A Dual-Capture and Dual-Output 3D DNA Walker System Integrated with Ligases Enables Ultrasensitive Detection of Single-Nucleotide Polymorphisms.

DNA walkers, as structurally and functionally programmable signal amplification tools, exhibit great potential for application in the field of biosensing. Traditional DNA walkers often rely on enzymes for operation, posing compatibility challenges, while the handful of existing enzyme-free DNA walkers demonstrate limited performance. To address this, we innovatively developed an efficient enzyme-free 3D DNA walker with dual capture and dual output capabilities.

An electrochemical biosensing platform initiated simultaneously from multi-directions with programmable enzyme-free strategy for DNA variant detection.

Single-nucleotide variations (SNVs) represent vital clinical and biological information in the onset and progression of many cancers, but lacking of cost-effective, high-sensitive and reliable SNVs detection method. In this study, we propose a programmable electrochemical biosensing strategy initiated simultaneously from multi-directions by enzyme-free amplifying circuit for high-sensitivity SNVs detection. Through elaborate design, we utilized the power of conventional enzyme-free catalytic reaction to activate a multidirectional initiation self-assembly process, enabling multiple amplification.

Entropy-Driven Circuit Integrated with Ligases to Regulate DNA-AuNP Network Disintegration for Colorimetric Detection of Single Nucleotide Polymorphisms.

In recent years, entropy-driven circuit (EDC) dynamic DNA networks have garnered significant attention in nucleic acid detection owing to their simplicity, efficiency, and flexible design. Nevertheless, conventional EDC reactions face a constraint in achieving optimal signal amplification due to a solitary and feeble driving force. To overcome this limitation, we innovatively devised a gold nanoparticle (AuNP) dispersion-enhanced EDC (Au-EDC) approach, pioneering a novel colorimetric signal amplification and output system.

A Low-Power General Matrix Multiplication Accelerator with Sparse Weight-and-Output Stationary Dataflow.

General matrix multiplication (GEMM) in machine learning involves massive computation and data movement, which restricts its deployment on resource-constrained devices. Although data reuse can reduce data movement during GEMM processing, current approaches fail to fully exploit its potential. This work introduces a sparse GEMM accelerator with a weight-and-output stationary (WOS) dataflow and a distributed buffer architecture.

A skin-mountable flexible biosensor based on Cu-MOF/PEDOT composites for sweat ascorbic acid monitoring.

Continuous monitoring of sweat nutrients offers valuable insights into metabolic cycling and health levels. However, existing methods often lack adaptability and real-time capabilities. Here, we propose a skin-mountable flexible biosensor integrated with metal-organic framework (MOF)-derived composites for real-time monitoring of sweat ascorbic acid (AA) levels.

A Graded Redox Interfacial Modifier for High-Performance Perovskite Solar Cells.

Perovskite solar cells have emerged as a potential competitor to the silicon photovoltaic technology. The most representative perovskite cells employ SnO and spiro-OMeTAD as the charge-transport materials. Despite their high efficiencies, perovskite cells with such a configuration show unsatisfactory lifespan, normally attributed to the instability of perovskites and spiro-OMeTAD.

Customizable Colorimetric Sensor Array via a High-Throughput Robot for Mitigation of Humidity Interference in Gas Sensing.

One challenge for gas sensors is humidity interference, as dynamic humidity conditions can cause unpredictable fluctuations in the response signal to analytes, increasing quantitative detection errors. Here, we introduce a concept: Select humidity sensors from a pool to compensate for the humidity signal for each gas sensor. In contrast to traditional methods that extremely suppress the humidity response, the sensor pool allows for more accurate gas quantification across a broader range of application scenarios by supplying customized, high-dimensional humidity response data as extrinsic compensation.

A dual-mode, image-enhanced, miniaturized microscopy system for incubator-compatible monitoring of live cells.

Imaging live cells under stable culture conditions is essential to investigate cell physiological activities and proliferation. To achieve this goal, typically, a specialized incubation chamber that creates desired culture conditions needs to be incorporated into a microscopy system to perform cell monitoring. However, such imaging systems are generally large and costly, hampering their wide applications.

Modeling and analysis of a two-stage tri-linear pendulum ultra-low frequency horizontal vibration isolator with experimental investigations.

In engineering practice, the external horizontal oscillations always influence the working performance of precise instruments, advanced manufacture equipment, and gravitational wave detection. In order to ensure the normal operation of these instruments, it is necessary to attenuate these vibrations adequately. The pendulum mechanism horizontal vibration isolator is an efficient method.