Mortality risks associated with ozone exposure: Modified by temperature and mediating temperature effects.

Background: Short-term exposure to ozone has been linked to increased mortality, but its role in temperature-health associations is still not fully understood. Beyond direct effects, ozone may influence mortality as both a factor modified by temperature and a mediator of temperature's impact.

Methods: We conducted a time-series study using quasi-Poisson generalized additive models (GAMs) to examine associations between short-term ozone exposure and cause-specific mortality in Hefei, China (2014-2022).

The effect of bullying victimization on internet addiction: mediated by cyberbullying perpetration and moderated by social support.

Background: Given the importance and high prevalence of Internet addiction (IA), this study aimed to investigate the relationship between bullying victimization and Chinese adolescent students' IA and its mechanism-mediated by cyberbullying perpetration and moderated by social support.

Methods: Participants completed the Internet Addiction Test (IAT) and provided information on their demographics, experiences with bullying, and social support. General linear modeling (GLM), structural equation modeling (SEM), and interaction item analysis were conducted.

Association between prenatal exposure to bisphenols and preterm birth: the interaction effect of anemia.

Maternal exposure to bisphenols (BPs) during pregnancy may negatively impact birth outcomes. However, research on the interaction between anemia and exposure in relation to preterm birth (PTB) is limited. A prospective birth cohort was used to assess the relationship between prenatal exposure to BPs and PTB, and to explore potential effect modification by maternal anemia.

Bisphenol AF exposure induced synaptic plasticity and neurobehavioral impairments via triggering the ROS-mediated PERK-eIF2α-ATF4 signaling pathway in adolescent mice.

Bisphenol AF (BPAF), a fluorinated homolog of BPA, has been produced as a replacement for BPA. However, the consequences and mechanisms of adolescent exposure to BPAF in terms of neurobehavioral injury remain unclear. In this study, using an in vivo model, we found that BPAF is able to cross the blood-brain barrier (BBB) and lead to anxiety- and depression-like behaviors and cognitive dysfunction in adolescent mice.

Age-period-cohort analysis of global, regional, and national cervical cancer prevalence trends in women of childbearing age (15-49 years), 1990-2021.

Purpose: Cervical cancer remains a significant global health challenge, particularly among women of childbearing age (15-49 years). Recent data indicate a steady rise in cervical cancer incidence and mortality. This study investigates how age, period, and cohort affect cervical cancer prevalence worldwide from 1990 to 2021, with a focus on regional variations in burden based on the socio-demographic index (SDI).

The relationship between prenatal perfluorine and polyfluoroalkyl substances (PFAS) exposure and infant neurodevelopment: Modifying effects of DHA revised.

Background: It has been found that prenatal perfluorine and polyfluoroalkyl substances (PFAS) exposure can affect infant neurodevelopment. On the other hand, docosahexaenoic acid (DHA) supplementation can improve neurodevelopment, but studies on whether it can improve neurodevelopmental delay caused by prenatal PFAS exposure are limited.

Objective: This study aimed to investigate the relationship between prenatal PFAS exposure and infant neurodevelopmental delay and evaluate the effects of postnatal DHA supplementation on infant neurodevelopment.

Comprehensive Analysis of Oncogenic, Prognostic, and Immunological Roles of FANCD2 in Hepatocellular Carcinoma: A Potential Predictor for Survival and Immunotherapy.

Objective: Hepatocellular carcinoma (HCC) is sensitive to ferroptosis, a new form of programmed cell death that occurs in most tumor types. However, the mechanism through which ferroptosis modulates HCC remains unclear. This study aimed to investigate the oncogenic role and prognostic value of FANCD2 and provide novel insights into the prognostic assessment and prediction of immunotherapy.

Impaired inflammatory resolution with severe SARS-CoV-2 infection in leptin knock out obese hamster.

Comorbidities, such as obesity, increase the risk of severe COVID-19. However, the mechanisms underlying severe illnesses in individuals with obesity are poorly understood. Here, we used gene-edited leptin knock out ( ) obese hamsters to establish a severe infection model.

The prevalence and association of traditional bullying and cyber bullying with mental health among adolescent and youth students in China: a study after the lifting of COVID-19 restrictions.

Background: Although bullying may affect students' mental health, its prevalence and impact on mental health among students in China after the lifting of COVID-19 restrictions remains unclear. This study aimed to explored the prevalence and association of traditional and cyber bullying with mental health among Chinese adolescent and youth students post-COVID-19 restrictions.

Methods: An online survey included 82,873 students from various educational levels in Sichuan Province, China, assessing traditional and cyber victimization, cyber perpetration, COVID-19 experiences, insomnia, anxiety, depression, and post-traumatic stress disorder (PTSD).

External validation of EncephalApp Stroop test to screen minimal hepatic encephalopathy patients with nonalcoholic cirrhosis.

