H1N1pdm09 returns: a comparative study in Anhui, China.

The 2022/2023 season witnessed a rapid resurgence of H1N1pdm09 in Anhui Province, China, surpassing previous years, prompting an examination of hemagglutinin (HA) gene mutations and cross-immunity in this study. Anhui Province's surveillance data established the detection threshold for H1N1pdm09 using the Moving Epidemic Method. Joinpoint regression compared weekly percent change (WPC) rates.

Understanding influenza-like illness dynamics in Jiangsu, China: impacts of COVID-19 control measures and meteorological factors on the population health during 2018-2023.

Background: Since the emergence of the COVID-19 pandemic, how meteorological factors and COVID-19 control measures in China impact the transmission dynamics of influenza-like illness (ILI) across age groups remains unclear.

Objective: This study aims to explore the changes in the seasonal ILI epidemics and the effects of meteorological factors across age groups in Jiangsu, China, before the COVID-19 pandemic and after the relaxation of COVID-19 control measures.

Methods: The time-varying reproduction number ( ) and doubling time of ILI were deployed to describe the trend and iteration time of the ILI epidemic, and the effect of Chinese government response to COVID-19 on the ILI epidemic, respectively.

Global, regional, and national burden of lead-attributable intellectual developmental disability in children and adolescents from 1990 to 2021, with projections up to 2040: the global burden of disease 2021 study.

Unlabelled: Long-term lead exposure damages the central nervous system, with chronic poisoning strongly linked to intellectual developmental disability (IDD) and disproportionately affecting children and adolescents. Using the Global Burden of Disease (GBD) 2021 database, this study analyzed temporal, spatial, and population-specific trends in lead-attributable IDD burden among global children/adolescents (1990-2021) and projected trends to 2040 to inform global public health strategies. GBD 2021 data characterized global, regional, and national distributions of lead-attributable IDD burden.

Volatile organic compounds exposure with risk of thyroid function in U.S. general population: 2007-2012 NHANES.

Background: The link between exposure to environmental hazards and thyroid function has been relatively well established. However, evidence on environmental exposure to volatile organic compounds (VOCs) and thyroid function in the general population remains unclear.

Objectives: To assess the impact of individual and joint effects of VOCs exposure on thyroid function in a representative sample of U.

A single-molecule biosensor based on multiple fluorophore nucleic acid probe and STORM imaging for detection of Hantaan virus.

Hemorrhagic fever with renal syndrome (HFRS), caused by Hantaan virus, poses a serious public health threat. Current diagnostic methods remain limited by low sensitivity, complex procedures, and high sample requirements. To address this, we developed a highly sensitive single-molecule biosensor using multi-fluorophore nucleic acid probes and STORM imaging for the detection of Hantaan virus RNA.

Planetary Health Diet and risk of mortality and chronic diseases: Results from US NHANES, UK Biobank, and a meta-analysis.

The health benefits of the Planetary Health Diet (PHD) require further validation. We examined associations between PHD adherence and risks of mortality and chronic diseases using data from two prospective cohorts-the US NHANES (1999-2018, 42,947 participants) and the UKB (125,372 participants)-and a meta-analysis of 37 published cohort studies (3,244,263 participants). Higher adherence to PHD was associated with lower all-cause mortality in both cohorts.

[Determination of 79 pesticide residues in fruits and vegetables by QuEChERS-ultra performance liquid chromatography-tandem mass spectrometry].

Pesticide residues in fruits and vegetables are becoming a serious issue. These residues can affect the quality of agricultural products and people's health. Therefore， it has become crucial to effectively monitor and control pesticide residues in the food safety field.

The correlation between lower limb spasticity and proprioceptive dysfunction in post-stroke patients.

Objective: To investigate the correlation between lower limb spasticity and proprioception in stroke patients, to analyze the influencing factors of spasticity, and to evaluate the predictive value of musculoskeletal ultrasound parameters on spasticity.

Methods: A cross-sectional study was used to enroll 80 stroke patients admitted to the Rehabilitation Center of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from October 2024 to April 2025. The degree of lower limb spasticity was evaluated by the modified Ashworth Scale (MAS), and the proprioceptive assessment module of the Pro-kin balance system was used to quantitatively detect the mean trajectory error (ATE) and the average weight-bearing asymmetry (AWA).

