A bibliometric analysis of the study of health equity of migrants.

Background: Research on migrants has grown significantly over the past 20 years. However, systematic reviews and summaries of the health equity of migrants are lacking.

Objective: This bibliometric analysis aims to reveal the knowledge structure, cooperation networks, and research frontiers in immigrant health equity for the first time, providing a framework and guidance for future studies.

Reactive oxygen species-responsive virus-mimicking nanodrug for the treatment of influenza A virus infection.

Drug therapy is an important measure to reduce the morbidity and mortality of influenza. However, small molecule drugs have inherent limitations, such as poor water solubility, non-specific biological distribution, and susceptibility to degradation during blood circulation, which impose a great burden on patients, both physically and mentally. Inspired by the high levels of reactive oxygen species (ROS) at the site of influenza A virus (IAV) infection, we have developed an intelligent responsive virus-mimicking nanodrug (Zana@HA-Lip) based on a biomimetic approach, reduces the damage of the drug to normal tissues or organs while achieving the purpose of antiviral therapy by precisely releasing the drug at the lesion site.

Chinese Healthy Eating Index (CHEI) and risk of hypertension: A prospective cohort study in China.

The Chinese Healthy Eating Index (CHEI) is a valuable tool for assessing dietary quality. However, the relationship between CHEI and the risk of hypertension remains unclear. Therefore, a total of 1342 adults without hypertension at baseline and provided at least two survey data from 1997 to 2018 were included.

Enhancing HIV Genotyping and Drug-Resistance Detection in Low Viral Load Samples Through Exosome Enrichment Technology.

Genotypic drug-resistance testing for HIV-1 with low viral loads (VLs) (<1,000 copies/mL) is clinically important but technically challenging. Due to the overlapping physical size characteristics of HIV-1 viral particles (100-120 nm) and exosomes (40-150 nm), simultaneous enrichment of both using size separation technology may offer a new strategy to improve the success rate of genotypic resistance testing in low VL samples. To evaluate the application of exosome enrichment technology in genotypic drug resistance testing for HIV-1 in low VL samples.

A Fall Prevention Program Integrated in Primary Health Care for Older People in Rural China: The FAMILY Cluster Randomized Clinical Trial.

Importance: With rapidly aging populations globally, there is a lack of evidence on effective fall prevention strategies among community-dwelling older people in resource-constrained areas.

Objective: To assess the effectiveness of a fall prevention program integrated in primary health care systems on the risk of falls among Chinese rural older adults.

Design, Setting, And Participants: A 12-month, open-label, cluster randomized clinical trial, conducted in 128 rural villages from 4 Chinese provinces, involving adults 60 years or older at risk of falls (recruitment from September 19, 2023, to November 15, 2023; last follow-up, January 15, 2025).

Global, regional, and national burdens of pertussis among adults: a systematic analysis of age-specific trends using Global Burden of Diseases 2021 data.

Background: Despite the high coverage of childhood vaccination, pertussis remains a significant global health challenge, with increasing adult cases attributed to waning immunity and enhanced diagnostic capability. This study quantified the global burden of pertussis in adults from 1990 to 2021 and evaluated the impact of the COVID-19 pandemic on disease trends.

Methods: Using data from the Global Burden of Disease Study 2021, we assessed pertussis incidence and disability-adjusted life years (DALYs) in adults, stratified by age, sex, sociodemographic factors, and geographic regions.

Impaired physical function in relation to later-life exposure to ambient fine particulate matter and ozone among Chinese middle-aged and older adults.

While ambient fine particulate matter (PM) and ozone (O) are extensively associated with population health, no studies have yet assessed the potential association between concurrent exposure to these two pollutants and physical function (PF) in middle-aged and elderly individuals. By collecting data from three phases of the China Health and Retirement Longitudinal Study (CHARLS), we included 8834 follow-up observations from 4110 participants aged 45 years and older who had undergone at least two physical examinations between 2011 and 2015. PF scores of enrolled participants were assessed through four objective tests including grip strength, balance, walking speed, and repeated chair stands.

Evidence of non-carcinogenicity of rhubarb extract: a 2-year feeding study in SD rats.

This study evaluated the carcinogenicity and determined the no observed adverse effect level (NOAEL) of rhubarb extract in Sprague-Dawley (SD) rats over two years.SD rats (104 per group, equal males/females) were randomly assigned to a control (0 mg/kg BW) and three treatment groups (101, 405, and 1620 mg/kg BW). The extract was administered via diet for 104 weeks.

