How Plans Prepare for Future Uncertainty: Integrating Land Change Modeling and the Plan Integration for Resilience Scorecard.

This study integrates Land Change Modeling with the Plan Integration for Resilience Scorecard methodology to assess coastal communities' preparedness for uncertain future urban growth and flood hazards. Findings indicate that, under static climate conditions, the network of plans in Tampa is well prepared across all urban growth scenarios, but less so in the face of a changing climate. Specifically, scenario outputs that consider climate change suggest the need for more resilient growth to reduce flood vulnerability compared with the current land use plan.

The synergistic effects of acute stress and exogenous oxytocin on males' decision-making under unfairness.

Oxytocin (OXT) plays a critical role in stress-induced affiliative behavior, with important implications for socio-economic decision-making. In this study, 95 healthy young males were randomly assigned to four groups, receiving either 32 IU of exogenous OXT or a placebo (PBO) before undergoing the Trier Social Stress Test (TSST) or a control procedure, followed by participation in the Ultimatum Game (UG) as responders, allocating ¥50. The results indicated that OXT inhibited the hypothalamic-pituitary-adrenal (HPA) axis stress response, enhanced sympathetic nervous system activity, and increased subjectively perceived stress.

Improvement of the Thermal Decomposition of Ammonium Perchlorate and Combustion of Aluminum Powder by Dual Core-Shell Ammonium Perchlorate-Based Composites Based on Self-Assembly Coating.

Ammonium perchlorate (AP), which is the most commonly used oxidant in composite propellants, plays a vital role in the combustion performance of propellants. In this work, by coating the AP surface with a self-assembled coating layer of gallic acid (GA) and transition metal ions (Cu or Fe) and then connecting it with a 1,1,2,2-perfluorodecyltrichlorosilane (PDTS) coating layer, the AP@GA-M@PDTS (M = Cu or Fe) composite was successfully prepared. Molecular dynamics simulation calculations show that GA and AP have a good binding ability.

A Dual-Capture and Dual-Output 3D DNA Walker System Integrated with Ligases Enables Ultrasensitive Detection of Single-Nucleotide Polymorphisms.

DNA walkers, as structurally and functionally programmable signal amplification tools, exhibit great potential for application in the field of biosensing. Traditional DNA walkers often rely on enzymes for operation, posing compatibility challenges, while the handful of existing enzyme-free DNA walkers demonstrate limited performance. To address this, we innovatively developed an efficient enzyme-free 3D DNA walker with dual capture and dual output capabilities.

Preserving coastal environments requires an integrated natural and cultural resources management approach.

Integration of natural and cultural resource management is urgently needed to combat the effects of climate change. Scientists must contend with how human-induced climate change and rapid population expansion are fundamentally reworking densely inhabited coastal zones. We propose that a merger of archaeology, environmental science, and land management policy-different yet intertwined domains-is needed to address dramatic losses to biocultural resources that comprise coupled cultural-natural systems.

A dual-trigger entropy driven circuit based on competitive hybridization for highly specific enzyme-free detection of single nucleotide polymorphisms.

Single nucleotide polymorphisms (SNPs) play a pivotal role in the detection of major diseases and the breeding of molecular designs. However, current SNP detection methods often rely heavily on expensive proteases, or alternatively, enzyme-free detection methods grapple with limited specificity. Addressing this issue, our study presents an enzyme-free, highly specific, simple, and efficient detection platform.

Comprehensive analysis of transplacental transfer of environmental pollutants detected in paired maternal and cord serums.

Prenatal exposure to hazardous environmental pollutants is a critical global concern due to their confirmed presence in umbilical cord blood, indicating the ability of pollutants to cross the placental barrier and expose the fetus to harmful compounds. However, the transplacental transfer efficiencies (TTEs) of many pollutants remain underexplored. Herein, we developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to quantitatively analyze 91 environmental pollutants, including 13 bisphenols (BPs), 18 organophosphorus flame retardants (OPFRs), 7 brominated and other flame retardants (BFRs), 34 phthalates (PAEs), and 19 per- and polyfluoroalkyl substances (PFASs), in paired maternal and cord serums.

