Identification of subtypes of type 2 diabetes in the Chinese population and their distinct complication risk profiles.

Aims: To identify and validate subgroups of type 2 diabetes in Chinese populations using clustering analysis and assess their complication risks.

Materials And Methods: Data from 5653 type 2 diabetes patients in the Shanghai Suburban Adult Cohort and Biobank (SSACB) and 6384 in the Southwest China Diabetic Chronic Complications Study were integrated. Using body mass index, fasting blood glucose, age at diabetes diagnosis, and triglycerides to high-density lipoprotein cholesterol ratio, k-means clustering was performed by sex in SSACB and validated in Southwest China Diabetic Chronic Complications Study.

Environmental noise exposure and cardiovascular diseases in a Shanghai cohort.

Background: Little is known about the impact of environmental noise on cardiovascular diseases (CVDs) in low- and middle-income countries, where high population density and complex sources of noise are prevalent. This study aimed to explore associations of environmental noise with CVDs and cardiovascular risk factors.

Methods: 27,444 participants aged 18-74 years were included in this study.

Age- and time-dependent waning vaccine effectiveness of PPV23 against community-acquired pneumonia among adults aged 60 and older: A cohort study.

The 23-valent pneumococcal polysaccharide vaccine (PPV23) is recommended for adults to prevent pneumococcal diseases, while its effectiveness over time remains unclear. This study aimed to assess the age- and time-dependent effectiveness of PPV23 in reducing community-acquired pneumonia (CAP) incidence among adults aged 60 and older in China. We conducted a prospective cohort study in Shanghai, China, identifying CAP cases via inpatient and outpatient medical records.

Refined Carbohydrate, Different Staple Foods Intake and Risk of Metabolic Dysfunction-Associated Steatotic Liver Disease: A Prospective Community-Based Cohort Study.

Introduction: Limited evidence exists regarding the association between intake of refined carbohydrates, different staple foods, and the risk of metabolic dysfunction-associated steatotic liver disease (MASLD).

Methods: We conducted a prospective cohort study among Chinese adults from Shanghai Suburban Adult Cohort and Biobank to investigate the associations between different carbohydrate foods and MASLD risk. Dietary intake was assessed by a validated food frequency questionnaire.

[A Prospective Cohort Study on Soy Product Intake and the Risk of Lung Cancer Based on Shanghai Suburban Adult Cohort and Biobank].

Background: Lung cancer is one of the malignant cancers with the highest incidence rate, and it is important to identify the factors contributing to lung cancer carcinogenesis for prevention. Lifestyle and genetic factors play important roles in cancer development, however the impact of dietary factors, such as soy product intake, on lung cancer risk remains inadequately understood. This study aims to explore the associations between soy product intake, genetic risk, and lung cancer incidence, and validate the consistent effects of soy product intake in European populations, thereby providing new insights for lung cancer prevention.

Association of Ambient Temperature and Relative Humidity With Respiratory Syncytial Virus Infections Among Hospitalized Children in Suzhou, Eastern China: A Time-Series Analysis.

Respiratory syncytial virus (RSV) is the leading cause of clinical pneumonia in children. We aimed to investigate the associations between ambient temperature, relative humidity, and pediatric RSV infections, and to assess the disease burden attributable to cold or humid conditions. Daily data on RSV hospitalizations among children aged ≤5 years, mean temperature, and relative humidity in Suzhou, China, from January 2016 to December 2019 were collected.

Adherence to the Mediterranean Diet and Risk of Depression: A Cohort Study in Chinese Community Residents.

Limited studies have investigated the association between compliance with a Mediterranean diet and depression in China. We sought to explore the potential association between the adherence to an alternate Mediterranean diet score (aMED) and the risk of developing depression among adults in Eastern China. : This study used a prospective cohort design that involved a total of 52,232 individuals in the Shanghai Suburban Adult Cohort and Biobank (SSACB).

Prevalence of pilus islets and association with clonal complex in isolated from children in Suzhou, China.

Pilus islets (PIs) in play a crucial role in bacterial adhesion and virulence. This study aims to investigate the prevalence of PIs and explore their associations with serotypes, clones, and antibiotic susceptibility in isolated from children in Suzhou, China. A total of 341 .

Contact patterns between index patients and their close contacts and assessing risk for COVID-19 transmission during different exposure time windows: a large retrospective observational study of 450 770 close contacts in Shanghai.

Introduction: To characterise age-mixing patterns among index cases and contacts of COVID-19, and explore when patients are most infectious during the disease process.

Methods: This study examined all initial 90 885 confirmed index cases in Shanghai and their 450 770 close contacts. A generalised additive mixed model was used to analyse the associations of the number of close contacts with different demographic and clinical characteristics.

Costs of Influenza Illness and Acute Respiratory Infections by Household Income Level: Catastrophic Health Expenditures and Implications for Health Equity.

Background: Seasonal influenza illness and acute respiratory infections can impose a substantial economic burden in low- and middle-income countries (LMICs). We assessed the cost of influenza illness and acute respiratory infections across household income strata.

Methods: We conducted a secondary analysis of data from a prior systematic review of costs of influenza and other respiratory illnesses in LMICs and contacted authors to obtain data on cost of illness (COI) for laboratory-confirmed influenza-like illness and acute respiratory infection.

Cis-Regulation of an mA Eraser by an Insertion Variant Associated with Survival of Patients With Non-Small Cell Lung Carcinoma.

N6-methyladenosine (mA) serves as one of the crucial RNA modifications for genes involved in cancer progression. Here, 7273 expression quantitative trait loci potentially regulating 30 m6A pathway genes are identified from the GTEx database, with 69 single nucleotide polymorphisms significantly associated with survival of non-small cell lung carcinoma (NSCLC) patients (n = 1523) from the ongoing genome-wide association study after false positive probability tests. Notably, the rs151198415 locus, situated in a potential enhancer region, demonstrated a prolonged survival effect with the C>CCACG insertion, which is validated in an independent prospective cohort (n = 237), yielding a pooled hazard ratio of 0.

