An endoscopy deliverable hydrogel dry powder for sealing and repairing gastric perforation.

Gastric perforation (GP) is characterized by full-thickness injury of the stomach wall, a severe and potentially life-threatening gastrointestinal disease. However, current treatment, including surgical sutures and endoscopic closure, faces limitations, achieving complete sealing of the perforation and favorable healing remains a great challenge and an acute clinical demand. Here, we report a hydrogel dry powder (PPCL@Mg) for the minimally invasive treatment of GP, which can be delivered to target perforation wounds by spraying via an endoscope, and rapidly absorbing interfacial water and spontaneously forming a hydrogel.

Nicotinamide mitigates visceral leishmaniasis by regulating inflammatory response and enhancing lipid metabolism.

Background: Currently, treatment regimens for visceral leishmaniasis (VL) are limited because of the presence of numerous adverse effects. Nicotinamide, a readily available and cost-effective vitamin, has been widely acknowledged for its safety profile. Several studies have demonstrated the anti-leishmanial effects of nicotinamide in vitro.