H1N1pdm09 returns: a comparative study in Anhui, China.

The 2022/2023 season witnessed a rapid resurgence of H1N1pdm09 in Anhui Province, China, surpassing previous years, prompting an examination of hemagglutinin (HA) gene mutations and cross-immunity in this study. Anhui Province's surveillance data established the detection threshold for H1N1pdm09 using the Moving Epidemic Method. Joinpoint regression compared weekly percent change (WPC) rates.

Mortality risks associated with ozone exposure: Modified by temperature and mediating temperature effects.

Background: Short-term exposure to ozone has been linked to increased mortality, but its role in temperature-health associations is still not fully understood. Beyond direct effects, ozone may influence mortality as both a factor modified by temperature and a mediator of temperature's impact.

Methods: We conducted a time-series study using quasi-Poisson generalized additive models (GAMs) to examine associations between short-term ozone exposure and cause-specific mortality in Hefei, China (2014-2022).

Epidemiological trends of laboratory-confirmed influenza cases driven by meteorological factors in Anhui Province, China: a multi-city time-series analysis.

Background: Influenza poses a significant threat to public health, potentially influenced by environmental factors. However, the role of meteorological factors (MFs) on influenza risks in China remains underexplored. This study explored the effect of MFs on laboratory-confirmed influenza (LCI) cases in Anhui, China.

Post-Marketing Safety Surveillance of HPV Vaccines in Anhui Province, China, 2017-2024.

The Human Papillomavirus (HPV) vaccine has been globally implemented to prevent HPV-associated diseases. Since its introduction in China in 2017, this vaccine has substantially reduced the burden of HPV-related health conditions. As more people get vaccinated these days, ongoing safety monitoring and evaluation have become critical.

Genomic Characteristics and Antibiotic Resistance Evolution of Vibrio cholerae O139 - Anhui Province, China, 2013-2024.

What Is Already Known About This Topic?: Cholera, a severe diarrheal disease caused by , remains a major global public health concern. In 2023, the World Health Organization reported 535,321 cholera cases and 4,007 deaths in 45 countries. Sporadic cases and epidemic outbreaks of the cholera serogroup O139 have been documented in various Chinese provinces since 1993.

Association between prenatal exposure to bisphenols and preterm birth: the interaction effect of anemia.

Maternal exposure to bisphenols (BPs) during pregnancy may negatively impact birth outcomes. However, research on the interaction between anemia and exposure in relation to preterm birth (PTB) is limited. A prospective birth cohort was used to assess the relationship between prenatal exposure to BPs and PTB, and to explore potential effect modification by maternal anemia.

Quantifying localized heatwave impact on mortality: a multi-country modeling study in the Asia-Pacific region.

Background: Heatwave is a global health threat. However, existing heatwave definitions often rely on fixed temperature thresholds without incorporating region-specific health outcomes or population acclimatization, limiting their applicability across diverse climatic and demographic contexts. We aimed to assess the impact of localized heatwave on mortality based on a proposed framework of health-based heatwave definition.

[Feasibility of the spatiotemporal filtering model for analyzing the spatiotemporal distribution of reported schistosomiasis cases].

Objective: To investigate the feasibility of the spatiotemporal filtering model in analysis of reported schistosomiasis cases, so as to provide insights into analysis of complicated data pertaining to schistosomiasis control.

Methods: Demographic and epidemiological data of reported schistosomiasis cases in Anhui Province from 1997 to 2010 were collected from Anhui Provincial Center for Disease Control and Prevention, and the annual prevalence of human infections was calculated. The meteorological data were captured from meteorological stations in counties (cities, districts) of Anhui Province where schistosomiasis cases were reported from 1997 to 2010 at the National Meteorological Information Center, including monthly average air temperature and precipitation.

The Factors Influencing the Incidence, Persistence, and Severity of Symptoms After SARS-CoV-2 Infection in Chinese Adults: A Case-Control Study.

Following the emergence of COVID-19, breakthrough SARS-CoV-2 infections have demonstrated substantial heterogeneity in both occurrence and clinical severity. This case-control study aimed to elucidate the factors associated with the incidence, duration, and severity of SARS-CoV-2 symptoms among Chinese adults during the Omicron wave. The analysis was based on data from a national COVID-19 surveillance program encompassing six provinces-Jiangsu, Chongqing, Shandong, Hunan, Anhui, and Yunnan-and included both laboratory-confirmed and clinically diagnosed cases.

[Content of fat, fatty acids and sugar of chocolates and its products in Anhui Province].

Objective: Analyze the levels of fat, fatty acids and sugar in 30 commercially available chocolates and their products.

