Weakly hydrophobic antibiotics leaching in an alpine soil of the Tibetan Plateau in responding to macropore flow.

In alpine meadow regions, macropore flow is a critical but inadequately understood pathway for antibiotic transport. The complex relationship between macropore structure, flow dynamics, and solute properties presents a significant research gap. Methodological limitations hinder the accurate characterization of solute migration mechanisms due to complex macropore structures.

Case Report: Multidimensional Analgesia via Asymmetric Dual-Target Deep Brain Stimulation of the Periaqueductal Gray and Ventral Posterior Thalamus in Central Post-stroke Pain.

Central post-stroke pain (CPSP) is an intractable neuropathic pain syndrome. Dual-target deep brain stimulation (DBS), which integrates sensory thalamic modulation and endogenous analgesic pathways, has emerged as a potential intervention; however, clinical evidence remains scarce. We report a 54-year-old woman who developed right-sided limb paresthesia progressing to persistent right hemibody pain following a left thalamic hemorrhage.

Extracts and Pimaradienoic Acid from Eleutherococcus trifoliatus L. S. Y. Hu for the Treatment of Rheumatoid Arthritis by Modulating NF-κB Signaling Pathway.

Ethnopharmacological Relevance: The use of Eleutherococcus trifoliatus L. S. Y.

Fatigue characteristics and mechanism of phosphogypsum stabilised red clay under dry and wet cycles.

Phosphogypsum is an acidic solid waste mainly composed of CaSO₄-2H₂O by-products of the wet process phosphoric acid industry, which has the characteristics of high impurity content, poor stability of stockpiling, but can be utilized in a resourceful way. Phosphogypsum waste utilization can reduce environmental pollution, save resources and create economic value. In order to investigate the fatigue characteristics and the mechanism of dynamic strength change of cement-phosphogypsum-red clay under wet and dry cycles, the cumulative deformation characteristics and the rule of change of critical dynamic stress of the mixed materials were investigated by dynamic triaxial fatigue test, SEM and XRD test, and the mechanism of dynamic strength change was analyzed according to the microstructure and the chemical mineral composition of the mixed materials.

Tailoring the Effects of Spin State and Intermediate Hydrogen Adsorption on NiPt/Ni Bridge Sites toward Robust Acidic Water Electrolysis.

Precise modulation of the electronic structure in transition metals, particularly the d-band center position and spin state, remains a critical challenge to expediting hydrogen evolution reaction (HER) kinetics. Herein, we report a NiPt/Ni-heterostructured catalyst enabling simultaneous optimization of the d-band electronic structure and spin state of Ni through regulation of the NiPt and Ni bridge sites. Combining operando spectroscopy, X-ray absorption spectroscopy, density functional theory, and ab initio molecular dynamics simulations, we establish that the coordination environment and spin states of Ni at the bridge sites were effectively modulated by altering the Pt content, achieving a transition of Ni centers from the low-spin to high-spin state, and optimized intermediate adsorption/desorption behaviors.

Danon Disease Diagnosed by Multimodal Imaging: A Case Report.

Danon disease is an X-chromosome dominant disorder caused by variants in lysosomal-associated membrane protein-2 (LAMP-2). Patients often present with cardiac lesions as their initial symptom, including hypertrophic cardiomyopathy, arrhythmia, and heart failure. We found a case of a 13-year-old male patient with multimodal imaging suggestive of left ventricular hypertrophy, decreased left ventricular myocardial perfusion, electrocardiographic abnormalities, and abnormal serologic parameters.

Prevalence and correlated factors of REM sleep behavior disorder in patients with progressive supranuclear palsy.

Background: Progressive supranuclear palsy (PSP) is a rapidly advancing tauopathy, and amongst rapid eye movement (REM) sleep behavior disorder (RBD) has been observed. Prior studies were limited by small samples and inconsistent results; meanwhile, research is lacking since the updated criteria for PSP. This cross-sectional study aimed to assess RBD in a sizable PSP cohort.

DNA nanostructures with 1D, 2D and 3D for intelligent drug delivery.