The holistic rehabilitation from acute severe fever with thrombocytopenia syndrome virus infection to 10 years after recovery: A cross-sectional study.

Acute viral infections may lead to long-term adverse health effects. Investigating the hematological and biochemical profiles during recovery can provide valuable insights into the prognosis of severe fever with thrombocytopenia syndrome (SFTS) virus infection. Herein, we performed a cross-sectional analysis of 24 hematological parameters and 12 liver and kidney function-related indicators in 143 naturally infected SFTS patients from the acute phase to 10 years post-recovery.

Direct sequencing of DNA 5-methylcytosine by engineered dioxygenase NTET-assisted eNAPS.

DNA methylation (5-methylcytosine, 5mC) represents the most prevalent modification in mammals, which is closely linked to disease pathogenesis and cancer development. Single-base resolution sequencing and quantitative analysis of 5mC are essential for elucidating its biological functions. However, current methods are still limited by resolution, sequencing bias, and false positives.

MGV-seq: a sensitive and culture-independent method for detecting microbial genetic variation.

Background: Precise detection of microbial genetic variation (MGV) at the strain level is essential for reliable disease diagnosis, pathogen surveillance, and reproducible research. Current methods, however, are constrained by limited sensitivity, specificity, and dependence on culturing. To address these challenges, we developed MGV-Seq, an innovative culture-independent approach that integrates multiplex PCR, high-throughput sequencing, and bioinformatics to analyze multiple dispersed nucleotide polymorphism (MNP) markers, enabling high-resolution strain differentiation.

Forecasting high-risk areas for dengue outbreaks in China: A trend analysis of Aedes albopictus and Aedes aegypti distributions from 2014 to 2030.

Background: Global warming, urbanization and the resumption of global population movements post-COVID-19 have made the prevention and control of dengue and its vector transmission more challenging. To tackle this issue, this study evaluated and predicted the suitable habitats of Aedes albopictus and Aedes aegypti in China. This study aims to identify the key influencing factors, analyze patterns of habitat expansion and contraction, and explore regions in China at risk of dengue fever outbreaks in the future.

Efficacy of music therapy as a non-pharmacological measure to support alzheimer's disease patients: a systematic review.

Background: Alzheimer's disease (AD) is a degenerative disease of the central nervous system characterized by progressive memory degradation and language and behavior disorders. Apart from curative pharmacological therapies, music therapy (MT) has been diffusely used as an efficient and economical non-pharmacological treatment for AD patients in recent years.

Methods: Three databases (PubMed, Web of Science and PsycINFO) were searched to analyse the efficacy of MT in patients with AD.

Immunogenicity and safety of sequential Sabin strain inactivated poliovirus vaccine from different manufacturers in infants: Randomized, blinded, controlled trial.

Objectives: The National Immunization Program allows using a different manufacturer's vaccine for follow-up doses when the same vaccine is unavailable. This study aimed to evaluate the safety and immunogenicity of administering a third dose of Sabin strain (sIPV) from a different manufacturer in infants who had previously received two doses of sIPV.

Methods: This randomized, blinded, controlled trial enrolled 200 healthy infants (≤12 months) to assess the safety and immunogenicity of sequential vaccination, who were randomly assigned to receive a third dose of sIPV from either a different manufacturer (experimental group) or the same manufacturer as the first two doses (control group).

Epidemiological features of nontyphoidal Salmonella infections reported to foodborne disease surveillance system in china, 2013-2022.

Background: Nontyphoidal Salmonella (NTS) is the most commonly reported foodborne gastrointestinal infection and ranks among the top three causes of foodborne bacterial outbreaks in China.

Methods: This study analyzed NTS data from the Foodborne Disease Surveillance System in China from 2013 to 2022 to summarize epidemiological features and assess reporting rate changes. We employed joinpoint regression model to calculate the annual percentage change in NTS reporting rate, sex reporting rate, as well as rural-urban reporting rate.

Safety evaluation of Nannochloropsis gaditana oil as a novel food.

To assess the safety of the Nannochloropsis gaditana oil as a new food ingredient, we conducted a comprehensive toxicological evaluation, including acute oral toxicity study, genotoxicity studies, teratogenicity study, and subchronic toxicity study. In the acute oral toxicity study, the LD > 8.4 g/kg BW.

Respiratory bacterial and viral pathogen spectrum among influenza-positive and influenza-negative patients.

