Are Sex-Specific Cutoffs Needed With a Next-Generation Urine Tenofovir Lateral Flow Assay for Antiretroviral Adherence Monitoring?

Accurate point-of-care tools are needed to detect early nonadherence to daily HIV regimens and support timely transitions to long-acting options. Emerging evidence suggests that females may require higher adherence than males to achieve equivalent protection. Our next-generation urine tenofovir assay showed high accuracy across sexes but lower urine drug levels among female participants.

Quinolone resistance in from Thai ducks: Mutation analysis of , and genes.

Background And Aim: is a Gram-negative bacterium causing systemic infections in ducks, often treated with quinolones. However, increasing resistance to quinolones poses a threat to effective treatment, and the molecular mechanisms underlying this resistance remain inadequately understood in Thailand. This study aimed to determine the minimum inhibitory concentrations (MICs) of nalidixic acid, ciprofloxacin, and enrofloxacin; identify mutations in the quinolone resistance-determining regions of and ; and detect () genes in isolates from Thai ducks.

Scopus-based bibliometric analysis of research trends in silage feed and its impact on rumen fermentation in ruminants.

Background And Aim: Silage plays a pivotal role in ruminant nutrition, significantly influencing rumen fermentation, animal productivity, and environmental sustainability. Despite extensive research on silage and fermentation, a comprehensive synthesis of global trends and collaborations in this domain has not been systematically explored. This study aimed to conduct a bibliometric analysis of global research on silage feed and its effects on rumen fermentation in ruminants.

Relationship Between Love Attitudes, Attachment Styles, and Personality Traits in Women Who Have Experienced Domestic Violence.

Objective: This study aimed to examine the relationship between attitudes toward love, attachment styles, and personality traits in women who have experienced domestic violence (DV).

Methods: The study consisted of 64 women who experienced DV and 64 women without such history. All participants completed a sociodemographic data form and three assessment scales.

Interleukin-5, Eosinophil, and Immunoglobulin A Levels in Schizophrenia Patients.

Objective: To analyze the correlation between interleukin-5 (IL-5), eosinophils (EOS), and immunoglobulin A (IgA) levels with schizophrenia, and assess their potential as auxiliary diagnostic markers for schizophrenia.

Methods: This study comprised 57 patients with first-episode schizophrenia and 340 patients with recurrent or chronic schizophrenia who were hospitalized at Beijing Huilongguan Hospital from March 2023 to August 2024, and 72 healthy volunteers were recruited as the control group. Fasting venous blood samples were collected from all participants on the second day after admission.

Humans exercising in the heat: A review on sweat models and a comparison to recent experimental datasets.

Sweating is a vital thermoregulatory mechanism in humans for maintaining thermal balance during exercise and exposure to hot environments. The development of models that predict sweat rate based on body temperature has been ongoing for over half a century. Here, we compared predicted water loss rates (WLR) from these models to actual observations collected during 780 participant-exposures in three independent laboratory-based experiments.

Validity of common body temperature sites and gait parameters during a heat tolerance test.

A heat tolerance test (HTT) can aid in return-to-play decision making following exertional heat stroke (EHS). The HTT uses rectal temperature (T, >38.5°C) and heart rate thresholds (HR; >150 bpm) to identify "heat intolerance.

Evaluating repeat transurethral resection after en bloc resection for non-muscle invasive bladder cancer.

Objective: Many studies have stressed the necessity of repeat transurethral resection (reTURB) following the initial conventional transurethral resection of the bladder for non-muscle invasive bladder cancer (NMIBC) patients. However, there have been few studies focusing on the role of reTURB after en bloc resection of bladder tumor (ERBT) for NMIBC by far. This study aimed to evaluate whether reTURB can be avoided after ERBT.

A thermochromic tissue-mimicking phantom for catheter-based radiofrequency ablation of heterogenous lesions.

Background: In catheter-based radiofrequency ablation (RFA), energy is delivered to heterogeneous thin-walled tissues to induce therapeutic heating. Variations in electrical and mechanical properties of tissue contents have a great effect on outcomes.

