A Digital Signal Processing-Based Multi-Channel Acoustic Emission Acquisition System with a Simplified Analog Front-End.

Advanced multi-channel acoustic emission (AE) monitoring systems often rely on complex and costly architectures, especially those requiring custom FPGA-based hardware. In this work, we present a digital signal processing (DSP)-based approach to high-performance AE acquisition, implemented using a simplified analog front-end (AFE) and a commercially available synchronous data acquisition (DAQ) card (NI USB-6356). This design eliminates the need for specialized FPGA development, improving accessibility and reducing system complexity.

Awareness and willingness to utilize HIV pre-exposure prophylaxis and associated factors among men who have sex with men in Maanshan, China.

Objective: Men who have sex with men (MSM) are disproportionately affected by HIV and represent the primary target population for pre-exposure prophylaxis (PrEP) use. However, PrEP adoption in China remains limited, partly due to its late regulatory approval. This study aims to investigate the awareness and willingness of PrEP use and associated factors among MSM in Maanshan city, so as to promote the popularization of PrEP.

Characterization of the gut microbiota in different immunological responses among PLWH.

Despite gut microbial dysbiosis has been demonstrated in people living with HIV (PLWH), the association between gut microbial and inflammatory cytokines in PLWH with different immunoreaction to antiretroviral therapy (ART) is poorly understood. The purpose of this study is to explore between gut microbial and inflammatory cytokines in PLWH with different immunoreaction. 68 PLWH and 27 healthy controls(HCs) in Anhui Province were recruited from December 2021 to March 2022, including 35 immunological responders (IRs) (CD4T-cell count ≥ 350 cells/µL) and 33 immunological non-responders (INRs) (CD4T-cell count < 350 cells/µL) without comorbidities.

Awareness of hepatitis C prevention and treatment and high-risk behaviors among the general population in Anhui Province: a cross-sectional study.

Background: The World Health Organization (WHO) set the goal of "eliminating viral hepatitis as a major public health threat by 2030" in 2016. In 2021, the National Health Commission of China (NHCC), issued an action plan to help achieve the WHO's goal of eliminating the Hepatitis C virus by 2030. Therefore, the primary objective of this study was to investigate the awareness of knowledge of hepatitis C prevention and treatment and high-risk behaviors among the general population of Anhui Province.

Self-Reported REM Sleep Behavior Disorder in Patients With Progressive Supranuclear Palsy: Clinical and F-Florzolotau PET Imaging Findings.

Background And Objectives: Rapid eye movement sleep behavior disorder (RBD) is increasingly recognized in patients with tauopathies, but its significance and underpinnings remain unclear. To address this gap, we investigated the prevalence of self-reported RBD in patients with progressive supranuclear palsy (PSP) and explored its clinical and imaging correlates using F-florzolotau PET imaging.

Methods: We consecutively enrolled patients meeting the 2017 Movement Disorder Society clinical criteria for PSP at a Chinese tertiary hospital between May 2019 and March 2022.

Rapid Cognitive Deterioration in Progressive Supranuclear Palsy: A 1-Year Follow-Up Study.

Background: Nowadays, cognitive impairment has been characterized as one of the most vital clinical symptoms in progressive supranuclear palsy (PSP).

Objectives: Based on a relatively large cohort, we aimed to show the cognitive deterioration in different PSP subtypes during 1-year follow-up and investigate potential contributors for disease prognosis.

Methods: One hundred seventeen patients from Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI) cohort underwent neuropsychological tests and 1-year follow-up, with 73 diagnosed as PSP-Richardson syndrome (PSP-RS) and 44 as PSP-non-RS.

Biological links between psychological factors and adolescent depression: childhood trauma, rumination, and resilience.

Background: The psychosocial factors play an important role in the development of depression in adolescents. we used metabolomics techniques to explore the links among childhood trauma, rumination, resilience, and adolescent depression.

Methods: We selected 57 adolescent depression patients and 53 healthy adolescents.

F-Florzolotau PET Imaging Unveils Tau Pathology in Dementia with Lewy Bodies.

Background: Dementia with Lewy bodies (DLB) commonly exhibits a complex neuropathology, sharing characteristics with Alzheimer's disease (AD), including tau aggregates. However, studies using the F-AV-1451 tau tracer have shown inconsistent findings regarding both the extent and topographical distribution of tau pathology in DLB.