Background: Respiratory tract infections are a significant burden on public health worldwide, with influenza being a prominent viral infection. Although influenza is known to predispose individuals to secondary bacterial infections, the precise spectrum of respiratory pathogens in influenza-positive and negative-patients remains unclear. This study aims to gain insights into the pathogenesis, epidemiology, and clinical implications of co-infections, facilitating the development of preventive and targeted interventions.

Cas12a Cis-cleavage mediated lateral flow assay enables multiplex and ultra-specific nucleic acid detection.

CRISPR technology holds significant promise for advancing nucleic acid assays. However, current CRISPR diagnostic techniques, reliant on indiscriminate trans-cleavage mechanisms, face challenges in developing multiplex detection formats. Moreover, chaotic trans-cleavage activity often results from mismatched targets, leading to specificity issues.

Peatland fires in Peninsular Malaysia act as primary source of dioxins, dioxin-like polychlorinated biphenyl, and particulate matter.

The emissions of polyhalogenated aromatic hydrocarbons released in the air from peatland fires pose significant environmental health hazards. The contribution of peatland fires to environmental pollution is increasing continually in Malaysia. The composition of the smoke emerging from such fires plays a pivotal role in elucidating health risks.

[Pollution characteristics and health risk assessment of indicator polychlorinated biphenyls in aquatic products in 10 provinces of China].

Objective: To investigate the pollution levels and characteristics of indicator polychlorinated biphenyls(PCBs) in aquatic products and assess the health risk of residents in 10 provinces of China.

Methods: A total of 629 aquatic product samples were collected from 10 provinces of China in 2023, including freshwater fish, marine fish and bivalves. The concentrations of seven indicator PCBs in aquatic products were determined by isotope dilution gas chromatography-mass spectrometry, and the pollution characteristics were analyzed.

Myeloid-Derived LGALS9-P4HB Immune Interaction Promotes Metastasis in Gastric Cancer Through Enhanced Cell Proliferation and Lipid Metabolism.

Metastasis remains the primary cause of mortality in gastric cancer patients; however, the underlying mechanisms driving this process remain incompletely understood. Here, we performed an integrated single-cell analysis of gastric cancer primary tumours and their corresponding liver and lymph node metastases to identify critical intercellular communication networks driving the metastatic process. Notably, gene expression analysis of metastatic tissues showed significant upregulation of cholesterol metabolism and PPAR signalling pathway (a nuclear receptor-mediated regulatory system that orchestrates lipid metabolism, adipogenesis and energy homeostasis) genes compared to primary tumours.

Pneumonia caused by : A case report.

As well known, the species of Bordetella, such as and are prevalent respiratory tract pathogens. , another species of Bordetella genus, could cause meningitis, bacteremia, lung disease, endocarditis, chronic cholangitis and soft tissue abscess. In this study, we reported a new case of infection in Asia with the clinical presentation and laboratory diagnosis.

Chemical Composition of Toona sinensis Extract and its Antibacterial, Antibiofilm, and Antioxidant Activities, with Antibacterial Mechanisms against Listeria monocytogenes ATCC 19112.

Toona sinensis is a traditional plant used in food and medicine, but no reports exist on its antibacterial and antibiofilm effects against Listeria monocytogenes. This study analyzed the chemical components of the ethyl acetate extract of T. sinensis and explored its antibacterial, antibiofilm, and antioxidant effects.

The oxacillinase variant, OXA-1152, in contributes to discrepancies in carbapenem resistance.

species are emerging multidrug-resistant pathogens with inconsistent carbapenem susceptibility, being resistant to meropenem but susceptible to imipenem, which complicates treatment. Here, we identified a previously uncharacterized oxacillinase gene, , in 12 strains from Wuhan, China. Deleting reduced meropenem and imipenem minimal inhibitory concentrations (MICs) by 64- and 4-fold, respectively, while reintroducing it into and restored resistance.

Longitudinal analysis of cytokine dynamics in severe fever with thrombocytopenia syndrome patients - High-incidence regions of China (2010-2023).

Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening tick-borne disease characterized by cytokine dysregulation and immune-mediated hyperinflammation. This multicenter retrospective study analyzed the dynamics of 17 cytokines across acute and recovery phases using 287 serum samples collected between 2010 and 2023 from high-incidence regions of China, evaluating their associations with disease severity, sex, age, and antibody responses. The results demonstrated that elevations of interleukin (IL)-6, interferon (IFN)-α, IL-8, and IFN-γ-induced protein 10 (IP-10) during the acute phase were associated with hyperinflammation, while IL-10 balanced inflammatory control and may have contributed to viral persistence.