Factors Associated With Digital Capacity for Health Promotion Among Primary Care Workers: Cross-Sectional Survey Study.

Background: Health education and promotion are recognized as effective strategies for fostering healthy ageing, reducing the disease burden, and addressing health inequalities, particularly when delivered through digital media. Primary care workers are often regarded as the key providers of these interventions. Despite the strong practical significance and substantial individual demand, the use of digital media for delivering health promotion practices was not widespread in China.

Unveiling the hidden dangers: enteropathogens carried by flies in Pudong New Area.

Background: Flies are acknowledged as vectors of diseases transmitted through mechanical means and represent a significant risk to human health. The study aimed to determine the prevalence of enteropathogens carried by flies in Pudong New Area to inform strategies for preventing and controlling flies.

Methods: Samples were collected from various locations in the area using cage trapping techniques between April and November 2021, encompassing various habitats such as parks, residential areas, restaurants, and farmers' markets.

Structural characterization of Aspalatus linearis polysaccharide and its improving effect on acute alcoholic liver injury.

Polysaccharides from natural sources can regulate the composition of intestinal flora through the "gut-liver axis" pathway, potentially ameliorating alcoholic liver injury. Aspalathus linearis, also known as rooibos, is one such natural product that has shown promise in this regard. This study looked at the structural properties of A.

Tailored design of NHS-SS-NHS cross-linked chitosan nano-hydrogels for enhanced anti-tumor efficacy by GSH-responsive drug release.

The traditional chemotherapeutic agents' disadvantages such as high toxicity, untargeting and poor water solubility lead to disappointing chemotherapy effects, which restricts its clinical application. In this work, novel size-appropriate and glutathione (GSH)-responsive nano-hydrogels were successfully prepared via the active ester method between chitosan (containing -NH) and cross-linker (containing NHS). Especially, the cross-linker was elaborately designed to possess a disulfide linkage (SS) as well as two terminal NHS groups, namely NHS-SS-NHS.

Ethanol Extract of Improves Dextran Sulfate Sodium-Induced Ulcerative Colitis by Alleviating Inflammation and Restoring Gut Microbiota Dysbiosis in Mice.

Ulcerative colitis (UC) is a kind of inflammatory bowel condition characterized by inflammation within the mucous membrane, rectal bleeding, diarrhea, and pain experienced in the abdominal region. Existing medications for UC have limited treatment efficacy and primarily focus on symptom relief. Limonium bicolor (LB), an aquatic traditional Chinese medicine (TCM), exerts multi-targeted therapeutic effects with few side effects and is used to treat anemia and hemostasis.

The neurocomputational signature of decision-making for unfair offers in females under acute psychological stress.

Stress is a crucial factor affecting social decision-making. However, its impacts on the behavioral and neural processes of females' unfairness decision-making remain unclear. Combining computational modeling and functional near-infrared spectroscopy (fNIRS), this study attempted to illuminate the neurocomputational signature of unfairness decision-making in females.

The association of dietary patterns with latent tuberculosis infection among young adults: A case-control study in Shanghai.

Introduction: In developing and underdeveloped countries, undernutrition plays a major role in subverting the immune system, leading to an increase in TB infections; this study investigated the associations between dietary patterns and latent tuberculosis infection risk among young adults in Shanghai.

Methodology: In a case-control study, 96 cases of latent tuberculosis infection and 192 healthy controls were studied among contacts of students in clusters of tuberculosis epidemics in colleges from January 2021 to March 2023. A standardized questionnaire assessing sociodemographic, lifestyle, and dietary characteristics was applied.

The burden of tuberculosis among adolescents and young adults in five Asian countries from 1990 to 2019.