Objectives: Our aim was to elucidate the topographical patterns of tau deposition in DLB and to investigate the in vivo pathological distinction between DLB and AD in virtue of the F-Florzolotau positron emission tomography (PET) imaging.

Characterization of the intestinal microbiota in MSM with HIV infection.

Background: HIV-infected persons demonstrate notable disturbances in their intestinal microbiota; however, the impact of intestinal microbiota on HIV susceptibility in men who have sex with men (MSM), as well as the effects of HIV and antiretroviral therapy (ART) on their gut microbiota, remains under active study. Thus, our research focuses on clarifying the distinctions in intestinal microbiota composition among uninfected MSM and non-MSM healthy controls, investigating the alterations in early-stage intestinal microbial communities following HIV infection, and assessing how ART affects the intestinal microbiota.

Methods: This study enrolled four participant groups: uninfected MSM, Recent HIV-1 infection (RHI) MSM, MSM on ART, and non-MSM healthy controls, with 30 individuals in each group.

Effects of alcohol on the composition and metabolism of the intestinal microbiota among people with HIV: A cross-sectional study.

Objectives: Alcohol consumption is not uncommon among people with HIV (PWH) and may exacerbate HIV-induced intestinal damage, and further lead to dysbiosis and increased intestinal permeability. This study aimed to determine the changes in the fecal microbiota and its association with alcohol consumption in HIV-infected patients.

Methods: A cross-sectional survey was conducted between November 2021 and May 2022, and 93 participants were recruited.

The prevalence and factors of willingness to accept circumcision among MSM in Maanshan City, China.

To investigate the prevalence of male circumcision and the willingness to undergo male circumcision and influencing factors among MSM in Maanshan City, we conducted a cross-sectional study from June 2016 to December 2019. Respondent-driven sampling (RDS) was used to recruit participants. Influential factors of willingness to accept circumcision were identified by a multivariable logistic regression model.

Revisiting the intersection of microglial activation and neuroinflammation in Alzheimer's disease from the perspective of ferroptosis.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by chronic neuroinflammation with amyloid beta-protein deposition and hyperphosphorylated tau protein. The typical clinical manifestation of AD is progressive memory impairment, and AD is considered a multifactorial disease with various etiologies (genetic factors, aging, lifestyle, etc.) and complicated pathophysiological processes.

Schisandrin B Alleviates Diabetic Cardiac Autonomic neuropathy Induced by P2X7 Receptor in Superior Cervical Ganglion via NLRP3.

Diabetic cardiovascular autonomic neuropathy (DCAN) is a common complication of diabetes mellitus which brings about high mortality, high morbidity, and large economic burden to the society. Compensatory tachycardia after myocardial ischemia caused by DCAN can increase myocardial injury and result in more damage to the cardiac function. The inflammation induced by hyperglycemia can increase P2X7 receptor expression in the superior cervical ganglion (SCG), resulting in nerve damage.

Enhanced dielectric properties of polystyrene by using graphene incorporated styrene-butyl acrylate microspheres.

In view of the current trend of capacitor materials, the development of capacitors with high dielectric permittivity and low dielectric loss is of great interest. In this work, the dielectric permittivity of reduced graphene oxide-incorporated styrene-butyl acrylate (rGO@SBA) composite microspheres synthesized by mini-emulsion polymerization was significantly improved. rGO with 2 wt% content gave a dielectric permittivity of 11 356 (at 1 KHz), which was 1925 times higher than that of pure SBA (5.

LncRNA-UC.25 + shRNA Alleviates P2Y Receptor-Mediated Diabetic Neuropathic Pain via STAT1.

Diabetic neuropathic pain (DNP) is a common complication of diabetes, and its complicated pathogenesis, as well as clinical manifestations, has brought great trouble to clinical treatment. The spinal cord is an important part of regulating the occurrence and development of DNP. Spinal microglia can regulate the activity of spinal cord neurons and have a regulatory effect on chronic pain.

Naringin Relieves Diabetic Cardiac Autonomic Neuropathy Mediated by P2Y Receptor in Superior Cervical Ganglion.

Diabetes mellitus (DM), an emerging chronic epidemic, contributes to mortality and morbidity around the world. Diabetic cardiac autonomic neuropathy (DCAN) is one of the most common complications associated with DM. Previous studies have shown that satellite glial cells (SGCs) in the superior cervical ganglia (SCG) play an indispensable role in DCAN progression.