Mortality risks associated with ozone exposure: Modified by temperature and mediating temperature effects.

Background: Short-term exposure to ozone has been linked to increased mortality, but its role in temperature-health associations is still not fully understood. Beyond direct effects, ozone may influence mortality as both a factor modified by temperature and a mediator of temperature's impact.

Methods: We conducted a time-series study using quasi-Poisson generalized additive models (GAMs) to examine associations between short-term ozone exposure and cause-specific mortality in Hefei, China (2014-2022).

Reactive oxygen species-responsive virus-mimicking nanodrug for the treatment of influenza A virus infection.

Drug therapy is an important measure to reduce the morbidity and mortality of influenza. However, small molecule drugs have inherent limitations, such as poor water solubility, non-specific biological distribution, and susceptibility to degradation during blood circulation, which impose a great burden on patients, both physically and mentally. Inspired by the high levels of reactive oxygen species (ROS) at the site of influenza A virus (IAV) infection, we have developed an intelligent responsive virus-mimicking nanodrug (Zana@HA-Lip) based on a biomimetic approach, reduces the damage of the drug to normal tissues or organs while achieving the purpose of antiviral therapy by precisely releasing the drug at the lesion site.

Influenza vaccination hesitancy and decision between parental and grandparental caregivers of preschoolers: a comparative study.

Background: Grandparents are increasingly involved in childcare, yet their role in childhood vaccination remains understudied. Generational differences shaped by historical and social experiences may influence vaccine attitudes, highlighting the need to compare parents and grandparents in addressing vaccine hesitancy.

Methods: This study conducted a field survey in five Chinese cities in 2024, collecting data from childhood caregivers.

Chinese Healthy Eating Index (CHEI) and risk of hypertension: A prospective cohort study in China.

The Chinese Healthy Eating Index (CHEI) is a valuable tool for assessing dietary quality. However, the relationship between CHEI and the risk of hypertension remains unclear. Therefore, a total of 1342 adults without hypertension at baseline and provided at least two survey data from 1997 to 2018 were included.

Over one-third of cancer cases and two-fifths of cancer deaths in southern China are preventable: Insights from the latest representative population-based cancer registry data and risk factor survey.

Assessing the impact of modifiable risk factors on cancer is crucial for prioritizing effective prevention interventions. This study aimed to quantify the cancer burden attributable to modifiable risk factors in Guangdong in 2019, thereby informing targeted prevention strategies tailored to the region. The population attributable fraction (PAF) was estimated by Levin's method, based on the 2010 prevalence of 15 risk factors and the latest representative relative risks.

Identification of subtypes of type 2 diabetes in the Chinese population and their distinct complication risk profiles.

Aims: To identify and validate subgroups of type 2 diabetes in Chinese populations using clustering analysis and assess their complication risks.

Materials And Methods: Data from 5653 type 2 diabetes patients in the Shanghai Suburban Adult Cohort and Biobank (SSACB) and 6384 in the Southwest China Diabetic Chronic Complications Study were integrated. Using body mass index, fasting blood glucose, age at diabetes diagnosis, and triglycerides to high-density lipoprotein cholesterol ratio, k-means clustering was performed by sex in SSACB and validated in Southwest China Diabetic Chronic Complications Study.

Epidemiological trends of laboratory-confirmed influenza cases driven by meteorological factors in Anhui Province, China: a multi-city time-series analysis.

Background: Influenza poses a significant threat to public health, potentially influenced by environmental factors. However, the role of meteorological factors (MFs) on influenza risks in China remains underexplored. This study explored the effect of MFs on laboratory-confirmed influenza (LCI) cases in Anhui, China.

Antithrombotic strategies in adult COVID-19 patients: a systematic review and Bayesian network meta-analysis.

Objectives: To systematically compare the effects of various antithrombotic strategies on prespecified outcomes including 28-day all-cause mortality (primary outcome), major thrombotic events and major bleeding events (secondary outcomes) in adult COVID-19 patients.

Design: Systematic review and Bayesian network meta-analysis (NMA).

Data Sources: PubMed, Web of Science, Embase, Cochrane Library and ClinicalTrials.

Long-term trends and projections of ovarian cancer burden in China (1990 to 2040): an age-period-cohort analysis based on GBD 2021 data.