The Association of Dietary Diversity with Hyperuricemia among Community Inhabitants in Shanghai, China: A Prospective Research.

Hyperuricemia, a major worldwide burden on public hygiene, is closely connected with dietary habits. However, few studies have evaluated the association of dietary diversity with hyperuricemia. To preliminarily reveal the status of a diversified diet in preventing hyperuricemia based on a neighborhood-based, massive-scale cohort in China, a total of 43,493 participants aged 20-74 years old, with no history of hyperuricemia at baseline, were enrolled in the research from April 2016 to December 2019.

The Epidemiologic and Clinical Features of Radiographic-Confirmed Community-acquired Pneumonia Among Chinese Children: A Retrospective Hospital-based Study.

Background: To help understand the disease burden of vaccine-preventable bacterial disease, we delineated the epidemiologic and clinical characteristics of radiographic-confirmed community-acquired pneumonia (CXR-CAP) among Chinese children.

Methods: We retrospectively screened the electronic database of the hospital information system to identify all pediatric CAP cases admitted to the Children's Hospital of Soochow University between 2010 and 2014. Radiographic findings and clinical data were extracted from the medical charts through individual chart reviews.

Healthy lifestyles are associated with alleviating the single-nucleotide polymorphism-based genetic risks of ischaemic stroke, intracerebral haemorrhage and myocardial infarction.

Background: Both genetic and lifestyle factors contribute to myocardial infarction (MI) and stroke, including ischaemic stroke (IS) and intracerebral haemorrhage (ICH). We explored how and the extent to which a healthy lifestyle, by considering a comprehensive list, could counteract the genetic risk of those diseases, respectively.

Methods: 315 044 participants free of stroke and MI at baseline were identified from the UK Biobank.

Relationships between minerals' intake and blood homocysteine levels based on three machine learning methods: a large cross-sectional study.

Background: Blood homocysteine (Hcy) level has become a sensitive indicator in predicting the development of cardiovascular disease. Studies have shown an association between individual mineral intake and blood Hcy levels. The effect of mixed minerals' intake on blood Hcy levels is unknown.

Healthier Dietary Patterns Are Associated with Better Sleep Quality among Shanghai Suburban Adults: A Cross-Sectional Study.

Background: More is to be explored between dietary patterns and sleep quality in the Chinese adult population.

Methods: A cross-sectional study including 7987 Shanghai suburban adults aged 20-74 years was conducted. Dietary information was obtained using a validated food frequency questionnaire.

Impact of COVID-19 Nonpharmaceutical Interventions on Respiratory Syncytial Virus Infections in Hospitalized Children.

Background: Nonpharmaceutical interventions (NPIs) targeted at SARS-CoV-2 have remarkably affected the circulation of other respiratory pathogens, including respiratory syncytial virus (RSV). This study aimed to assess the changes in epidemiological and clinical characteristics of RSV infections in hospitalized children before and during the pandemic in Suzhou, China.

Methods: We prospectively enrolled children aged < 18 years who were hospitalized in Soochow University Affiliated Children's Hospital with acute lower respiratory infection (ALRIs) from January 2018 to July 2022.

Associations of Sedentary Behavior with Risks of Cardiovascular Disease Events among Chinese Adults.

Aims: Evidence regarding the modification effects of age, sex, ethnicity, socioeconomic status, or weight status on the associations of sedentary behavior (SB) with cardiovascular diseases (CVDs) is limited. Moreover, the mechanisms for the associations also remain unclear. We aimed to investigate the possible influence of these factors on the associations of SB with CVD events and whether the associations are mediated by metabolic phenotypes.

Dairy products intake and prevalence, incidence, and recovery of non-alcoholic fatty liver disease in Chinese population.

Background: Non-alcoholic fatty liver disease (NAFLD) is a growing public health concern. Modifiable factors such as diet and lifestyle are of research interest in preventing or reversing the disease. The relationship between dairy products and NAFLD remains unclear.

Differences in antibiotic use between COPD and non-COPD residents based on the health information system.

Objectives: To compare the differences in antibiotic use between COPD and non-COPD residents, and to explore the effect of COPD on antibiotic use.

Methods: Participants aged 40 years old or over from the Songjiang Adult Cohort were included. Information on prescription and baseline survey was collected based on the health information system.

Fever clinic construction and management targeted to prevention and control of healthcare-associated respiratory viral infections in Jiangsu, China: A cross-sectional observational study.

To analyze the post-COVID-19 construction and management of fever clinics targeted to prevention and control of healthcare-associated respiratory viral infections in medical institutions at all levels in China, and to provide a basis for promoting their standardized construction, we conducted this survey on the construction of fever clinics in 429 medical institutions of Jiangsu Province from July to December 2020. Contents of the questionnaire included the general situation of medical institutions, the construction status and future construction plans of fever clinics. We find the construction rate of fever clinic in medical institutions of Jiangsu province was 75.

Effectiveness of 13-valent pneumococcal conjugate vaccine against vaccine-serotype community acquired pneumococcal diseases among children in China: A test-negative case-control study.

Background: In 2016, China licensed 13-valent pneumococcal conjugate vaccine (PCV13) based on a study that demonstrated its immunogenicity is non-inferior to PCV7. However, the real-world effectiveness of PCV13 against vaccine-serotype pneumococcal diseases in China has limited evidence.

Methods: A test-negative case-control study was conducted among children under 5 years old admitted to the Children's Hospital of Soochow University (SCH) with respiratory tract infections from January 2018 to December 2020.