies suffer from inefficient enzyme activity, poor mass transport, and inconsistent probe orientation, which compromise the amplification efficiency, reproducibility, and practical applicability. To address these limitations, we report a programmable dual-phase electrochemical biosensing system that decouples amplification from signal transduction.

Natural Products for Regulation of Autoimmune Diseases: Chemical Diversity, Pharmacology, and Therapeutic Applications.

Autoimmune diseases (AIDs), defined by irregularities in immune system function, pose a substantial health challenge worldwide, impacting millions with persistent and frequently debilitating conditions. Conventional treatments, such as glucocorticoid-based immunosuppressive therapies, are associated with notable drawbacks and limitations. In response to these difficulties, recent scientific efforts have increasingly focused on natural compounds as potential therapeutic agents.

Wnt/β-Catenin Signaling Pathway Targeting Androgenetic Alopecia: How Far Can We Go Beyond Minoxidil and Finasteride?

The prevalence of AGA is continuously rising, with an earlier age of onset. Currently, only minoxidil and finasteride have received FDA approval for the treatment of AGA, inadequately addressing the pressing clinical needs. Recently, the involvement of the Wnt/β-catenin signaling pathway in AGA has attracted increased research interest.

Genome imbalance modulates the expression of long non-coding RNAs in maize.

Genome imbalance, resulting from varying the dosage of individual chromosomes (aneuploidy), has a more detrimental effect than changes in complete sets of chromosomes (haploidy/polyploidy). This imbalance is likely due to disruptions in stoichiometry and interactions among macromolecular assemblies. Previous research has shown that aneuploidy causes global modulation of protein-coding genes (PCGs), microRNAs, and transposable elements (TEs), affecting both the varied chromosome (cis-located) and unvaried genome regions (trans-located) across various taxa.

Expanded field OCTA Biomarkers Associated with the Development of Tractional Retinal Detachment in Proliferative Diabetic Retinopathy.

Purpose: To investigate associations among expanded field swept-source optical coherence tomography angiography (SS-OCTA) biomarkers and the development of tractional retinal detachment (TRD) in patients with proliferative diabetic retinopathy (PDR).

Methods: Patients with PDR without TRD at baseline were imaged with SS-OCTA. Quantitative and qualitative OCTA metrics were independently evaluated by two trained graders.

sp. nov., a novel halotolerant, flexirubin-type pigment-producing bacterium of the family .

A Gram-staining-negative, non-motile, aerobic, rod-shaped bacterium, designated 14752, was isolated from a saline lake in Xinjiang Uygur Autonomous Region, China. The strain was subjected to a taxonomic study using a polyphasic approach. Strain 14752 was able to grow at 4-40 ℃ (optimum 28 ℃), pH 6.

Silicate Enhances the Long-Term Dechlorination Performance of Sulfidized Zero-Valent Iron: Trade-Off between Passivation and In Situ Oxidation.

Sulfidized zero-valent iron (S-ZVI) holds promise in the remediation of chlorinated hydrocarbons. However, S-ZVI is susceptible to corrosion in aquifers with elevated dissolved oxygen (DO) levels. This study demonstrates, for the first time, that a trade-off between the passivation and oxidative corrosion of aged S-ZVI can be achieved in the presence of silicate to promote its dechlorination performance on trichloroethylene.

Effect of knee joint position on soleus muscle function during isokinetic plantarflexion.

Purpose: Contribution of the gastrocnemii muscles to ankle moment is influenced by the knee joint position because they span the knee and the ankle joint as well. However, limited information is available on the effect of knee joint position on soleus activation under dynamic plantarflexion, hence the aim of this study was to investigate if soleus have a compensatory strategy in fascicle behavior or EMG activity during knee flexed plantarflexion in order to reduce the magnitude of the decrement in ankle moment.

Equipment And Methods: Isokinetic dynamometry with EMG and ultrasound measurements was used to estimate medial gastrocnemius and soleus behavior during knee flexed and extended plantarflexions using three angular velocities.

Carrot-Derived Nitrogen-Doped Dual-Emission Carbon Dots for Ratiometric Detection of Tetracycline and Oxytetracycline.

The antibiotic contamination in aquatic environments, particularly in aquaculture systems, poses substantial risks to ecological balance and human health. To address this issue, we engineered a novel ratiometric fluorescent probe utilizing dual-emission carbon dots (D-CDs) synthesized from sustainable biomass carrot and nitrogen-rich precursors (melamine and o-phenylenediamine) through an efficient one-pot hydrothermal approach. The D-CDs exhibited dual emission peaks at 425nm and 540 nm under 370nm excitation.

S100A8/A9-MCAM signaling promotes gastric cancer cell progression via ERK-c-Jun activation.

S100 protein family members S100A8 and S100A9 function primarily as a heterodimer complex (S100A8/A9) in vivo. This complex has been implicated in various cancers, including gastric cancer (GC). Recent studies suggest that these proteins play significant roles in tumor progression, inflammation, and metastasis.