Background: The growing burden of ovarian cancer is attracting widespread attention; the impact factors and the evolution trend of ovarian cancer burden need to be further studied.

Methods: Ovarian cancer disease burden data for Chinese women were obtained from the Global Burden of Disease study 2021. We performed Age-Period-Cohort (APC) analysis to evaluate evolution trends across age, period, and cohort dimensions and identify contributing factors.

Impact of vaccination strategy adjustments on antibody levels against measles, rubella, mumps, and varicella in China: a single-center serological survey.

Objective: This study evaluated trends in population immunity against measles, rubella, mumps, and varicella in Suqian City (2005-2024) using serological surveys (2019-2024) and incidence data, incorporating participants with known/unknown vaccination statuses to explore immunity dynamics amid evolving policies, and inform public health planning.

Methods: Serum samples from 541 (2019) and 506 (2024) healthy participants were analyzed for virus-specific IgG antibodies using ELISA. Disease incidence data were obtained from China's National Notifiable Disease Reporting System.

Enhancing HIV Genotyping and Drug-Resistance Detection in Low Viral Load Samples Through Exosome Enrichment Technology.

Genotypic drug-resistance testing for HIV-1 with low viral loads (VLs) (<1,000 copies/mL) is clinically important but technically challenging. Due to the overlapping physical size characteristics of HIV-1 viral particles (100-120 nm) and exosomes (40-150 nm), simultaneous enrichment of both using size separation technology may offer a new strategy to improve the success rate of genotypic resistance testing in low VL samples. To evaluate the application of exosome enrichment technology in genotypic drug resistance testing for HIV-1 in low VL samples.

Risk analysis of food-pathogen combinations based on disease burden of bacterial foodborne disease outbreaks in Zhejiang Province, China.

Bacterial foodborne disease outbreaks (FBDOs) pose significant public health risks. This study aimed to assess the risk of food-pathogen combinations in bacterial FBDOs in Zhejiang Province using Disability-Adjusted Life Years (DALYs) to inform targeted prevention and control strategies. Data from the Foodborne Disease Outbreak Surveillance System (FDOSS) between 2010 and 2022 were analyzed, focusing on outbreaks with identified food-pathogen combinations.

Associations of Stressful Life Events With Diabetes Incidence in China: Insights From the China Kadoorie Biobank.

Background: Limited empirical evidence exists on the link between exposure to various stressful life events (SLEs) and the heightened risk of Diabetes Mellitus (DM) within the mainland Chinese population.

Methods: We conducted this prospective cohort study with 455,464 participants from the China Kadoorie Biobank (CKB); we examined associations between SLEs exposures and DM outcomes. We employed multivariable Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for potential confounders.

Machine learning-based analysis and prediction of factors influencing mental health among children and adolescents in Jiangsu Province.

Background: This study investigates the current mental health status among children and adolescents in Jiangsu Province by analyzing symptoms of depression, anxiety, and stress using standardized psychological scales. Machine learning models were utilized to identify key influencing variables and predict mental health outcomes, aiming to establish a rapid psychological well-being assessment framework for this population.

Objective: A cross-sectional survey was conducted via random cluster sampling across 98 counties (cities/districts) in Jiangsu Province, enrolling 141,725 students (47,502 primary, 47,274 junior high, 11,619 vocational high school students, and 35,330 senior high ).

Tea Consumption and Liver Cancer: A Population-Based Case-Control Study in Eastern China.

: Identifying dietary factors influencing liver cancer is crucial for developing preventive measures. While tea polyphenols have demonstrated cancer-preventive activities in animal models, the evidence in humans is not definitive. This study aims to explore the association between tea consumption and liver cancer, as well as the interaction between tea drinking and other risk factors, in China, a country with a high incidence of liver cancer and substantial tea consumption.

Association between the metabolic score for insulin resistance trajectory and new-onset metabolic syndrome: a retrospective cohort study based on health check-up data in China.

Background: The Metabolic Score for Insulin Resistance (METS-IR) is a novel biomarker for evaluation of insulin resistance (IR). Emerging evidence suggests this metric may be able to predict the onset of metabolic syndrome (MetS). The aim of this study was to determine whether there is a correlation between sustained METS-IR values and the future risk of MetS.