Methods: The contents of fat, fatty acids, and sugar in 30 chocolate products were tested. Principal component analysis was conducted on the fatty acid composition, and the proportions of different functional fatty acids were compared.

[Association between handgrip strength and chronic kidney disease in adult residents in Anhui Province].

To explore the independent association between handgrip strength and chronic kidney disease (CKD) in adult residents in Anhui Province using data from the China Adult Chronic Disease and Risk Factor Surveillance (2023). A multi-stage stratified cluster random sampling method was used to select residents aged ≥18 years for surveys, physical measurements, and laboratory tests. Relevant covariates were adjusted, and a multivariable logistic regression model was established to infer the association between handgrip strength and CKD, followed by subgroup analysis.

Decreased CD4 T cell counts drive aberrant B cell repertoire alterations in people living with HIV.

Understanding the evolution of broadly neutralizing antibody (bNAb) activity in people living with HIV is crucial for vaccine design and immunization strategies. It has been proposed that antibody cross-reactive activity is associated with lower CD4 T cell counts during people living with HIV, but the underlying mechanisms remain unclear. To further explore the correlation between antibody reactivity and CD4 T cell counts, we recruited people living with HIV with varying CD4 T cell counts: (i) CD4 T cell ≤50 cells/μL, (ii) 50 cells/μL < CD4 T cell ≤200 cells/μL, (iii) 200 cells/μL < CD4 T cell ≤500 cells/μL, (iv) 500 cells/μL < CD4 T cell.

Study on the characteristics and influencing factors on non-marital non-commercial heterosexual transmission of HIV/AIDS in Anhui Province, China, 2015-2022.

Background: To understand the newly reported prevalence rate and its influencing factors of non-marital non-commercial heterosexual contact (NMNCHC) of persons with HIV from 2015 to 2022, in Anhui Province, China. In order to provide a reference basis of HIV prevention and control for targeted people.

Methods: The information of newly reported persons with HIV in Anhui Province from the year 2015 to 2022 was downloaded from the Chinese HIV/AIDS Comprehensive Response Information Management System (CRIMS).

Bidirectional interdomain crosstalk in a chimeric enzyme coordinates catalytic synergy for aromatic amino acid biosynthesis.

The shikimate pathway, critical for bacterial aromatic amino acid biosynthesis, represents a prime therapeutic target due to its absence in humans. This study elucidates the structural and functional interplay within the bifunctional enzyme DAH7PS-CM from (DAH7PS-CM), a keystone periodontal pathogen. Integrating AlphaFold3-predicted models with biochemical validation, we identified two interdomain interfaces: a conserved DAH7PS dimerization interface and a polar interaction-driven D-CM interface (e.

The relationship between prenatal perfluorine and polyfluoroalkyl substances (PFAS) exposure and infant neurodevelopment: Modifying effects of DHA revised.

Background: It has been found that prenatal perfluorine and polyfluoroalkyl substances (PFAS) exposure can affect infant neurodevelopment. On the other hand, docosahexaenoic acid (DHA) supplementation can improve neurodevelopment, but studies on whether it can improve neurodevelopmental delay caused by prenatal PFAS exposure are limited.

Objective: This study aimed to investigate the relationship between prenatal PFAS exposure and infant neurodevelopmental delay and evaluate the effects of postnatal DHA supplementation on infant neurodevelopment.

One Health integrated surveillance: a way forward to accelerate schistosomiasis elimination in China.

Surveillance is an effective approach for disease control and prevention. Being a vector-borne and zoonotic parasitic disease, schistosomiasis has been under comprehensive surveillance in China for several decades, with focus on indicators related to definitive hosts, intermediate hosts, as well as changes of influencing factors. This article reviewed the surveillance system of schistosomiasis in China from the perspective of One Health to provide evidence for the acceleration of elimination.

Maternal Perinatal Depression and Infant Behavioural Development: A Potential Cumulative Effect.

Limited research has examined the relationship between maternal perinatal depression and infant behaviours, as well as the potential cumulative effects. A sample of 686 mother-child pairs from the Wuhu Birth Cohort Study was used. Maternal depression levels were repeatedly assessed during the first trimester, second trimester, third trimester, and 3-months postpartum using the Edinburgh Postnatal Depression Scale.

Longitudinal analysis of cytokine dynamics in severe fever with thrombocytopenia syndrome patients - High-incidence regions of China (2010-2023).

Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening tick-borne disease characterized by cytokine dysregulation and immune-mediated hyperinflammation. This multicenter retrospective study analyzed the dynamics of 17 cytokines across acute and recovery phases using 287 serum samples collected between 2010 and 2023 from high-incidence regions of China, evaluating their associations with disease severity, sex, age, and antibody responses. The results demonstrated that elevations of interleukin (IL)-6, interferon (IFN)-α, IL-8, and IFN-γ-induced protein 10 (IP-10) during the acute phase were associated with hyperinflammation, while IL-10 balanced inflammatory control and may have contributed to viral persistence.

Association between multimorbidity and intrinsic capacity among older Chinese adults: evidence from the CHARLS 2011-2015.

Purpose: To investigate the relationships between multimorbidity, patterns, and intrinsic capacity (IC) transitions in older Chinese adults.

Methods: The data were obtained from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2015. IC evaluations were conducted in 2011 and 2015, encompassing cognition capacity, locomotion capacity, vitality capacity, psychological capacity, and sensory capacity.

Application of Remote Sensing Methods in Predicting the Dynamics of - Anhui Province, China, 2019-2023.

What Is Already Known About This Topic?: Remote sensing information provides indirect insights into infectious disease dynamics. Public health practice has significantly benefited from the increasing availability and accessibility of remote sensing data.

What Is Added By This Report?: This study explores the relationship between meteorological and environmental factors and malaria vector abundance using remote sensing technology, establishing predictive models for population dynamics.

Impact of the pandemic on traffic injuries in Macao: an analysis of interrupted time-series data.

Objective: With social restrictions serving as a mitigating factor against the severe consequences of public health emergencies, this study investigates the impact of episodic travel restrictions on road traffic injuries (TIs) in Macao during the pandemic, employing Interrupted Time Series Analysis (ITSA) models.

Methods: We used ITSA models, including Bayesian Structured Time Series and Seasonal Autoregressive Integrated Moving Average models, to assess traffic outcomes, particularly focusing on total road traffic crashes (RTCs) and TIs. Predictive models were developed for traffic fatalities, fatal RTCs, RTCs involving injuries and vehicles sustaining damage.

Indoor concentrations and exposure levels of CO, SO₂, NO₂, and O₃ in Chinese residences, schools, and offices (2000-2021): A systematic review.

This systematic review addressed critical knowledge gaps regarding the spatiotemporal patterns and human exposure to indoor gaseous pollutants (CO, SO₂, NO₂, O₃) in Chinese civil buildings (residences, schools, offices) from 2000 to 2021. A total of 108 field measurement studies revealed divergent temporal trends: a decline in indoor CO, SO, and NO concentrations over the past two decades in China, alongside a rise in indoor O concentrations. The highest CO (8.

Characterization of the gut microbiota in different immunological responses among PLWH.

Despite gut microbial dysbiosis has been demonstrated in people living with HIV (PLWH), the association between gut microbial and inflammatory cytokines in PLWH with different immunoreaction to antiretroviral therapy (ART) is poorly understood. The purpose of this study is to explore between gut microbial and inflammatory cytokines in PLWH with different immunoreaction. 68 PLWH and 27 healthy controls(HCs) in Anhui Province were recruited from December 2021 to March 2022, including 35 immunological responders (IRs) (CD4T-cell count ≥ 350 cells/µL) and 33 immunological non-responders (INRs) (CD4T-cell count < 350 cells/µL) without comorbidities.

Impact of CD4+ T cell and TCR repertoires on SARS-CoV-2-Specific antibody responses in PLWH following COVID-19 vaccination.

In people living with human immunodeficiency virus (HIV, PLWH), the coronavirus disease 2019 (COVID-19) vaccine often results in a limited humoral immune response. While a reduced absolute CD4+ T cell count is a known factor, other determinants remain unclear. To investigate variables influencing the differential antibody response to the COVID-19 vaccine in PLWH, 43 HIV-1/AIDS patients receiving antiretroviral therapy (ART) and 2 doses of the COVID-19 vaccine were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immunoglobulin G (IgG) levels and neutralizing antibody (NAb) titers.

The Spatiotemporal Epidemiology and Influencing Factor Analysis of Leptospirosis - Anhui Province, China, 2004-2023.

Introduction: Leptospirosis has historically been a severe public health concern across multiple Chinese provinces. Despite an overall decline in incidence in recent years, the disease continues to exhibit fluctuations and occasionally triggers localized outbreaks. This study aimed to characterize the demographic and spatiotemporal patterns of leptospirosis in Anhui Province - a historically significant epidemic region - from 2004 to 2023, to investigate potential climatic and environmental risk factors, and to identify critical targets for disease prevention and control.