Structural DNA nanotechnology has emerged as a powerful tool in modern medicine, offering precise self-assembly and spatial programmability for the design of functional nanocarriers. DNA nanostructures can be categorized into one-dimensional (1D), two-dimensional (2D), and three-dimensional (3D) architectures, each with distinct advantages: 1D structures are suited for studying cellular responses to physical cues, 2D structures provide large surface areas for enhanced molecular recognition, and 3D structures enable improved cellular uptake and tissue penetration. Despite their potential, there is still no widespread consensus on the optimal structural design for specific diseases.

Estimating resting energy expenditure in severely obese patients with laparoscopic sleeve gastrectomy: Normalized lean weight appears to be more accurate-A prospective observational study.

Background: The accurate estimation of energy requirements in severely obese patients poses a significant challenge. This study compared the measured resting energy expenditure (mREE) obtained using indirect calorimetry with the estimated energy target in severely obese patients who underwent laparoscopic sleeve gastrectomy.

Methods: This study enrolled patients who underwent elective bariatric surgery for metabolic syndrome and were admitted to the ICU between September 2023 and October 2024 because of severe clinical complications.

Strategic Insights From Voluntary and Mandatory ESG Evaluations in a Competitive Market.

Environmental, social, and governance (ESG) considerations are garnering increasing interest from various stakeholders. Nevertheless, the impact of ESG evaluation policies-whether voluntary or mandatory-are complex, particularly in competitive markets. Consequently, this study develops a game-theoretic model to investigate the propensity of competing manufacturers to invest in ESG initiatives.

Investigating factors influencing injury severity in crashes involving vulnerable road users in Pakistan.

Road traffic crashes claim around 1.19 million lives annually worldwide, with over half of the fatalities involving vulnerable road users (VRUs). While several studies have explored the risk factors associated with specific categories of VRUs in Pakistan, research focusing on VRUs collectively, considering all categories and their unique safety challenges, remains limited.

Dual surface modification strategies for enhanced osteogenesis of titanium through the biomimetic Haversian osteon with deposited CaP to assemble salidroside.

Titanium (Ti) and Ti alloy are the most widely used implant metals, but the limited bioactivity hinders the further clinical application. Aiming to enhance their osteogenesis, dual biomimetic strategies were utilized to decorate the surface of Ti by topological and biochemical cues. Firstly, a series of concentric circles with TiO nanotubes on Ti were fabricated by photolithography and anodic oxidation.

Resilience enhancement of an urban road network during traffic accidents by optimally dispatching rescue teams.

The efficient dispatch of rescue teams (RTs) during traffic accidents is crucial for the rapid restoration of normal operations in the affected urban road network (URN), thereby enhancing the network's resilience during such events. However, previous studies focusing on optimizing RT dispatch strategies to enhance URN resilience remain limited. To address this gap, this paper develops a mixed-integer linear programming model aimed at optimizing RT dispatch during traffic accidents.

Breaking through Hydration Layer Barrier: a Novel Ultra-Strong Underwater Hydrogel Adhesive Toward Full-Thickness Cartilage Repair.

The absence of blood vessels and nerves in cartilage severely restricts its self-healing capacity. Meanwhile, the inherent anti-adhesive nature of articular cartilage matrix further complicates the integration of implanted scaffolds, leading to common issues such as scaffold displacement, reduced mechanical stability, impaired cell migration, and insufficient tissue regeneration. These challenges collectively render articular cartilage repair a formidable global issue.

Adolescent-Perceived Maternal Responses to Their Negative Emotions Predict Adolescents' Willingness to Share Emotional Distress With Mothers: A Cross-Lagged Panel Network Model.

The open communication about adolescents' emotions between parents and adolescents is pivotal, as it helps adolescents to understand and manage emotional experiences. Utilizing longitudinal data, we aimed to explore whether maternal supportive or nonsupportive responses to adolescents' negative emotions could predict the communication patterns of adolescents' emotional distress (CPAED) between parents and adolescents. Two hundred Chinese adolescents (65.

Exploring Novel Biomarkers for Rosacea Through Cohort Study and Mendelian Randomisation.

The current therapeutic landscape for rosacea is notably deficient in targeted medications, underscoring an urgent need for the identification of novel biomarkers. Utilising a longitudinal cohort of 54 306 individuals from the UK Biobank (UKB), we conducted a comprehensive assessment of the associations between 2923 serum proteins and the risk for rosacea. Our cohort analysis identified 18 proteins significantly associated with rosacea risk.

Investigating the performance of asphalt pavements modified with reclaimed asphalt and crumb rubber.