Background: Previous studies have shown that the risk of tuberculosis (TB) increases dramatically during adolescence. The objective of this article was to analyze the burdens and trends of TB incidence and mortality rates in Asian adolescents and young adults.

Methods: Time series ecological study of TB incidence and mortality rates of adolescents and young adults aged 10-24 years from 1990 to 2019, using data extracted from the Global Burden of Disease website for 5 Asian countries.

Single-Base Resolution Detection of -Methyladenosine in RNA by Adenosine Deamination Sequencing.

-Methyladenosine (mA) is one of the most abundant and prevalent natural modifications occurring in diverse RNA species. mA plays a wide range of roles in physiological and pathological processes. Revealing the functions of mA relies on the faithful detection of individual mA sites in RNA.

A polysaccharide from L. flowers relieves ulcerative colitis by regulating the inflammatory signaling pathway and gut microbiota.

A polysaccharide fraction named ATFP was isolated and purified from L. flowers. Its primary structure and therapeutic effects on mice with acute ulcerative colitis were investigated in the present study.

Ramulus Cinnamomi essential oil exerts an anti-inflammatory effect on RAW264.7 cells through N-acylethanolamine acid amidase inhibition.

Ethnopharmacological Relevance: Ramulus Cinnamomi, the dried twig of Cinnamomum cassia (L.) J.Presl.

Enzymatic Cleavage-Mediated Extension Stalling Enables Accurate Recognition and Quantification of Locus-Specific Uracil Modification in DNA.

Chemical modifications in DNA have profound influences on the structures and functions of DNA. Uracil, a naturally occurring DNA modification, can originate from the deamination of cytosine or arise from misincorporation of dUTP into DNA during DNA replication. Uracil in DNA will imperil genomic stability due to their potential in producing detrimental mutations.

The normalization of the active surface sites of bimetallic Pd-Pt catalysts, their inhomogeneity, and their roles in methane activation.

Multi-metallic catalysts containing Pt species are widely used. As there is no methodology to evaluate the quantity of active surface sites of Pt or other metal species, researchers have only published the total conversion or selectivity of all active surface sites. This study focuses on Pt-Pd bimetallic catalysts and uses both methane reaction kinetics and infrared (IR) spectroscopy to characterize the surface Pd and Pt sites.

Bile duct ligation increased dopamine levels in the cerebral cortex of rats partly due to induction of tyrosine hydroxylase.

Background And Purpose: Liver failure is associated with psychiatric alterations, partly resulting from the increased brain dopamine levels. We investigated the relationship between increased dopamine levels and mental abnormalities using bile duct ligation (BDL) rats and the mechanism by which liver failure increased dopamine levels in SH-SY5Y cells. Behavioural tests were carried out on day 13 and 27 following BDL, along with measurements of dopamine and metabolites, expressions of enzymes and transporters related to dopamine metabolism, and its transport into the cortex and the hippocampus.

Epidemiology and Genetic Characteristics of Porcine Reproductive and Respiratory Syndrome Virus in the Hunan and Hebei Provinces of China.

Porcine reproductive and respiratory syndrome virus (PRRSV) is a significant threat to the pig industry in China. However, the epidemiological characteristics of PRRSV after the outbreak of African swine fever in China were not thoroughly investigated. In the present study, the serological and epidemiological investigations of PRRSV in pigs from the Hunan and Hebei provinces of China were assessed.

Plan integration and plan quality: combining assessment tools to align local infrastructure priorities to reduce hazard vulnerability.

Hazard vulnerability is a characteristic of disaster risks from natural hazards, worsening climate challenges, complex geopolitical governance dynamics, and local development conditions. Comprehensive planning documents often articulate a community's infrastructure strategies, policies, and capital improvement investments, and are pivotal for sustainable development of cities. This article introduces a new approach for an evidence-based enhanced preparatory technique for comprehensive plans, called Plan I.