Purpose: The objective of this study is to develop models that replicate tissue heterogeneity and visualize ablation zones for effective evaluation and optimization.

Photoacoustic-imaging nanomotors enhance tumor penetration and alleviate hypoxia for photodynamic therapy of breast cancer.

Breast cancer is the most prevalent malignancy worldwide, yet conventional therapies are invasive and prone to resistance, recurrence, and metastasis. Photodynamic therapy (PDT) is a promising noninvasive modality, but its efficacy is limited by tumor hypoxia and poor photosensitizer delivery. Here, we report a photoacoustic-imaging nanomotor, PPIC, which addresses these challenges through integrated functions of oxygen production, deep tissue penetration and photoacoustic imaging.

Research status of small molecule inhibitors, probes, and degraders of NSDs: a comprehensive review.

The nuclear receptor binding SET domain (NSD) family of histone methyltransferases, which comprised NSD1, NSD2, and NSD3. They play a pivotal role in catalyzing mono- and dimethylation of histone H3 at lysine 36 (H3K36me1/2), a modification critical for maintaining chromatin structure and transcriptional fidelity. Dysregulation of NSD enzymes, often through overexpression, mutation, or chromosomal translocation, has been implicated in a broad spectrum of malignancies and various diseases.

Notoginsenoside R1 Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Apoptosis via Activating Wnt/β-Catenin Signaling.

Notoginsenoside R1 (NGR1), a natural triterpenoid saponin, is extracted from , and has cardiovascular and cerebrovascular protective effects due to anti-inflammatory, anti-oxidant, and anti-apoptotic properties. Previous research has suggested a protective role for NGR1 in myocardial ischemia/reperfusion (MI/R) injury. However, the potential mechanisms involved have not been fully elucidated.

A unique hybrid of vanadium carbide and oxycarbide derived carbon from a preceramic polymer route with faradaic and supercapacitive charge storage.

Polymer-derived ceramics are a versatile class of multifunctional materials synthesized the high-temperature treatment of a preceramic polymer. In this work, we report the synthesis of a vanadium carbide-embedded carbonaceous hybrid by pyrolyzing a modified preceramic polymer incorporating vanadium acetylacetonate in a polysilsesquioxane followed by hydrofluoric acid etching. The structural and microscopic characterisation confirmed the uniform distribution of nanoparticulate vanadium carbide in the matrix.

Harnessing the potential of phytochemicals to design anti-filarial molecules targeting the MurE enzyme of : a hierarchical virtual screening and molecular dynamics simulation study.

, a causative agent of lymphatic filariasis, relies on its endosymbiont for survival. MurE ligase, a key enzyme in peptidoglycan biosynthesis, serves as a promising drug target for anti-filarial therapy. In this study, we employed a hierarchical virtual screening pipeline to identify phytochemical inhibitors targeting the MurE enzyme of the endosymbiont of (MurE).

A directional self-priming continuous-driven compartmentalized microfluidic chip for multiplexed pathogen detection.

Rapid and efficient screening of foodborne pathogens is crucial for preventing bacterial spread and food poisoning. However, developing a multi-detection method that is easy to operate, offers good stability, and achieves high efficiency remains an enormous challenge. Existing multiplexed nucleic acid detection methods suffer from complex designs, leading to complicated operations, and non-robust sample introduction, causing primer/probe crosstalk and false-positive results.

Lightweight hybrid Mamba2 for unsupervised medical image registration.

Background: Deformable medical image registration is a critical task in medical imaging-assisted diagnosis and treatment. In recent years, medical image registration methods based on deep learning have made significant success by leveraging prior knowledge, and the registration accuracy and computational efficiency have been greatly improved. Models based on Transformers have achieved better performance than convolutional neural network methods (ConvNet) in image registration.

Synthesis and Reactivity of a Crystalline Zinc-cAAC Radical.