This research provides useful insights into sustainable and cost-effective pavement rehabilitation by evaluating the combined effects of both Reclaimed Asphalt Pavement (RAP) and Crumb Rubber (CR) modification on flexible pavement performance using actual motorway sections. Pavement rehabilitation and maintenance can enhance the design and serviceable life of the pavement. Additionally, modification of asphalt with Crumb Rubber (CR) and Reclaimed Asphalt Pavement (RAP) not only proves to be economical but can also increase the resistance of flexible pavement concerning rutting, fatigue, and moisture damage.

MXene-Powered Terahertz Metamaterials as a Real-Time Biosensing Platform for In Vivo Thrombus Monitoring.

Precise, timely, and personalized in vivo thrombus monitoring is critical for improving the treatment effectiveness and clinical outcomes of cardiovascular diseases (CVDs). Terahertz (THz) spectroscopy has become increasingly important as a novel tool in biomedical engineering due to its rapid analysis ability, high temporal resolution, and label-free measurement modality. However, achieving high thrombus sensing performance in real blood environments remains a significant challenge.

An endoscopy deliverable hydrogel dry powder for sealing and repairing gastric perforation.

Gastric perforation (GP) is characterized by full-thickness injury of the stomach wall, a severe and potentially life-threatening gastrointestinal disease. However, current treatment, including surgical sutures and endoscopic closure, faces limitations, achieving complete sealing of the perforation and favorable healing remains a great challenge and an acute clinical demand. Here, we report a hydrogel dry powder (PPCL@Mg) for the minimally invasive treatment of GP, which can be delivered to target perforation wounds by spraying via an endoscope, and rapidly absorbing interfacial water and spontaneously forming a hydrogel.

Predicting the detonation properties of energetic materials through phonons.

Context: Understanding the microscopic mechanisms underlying the detonation behavior of energetic materials is crucial for the development of safer and more efficient explosives. In this work, we employ first-principles calculations to optimize the molecular geometries of eight energetic compounds and analyze their phonon characteristics, including the number of molecular vibration modes in the doorway region (j) and the frequency gap (∆w). A new parameter, the phonon energy transfer rate, is defined and found to exhibit a strong linear correlation with detonation velocity (R = 0.

Insulin resistance, left atrial anatomical remodeling, and recurrence in patients with atrial fibrillation undergoing radiofrequency ablation.

Background: Insulin resistance (IR) is associated with both the anatomical remodeling of the left atrium and the pathogenesis of atrial fibrillation (AF). However, the exact extent of this correlation and its influence on AF recurrence in individuals undergoing radiofrequency catheter ablation (RFCA) remains unclear.

Methods: A total of 910 patients with AF who underwent RFCA were included in this analysis.

Full-Field Dynamic Parameters and Tension Identification of Stayed Cables Using a Novel Holographic Vision-Based Method.

Due to the slender geometry and low-amplitude vibrations of stayed cables, existing vision-based methods often fail to accurately identify their full-field dynamic parameters, especially the higher-order modes. This paper proposes a novel holographic vision-based method to accurately identify the high-order full-field dynamic parameters and estimate the tension of the stayed cables. Particularly, a full-field optical flow tracking algorithm is proposed to obtain the full-field dynamic displacement information of the stayed cable by tracking the changes in the optical flow field of the continuous motion signal spectral components of holographic feature points.

Effects of Temperature-Control Admixtures on Shrinkage and Mechanical Properties of Fly Ash Concrete: Experiments and Modeling.

The mitigation of early-age shrinkage and thermal cracking remains a pressing challenge in mass concrete structures. This study introduces a novel temperature-control admixture (TCA), formulated with gel-forming inorganic compounds, designed to suppress internal temperature rise while improving the mechanical stability of fly ash concrete. Four concrete mixes with TCA dosages of 0, 0.

Association between constipation and risk of stroke: a systematic review and meta-analysis.

Objective: This systematic review and meta-analysis aimed to evaluate the association between constipation and stroke risk, with subgroup analyses exploring effects on stroke subtypes.

Methods: We systematically searched PubMed, Web of Science, and Cochrane Library until February 2025. Published studies reporting adjusted odds ratios (ORs), hazard ratios (HRs), or relative risks (RRs) for stroke in constipated versus non-constipated individuals were included.