Background: Neurocognitive impairment, including minimal hepatic encephalopathy (MHE) and overt hepatic encephalopathy, is one of the most common complications of all types of primary liver diseases, such as hepatitis B, biliary cholangitis, and autoimmune hepatitis. The EncephalApp Stroop test is a smartphone application-based test that is time-saving for MHE screening. However, neurocognitive impairment is different between alcoholic cirrhosis patients and nonalcoholic cirrhosis patients, so the cutoff value for MHE diagnosis might be inflated.

Paediatric Drug Development in China: Current Status and Future Prospects.

For more than two decades, regulatory agencies throughout the world released guidelines, rules and laws to stimulate and assist in paediatric drug development. In 2014, the National Health and Family Planning Commission (now known as the National Health Commission, NHC) and five other departments in China jointly issued 'Several Opinions on Safeguarding Medication for Children', after which several policies and regulations were issued to implement the priority review and approval of paediatric medicinal products and support the development of new drugs, including new dosage forms and strengths, for children. A total of 172 special medicinal products for children were approved from 2018 to 2022.

Clinical study on the difference in intestinal microecology between patients with preeclampsia and pregnant women at different stages of pregnancy.

To explore the difference in intestinal microecology between patients with preeclampsia and pregnant women at different stages of pregnancy. From January 2020 to January 2022, clinical data, including blood routine, lipid profile, and renal function indicators, were gathered from a cohort consisting of 5 cases of preeclampsia and 34 cases of non-preeclampsia. The non-preeclampsia group was further categorized into 6 cases in the First trimester, 13 cases in the Second trimester, and 15 cases in the Third trimester.

Polyketides with α-glucosidase inhibitory and neuroprotective activities from associated with .

, an endophytic fungus associated with the herbal medicine , produced four new polyketides, aspeversins A-D (1-2 and 5-6) and four known compounds, -methylaverufin (2), aversin (3), varilactone A (7) and spirosorbicillinol A (8). Their structures were elucidated by extensive spectroscopic data analysis, and their absolute configurations were determined by calculated electronic circular dichroism (ECD) and Mo(AcO)-induced CD data. Compound 5 was found to exhibit α-glucosidase inhibitory activity with an IC value of 25.

Roxadustat Versus Erythropoietin: The Comparison of Efficacy in Reversing Ventricular Remodeling in Dialysis Patients with Anaemia.

Renal anaemia and left ventricular hypertrophy are the main complications of chronic kidney disease and are shared among dialysis patients. This retrospective study aimed to compare the efficacies of the hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat and recombinant human erythropoietin in reversing ventricular remodeling in dialysis patients with renal anaemia. A total of 204 participants underwent baseline examinations, including echocardiograms and laboratory tests, before being administered either treatment for at least 24 weeks from January 2018 to October 2021, after which follow-up examinations were conducted at 6 months.

Synthesis, structure, theoretical calculation and antibacterial property of two novel Zn(II)/Ni(II) compounds based on 3, 5-dichlorosalicylaldehyde thiocarbamide ligand.

Two new compounds namely [Zn(L1)phen]1 and Ni(L1)phen(MeOH) 2 (L1 = 3, 5-dichlorosalicylaldehyde thiosemicarbazone) were synthesized by the slow evaporation method at room temperature. The structure of ligand L1 was determined using H NMR and C NMR spectra. X-ray single crystal diffraction analysis revealed that compounds 1-2 can form 3D supramolecular network structures through π···π stacking and hydrogen bonding interactions.

The ratio of neutrophils to lymphocytes effectively predicts clinical outcomes in idiopathic membranous nephropathy.

Background: Systemic inflammatory indicators are important in the prognoses of various diseases. Such indicators, including the neutrophil-to-lymphocyte ratio (NLR), can be meaningful in predicting the clinical outcome in patients diagnosed with idiopathic membranous nephropathy (IMN).

Materials And Methods: 112 IMN patients diagnosed by renal biopsy were recruited retrospectively.

Activation of acetyl-CoA synthetase 2 mediates kidney injury in diabetic nephropathy.

Albuminuria and podocyte injury are the key cellular events in the progression of diabetic nephropathy (DN). Acetyl-CoA synthetase 2 (ACSS2) is a nucleocytosolic enzyme responsible for the regulation of metabolic homeostasis in mammalian cells. This study aimed to investigate the possible roles of ACSS2 in kidney injury in DN.

Treatment of maternal syphilis for preventing congenital syphilis: an observational study of adherence to treatment recommendation in Suzhou, China, 2019-2021.

Background: China is one of the countries that set the goal to eliminate mother-to-child transmission (EMTCT) of syphilis by a target date. Active screening for syphilis among pregnant women, followed by effective treatment of maternal syphilis, is critical for achieving the goal. The China health authority issued national implementation protocols to guide EMTCT practice in health facilities.

Identification of TMEM53 as a novel SADS-CoV restriction factor that targets viral RNA-dependent RNA polymerase.

Zoonotic transmission of coronaviruses (CoVs) poses a serious public health threat. Swine acute diarrhea syndrome coronavirus (SADS-CoV), originating from a bat HKU2-related CoV, causes devastating swine diseases and poses a high risk of spillover to humans. Currently, licensed therapeutics that can prevent potential human outbreaks are unavailable.