Reaction of LZnI [L = BuC(N-DIPP), DIPP = 2,6-Pr-CH] with KC in the presence of cyclic (alkyl)(amino)carbene (cAAC) affords a stable radical complex [LZn(cAAC)] (3). Single-crystal structural analysis of 3 shows a short Zn─C bond and concomitant elongation of C─N bond within the cAAC ligand, indicating a significant π-backbonding from the metal to the cAAC ligand. EPR spectroscopy and DFT calculations reveal that the spin density is mainly localized on the carbenic carbon atom, with a small portion on the zinc center.

Single-Molecule Dual-Anchor Design Enables Extreme-Condition Lithium Metal Batteries Through Solvation Reconstruction and Cathode Polymerization.

Lithium metal batteries (LMBs) have emerged as the most promising candidate for next-generation high-energy-density energy storage systems. However, their practical implementation is hindered by the inability of conventional carbonate electrolytes to simultaneously stabilize the lithium metal anode and LiNiCoMnO (NCM811) cathode interfaces, particularly under extreme operating conditions. Herein, we present a transformative molecular design using 3,5-difluorophenylboronic acid neopentyl glycol ester (DNE), which uniquely integrates dual interfacial stabilization mechanisms in a single molecule.

Smaller hippocampal tail volume is associated with plasma CCL11 levels in patients with major depressive disorder.

Background: This study investigates structural abnormalities in hippocampal subfield volumes and shapes, and their association with plasma CC chemokines in individuals with major depressive disorder (MDD).

Methods: A total of 61 patients with MDD and 65 healthy controls (HC) were recruited. All participants underwent high-resolution T1-weighted imaging and provided blood samples for the detection of CC chemokines (CCL2, CCL7, and CCL11).

Inverting the Rhodamine Paradigm: Closed-Form Fluorescence with 280 nm Stokes Shift Drives Plastic Circularity.

Rhodamine derivatives exhibiting inverted open-closed form fluorescence behavior redefines conventional photochemical paradigms while illuminating new structure-property relationships and fascinating application potentials. Herein, we report a donor-acceptor engineering strategy that activates closed form emission in rhodamines, achieving unprecedented Stokes shifts (>280 nm) while overcoming aggregation-caused quenching. The new class of rhodamines with inverted open-close form emission behavior are created through simultaneous substitution of N,N-diethyl groups with indole (donor) and conversion of spiro-lactam to benzene sulfonamide (acceptor).

Bibliometric analysis of the association between air pollution and allergic rhinitis.

Background: Allergic rhinitis (AR) is an increasingly prominent global public health issue, where air pollution significantly contributes to its rising incidence. Although numerous studies have explored the link between air pollution and AR pathogenesis, comprehensive summaries are still limited.

Objective: This study performs a bibliometric analysis to identify research hotspots and emerging trends, offering insights into AR prevention and management.

A single-component white-light-emitting hybrid copper(I) halide constructed using a supramolecular cation for WLEDs.

Single-component white-light-emitters ensure color stability while reducing device complexity, and are ideal candidates for white light-emitting diodes (WLEDs). However, the realization of single-component white-light emission with high efficiency and stability is still a challenge. Herein, a supramolecular cation strategy was used to synthesize the organic-inorganic hybrid copper(I) halide [(AMTA)(18C6)]CuI (1), with AMTA = 1-adamantanamine and 18C6 = 18-crown-6.

Protonation Enables Durable and Efficient Water Oxidation on Commercial TiO/IrO.

The oxygen evolution reaction (OER) performance of commercial TiO-supported IrO (IrO/TiO) suffers from the high electron transfer barriers at the IrO/TiO interface. Herein, we develop a cathodic polarization strategy to protonate TiO (p-TiO) in a commercial IrO/TiO catalyst. The high-density Ti-OH polaronic states on the surface of protonated TiO greatly contribute to the decrease in the electron transfer barriers at the IrO/TiO interface.

NOTIFICATION: Laparoscopic Ventral Mesh Rectopexy in Male Patients with Internal or External Rectal Prolapse.

A.E. Owais, H.

NOTIFICATION: A Prospective Evaluation of Stapled Haemorrhoidopexy/Rectal Mucosectomy in the Management of 3rd and 4th Degree Haemorrhoids.

S. Slawik, N. Kenefick, G.